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Conserved domains on  [gi|165971293|gb|AAI58779|]
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Ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-442 3.01e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 3.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgtqgQPSGHSSHILCMAISSDGKYLASGD 221
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 301
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 302 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 379
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 165971293 380 fWISSVAALLNTDLVATGSHNACVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSGGDFLVAG 442
Cdd:cd00200  221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-442 3.01e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 3.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgtqgQPSGHSSHILCMAISSDGKYLASGD 221
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 301
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 302 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 379
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 165971293 380 fWISSVAALLNTDLVATGSHNACVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSGGDFLVAG 442
Cdd:cd00200  221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
135-442 1.28e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.63  E-value: 1.28e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 135 QAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgtqgqpSGHSSHILCMAISSDG 214
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-----------TGHSGAVTSVAFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 215 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdA 294
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 295 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLH 371
Cdd:COG2319  254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 165971293 372 GEPGleqpfWISSVAALLNTDLVATGSHNACVRLWQcGEGFRQLDPLcdIPLVGFINSLKFSSGGDFLVAG 442
Cdd:COG2319  328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTL--TGHTGAVTSVAFSPDGRTLASG 390
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 201-442 7.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 7.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 201 HSSHILC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 271
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 272 NAAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 320
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 321 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWISsva 386
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 165971293 387 alLNTDLVATGSHNACVRLWQ-------CGEGFRQLDPLCDIPL---VGFINSLKFSSGGDFLVAG 442
Cdd:PLN00181 718 --VSDGYIATGSETNEVFVYHkafpmpvLSYKFKTIDPVSGLEVddaSQFISSVCWRGQSSTLVAA 781
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-272 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 165971293   233 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 272
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
235-272 6.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 165971293  235 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 272
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-442 3.01e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 3.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHviprakkgtqgQPSGHSSHILCMAISSDGKYLASGD 221
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----------TLKGHTGPVRDVAASADGTYLASGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 301
Cdd:cd00200   71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 302 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 379
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 165971293 380 fWISSVAALLNTDLVATGSHNACVRLWQcgegFRQLDPLCDIPLV-GFINSLKFSSGGDFLVAG 442
Cdd:cd00200  221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
135-442 1.28e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.63  E-value: 1.28e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 135 QAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgtqgqpSGHSSHILCMAISSDG 214
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-----------TGHSGAVTSVAFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 215 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdA 294
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 295 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLH 371
Cdd:COG2319  254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 165971293 372 GEPGleqpfWISSVAALLNTDLVATGSHNACVRLWQcGEGFRQLDPLcdIPLVGFINSLKFSSGGDFLVAG 442
Cdd:COG2319  328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTL--TGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 142-407 3.93e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 3.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgtqgqpSGHSSHILCMAISSDGKYLASGD 221
Cdd:cd00200   44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL-----------TGHTSYVSSVAFSPDGRILSSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCV 301
Cdd:cd00200  113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 302 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqp 379
Cdd:cd00200  193 LSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTN---- 262

                        250       260
                 ....*....|....*....|....*...
gi 165971293 380 fWISSVAALLNTDLVATGSHNACVRLWQ 407
Cdd:cd00200  263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
142-407 1.96e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 1.96e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgtqgqpsGHSSHILCMAISSDGKYLASGD 221
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-----------GHTGAVRSVAFSPDGKLLASGS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRE-CC 300
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFSPDgKL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 301 VTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGlhgepgleq 378
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--------- 373

                        250       260
                 ....*....|....*....|....*....
gi 165971293 379 pfWISSVAALLNTDLVATGSHNACVRLWQ 407
Cdd:COG2319  374 --AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
93-442 2.23e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.07  E-value: 2.23e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293  93 LRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCT 172
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 173 IIKWSVETGRKLHviprakkgtqgQPSGHSSHILCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 252
Cdd:COG2319  102 VRLWDLATGLLLR-----------TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 253 RRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRE-CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSI 330
Cdd:COG2319  171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDgKLLASGSADGTVRLWDLATGKLLrTLTGHSGSV 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 331 DCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqreahgLHGEPGleqpfWISSVAALLNTDLVATGSHNACVRLWQCG 409
Cdd:COG2319  250 RSVAFsPDGRLLASGSADGTVRLWDLATGELLRT------LTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                        330       340       350
                 ....*....|....*....|....*....|...
gi 165971293 410 EGfRQLDPLcdIPLVGFINSLKFSSGGDFLVAG 442
Cdd:COG2319  319 TG-KLLRTL--TGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
142-356 1.71e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 1.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPrakkgtqgqpsGHSSHILCMAISSDGKYLASGD 221
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-----------GHSGSVRSVAFSPDGRLLASGS 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 222 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALdALSRECCV 301
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKT 344

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 165971293 302 TA-GGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLS 356
Cdd:COG2319  345 LAsGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
118-459 1.53e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 118 DVLEQRGRLQKLVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHViprakkgtqgq 197
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT----------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 198 PSGHSSHILCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENS 277
Cdd:COG2319   74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 278 YVETLFGHQDAVAALdALS----ReccVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVA 351
Cdd:COG2319  154 LLRTLTGHSGAVTSV-AFSpdgkL---LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 352 LWGLSKKRPLALqreahgLHGEPGleqpfWISSVAALLNTDLVATGSHNACVRLWQCGEGfRQLDPLCDIPlvGFINSLK 431
Cdd:COG2319  230 LWDLATGKLLRT------LTGHSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHS--GGVNSVA 295

                        330       340
                 ....*....|....*....|....*...
gi 165971293 432 FSSGGDFLVAGvGQEHRLgRWWRIKEAR 459
Cdd:COG2319  296 FSPDGKLLASG-SDDGTV-RLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
209-442 4.86e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 4.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 209 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDA 288
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 289 VAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqre 366
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRT--- 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 165971293 367 ahgLHGEPGleqpfWISSVAALLNTDLVATGSHNACVRLWQCGEGfRQLDPLCDIPlvGFINSLKFSSGGDFLVAG 442
Cdd:COG2319  158 ---LTGHSG-----AVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
142-233 5.56e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 5.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIprakkgtqgqpSGHSSHILCMAISSDGKYLASGD 221
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-----------TGHTGAVTSVAFSPDGRTLASGS 391

                         90
                 ....*....|..
gi 165971293 222 RSKLILIWEAQS 233
Cdd:COG2319  392 ADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 201-442 7.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 7.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 201 HSSHILC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 271
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 272 NAAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 320
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165971293 321 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWISsva 386
Cdd:PLN00181 641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 165971293 387 alLNTDLVATGSHNACVRLWQ-------CGEGFRQLDPLCDIPL---VGFINSLKFSSGGDFLVAG 442
Cdd:PLN00181 718 --VSDGYIATGSETNEVFVYHkafpmpvLSYKFKTIDPVSGLEVddaSQFISSVCWRGQSSTLVAA 781
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-272 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 165971293   233 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 272
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
235-272 6.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 6.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 165971293  235 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 272
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-230 2.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 165971293   199 SGHSSHILCMAISSDGKYLASGDRSKLILIWE 230
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
199-230 6.73e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.73e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 165971293  199 SGHSSHILCMAISSDGKYLASGDRSKLILIWE 230
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-177 2.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 165971293   142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWS 177
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-177 4.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 165971293  142 IRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWS 177
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
279-313 7.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 165971293  279 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 313
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-314 2.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 165971293   277 SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 314
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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