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Conserved domains on  [gi|206285|gb|AAA41903|]
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preproopiomelanocortin [Rattus norvegicus]

Protein Classification

NPP and Op_neuropeptide domain-containing protein( domain architecture ID 10551814)

protein containing domains NPP, ACTH_domain, and Op_neuropeptide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.59e-18

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


:

Pssm-ID: 429962  Cd Length: 43  Bit Score: 75.53  E-value: 2.59e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 206285      28 CLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 205-232 5.66e-10

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


:

Pssm-ID: 462343  Cd Length: 30  Bit Score: 52.83  E-value: 5.66e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 206285     205 YGGFMTS--EKSQTPLVTLFKNAIIKNVHK 232
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
186-204 6.93e-06

Corticotropin ACTH domain;


:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 41.48  E-value: 6.93e-06
                          10
                  ....*....|....*....
gi 206285     186 DGPYRVEHFRWGNPPKDKR 204
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain super family cl03048
Corticotropin ACTH domain;
122-140 1.64e-04

Corticotropin ACTH domain;


The actual alignment was detected with superfamily member pfam00976:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.63  E-value: 1.64e-04
                          10
                  ....*....|....*....
gi 206285     122 KRSYSMEHFRWGKPVGKKR 140
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain super family cl03048
Corticotropin ACTH domain;
74-91 5.31e-04

Corticotropin ACTH domain;


The actual alignment was detected with superfamily member pfam00976:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 36.47  E-value: 5.31e-04
                          10
                  ....*....|....*...
gi 206285      74 PRKYVMGHFRWDRFGPRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.59e-18

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 75.53  E-value: 2.59e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 206285      28 CLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 205-232 5.66e-10

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 52.83  E-value: 5.66e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 206285     205 YGGFMTS--EKSQTPLVTLFKNAIIKNVHK 232
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
186-204 6.93e-06

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 41.48  E-value: 6.93e-06
                          10
                  ....*....|....*....
gi 206285     186 DGPYRVEHFRWGNPPKDKR 204
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
122-140 1.64e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.63  E-value: 1.64e-04
                          10
                  ....*....|....*....
gi 206285     122 KRSYSMEHFRWGKPVGKKR 140
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
74-91 5.31e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 36.47  E-value: 5.31e-04
                          10
                  ....*....|....*...
gi 206285      74 PRKYVMGHFRWDRFGPRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 28-70 2.59e-18

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 75.53  E-value: 2.59e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 206285      28 CLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPL 70
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQPL 43
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 205-232 5.66e-10

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 52.83  E-value: 5.66e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 206285     205 YGGFMTS--EKSQTPLVTLFKNAIIKNVHK 232
Cdd:pfam08035   1 YGGFMKSwdERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
186-204 6.93e-06

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 41.48  E-value: 6.93e-06
                          10
                  ....*....|....*....
gi 206285     186 DGPYRVEHFRWGNPPKDKR 204
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
122-140 1.64e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 37.63  E-value: 1.64e-04
                          10
                  ....*....|....*....
gi 206285     122 KRSYSMEHFRWGKPVGKKR 140
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
74-91 5.31e-04

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 36.47  E-value: 5.31e-04
                          10
                  ....*....|....*...
gi 206285      74 PRKYVMGHFRWDRFGPRN 91
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSK 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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