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Conserved domains on  [gi|30582305|gb|AAP35379|]
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matrix Gla protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gla super family cl02449
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 32-96 1.31e-18

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


The actual alignment was detected with superfamily member smart00069:

Pssm-ID: 470582  Cd Length: 65  Bit Score: 72.73  E-value: 1.31e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30582305     32 NPFINRRNANTFISPQQRWRAKVQERIRERSKPvHELNREACDDYRLCERYAMVYGYNAAYNRYF 96
Cdd:smart00069   2 SVFLSRQEANKVLRRQRRANAFLLEELRPGNLE-RECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
 
Name Accession Description Interval E-value
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 32-96 1.31e-18

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 72.73  E-value: 1.31e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30582305     32 NPFINRRNANTFISPQQRWRAKVQERIRERSKPvHELNREACDDYRLCERYAMVYGYNAAYNRYF 96
Cdd:smart00069   2 SVFLSRQEANKVLRRQRRANAFLLEELRPGNLE-RECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
 
Name Accession Description Interval E-value
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 32-96 1.31e-18

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 72.73  E-value: 1.31e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30582305     32 NPFINRRNANTFISPQQRWRAKVQERIRERSKPvHELNREACDDYRLCERYAMVYGYNAAYNRYF 96
Cdd:smart00069   2 SVFLSRQEANKVLRRQRRANAFLLEELRPGNLE-RECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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