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Conserved domains on  [gi|393694650|gb|AFN12571|]
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chitin synthase, partial [Alternaria multirostrata]

Protein Classification

DEK C-terminal domain-containing protein( domain architecture ID 10555627)

DEK C-terminal domain-containing protein similar to Arabidopsis thaliana Mediator-associated protein 3 that is associated with the Mediator complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chitin_synth_2 super family cl37687
Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They ...
 1-68 2.15e-34

Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).


The actual alignment was detected with superfamily member pfam03142:

Pssm-ID: 367353 [Multi-domain]  Cd Length: 527  Bit Score: 127.18  E-value: 2.15e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 393694650    1 GWMIIYIFATPVFAFGLPLYSFWYMDDFSWGNTRVVVGEKGQKIVVTDEGKFDPASIPKKRWEEYQAE 68
Cdd:pfam03142 460 GWMLVYLLALPIWNFVLPLYAFWHFDDFSWGNTRVVAGEKGKKVHGTDEGEFDPSKIPMKRWEEFERE 527
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 144-197 1.52e-18

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


:

Pssm-ID: 462592  Cd Length: 54  Bit Score: 75.12  E-value: 1.52e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 393694650  144 PSDDAILIEIKDILSKSDLMNVTKKQIKGELEQRFGCDLTLKKQFIGSAVESLL 197
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLGVDLSERKAFINALIDEIL 54
 
Name Accession Description Interval E-value
Chitin_synth_2 pfam03142
Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They ...
 1-68 2.15e-34

Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).


Pssm-ID: 367353 [Multi-domain]  Cd Length: 527  Bit Score: 127.18  E-value: 2.15e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 393694650    1 GWMIIYIFATPVFAFGLPLYSFWYMDDFSWGNTRVVVGEKGQKIVVTDEGKFDPASIPKKRWEEYQAE 68
Cdd:pfam03142 460 GWMLVYLLALPIWNFVLPLYAFWHFDDFSWGNTRVVAGEKGKKVHGTDEGEFDPSKIPMKRWEEFERE 527
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 144-197 1.52e-18

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


Pssm-ID: 462592  Cd Length: 54  Bit Score: 75.12  E-value: 1.52e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 393694650  144 PSDDAILIEIKDILSKSDLMNVTKKQIKGELEQRFGCDLTLKKQFIGSAVESLL 197
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLGVDLSERKAFINALIDEIL 54
 
Name Accession Description Interval E-value
Chitin_synth_2 pfam03142
Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They ...
 1-68 2.15e-34

Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).


Pssm-ID: 367353 [Multi-domain]  Cd Length: 527  Bit Score: 127.18  E-value: 2.15e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 393694650    1 GWMIIYIFATPVFAFGLPLYSFWYMDDFSWGNTRVVVGEKGQKIVVTDEGKFDPASIPKKRWEEYQAE 68
Cdd:pfam03142 460 GWMLVYLLALPIWNFVLPLYAFWHFDDFSWGNTRVVAGEKGKKVHGTDEGEFDPSKIPMKRWEEFERE 527
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 144-197 1.52e-18

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


Pssm-ID: 462592  Cd Length: 54  Bit Score: 75.12  E-value: 1.52e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 393694650  144 PSDDAILIEIKDILSKSDLMNVTKKQIKGELEQRFGCDLTLKKQFIGSAVESLL 197
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLGVDLSERKAFINALIDEIL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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