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Conserved domains on  [gi|55249759|gb|AAH85857|]
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Bcl2-associated athanogene 3 [Rattus norvegicus]

Protein Classification

WW domain-containing protein( domain architecture ID 11269963)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 423-500 3.17e-24

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 96.22  E-value: 3.17e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55249759    423 GVLKVEAILEKVQG-LEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKA 500
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 23-55 4.88e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


:

Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 49.14  E-value: 4.88e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 55249759     23 PLPPGWEIKIDPQtGWPFFVDHNSRTTTWNDPR 55
Cdd:smart00456   1 PLPPGWEERKDPD-GRPYYYNHETKETQWEKPR 32
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
260-372 5.56e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14950:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55249759  260 PRPLRATSPFRSPVRgassreGSPARSGTP-VHCPSPIRVHTVVDRPQPMTHREPPPVTQPenKPESKPglAGPDLPPGH 338
Cdd:PRK14950 366 PQPAKPTAAAPSPVR------PTPAPSTRPkAAAAANIPPKEPVRETATPPPVPPRPVAPP--VPHTPE--SAPKLTRAA 435

                         90       100       110
                 ....*....|....*....|....*....|....
gi 55249759  339 IPIQVirreadsKPVSQKPPPPAEkvEVKVSSAP 372
Cdd:PRK14950 436 IPVDE-------KPKYTPPAPPKE--EEKALIAD 460
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 423-500 3.17e-24

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 96.22  E-value: 3.17e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55249759    423 GVLKVEAILEKVQG-LEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKA 500
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 427-499 1.44e-22

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 91.52  E-value: 1.44e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55249759   427 VEAILEKVQGLEQAVDNFEG----KKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQK 499
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGsppsKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 23-55 4.88e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 49.14  E-value: 4.88e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 55249759     23 PLPPGWEIKIDPQtGWPFFVDHNSRTTTWNDPR 55
Cdd:smart00456   1 PLPPGWEERKDPD-GRPYYYNHETKETQWEKPR 32
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 25-55 1.14e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.91  E-value: 1.14e-07
                        10        20        30
                ....*....|....*....|....*....|.
gi 55249759  25 PPGWEIKIDPQtGWPFFVDHNSRTTTWNDPR 55
Cdd:cd00201   1 PPGWEERWDPD-GRVYYYNHNTKETQWEDPR 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 24-54 1.39e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.50  E-value: 1.39e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 55249759    24 LPPGWEIKIDPQtGWPFFVDHNSRTTTWNDP 54
Cdd:pfam00397   1 LPPGWEERWDPD-GRVYYYNHETGETQWEKP 30
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 260-372 5.56e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55249759  260 PRPLRATSPFRSPVRgassreGSPARSGTP-VHCPSPIRVHTVVDRPQPMTHREPPPVTQPenKPESKPglAGPDLPPGH 338
Cdd:PRK14950 366 PQPAKPTAAAPSPVR------PTPAPSTRPkAAAAANIPPKEPVRETATPPPVPPRPVAPP--VPHTPE--SAPKLTRAA 435

                         90       100       110
                 ....*....|....*....|....*....|....
gi 55249759  339 IPIQVirreadsKPVSQKPPPPAEkvEVKVSSAP 372
Cdd:PRK14950 436 IPVDE-------KPKYTPPAPPKE--EEKALIAD 460
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 423-500 3.17e-24

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 96.22  E-value: 3.17e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55249759    423 GVLKVEAILEKVQG-LEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKA 500
Cdd:smart00264   1 SIKKINEVLDEVQKkIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 427-499 1.44e-22

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 91.52  E-value: 1.44e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55249759   427 VEAILEKVQGLEQAVDNFEG----KKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQK 499
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGsppsKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 23-55 4.88e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 49.14  E-value: 4.88e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 55249759     23 PLPPGWEIKIDPQtGWPFFVDHNSRTTTWNDPR 55
Cdd:smart00456   1 PLPPGWEERKDPD-GRPYYYNHETKETQWEKPR 32
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 25-55 1.14e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.91  E-value: 1.14e-07
                        10        20        30
                ....*....|....*....|....*....|.
gi 55249759  25 PPGWEIKIDPQtGWPFFVDHNSRTTTWNDPR 55
Cdd:cd00201   1 PPGWEERWDPD-GRVYYYNHNTKETQWEDPR 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 24-54 1.39e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.50  E-value: 1.39e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 55249759    24 LPPGWEIKIDPQtGWPFFVDHNSRTTTWNDP 54
Cdd:pfam00397   1 LPPGWEERWDPD-GRVYYYNHETGETQWEKP 30
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 260-372 5.56e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55249759  260 PRPLRATSPFRSPVRgassreGSPARSGTP-VHCPSPIRVHTVVDRPQPMTHREPPPVTQPenKPESKPglAGPDLPPGH 338
Cdd:PRK14950 366 PQPAKPTAAAPSPVR------PTPAPSTRPkAAAAANIPPKEPVRETATPPPVPPRPVAPP--VPHTPE--SAPKLTRAA 435

                         90       100       110
                 ....*....|....*....|....*....|....
gi 55249759  339 IPIQVirreadsKPVSQKPPPPAEkvEVKVSSAP 372
Cdd:PRK14950 436 IPVDE-------KPKYTPPAPPKE--EEKALIAD 460
PHA03247 PHA03247
large tegument protein UL36; Provisional
 259-389 3.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55249759   259 EPRPLRATSPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTvvdrpqPMTHREPPPVTQPENKPESKPGLAGPDLPPGH 338
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT------PGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 55249759   339 IPIQVIRREADSKPVSQKPPPPAEKVEVKVSSAPIPCPSPGPA------PSAVPSSP 389
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpppTSAQPTAP 2839
PHA03247 PHA03247
large tegument protein UL36; Provisional
 275-422 4.00e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55249759   275 GASSREGSPARSGTPVHCPSPIRVHTVvdrPQPMTHREPPPVTQPENKPESKPGLAGPDLPPGHIPIQVIRREADSKPVS 354
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRL---ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55249759   355 QKPPPPAekvevkvssAPIPCPSPGPAPSAVPSSPKNVAAEPKAAPSPAPAEAASLKSGDAEAPHKHP 422
Cdd:PHA03247 2937 PRPQPPL---------APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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