apolipoprotein L5 [Homo sapiens]
Protein Classification
protein kinase family protein( domain architecture ID 10527210)
protein kinase family protein, may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| ApoL | pfam05461 | Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ... |
51-345 | 2.46e-135 | |||||
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. : Pssm-ID: 461657 Cd Length: 298 Bit Score: 390.47 E-value: 2.46e-135
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| Name | Accession | Description | Interval | E-value | |||||
| ApoL | pfam05461 | Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ... |
51-345 | 2.46e-135 | |||||
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. Pssm-ID: 461657 Cd Length: 298 Bit Score: 390.47 E-value: 2.46e-135
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| ClyA_MakA-like | cd22655 | Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; ... |
112-197 | 2.14e-04 | |||||
Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; This model includes Vibrio cholerae motility associated killing factor A (MakA) cytotoxin, a member of the cytolysin A (ClyA) family of alpha pore-forming toxins (alpha-PFTs). The MakA protein is encoded by the mak operon. Transport of the MakA protein from the bacteria is shown to occur by flagellum-dependent secretion, highlighting a non-conventional and direct role of flagella in pathogenesis of V. cholerae; a conserved N-terminal FTPP motif is essential for MakA secretion via the flagellum channel in a proton motive force-dependent manner. Structure of MakA shows an elongated, almost entirely alpha-helical protein, with the head domain consisting of two helices and three beta-strands that together with the short beta-strand of the tail domain forms a four-stranded sheet. MakA has been demonstrated to cause toxicity in both Caenorhabditis elegans and zebrafish. Pssm-ID: 439153 [Multi-domain] Cd Length: 342 Bit Score: 43.04 E-value: 2.14e-04
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| Name | Accession | Description | Interval | E-value | |||||
| ApoL | pfam05461 | Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ... |
51-345 | 2.46e-135 | |||||
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. Pssm-ID: 461657 Cd Length: 298 Bit Score: 390.47 E-value: 2.46e-135
|
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| ClyA_MakA-like | cd22655 | Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; ... |
112-197 | 2.14e-04 | |||||
Vibrio cholerae cytotoxin MakA (motility associated killing factor A), and similar proteins; This model includes Vibrio cholerae motility associated killing factor A (MakA) cytotoxin, a member of the cytolysin A (ClyA) family of alpha pore-forming toxins (alpha-PFTs). The MakA protein is encoded by the mak operon. Transport of the MakA protein from the bacteria is shown to occur by flagellum-dependent secretion, highlighting a non-conventional and direct role of flagella in pathogenesis of V. cholerae; a conserved N-terminal FTPP motif is essential for MakA secretion via the flagellum channel in a proton motive force-dependent manner. Structure of MakA shows an elongated, almost entirely alpha-helical protein, with the head domain consisting of two helices and three beta-strands that together with the short beta-strand of the tail domain forms a four-stranded sheet. MakA has been demonstrated to cause toxicity in both Caenorhabditis elegans and zebrafish. Pssm-ID: 439153 [Multi-domain] Cd Length: 342 Bit Score: 43.04 E-value: 2.14e-04
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