BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDEVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFFD 85
Cdd:cd18419    1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134025642  86 RDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419   81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  468 SASLIESQHHHLLHCLEKTTglsylvddpllsvrtstmkNHEFMDEQMFEQNCRESSMQNYPSSRSPSLSsNHGLTTSCC 547
Cdd:pfam11879   1 STSLFESQHHHLLHCLEKTT-------------------NHEFVDEQTYEQNCLEVSLQNRPSRSPSLSS-QDGLTSSCC 60

                          90
                  ....*....|....*.
gi 134025642  548 SRRNKKTTHLPNSNVP 563
Cdd:pfam11879  61 SRRAKRNTRLPNSSVP 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDEVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFFD 85
Cdd:cd18419    1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134025642  86 RDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419   81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642   42 IILNVSGRRFQTWRTTLERYPDTLLGSTEKE--FFFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEEL 118
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 134025642  119 AFYGILPEIIGDC 131
Cdd:pfam02214  81 EFYGLDELALELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642    42 IILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRyECISAYDEELAFY 121
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPE-ENVEELLELADYL 80

                           90
                   ....*....|....*...
gi 134025642   122 GIlPEIIGDCCYEEYKDR 139
Cdd:smart00225  81 QI-PGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642   6 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDEVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFFD 85
Cdd:cd18419    1 AAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 134025642  86 RDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18419   81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642   7 AWLPFARAAAIGWMPVANCPMPLAPADKNKRQ--DEVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFF 84
Cdd:cd18420    1 AWLPFARAAAIGWVPIANNPLPPPPVDQERRRtdDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 134025642  85 DRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18420   81 DRDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  41 VIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAF 120
Cdd:cd18418    1 LIVLNVSGTRFQTWRNTLERYPDTLLGSSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAF 80

                         90       100
                 ....*....|....*....|...
gi 134025642 121 YGILPEIIGDCCYEEYKDRKREN 143
Cdd:cd18418   81 FGIIPEIIGDCCYEEYKDRRREN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLGSTEK---EFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEEL 118
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKpgrEFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLREEC 80

                 ...
gi 134025642 119 AFY 121
Cdd:cd18187   81 DFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAF 120
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKlAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                 ..
gi 134025642 121 YG 122
Cdd:cd18317   81 WG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLGS-TEKE---FFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEE 117
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWlTETEasaFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80

                         90       100
                 ....*....|....*....|....*...
gi 134025642 118 LAFYGILPEIIGDCCYEEYkdRKRENAE 145
Cdd:cd18379   81 LAFWGIDETQIEPCCWMTY--RQHRDAQ 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  39 DEVIILNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEE 117
Cdd:cd18416    1 ENRVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                         90
                 ....*....|....*....
gi 134025642 118 LAFYGILPEIIGDCCYEEY 136
Cdd:cd18416   81 LEFWGLDANQVEPCCWMTY 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  39 DEVIILNVSGRRFQTWRTTLERYPDT---LLGSTEKE-------------FFFNEETKEYFFDRDPEVFRCILNFYRTGK 102
Cdd:cd18415    1 NERIILNVGGTRHETYRSTLKTLPGTrlaLLASSDPQgdcltqcsqvggsDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 134025642 103 LHYPRYECISAYDEELAFYGILPEIIGDCCYEEYkdRKRENAE 145
Cdd:cd18415   81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTY--RQHRDAE 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEE 117
Cdd:cd18377    1 ERVVINVSGLRFETQLKTLAQFPNTLLGDPNKRMrFFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFLEE 80

                 ....
gi 134025642 118 LAFY 121
Cdd:cd18377   81 IRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEE 117
Cdd:cd18408    6 ERVVLNVAGLRFETRARTLGRFPDTLLGDpARRGRFYDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRPAHVPLDVFLEE 85

                         90
                 ....*....|..
gi 134025642 118 LAFYGILPEIIG 129
Cdd:cd18408   86 VAFYGLGAAALA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYE 109
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAAlfSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDF 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLG----STEKEFF------FNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECI 111
Cdd:cd18413    4 VVINVGGVKHEVLWRTLDRMPHTRLGklrdSNTHEAIvelcddYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83

                         90       100
                 ....*....|....*....|....*
gi 134025642 112 SAYDEELAFYGILPEIIGDCCYEEY 136
Cdd:cd18413   84 LAFSDDLEYWGVDELYLESCCQHKY 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  27 MPLAPAD--KNKRQDEVIILNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEETKEYFFDRDPEVFRCI 94
Cdd:cd18412    2 LPPEPVEiiRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGklrdcNTHESLLevcddYNLNENEYFFDRHPGAFTSI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 134025642  95 LNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRK 140
Cdd:cd18412   82 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHyPRYECISAYDEE 117
Cdd:cd18393    2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSllSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHE 80

                 ....*...
gi 134025642 118 LAFYGILP 125
Cdd:cd18393   81 AQFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6); KCNA6, also called voltage-gated potassium channel HBK2 or voltage-gated potassium channel subunit Kv1.6, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA6 is distributed primarily in neurons of central and peripheral nervous systems. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA6 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEE 117
Cdd:cd18407    1 ERLVINISGLRFETQLRTLSIFPDTLLGDPSRRVrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVHVPLDIFLEE 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134025642 118 LAFYGilpeiIGDCCYEEYKDrkrenaerlmDDNEFENNQEAMPSLTLRQTMWRAFENPHTS 179
Cdd:cd18407   81 IRFYQ-----LGQEAIETFRE----------DEGFIPEEEKPLPSHHFQRQVWLLFEYPESS 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEE 117
Cdd:cd18406    1 ERVIINIAGLRFETQLGTLNQFPDTLLGDPDKRMrYFDPLRNEYFFDRNRPSFDGILYFYQSgGKIRRPVNVSIDVFADE 80

                 ....
gi 134025642 118 LAFY 121
Cdd:cd18406   81 IRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  44 LNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISA 113
Cdd:cd18411   14 LNVGGLAHEVLWRTLDRLPRTRLGklrdcNTHESLMeicddYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALS 93

                         90       100
                 ....*....|....*....|...
gi 134025642 114 YDEELAFYGILPEIIGDCCYEEY 136
Cdd:cd18411   94 FSQELDYWGIDEIYLESCCQARY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  39 DEVIILNVSGRRFQTWRTTLERYPDT----LLG---STEKEfffneETKEYFFDRDPEVFRCILNFYRTGKLHYPRYEcI 111
Cdd:cd18363    1 GDIINLNVGGKRFSTSRQTLTWIPDSfftsLLSgriSSLKD-----ETGAIFIDRDPKLFSIILNYLRTKEIDLRNVD-I 74

                         90
                 ....*....|..
gi 134025642 112 SAYDEELAFYGI 123
Cdd:cd18363   75 SSLRHEAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF-----FNEETKEYFFDRDPEVFRCILNFYRTGKLHYPRYECI 111
Cdd:cd18423    4 IIINVGGIKYLMPWSTLDEFPLTRLGklkfcSSYEEIVqicddYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREMCA 83

                         90       100
                 ....*....|....*....|..
gi 134025642 112 SAYDEELAFYGILPEIIGDCCY 133
Cdd:cd18423   84 LSFQEELTYWGIEEANLERCCL 105

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  328 LTMAIIIFATVMFYAEKGSSSSKFTSipasFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFS 407
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEGWEWSFLDA----LYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77

                  .
gi 134025642  408 R 408
Cdd:pfam07885  78 E 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEETKEYFFDRDPEVFRCILNFYRT-GKLHYPRYECISAYDEE 117
Cdd:cd18402    9 ERVVINIAGLRFETQLKTLAQFPNTLLGNPKKRMrYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDMFSEE 88

                 ....
gi 134025642 118 LAFY 121
Cdd:cd18402   89 IKFY 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLGSTEKEFF--FNEETKEYFFDRDPEVFRCILNFYRTGKLHYPR-YECISAYDEEL 118
Cdd:cd18394    5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFptARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVdFKEFDLLRKEA 84

                 ....*....
gi 134025642 119 AFYGILPEI 127
Cdd:cd18394   85 DFYQIEPLI 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGSTekeFFFNEETKE-----YFFDRDPEVFRCILNFYRTGKLHYPryECISAY 114
Cdd:cd18365    1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAM---FSGSMPTTRddqgnYFIDRDGTLFRYILNFLRSSQLSLP--EDFKEY 75

                         90
                 ....*....|....*.
gi 134025642 115 DE---ELAFYGILPEI 127
Cdd:cd18365   76 DLllrEADFYQIEPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  40 EVIILNVSGRRFQTWRTTLERYPDTLLGS--TEKEFFFNEETKEYFFDRDPEVFRCILNFYRTGKLHyPRYECISAYDEE 117
Cdd:cd18366    4 EVVPLNVGGMHFTTRLSTLRKYEDSMLAAmfSGRHHIPKDSEGRYFIDRDGSYFGYILNFLRDGDLP-PRERARAVYKEA 82

                 ....*...
gi 134025642 118 LaFYGILP 125
Cdd:cd18366   83 Q-YYGIGP 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134025642  42 IILNVSGRRFQTWRTTLERYPDTLLG-------STEKEfffneETKEYFFDRDPEVFRCILNFYRTGKLHYPrYECISAY 114
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTKDPDSMLAamfsgrhSLKKD-----EDGSYFIDRDGTHFRHILNYLRDGEVKIP-TEDRSVL 74

                         90
                 ....*....|....
gi 134025642 115 DE---ELAFYGILP 125
Cdd:cd18376   75 KElleEAEYYQLRG 88