View
Concise Results
Standard Results
Full Results
Chain B, Fanconi anemia group D2 protein homolog
Protein Classification
fanconi anemia group D2 protein ( domain architecture ID 11235073 )
fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing
List of domain hits
Name
Accession
Description
Interval
E-value
FancD2
pfam14631 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
1-1323
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2365.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1 SH NSH EVEENGSVFVKLLK AS G LT LKTGENQN QLG VDQVIFQ R KL F QALRKHP A YPKVIEEF VN GLESY T ED SESL RNCL 80
Cdd:pfam14631 1 SH AQN EVEENGSVFVKLLK TA G VI LKTGENQN EIA VDQVIFQ K KL Q QALRKHP S YPKVIEEF IT GLESY I ED RDTF RNCL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 81 L S C ER LQ D EEA - SM G T F Y SK SLIKLLLGI D ILQPAIIK M LFEK V P Q F L FES E N R DG I NM A RLIINQLKWLDRIVDGKDLT 159
Cdd:pfam14631 81 L P C VP LQ S EEA s SM V T S Y QE SLIKLLLGI E ILQPAIIK T LFEK L P E F M FES V N S DG L NM P RLIINQLKWLDRIVDGKDLT 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 160 AQM MQLISVAPV N LQHD F ITSLPEIL G DSQH AN V GK EL GE LLV Q NT S LTVPILD VF SSL R LDP NF LS KI RQ L VMG K LS S V 239
Cdd:pfam14631 161 SKL MQLISVAPV E LQHD I ITSLPEIL E DSQH ND V AR EL SS LLV E NT Q LTVPILD AL SSL N LDP TL LS EV RQ A VMG T LS A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 240 R LED F PV I VKF L LHSV TD T TSL EVI A ELR EN L NVQ Q FI LP SRI QASQSKLKSKG L ASSSGNQ EN S DK DCI V LVFDVIKSA 319
Cdd:pfam14631 241 Q LED L PV V VKF I LHSV SA T DAY EVI S ELR KK L DLE Q CV LP PVL QASQSKLKSKG A ASSSGNQ AS S SQ DCI S LVFDVIKSA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 320 I R YE KTISEAW F KAIE R I E S AAE HK S LD VV ML L IIYST STQT KKG V E KL LRNK IQ S D CIQEQLL D S A F S TH Y LVL K D IC P 399
Cdd:pfam14631 321 V R FQ KTISEAW L KAIE N I D S VSD HK V LD LL ML F IIYST NANQ KKG I E RV LRNK VR S G CIQEQLL Q S T F R TH A LVL R D YF P 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 400 SIL L LAQ T L F HS Q DQ R I IL FGS LL YKYAF KF FD T YCQQEVVGALVTHVCSG T EAEVD T AL DV LLEL I VL NA SAMRL N A A F 479
Cdd:pfam14631 401 SIL A LAQ S L L HS P DQ S I VS FGS HM YKYAF TA FD S YCQQEVVGALVTHVCSG N EAEVD V AL EL LLEL V VL KP SAMRL Y A V F 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 480 VKGILDY LE N MS PQQIRK I F C ILSTLAFSQQ PGT S N HIQDDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MA E DRS V p S 559
Cdd:pfam14631 481 VKGILDY MD N LT PQQIRK L F H ILSTLAFSQQ HEQ S S HIQDDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MA A DRS K - S 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 560 N SS QR SA NV S S EQ RT QVTSLL Q LVHSC T E H SP W A SS LYYDE F ANLIQ ER KL A PK T LEW V GQ TIF NDFQD A FVVD FCAAP E 639
Cdd:pfam14631 560 G SS SQ SA SL S K EQ CR QVTSLL E LVHSC S E Q SP Q A AA LYYDE L ANLIQ KG KL D PK V LEW I GQ SVL NDFQD D FVVD LGPDI E 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 640 GDFPFPVKALYGLEE YST Q D GI V INLLPL FY - Q E C AKD ASRA T S QE SS Q RSM S S LCL ASH FRLLRLCV AR QHDG N L D EID 718
Cdd:pfam14631 640 GDFPFPVKALYGLEE EES Q G GI A INLLPL LA k D E Q AKD EGEV T A QE KG Q KRV S P LCL SPF FRLLRLCV EK QHDG D L E EID 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 719 GLL D CPL F L P DLE P GEKLES M S A K D R SLM CSL T F L T F NWFREVVNAFCQQ TS PEMKGKVL S RL KDLV ELQ GI LEKYLAV I 798
Cdd:pfam14631 720 GLL G CPL I L T DLE V GEKLES L S K K E R EFL CSL L F H T I NWFREVVNAFCQQ KD PEMKGKVL T RL QNIT ELQ SL LEKYLAV T 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 799 P D YVPP F A SV DLD TL -------- DMMPR -------------- KT F VSLQ N YRAFFRELDIEVFS I LH S GL V TK FI LDTEM 856
Cdd:pfam14631 800 P G YVPP L A NF DLD SS qkeeasea EESQS eksqlekefkgkeg KT G VSLQ S YRAFFRELDIEVFS V LH C GL L TK SL LDTEM 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 857 HT E A T E V VQLGPAELLFLLEDLS Q KLE N MLT APF AKR ICCF K N KG RQ N I GFSHL H QRS V Q D I V HCVVQLL T P M CNHLENI 936
Cdd:pfam14631 880 HT K A R E E VQLGPAELLFLLEDLS R KLE F MLT PAP AKR APFL K G KG DR N V GFSHL Q QRS A Q E I A HCVVQLL P P L CNHLENI 959
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 937 HN F FQCL G AE HLSAD D KARATA QE QHT M AC CYQ K LLQVLH A LFAW K GF THQSKHR LL H SAL E VL SN RLK QM E QDQP LEEL 1016
Cdd:pfam14631 960 HN Y FQCL L AE NHGVV D GPGVDV QE HQL M SS CYQ L LLQVLH T LFAW S GF SQPENRS LL K SAL G VL AG RLK EG E AELT LEEL 1039
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1017 VS Q SF S YLQNF HH SVPSFQC G L Y L LR LL MALL EKS AV P NQ K K EK L ASLA K Q L LC RA W -- P H GEKEK NPT FND H LH DV L Y I 1094
Cdd:pfam14631 1040 VS H SF E YLQNF RS SVPSFQC A L C L IQ LL IVIA EKS GN P AA K R EK I ASLA R Q F LC QV W vt P S GEKEK GNK FND A LH TL L C I 1119
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1095 YLEHTD N VLKAIEEI T G V GVPEL VSAP KDA A SSTFPTLTR H TF VI FFRVMMAELEK T V KGL Q A GTA A DSQ Q V H EEKLLYW 1174
Cdd:pfam14631 1120 YLEHTD D VLKAIEEI A G E GVPEL INSS KDA S SSTFPTLTR Q TF LV FFRVMMAELEK S V RKI Q P GTA S DSQ E V Q EEKLLYW 1199
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1175 NMAVRDF S IL L NL M KVFDS Y PVLHVCLKYGR R FVEAFLK QC MPLLDFSF R KHREDV L SLL Q T L QL N TR L LHH L CGHSKI R 1254
Cdd:pfam14631 1200 NMAVRDF H IL V NL V KVFDS R PVLHVCLKYGR L FVEAFLK LG MPLLDFSF K KHREDV Q SLL K T F QL S TR Q LHH M CGHSKI H 1279
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S4W_B 1255 QDT R LT K HVPLLKKSLEL L V C RVKAMLVLNNC R EAFWLG T LKNRDLQGEEI I SQ D ps S S ES NA E DS ED G 1323
Cdd:pfam14631 1280 QDT G LT N HVPLLKKSLEL F V Y RVKAMLVLNNC Q EAFWLG N LKNRDLQGEEI L SQ R -- S Q ES DE E EE ED S 1346
Name
Accession
Description
Interval
E-value
FancD2
pfam14631 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
1-1323
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2365.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1 SH NSH EVEENGSVFVKLLK AS G LT LKTGENQN QLG VDQVIFQ R KL F QALRKHP A YPKVIEEF VN GLESY T ED SESL RNCL 80
Cdd:pfam14631 1 SH AQN EVEENGSVFVKLLK TA G VI LKTGENQN EIA VDQVIFQ K KL Q QALRKHP S YPKVIEEF IT GLESY I ED RDTF RNCL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 81 L S C ER LQ D EEA - SM G T F Y SK SLIKLLLGI D ILQPAIIK M LFEK V P Q F L FES E N R DG I NM A RLIINQLKWLDRIVDGKDLT 159
Cdd:pfam14631 81 L P C VP LQ S EEA s SM V T S Y QE SLIKLLLGI E ILQPAIIK T LFEK L P E F M FES V N S DG L NM P RLIINQLKWLDRIVDGKDLT 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 160 AQM MQLISVAPV N LQHD F ITSLPEIL G DSQH AN V GK EL GE LLV Q NT S LTVPILD VF SSL R LDP NF LS KI RQ L VMG K LS S V 239
Cdd:pfam14631 161 SKL MQLISVAPV E LQHD I ITSLPEIL E DSQH ND V AR EL SS LLV E NT Q LTVPILD AL SSL N LDP TL LS EV RQ A VMG T LS A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 240 R LED F PV I VKF L LHSV TD T TSL EVI A ELR EN L NVQ Q FI LP SRI QASQSKLKSKG L ASSSGNQ EN S DK DCI V LVFDVIKSA 319
Cdd:pfam14631 241 Q LED L PV V VKF I LHSV SA T DAY EVI S ELR KK L DLE Q CV LP PVL QASQSKLKSKG A ASSSGNQ AS S SQ DCI S LVFDVIKSA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 320 I R YE KTISEAW F KAIE R I E S AAE HK S LD VV ML L IIYST STQT KKG V E KL LRNK IQ S D CIQEQLL D S A F S TH Y LVL K D IC P 399
Cdd:pfam14631 321 V R FQ KTISEAW L KAIE N I D S VSD HK V LD LL ML F IIYST NANQ KKG I E RV LRNK VR S G CIQEQLL Q S T F R TH A LVL R D YF P 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 400 SIL L LAQ T L F HS Q DQ R I IL FGS LL YKYAF KF FD T YCQQEVVGALVTHVCSG T EAEVD T AL DV LLEL I VL NA SAMRL N A A F 479
Cdd:pfam14631 401 SIL A LAQ S L L HS P DQ S I VS FGS HM YKYAF TA FD S YCQQEVVGALVTHVCSG N EAEVD V AL EL LLEL V VL KP SAMRL Y A V F 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 480 VKGILDY LE N MS PQQIRK I F C ILSTLAFSQQ PGT S N HIQDDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MA E DRS V p S 559
Cdd:pfam14631 481 VKGILDY MD N LT PQQIRK L F H ILSTLAFSQQ HEQ S S HIQDDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MA A DRS K - S 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 560 N SS QR SA NV S S EQ RT QVTSLL Q LVHSC T E H SP W A SS LYYDE F ANLIQ ER KL A PK T LEW V GQ TIF NDFQD A FVVD FCAAP E 639
Cdd:pfam14631 560 G SS SQ SA SL S K EQ CR QVTSLL E LVHSC S E Q SP Q A AA LYYDE L ANLIQ KG KL D PK V LEW I GQ SVL NDFQD D FVVD LGPDI E 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 640 GDFPFPVKALYGLEE YST Q D GI V INLLPL FY - Q E C AKD ASRA T S QE SS Q RSM S S LCL ASH FRLLRLCV AR QHDG N L D EID 718
Cdd:pfam14631 640 GDFPFPVKALYGLEE EES Q G GI A INLLPL LA k D E Q AKD EGEV T A QE KG Q KRV S P LCL SPF FRLLRLCV EK QHDG D L E EID 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 719 GLL D CPL F L P DLE P GEKLES M S A K D R SLM CSL T F L T F NWFREVVNAFCQQ TS PEMKGKVL S RL KDLV ELQ GI LEKYLAV I 798
Cdd:pfam14631 720 GLL G CPL I L T DLE V GEKLES L S K K E R EFL CSL L F H T I NWFREVVNAFCQQ KD PEMKGKVL T RL QNIT ELQ SL LEKYLAV T 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 799 P D YVPP F A SV DLD TL -------- DMMPR -------------- KT F VSLQ N YRAFFRELDIEVFS I LH S GL V TK FI LDTEM 856
Cdd:pfam14631 800 P G YVPP L A NF DLD SS qkeeasea EESQS eksqlekefkgkeg KT G VSLQ S YRAFFRELDIEVFS V LH C GL L TK SL LDTEM 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 857 HT E A T E V VQLGPAELLFLLEDLS Q KLE N MLT APF AKR ICCF K N KG RQ N I GFSHL H QRS V Q D I V HCVVQLL T P M CNHLENI 936
Cdd:pfam14631 880 HT K A R E E VQLGPAELLFLLEDLS R KLE F MLT PAP AKR APFL K G KG DR N V GFSHL Q QRS A Q E I A HCVVQLL P P L CNHLENI 959
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 937 HN F FQCL G AE HLSAD D KARATA QE QHT M AC CYQ K LLQVLH A LFAW K GF THQSKHR LL H SAL E VL SN RLK QM E QDQP LEEL 1016
Cdd:pfam14631 960 HN Y FQCL L AE NHGVV D GPGVDV QE HQL M SS CYQ L LLQVLH T LFAW S GF SQPENRS LL K SAL G VL AG RLK EG E AELT LEEL 1039
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1017 VS Q SF S YLQNF HH SVPSFQC G L Y L LR LL MALL EKS AV P NQ K K EK L ASLA K Q L LC RA W -- P H GEKEK NPT FND H LH DV L Y I 1094
Cdd:pfam14631 1040 VS H SF E YLQNF RS SVPSFQC A L C L IQ LL IVIA EKS GN P AA K R EK I ASLA R Q F LC QV W vt P S GEKEK GNK FND A LH TL L C I 1119
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1095 YLEHTD N VLKAIEEI T G V GVPEL VSAP KDA A SSTFPTLTR H TF VI FFRVMMAELEK T V KGL Q A GTA A DSQ Q V H EEKLLYW 1174
Cdd:pfam14631 1120 YLEHTD D VLKAIEEI A G E GVPEL INSS KDA S SSTFPTLTR Q TF LV FFRVMMAELEK S V RKI Q P GTA S DSQ E V Q EEKLLYW 1199
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1175 NMAVRDF S IL L NL M KVFDS Y PVLHVCLKYGR R FVEAFLK QC MPLLDFSF R KHREDV L SLL Q T L QL N TR L LHH L CGHSKI R 1254
Cdd:pfam14631 1200 NMAVRDF H IL V NL V KVFDS R PVLHVCLKYGR L FVEAFLK LG MPLLDFSF K KHREDV Q SLL K T F QL S TR Q LHH M CGHSKI H 1279
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S4W_B 1255 QDT R LT K HVPLLKKSLEL L V C RVKAMLVLNNC R EAFWLG T LKNRDLQGEEI I SQ D ps S S ES NA E DS ED G 1323
Cdd:pfam14631 1280 QDT G LT N HVPLLKKSLEL F V Y RVKAMLVLNNC Q EAFWLG N LKNRDLQGEEI L SQ R -- S Q ES DE E EE ED S 1346
FANCD2
cd11721 Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
56-1308
0e+00
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.
Pssm-ID: 212595
Cd Length: 1161
Bit Score: 1397.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 56 P KVIE EF VN GLE SYTE D SES LR NC LL S C ER L QD E EA S MGTFYSK SLI K LLL GI D I LQP AI I KM L F EK V P Q FL F E SEN - RD 134
Cdd:cd11721 1 P ENVD EF LS GLE DFLA D RDR LR KA LL P C NL L TT E SS S ASSVPQD SLI R LLL QV D P LQP KV I EL L L EK L P E FL D E DAS v PS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 135 GI N MA RLI I NQ L KWLD R IVD GK DLT AQMMQ L I SVAP VN LQ HDF ITSLPEI L GDSQH AN V GK EL GE LL VQ N TS LTVPILD V 214
Cdd:cd11721 81 ED N LP RLI L NQ F KWLD H IVD SE DLT EKLLE L L SVAP SE LQ KEI ITSLPEI I GDSQH ED V AE EL CK LL QE N SE LTVPILD A 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 215 F S S L R L D P NF LS K IR QL V MGK L SS V R LED F PV I VKFLL H S V T D T TS LE V I AE LR E NL NVQQFIL PS RI qasqsklkskgl 294
Cdd:cd11721 161 L S N L N L S P EL LS E IR EK V LSC L KT V P LED L PV L VKFLL Q S I T A T EA LE I I SK LR K NL DFSPLSD PS SS ------------ 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 295 a S SS GNQEN S DKD C IV L VFDV IKSA I R YE K TIS EAW F K A I ER I ESAAE HK SL D VVM LLI I YST STQTK K GV E K LL RN KI Q 374
Cdd:cd11721 229 - G SS DKSKA S ANS C QS L ILEA IKSA L R FS K LLA EAW I K V I SS I DAPQD HK VI D LIL LLI L YST NEDKR K SI E S LL KK KI K 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 375 S DC I QEQ LLD S AF ST H YL VLKD ICP S I L L LA QT L FH S QDQRIIL FGS L LYK YA FK F FD T Y C QQEVVGAL V TH VC SG TEA E 454
Cdd:cd11721 308 S GF I RTS LLD L AF TG H SQ VLKD YFK S L L S LA DN L LR S AEPVVRE FGS H LYK LL FK H FD R Y Y QQEVVGAL I TH IG SG NSS E 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 455 VD T ALDVL L EL IVL N ASAMRLN A A F V KGILDYL ENMSPQ QIR KI F C IL ST LAFS QQ P - GTSNH IQDD M H LVI RKQLS STV 533
Cdd:cd11721 388 VD A ALDVL R EL AEK N PDELLPY A T F I KGILDYL DSLNLK QIR QL F D IL CH LAFS ER P l SEGSS IQDD L H IIV RKQLS NSS 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 534 F KYK LI GIIGAVT MAGIM A EDR S VPSN --- SS QRSANVSS E QRT Q VTS LL Q LV H S CTEH SP W A SS L Y YDE F AN L I - Q ERK 609
Cdd:cd11721 468 P KYK RM GIIGAVT LVKHL A SAN S SDDA ver SS SNGSSLPD E RLK Q AAN LL E LV L S SCKN SP E A LA L F YDE L AN I I s Q ASN 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 610 L A PK T LEW V G Q TI FN DFQ DA FVVD FC aapegdfpfpvkalygleeystqdgivinllplfyqecakdasratsqessqr S 689
Cdd:cd11721 548 L D PK F LEW L G E TI TE DFQ ES FVVD LD ----------------------------------------------------- E 574
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 690 M SS LC LAS H FRLLRL CVAR Q HD G N LDEID G LL D CPL F LPD L E PG EK LE S M S AKD RS LMCSLT F LTF NWFREV V NAF CQ Q T 769
Cdd:cd11721 575 T SS AI LAS L FRLLRL LERS Q QG G S LDEID A LL G CPL V LPD F E VD EK FD S L S TEQ RS VVLDCL F YAI NWFREV I NAF AT Q K 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 770 SPEM K G KVL S RL KD L V EL Q G I L E K Y LA V ipdyvppfasvdldtldmmprktfvslqnyr AF FRELD I EVFS I L H SGLVT K 849
Cdd:cd11721 655 DAST K K KVL K RL RN L I EL E G R L S K L LA H ------------------------------- CY FRELD L EVFS L L K SGLVT D 703
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 850 FI L dtem HTEAT E V V Q LGP A EL L FLLEDL SQ KLE NM LT A P FA KR I c CFKNKGRQNI GFS H L H Q R S VQDIVHCV V Q LL TPM 929
Cdd:cd11721 704 TS L ---- ELSEE E G V H LGP K EL R FLLEDL NR KLE HV LT S P KK KR M - PLLKPLKKGQ GFS S L S Q K S PKEVLKAL V P LL PHL 778
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 930 C N HLE N IHN FF Q C L GAEHLSAD D KARATA QE QHTMAC CY QK LLQ V L HA LFAW K GF TH QS KHR LL H SAL EVLSN RLK - QME 1008
Cdd:cd11721 779 C K HLE K IHN YL Q N L LLSNAGQL D APGPFV QE NQYAKS CY GL LLQ C L RL LFAW P GF SS QS NRV LL K SAL RAIAS RLK e STG 858
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1009 Q D Q PL E ELVS QS F S YL QN F HH SVPS FQCGLY L LR LL M AL L EKS AVPN Q KK EKLA S LA KQL LCR A WP H -- GE K EK NPTF ND 1086
Cdd:cd11721 859 K D L PL K ELVS SL F K YL KS F EP SVPS LSTAVS L VQ LL Q AL M EKS PDRP Q LR EKLA D LA RNF LCR Q WP D ls GE S EK GQKY ND 938
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1087 HLHDV L Y IYLEH T D NV LK AI EEI T G VGV PEL VSAP KD - A A SS TFPTL TRH TF V IFFRV M M AE L EKT VK GLQAG t AAD SQQ 1165
Cdd:cd11721 939 LIDTL L R IYLEH S D DP LK KL EEI A G EAL PEL LEKK KD k D A LE TFPTL SKS TF P IFFRV L M EA L IES VK KILSS - AAD TGG 1017
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1166 VHE E K LL Y W NM AVR D F SI L L NL M K V FD SY PVL HV CLKYGR R F VEA FLK QC MPLL DFS F RK H R E D V LS LL Q TLQ LN TR L LH 1245
Cdd:cd11721 1018 GEM E R LL L W QS AVR V F KA L V NL V K T FD KR PVL AI CLKYGR L F LKL FLK LG MPLL EKL F KN H K E E V QE LL K TLQ QS TR Y LH 1097
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|...
3S4W_B 1246 H L C G HSKI RQ DT R LT K HVP L LKKSLE L LV C RVKAMLV L NNC R EAFW L G T LKN R DLQGEEI I SQ 1308
Cdd:cd11721 1098 H I C C HSKI HK DT A LT N HVP A LKKSLE T LV Y RVKAMLV A NNC S EAFW M G N LKN K DLQGEEI L SQ 1160
Name
Accession
Description
Interval
E-value
FancD2
pfam14631 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
1-1323
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2365.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1 SH NSH EVEENGSVFVKLLK AS G LT LKTGENQN QLG VDQVIFQ R KL F QALRKHP A YPKVIEEF VN GLESY T ED SESL RNCL 80
Cdd:pfam14631 1 SH AQN EVEENGSVFVKLLK TA G VI LKTGENQN EIA VDQVIFQ K KL Q QALRKHP S YPKVIEEF IT GLESY I ED RDTF RNCL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 81 L S C ER LQ D EEA - SM G T F Y SK SLIKLLLGI D ILQPAIIK M LFEK V P Q F L FES E N R DG I NM A RLIINQLKWLDRIVDGKDLT 159
Cdd:pfam14631 81 L P C VP LQ S EEA s SM V T S Y QE SLIKLLLGI E ILQPAIIK T LFEK L P E F M FES V N S DG L NM P RLIINQLKWLDRIVDGKDLT 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 160 AQM MQLISVAPV N LQHD F ITSLPEIL G DSQH AN V GK EL GE LLV Q NT S LTVPILD VF SSL R LDP NF LS KI RQ L VMG K LS S V 239
Cdd:pfam14631 161 SKL MQLISVAPV E LQHD I ITSLPEIL E DSQH ND V AR EL SS LLV E NT Q LTVPILD AL SSL N LDP TL LS EV RQ A VMG T LS A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 240 R LED F PV I VKF L LHSV TD T TSL EVI A ELR EN L NVQ Q FI LP SRI QASQSKLKSKG L ASSSGNQ EN S DK DCI V LVFDVIKSA 319
Cdd:pfam14631 241 Q LED L PV V VKF I LHSV SA T DAY EVI S ELR KK L DLE Q CV LP PVL QASQSKLKSKG A ASSSGNQ AS S SQ DCI S LVFDVIKSA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 320 I R YE KTISEAW F KAIE R I E S AAE HK S LD VV ML L IIYST STQT KKG V E KL LRNK IQ S D CIQEQLL D S A F S TH Y LVL K D IC P 399
Cdd:pfam14631 321 V R FQ KTISEAW L KAIE N I D S VSD HK V LD LL ML F IIYST NANQ KKG I E RV LRNK VR S G CIQEQLL Q S T F R TH A LVL R D YF P 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 400 SIL L LAQ T L F HS Q DQ R I IL FGS LL YKYAF KF FD T YCQQEVVGALVTHVCSG T EAEVD T AL DV LLEL I VL NA SAMRL N A A F 479
Cdd:pfam14631 401 SIL A LAQ S L L HS P DQ S I VS FGS HM YKYAF TA FD S YCQQEVVGALVTHVCSG N EAEVD V AL EL LLEL V VL KP SAMRL Y A V F 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 480 VKGILDY LE N MS PQQIRK I F C ILSTLAFSQQ PGT S N HIQDDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MA E DRS V p S 559
Cdd:pfam14631 481 VKGILDY MD N LT PQQIRK L F H ILSTLAFSQQ HEQ S S HIQDDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MA A DRS K - S 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 560 N SS QR SA NV S S EQ RT QVTSLL Q LVHSC T E H SP W A SS LYYDE F ANLIQ ER KL A PK T LEW V GQ TIF NDFQD A FVVD FCAAP E 639
Cdd:pfam14631 560 G SS SQ SA SL S K EQ CR QVTSLL E LVHSC S E Q SP Q A AA LYYDE L ANLIQ KG KL D PK V LEW I GQ SVL NDFQD D FVVD LGPDI E 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 640 GDFPFPVKALYGLEE YST Q D GI V INLLPL FY - Q E C AKD ASRA T S QE SS Q RSM S S LCL ASH FRLLRLCV AR QHDG N L D EID 718
Cdd:pfam14631 640 GDFPFPVKALYGLEE EES Q G GI A INLLPL LA k D E Q AKD EGEV T A QE KG Q KRV S P LCL SPF FRLLRLCV EK QHDG D L E EID 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 719 GLL D CPL F L P DLE P GEKLES M S A K D R SLM CSL T F L T F NWFREVVNAFCQQ TS PEMKGKVL S RL KDLV ELQ GI LEKYLAV I 798
Cdd:pfam14631 720 GLL G CPL I L T DLE V GEKLES L S K K E R EFL CSL L F H T I NWFREVVNAFCQQ KD PEMKGKVL T RL QNIT ELQ SL LEKYLAV T 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 799 P D YVPP F A SV DLD TL -------- DMMPR -------------- KT F VSLQ N YRAFFRELDIEVFS I LH S GL V TK FI LDTEM 856
Cdd:pfam14631 800 P G YVPP L A NF DLD SS qkeeasea EESQS eksqlekefkgkeg KT G VSLQ S YRAFFRELDIEVFS V LH C GL L TK SL LDTEM 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 857 HT E A T E V VQLGPAELLFLLEDLS Q KLE N MLT APF AKR ICCF K N KG RQ N I GFSHL H QRS V Q D I V HCVVQLL T P M CNHLENI 936
Cdd:pfam14631 880 HT K A R E E VQLGPAELLFLLEDLS R KLE F MLT PAP AKR APFL K G KG DR N V GFSHL Q QRS A Q E I A HCVVQLL P P L CNHLENI 959
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 937 HN F FQCL G AE HLSAD D KARATA QE QHT M AC CYQ K LLQVLH A LFAW K GF THQSKHR LL H SAL E VL SN RLK QM E QDQP LEEL 1016
Cdd:pfam14631 960 HN Y FQCL L AE NHGVV D GPGVDV QE HQL M SS CYQ L LLQVLH T LFAW S GF SQPENRS LL K SAL G VL AG RLK EG E AELT LEEL 1039
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1017 VS Q SF S YLQNF HH SVPSFQC G L Y L LR LL MALL EKS AV P NQ K K EK L ASLA K Q L LC RA W -- P H GEKEK NPT FND H LH DV L Y I 1094
Cdd:pfam14631 1040 VS H SF E YLQNF RS SVPSFQC A L C L IQ LL IVIA EKS GN P AA K R EK I ASLA R Q F LC QV W vt P S GEKEK GNK FND A LH TL L C I 1119
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1095 YLEHTD N VLKAIEEI T G V GVPEL VSAP KDA A SSTFPTLTR H TF VI FFRVMMAELEK T V KGL Q A GTA A DSQ Q V H EEKLLYW 1174
Cdd:pfam14631 1120 YLEHTD D VLKAIEEI A G E GVPEL INSS KDA S SSTFPTLTR Q TF LV FFRVMMAELEK S V RKI Q P GTA S DSQ E V Q EEKLLYW 1199
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1175 NMAVRDF S IL L NL M KVFDS Y PVLHVCLKYGR R FVEAFLK QC MPLLDFSF R KHREDV L SLL Q T L QL N TR L LHH L CGHSKI R 1254
Cdd:pfam14631 1200 NMAVRDF H IL V NL V KVFDS R PVLHVCLKYGR L FVEAFLK LG MPLLDFSF K KHREDV Q SLL K T F QL S TR Q LHH M CGHSKI H 1279
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S4W_B 1255 QDT R LT K HVPLLKKSLEL L V C RVKAMLVLNNC R EAFWLG T LKNRDLQGEEI I SQ D ps S S ES NA E DS ED G 1323
Cdd:pfam14631 1280 QDT G LT N HVPLLKKSLEL F V Y RVKAMLVLNNC Q EAFWLG N LKNRDLQGEEI L SQ R -- S Q ES DE E EE ED S 1346
FANCD2
cd11721 Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
56-1308
0e+00
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.
Pssm-ID: 212595
Cd Length: 1161
Bit Score: 1397.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 56 P KVIE EF VN GLE SYTE D SES LR NC LL S C ER L QD E EA S MGTFYSK SLI K LLL GI D I LQP AI I KM L F EK V P Q FL F E SEN - RD 134
Cdd:cd11721 1 P ENVD EF LS GLE DFLA D RDR LR KA LL P C NL L TT E SS S ASSVPQD SLI R LLL QV D P LQP KV I EL L L EK L P E FL D E DAS v PS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 135 GI N MA RLI I NQ L KWLD R IVD GK DLT AQMMQ L I SVAP VN LQ HDF ITSLPEI L GDSQH AN V GK EL GE LL VQ N TS LTVPILD V 214
Cdd:cd11721 81 ED N LP RLI L NQ F KWLD H IVD SE DLT EKLLE L L SVAP SE LQ KEI ITSLPEI I GDSQH ED V AE EL CK LL QE N SE LTVPILD A 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 215 F S S L R L D P NF LS K IR QL V MGK L SS V R LED F PV I VKFLL H S V T D T TS LE V I AE LR E NL NVQQFIL PS RI qasqsklkskgl 294
Cdd:cd11721 161 L S N L N L S P EL LS E IR EK V LSC L KT V P LED L PV L VKFLL Q S I T A T EA LE I I SK LR K NL DFSPLSD PS SS ------------ 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 295 a S SS GNQEN S DKD C IV L VFDV IKSA I R YE K TIS EAW F K A I ER I ESAAE HK SL D VVM LLI I YST STQTK K GV E K LL RN KI Q 374
Cdd:cd11721 229 - G SS DKSKA S ANS C QS L ILEA IKSA L R FS K LLA EAW I K V I SS I DAPQD HK VI D LIL LLI L YST NEDKR K SI E S LL KK KI K 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 375 S DC I QEQ LLD S AF ST H YL VLKD ICP S I L L LA QT L FH S QDQRIIL FGS L LYK YA FK F FD T Y C QQEVVGAL V TH VC SG TEA E 454
Cdd:cd11721 308 S GF I RTS LLD L AF TG H SQ VLKD YFK S L L S LA DN L LR S AEPVVRE FGS H LYK LL FK H FD R Y Y QQEVVGAL I TH IG SG NSS E 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 455 VD T ALDVL L EL IVL N ASAMRLN A A F V KGILDYL ENMSPQ QIR KI F C IL ST LAFS QQ P - GTSNH IQDD M H LVI RKQLS STV 533
Cdd:cd11721 388 VD A ALDVL R EL AEK N PDELLPY A T F I KGILDYL DSLNLK QIR QL F D IL CH LAFS ER P l SEGSS IQDD L H IIV RKQLS NSS 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 534 F KYK LI GIIGAVT MAGIM A EDR S VPSN --- SS QRSANVSS E QRT Q VTS LL Q LV H S CTEH SP W A SS L Y YDE F AN L I - Q ERK 609
Cdd:cd11721 468 P KYK RM GIIGAVT LVKHL A SAN S SDDA ver SS SNGSSLPD E RLK Q AAN LL E LV L S SCKN SP E A LA L F YDE L AN I I s Q ASN 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 610 L A PK T LEW V G Q TI FN DFQ DA FVVD FC aapegdfpfpvkalygleeystqdgivinllplfyqecakdasratsqessqr S 689
Cdd:cd11721 548 L D PK F LEW L G E TI TE DFQ ES FVVD LD ----------------------------------------------------- E 574
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 690 M SS LC LAS H FRLLRL CVAR Q HD G N LDEID G LL D CPL F LPD L E PG EK LE S M S AKD RS LMCSLT F LTF NWFREV V NAF CQ Q T 769
Cdd:cd11721 575 T SS AI LAS L FRLLRL LERS Q QG G S LDEID A LL G CPL V LPD F E VD EK FD S L S TEQ RS VVLDCL F YAI NWFREV I NAF AT Q K 654
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 770 SPEM K G KVL S RL KD L V EL Q G I L E K Y LA V ipdyvppfasvdldtldmmprktfvslqnyr AF FRELD I EVFS I L H SGLVT K 849
Cdd:cd11721 655 DAST K K KVL K RL RN L I EL E G R L S K L LA H ------------------------------- CY FRELD L EVFS L L K SGLVT D 703
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 850 FI L dtem HTEAT E V V Q LGP A EL L FLLEDL SQ KLE NM LT A P FA KR I c CFKNKGRQNI GFS H L H Q R S VQDIVHCV V Q LL TPM 929
Cdd:cd11721 704 TS L ---- ELSEE E G V H LGP K EL R FLLEDL NR KLE HV LT S P KK KR M - PLLKPLKKGQ GFS S L S Q K S PKEVLKAL V P LL PHL 778
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 930 C N HLE N IHN FF Q C L GAEHLSAD D KARATA QE QHTMAC CY QK LLQ V L HA LFAW K GF TH QS KHR LL H SAL EVLSN RLK - QME 1008
Cdd:cd11721 779 C K HLE K IHN YL Q N L LLSNAGQL D APGPFV QE NQYAKS CY GL LLQ C L RL LFAW P GF SS QS NRV LL K SAL RAIAS RLK e STG 858
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1009 Q D Q PL E ELVS QS F S YL QN F HH SVPS FQCGLY L LR LL M AL L EKS AVPN Q KK EKLA S LA KQL LCR A WP H -- GE K EK NPTF ND 1086
Cdd:cd11721 859 K D L PL K ELVS SL F K YL KS F EP SVPS LSTAVS L VQ LL Q AL M EKS PDRP Q LR EKLA D LA RNF LCR Q WP D ls GE S EK GQKY ND 938
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1087 HLHDV L Y IYLEH T D NV LK AI EEI T G VGV PEL VSAP KD - A A SS TFPTL TRH TF V IFFRV M M AE L EKT VK GLQAG t AAD SQQ 1165
Cdd:cd11721 939 LIDTL L R IYLEH S D DP LK KL EEI A G EAL PEL LEKK KD k D A LE TFPTL SKS TF P IFFRV L M EA L IES VK KILSS - AAD TGG 1017
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1166 VHE E K LL Y W NM AVR D F SI L L NL M K V FD SY PVL HV CLKYGR R F VEA FLK QC MPLL DFS F RK H R E D V LS LL Q TLQ LN TR L LH 1245
Cdd:cd11721 1018 GEM E R LL L W QS AVR V F KA L V NL V K T FD KR PVL AI CLKYGR L F LKL FLK LG MPLL EKL F KN H K E E V QE LL K TLQ QS TR Y LH 1097
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|...
3S4W_B 1246 H L C G HSKI RQ DT R LT K HVP L LKKSLE L LV C RVKAMLV L NNC R EAFW L G T LKN R DLQGEEI I SQ 1308
Cdd:cd11721 1098 H I C C HSKI HK DT A LT N HVP A LKKSLE T LV Y RVKAMLV A NNC S EAFW M G N LKN K DLQGEEI L SQ 1160
FANC
cd11719 Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
96-1186
0e+00
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.
Pssm-ID: 212593
Cd Length: 977
Bit Score: 1369.23
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 96 FYSKS L IKLL L GID ---- ILQPAIIKMLFEKVP Q FLFESENR - D GINMARLIINQLKWLDRIVDGK DL TAQMMQLISVAP 170
Cdd:cd11719 1 RAVGT L LRAV L KGS pcse EDGALRRYKIYSCCI Q LVESGDLQ q D VASEIIGLLMLEVHHFPGPLLV DL ASDFVGAVREDR 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 171 VNLQHDFITSLPEILG ----------------- DSQHANVGKE L GELL v QNTSLTVPILD VF SSLR L D P NFLSKIRQL V M 233
Cdd:cd11719 81 LVNGKSLELLPIILTA latkkevlacgkgdlng EEYKRQLIDT L CSVR - WPQRYMIQLTS VF KDVC L T P EEMNLVVAK V L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 234 GKL S SVR L EDF P VI V KF LL HS --- VTDTTS L EV I AELREN L NV Q QFILP S RIQA sqsklkskgl ASSSGNQENSDKDCIV 310
Cdd:cd11719 160 TMF S KLN L QEI P PL V YQ LL VL ssk GSRRSV L DG I IAFFRE L DK Q HREEQ S SDEL ---------- SELITAPADELYHVEG 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 311 L V FDV I KS AI RYE - KTIS E AWFKAIERIESA -- AEHKSLDVVM LL IIYSTSTQTKKGVEK L LRNKIQ S DC ---------- 377
Cdd:cd11719 230 T V ILH I VF AI KLD c ELGR E LLKHLKAGQQGD ps KCLCPFSIAL LL SLTRIQRFEEQVFDL L KTSVVK S FK dlqllqgskf 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 378 --------- IQEQLLDSAFSTHYLVLKDICPSILLLAQT L FH S --------------------- QD Q RIILF G SLLYKYA 427
Cdd:cd11719 310 lqtlvpqrt CVSTMILEVVRNSVHSWDHVTQGLIEFGFI L MD S ygpkkildgkaveigtslskm TN Q HACKL G ANILLET 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 428 FK f FDTYCQ QE VVGALVTH V CSG T EAEVDTA LD VLLEL I VLNASA m RL N AAF V KGIL DYL ENMSP Q QIRKIFCILST L AF 507
Cdd:cd11719 390 FK - IHEMIR QE ILEQVLNR V VTR T SSPINHF LD LFSDI I MYAPLI - LQ N CSK V TETF DYL TFLPL Q TVQGLLKAVQP L LK 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 508 SQ qpgts NHIQ D DMH LV I RK QLSSTVFKYKLIGII G AVTMAGIMAEDR S V PS NS ------------ SQR S ANVSSEQR T Q 575
Cdd:cd11719 468 IS ----- MSMR D SLI LV L RK AMFASQLDARKSAVA G FLLLLKNFKVLG S L PS SQ ctqsigvtqvrv DVH S RYSAVANE T F 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 576 VTSLLQLVHSCTEHSPWASSLY YD efanliq ERKLAPKTLEWVGQT I FNDFQDAFVVDFCAA P EGDF P FPV kalygleey 655
Cdd:cd11719 543 CLEIIDSLKRSLGQQADIRLML YD ------- GFYDVLRRNSQLASS I MQTLFSQLKQFYEPE P DLLP P LKL --------- 606
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 656 stqdgivinllplfyqecakdas R A TSQESSQRSMSSLC L ASHFRLLRL C V A RQ hdgnldeidglldcplflpdlepgek 735
Cdd:cd11719 607 ----------------------- G A CVLTQGSQIFLQEP L DHLLSCIQH C L A WY -------------------------- 637
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 736 lesmsakdrslmcsltfl TFNWFREVVNAFCQQT S PE ----- MKGKV LS RLKDLVELQG I lekylavipdyvppfasvdl 810
Cdd:cd11719 638 ------------------ ACLIMGVCEVLMEYNF S IS nfsks KFEEI LS LFTCYKKFSD I -------------------- 679
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 811 dtldmmprktfvslqnyraffrel DIEVFSILHSG L VTKFILDT --- E MHTEATEVVQLGPAE L LF L LEDL S QK L EN mlt 887
Cdd:cd11719 680 ------------------------ IFQNLCDITRV L LWRYTSIP tsv E ESGKKEKGKSISLLC L EG L QKTF S VV L QF --- 732
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 888 apfakriccfknkgrqnigfshlhqrsvqd IVHC V V Q L L ----------------- T PMCNHLENIHNFFQCLGAE hlsa 950
Cdd:cd11719 733 ------------------------------ YQPK V Q Q F L qaldvmgteeeeagvtv T QRASFQIRQFQRSLLNLLS ---- 778
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 951 ddk ARATAQEQHTMACCYQK L LQVLHA L FA wkgfthqskhrllhsalevlsnrlkqmeqdqpleel V S QS F SYLQNFHH - 1029
Cdd:cd11719 779 --- SEEDDFNSKEALLLIAV L STLSRL L EP ------------------------------------ T S PQ F VQMLSWTS k 819
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1030 --------- SVPSFQCGLYLLR L LMALLE ksavpnqkkekl ASLAKQL L CRAWPHGEK ----------------- EKNPT 1083
Cdd:cd11719 820 ickeysqed ASFCKSLMNLFFS L HVLYKS ------------ PVTLLRD L SQDIHGQLG didqdveiektdhfavv NLRTA 887
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S4W_B 1084 FNDHLHD VL YIYLE ht DNV L KAIEEITGVG V PE lvsapkdaas STFPTLTRH T FVIFFRVMMAE L EKT VK GLQAGT a AD S 1163
Cdd:cd11719 888 APTVCLL VL SQAEK -- VMQ L GTLVTFFHEL V QT ---------- ALPSGSCVD T LLKGLSKIYST L TAF VK YYLQVC - QS S 954
1210 1220
....*....|....*....|...
3S4W_B 1164 QQVHEEKLLYWNMAVRDFSILLN 1186
Cdd:cd11719 955 RGIPNTVEKLVKLSGSHLTPVCY 977
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
