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Conserved domains on  [gi|16553036|dbj|BAB71452|]
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unnamed protein product [Homo sapiens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1001407)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to nitrite reductase large subunit NirB

CATH:  3.30.390.30
EC:  1.-.-.-
Gene Ontology:  GO:0016491
PubMed:  2445993
SCOP:  4000121

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NirB super family cl34210
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
23-128 3.18e-07

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


The actual alignment was detected with superfamily member COG1251:

Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 51.30  E-value: 3.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16553036  23 KIIVVGASSVGISFLETLVfcshmKFNN---LTLIS------------THGLPGKKlldTEQRKFLASDHCFNDKDyalm 87
Cdd:COG1251   3 RIVIIGAGMAGVRAAEELR-----KLDPdgeITVIGaephppynrpplSKVLAGET---DEEDLLLRPADFYEENG---- 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 16553036  88 slcswVNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTG 128
Cdd:COG1251  71 -----IDLRLGtRVTAIDRAARTVTLADGETLPYDKLVLATG 107
 
Name Accession Description Interval E-value
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
23-128 3.18e-07

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 51.30  E-value: 3.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16553036  23 KIIVVGASSVGISFLETLVfcshmKFNN---LTLIS------------THGLPGKKlldTEQRKFLASDHCFNDKDyalm 87
Cdd:COG1251   3 RIVIIGAGMAGVRAAEELR-----KLDPdgeITVIGaephppynrpplSKVLAGET---DEEDLLLRPADFYEENG---- 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 16553036  88 slcswVNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTG 128
Cdd:COG1251  71 -----IDLRLGtRVTAIDRAARTVTLADGETLPYDKLVLATG 107
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 24-134 5.42e-03

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 38.66  E-value: 5.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16553036    24 IIVVGASSVGISFLETL-----------VFCS--HMKFNNLTLISthglpgkklldteqrkFLASDHcfndkDYALMSLC 90
Cdd:TIGR02374   1 LVLVGNGMAGHRCIEEVlklnrhmfeitIFGEepHPNYNRILLSS----------------VLQGEA-----DLDDITLN 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16553036    91 SW-------VNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTGQQYQVP 134
Cdd:TIGR02374  60 SKdwyekhgITLYTGeTVIQIDTDQKQVITDAGRTLSYDKLILATGSYPFIL 111
 
Name Accession Description Interval E-value
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
23-128 3.18e-07

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 51.30  E-value: 3.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16553036  23 KIIVVGASSVGISFLETLVfcshmKFNN---LTLIS------------THGLPGKKlldTEQRKFLASDHCFNDKDyalm 87
Cdd:COG1251   3 RIVIIGAGMAGVRAAEELR-----KLDPdgeITVIGaephppynrpplSKVLAGET---DEEDLLLRPADFYEENG---- 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 16553036  88 slcswVNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTG 128
Cdd:COG1251  71 -----IDLRLGtRVTAIDRAARTVTLADGETLPYDKLVLATG 107
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
93-128 1.59e-05

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 45.89  E-value: 1.59e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 16553036  93 VNVVVGRMTGIDRAAKHVVLSTDEIVPYDHPILCTG 128
Cdd:COG1252  71 VRFIQGEVTGIDPEARTVTLADGRTLSYDYLVIATG 106
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 93-128 2.62e-04

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 42.11  E-value: 2.62e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 16553036  93 VNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTG 128
Cdd:COG0446  51 IDVRTGtEVTAIDPEAKTVTLRDGETLSYDKLVLATG 87
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
 24-134 5.42e-03

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 38.66  E-value: 5.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16553036    24 IIVVGASSVGISFLETL-----------VFCS--HMKFNNLTLISthglpgkklldteqrkFLASDHcfndkDYALMSLC 90
Cdd:TIGR02374   1 LVLVGNGMAGHRCIEEVlklnrhmfeitIFGEepHPNYNRILLSS----------------VLQGEA-----DLDDITLN 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16553036    91 SW-------VNVVVG-RMTGIDRAAKHVVLSTDEIVPYDHPILCTGQQYQVP 134
Cdd:TIGR02374  60 SKdwyekhgITLYTGeTVIQIDTDQKQVITDAGRTLSYDKLILATGSYPFIL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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