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Conserved domains on  [gi|158512807|sp|A2RRD8|]
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RecName: Full=Zinc finger protein 320

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017008)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 158512807    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048  128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048  208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        410
                 ....*....|....
gi 158512807 470 KCHQCGKVFSLRSL 483
Cdd:COG5048  448 LCSILKSFRRDLDL 461
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189  234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189  302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 158512807 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189  371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 158512807    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 8.34e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 8.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 158512807     8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 5.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 5.31e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 158512807   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048  128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048  208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        410
                 ....*....|....
gi 158512807 470 KCHQCGKVFSLRSL 483
Cdd:COG5048  448 LCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189  234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189  302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 158512807 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189  371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 1.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 158512807  343 HLERHRRIHTGEKPYKCKVCDKAFRS 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 2.49e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 2.49e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 158512807    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 8.34e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 8.34e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 158512807     8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 5.31e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 5.31e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 158512807   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-483 6.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 147 HLRRHRRIHTGEKPYKC--EECEKVFSCKSHLEIHRIIHTGEKPYKCK-----------------------VCDKAFKHD 201
Cdd:COG5048   48 HLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsnDNNLLSSHS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 202 SHLAKHTRIH---------RGDKHYTCNECGKVFDQKA-------------------TLACHHRSHTGEKPYKCNECGKT 253
Cdd:COG5048  128 LPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSS 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 254 FSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGE------- 326
Cdd:COG5048  208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfs 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 327 KPYRCEECDKVFSRKSHLERHRR--IHTGE--KPYKCKV--CDKAFRSDSRLAEHQRVHTGERPYTC--NECGKVFSTKA 398
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 399 Y-----LACHQKLHTGEKLYECE--ECDKVYIRKSHLERHRRIHTGEKPH--KCGDCGKAFNSPSHLIRHQRIHTGQKSY 469
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        410
                 ....*....|....
gi 158512807 470 KCHQCGKVFSLRSL 483
Cdd:COG5048  448 LCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 25-216 8.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807  25 LDPAQRTLYRDVMLENyRNLVSLDISSKC---MMNTLSSTGQGNTEVIHTGTLqrqasyhigAFCSQEIEKDIHDFvfQW 101
Cdd:COG5189  234 IDIGHMMDTHQFYLED-VDLMDDDILGPSneeMLYKYISPSQGSAELFEESSL---------GFDYEFIHKSVGNK--EI 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 102 QEDETNDHeapMTEIKKLTSSTDRYDQRHAGNKPIKGQLESRfhlhlrrhRRIHTGEKPYKCE--ECEKVFSCKSHLEIH 179
Cdd:COG5189  302 RGGISTGE---MIDVRKLPCTNSSSNGKLAHGGERNIDTPSR--------MLKVKDGKPYKCPveGCNKKYKNQNGLKYH 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 158512807 180 R-------------------IIHTGEKPYKCKVCDKAFKHDSHLakhtRIHRGDKH 216
Cdd:COG5189  371 MlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGL----KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 1.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 158512807  343 HLERHRRIHTGEKPYKCKVCDKAFRS 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 185-263 1.87e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 185 GEKPYKCKV--CDKAFKHDSHLAKHTrihrgdKHYTCNecgkvfdQKATLACHHRSHTG----EKPYKCNECGKTFSQTS 258
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHM------LHGHQN-------QKLHENPSPEKMNIfsakDKPYRCEVCDKRYKNLN 412


                 ....*
gi 158512807 259 HLVYH 263
Cdd:COG5189  413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-172 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 158512807  147 HLRRHRRIHTGEKPYKCEECEKVFSC 172
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
243-509 2.94e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 243 KPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCN--ECGKTFARNSVLVIH---------------------KAVHTAE- 298
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHlrthhnnpsdlnskslplsnsKASSSSLs 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 299 -------KPYKCNECGKVFKQRATLAGHRRVHTGEKPYRCEEC----------------------DKVFSRKSHLERHRR 349
Cdd:COG5048  112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 350 IHTGEKPYKCKVCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLA------CHQKLHTGEKLYECEECDKVYI 423
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 424 RKSHLERHRRIHTG-EKPHKCGDCGKAFNSPSHLIRHQR--IHTGQ--KSYKC--HQCGKVFSLRSLLAEHQKIPFGDNC 496
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|...
gi 158512807 497 FKCNEYSKPSSIN 509
Cdd:COG5048  352 AKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-452 4.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 158512807  427 HLERHRRIHTGEKPHKCGDCGKAFNS 452
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-200 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 158512807  175 HLEIHRIIHTGEKPYKCKVCDKAFKH 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 348-432 1.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 348 RRIHT-GEKPYKCKV--CDKAFRSDSRLAEHqRVHTGERPYTCNECGKVfstkaylaCHQKLHTGEKLYECEECDKVYIR 424
Cdd:COG5189  340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*...
gi 158512807 425 KSHLERHR 432
Cdd:COG5189  411 LNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 329-351 1.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|...
gi 158512807  329 YRCEECDKVFSRKSHLERHRRIH 351
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 318-380 3.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158512807 318 GHRRVHTGEKPYRCE--ECDKVFSRKSHLERHRR-------------------IHTGEKPYKCKVCDKAFRSDSRLAEHq 376
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                 ....
gi 158512807 377 RVHT 380
Cdd:COG5189  418 RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 158512807  259 HLVYHHRLHTGEKPYKCNECGKTFAR 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-479 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*
gi 158512807  455 HLIRHQRIHTGQKSYKCHQCGKVFS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 9.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.57e-03
                          10        20
                  ....*....|....*....|...
gi 158512807  441 HKCGDCGKAFNSPSHLIRHQRIH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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