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Conserved domains on  [gi|1767231908|sp|D3ZUE1|]
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RecName: Full=GAS2-like protein 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 5.60e-78

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 248.77  E-value: 5.60e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  23 PFKSSEQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPERVQKIPMPQ-VGVFCNG 101
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPrEVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231908 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 1.75e-40

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 142.74  E-value: 1.75e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767231908 206 LDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 278-527 5.03e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPLMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSSGPRSEfPARARTPREM 357
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS-PISASASSPA 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  358 APFLRSQEKPTLSQRMSSPGPQLSSPCRGPDLQSTLSERRVNRSPGelpRGRTPTSWVPKEADSQGAHTKAPIPQRlqip 437
Cdd:PHA03307   222 PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT---RIWEASGWNGPSSRPGPASSSSSPRER---- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  438 etTSKKTPARGPSPPPRSSSLASPHtiWLPDQGASPEISEPMSAQSSSPGKGLTKipirlSPARPPTPGRGSLGTEGGGS 517
Cdd:PHA03307   295 --SPSPSPSSPGSGPAPSSPRASSS--SSSSRESSSSSTSSSSESSRGAAVSPGP-----SPSRSPSPSRPPPPADPSSP 365

                          250
                   ....*....|
gi 1767231908  518 MQRGSLSSRA 527
Cdd:PHA03307   366 RKRPRPSRAP 375
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 5.60e-78

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 248.77  E-value: 5.60e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  23 PFKSSEQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPERVQKIPMPQ-VGVFCNG 101
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPrEVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231908 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 1.75e-40

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 142.74  E-value: 1.75e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767231908 206 LDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 205-276 3.09e-32

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 119.48  E-value: 3.09e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231908  205 NLDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTS 276
Cdd:smart00243   2 KIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 32-158 6.22e-13

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 65.77  E-value: 6.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  32 EVMKEDLAEWLRDLYGLDIDA---ANFLRVLETGLVLCRHANTVTeaalaflaeaPERVQKIpmpqvgvfcngAAQPGTF 108
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKLA----------PGLVDKK-----------KLNKSEF 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1767231908 109 QARDNISNFIQWCRKEMGIQEVLMfETEDLVLRKNvKSVVLCLLELGRRA 158
Cdd:pfam00307  60 DKLENINLALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRF 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 36-154 2.51e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.40  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908   36 EDLAEWLRDLYGLDIDAA--NFLRVLETGLVLCRHANTVteaalaflaeapeRVQKIPMPQVgvfcngAAQPGTFQARDN 113
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPvtNFSSDLKDGVALCALLNSL-------------SPGLVDKKKV------AASLSRFKKIEN 61

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1767231908  114 ISNFIQWCRKEMGIqeVLMFETEDLVL-RKNVKSVVLCLLEL 154
Cdd:smart00033  62 INLALSFAEKLGGK--VVLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
18-168 1.13e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.84  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  18 VRSIRPFKSSEQylevMKEDLAEWLRDLYGLDIDAA-NFLRVLETGLVLCRHANTVTEAALaflaeapeRVQKIPMPqvg 96
Cdd:COG5199     2 VNTKNRCPGMDK----QQKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNEASPLDI--------KYKESKMP--- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231908  97 vfcngaaqpgtFQARDNISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA-----WRFGVAAPSL 168
Cdd:COG5199    67 -----------FVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAqkermFSGPFLGPHL 131
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 278-527 5.03e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPLMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSSGPRSEfPARARTPREM 357
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS-PISASASSPA 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  358 APFLRSQEKPTLSQRMSSPGPQLSSPCRGPDLQSTLSERRVNRSPGelpRGRTPTSWVPKEADSQGAHTKAPIPQRlqip 437
Cdd:PHA03307   222 PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT---RIWEASGWNGPSSRPGPASSSSSPRER---- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  438 etTSKKTPARGPSPPPRSSSLASPHtiWLPDQGASPEISEPMSAQSSSPGKGLTKipirlSPARPPTPGRGSLGTEGGGS 517
Cdd:PHA03307   295 --SPSPSPSSPGSGPAPSSPRASSS--SSSSRESSSSSTSSSSESSRGAAVSPGP-----SPSRSPSPSRPPPPADPSSP 365

                          250
                   ....*....|
gi 1767231908  518 MQRGSLSSRA 527
Cdd:PHA03307   366 RKRPRPSRAP 375
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 23-163 5.60e-78

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 248.77  E-value: 5.60e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  23 PFKSSEQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPERVQKIPMPQ-VGVFCNG 101
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLKLPPrEVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231908 102 AAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 28-162 2.97e-50

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 172.84  E-value: 2.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  28 EQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPErvqKIPMPQVGVFCNGAAQPGT 107
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKK---NGPPPSYKLKCNENAKPGS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1767231908 108 FQARDNISNFIQWCRKEmGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFG 162
Cdd:cd21204    78 FFARDNVANFLRWCRKL-GVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 206-274 1.75e-40

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 142.74  E-value: 1.75e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767231908 206 LDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRC 274
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 205-276 3.09e-32

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 119.48  E-value: 3.09e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767231908  205 NLDQMVQSLVSHCTCPVQFSMVKISDGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTS 276
Cdd:smart00243   2 KIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 28-163 3.06e-30

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 116.19  E-value: 3.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  28 EQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAFLAEAPERVQKIPMPQVGvfCNGAAQPGT 107
Cdd:cd21267     2 EASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANKPGKSLPVRKIP--CRANAPSGS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1767231908 108 FQARDNISNFIQWCRkEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGV 163
Cdd:cd21267    80 FFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 28-162 2.94e-26

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 104.53  E-value: 2.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  28 EQYLEVMKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVteAALAFLAEAPERVQKIPMPQVGvfCNGAAQPGT 107
Cdd:cd21269     1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVL--QSKIKECCSTEELKHFPMRKVP--CKKDAPSGS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1767231908 108 FQARDNISNFIQWCRkEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFG 162
Cdd:cd21269    77 FFARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 35-156 4.45e-14

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 68.90  E-value: 4.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  35 KEDLAEWLRDLYG--LDIDAANFLRVLETGLVLCRHANTVTeaalaflaeaPERVQKIPMPQvgvfcngaaqPGTFQARD 112
Cdd:cd00014     1 EEELLKWINEVLGeeLPVSITDLFESLRDGVLLCKLINKLS----------PGSIPKINKKP----------KSPFKKRE 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1767231908 113 NISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd00014    61 NINLFLNACKK-LGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 32-158 6.22e-13

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 65.77  E-value: 6.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  32 EVMKEDLAEWLRDLYGLDIDA---ANFLRVLETGLVLCRHANTVTeaalaflaeaPERVQKIpmpqvgvfcngAAQPGTF 108
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKLA----------PGLVDKK-----------KLNKSEF 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1767231908 109 QARDNISNFIQWCRKEMGIQEVLMfETEDLVLRKNvKSVVLCLLELGRRA 158
Cdd:pfam00307  60 DKLENINLALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRF 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 34-156 2.63e-12

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 63.54  E-value: 2.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  34 MKEDLAEWLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALAflaeapeRVQKIPMPqvgvfcngaaqpgtFQARDN 113
Cdd:cd21210     1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLANRILPADIR-------KYKESKMP--------------FVQMEN 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1767231908 114 ISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd21210    60 ISAFLNAARK-LGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 40-156 4.03e-11

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 60.40  E-value: 4.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  40 EWLRDLYGLDIDAA-NFLRVLETGLVLCRHANTVteaalaflaeAPERVQKIpmpqvgvfcNGAAQPgtFQARDNISNFI 118
Cdd:cd21207    12 DWIEAVTGEKLDDGkDYEDVLKDGVILCKLINIL----------KPGSVKKI---------NTSKMA--FKLMENIENFL 70

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1767231908 119 QWCrKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGR 156
Cdd:cd21207    71 TAC-KGYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 36-154 2.51e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.40  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908   36 EDLAEWLRDLYGLDIDAA--NFLRVLETGLVLCRHANTVteaalaflaeapeRVQKIPMPQVgvfcngAAQPGTFQARDN 113
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPvtNFSSDLKDGVALCALLNSL-------------SPGLVDKKKV------AASLSRFKKIEN 61

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1767231908  114 ISNFIQWCRKEMGIqeVLMFETEDLVL-RKNVKSVVLCLLEL 154
Cdd:smart00033  62 INLALSFAEKLGGK--VVLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
18-168 1.13e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.84  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  18 VRSIRPFKSSEQylevMKEDLAEWLRDLYGLDIDAA-NFLRVLETGLVLCRHANTVTEAALaflaeapeRVQKIPMPqvg 96
Cdd:COG5199     2 VNTKNRCPGMDK----QQKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRILNEASPLDI--------KYKESKMP--- 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767231908  97 vfcngaaqpgtFQARDNISNFIQWCRKeMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA-----WRFGVAAPSL 168
Cdd:COG5199    67 -----------FVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAqkermFSGPFLGPHL 131
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 35-154 1.27e-05

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 45.10  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  35 KEDLAEWLRDLYGLDIDA----ANFLRVLETGLVLCRHANTVteaalaflaeAPERVQKIpmPQVGVFCNGAAQpGTFQA 110
Cdd:cd21203     2 RYEAAEWIQNVLGVLVLPdpseEEFRLCLRDGVVLCKLLNKL----------QPGAVPKV--VESPDDPDGAAG-SAFQY 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1767231908 111 RDNISNFIQWCrKEMGIQevlMFETEDL--VLRKNVKSVVLCLLEL 154
Cdd:cd21203    69 FENVRNFLVAI-EEMGLP---TFEASDLeqGGGGSRPRVVDCILAL 110
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 112-151 6.12e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 43.37  E-value: 6.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1767231908 112 DNISNFIQWCrKEMGIQEVLMFETEDLVLRKNVKSVVLCL 151
Cdd:cd21206    69 DNINHFLRAL-KKIGLPKIFHFETTDLYEKKNIPKVIYCL 107
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 54-159 7.80e-05

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 43.10  E-value: 7.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  54 NFLRVLETGLVLCRHANTVteaalaflaeAPERVQKIPMPqvgvfcngaaqPGTFQARDNISNFIQWCRkEMGIQEVLMF 133
Cdd:cd21208    21 DFRESLEDGILLCELINAI----------KPGSIKKINRL-----------PTPIAGLDNLNLFLKACE-DLGLKDSQLF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1767231908 134 ETEDLV---------------LRKNVKSVVLCLLELGRRAW 159
Cdd:cd21208    79 DPTDLQdlsnrriathvrkkeDERRLKNVAITLYWLGRAAR 119
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 39-154 1.08e-03

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 39.55  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  39 AEWLRDLYGL---------DIDAANFLRVLETGLVLCRHANTVteaalaflaeapeRVQKIPMPQVGVfcngAAQPGTFQ 109
Cdd:cd21201     7 ADWLIRCGVLppdhratqpNATVFDLAQALRDGVLLCQLLNRL-------------SPGSVDDREINL----RPQMSQFL 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1767231908 110 ARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLEL 154
Cdd:cd21201    70 CLKNIRTFLQACRTVFGLRSADLFEPEDLYDVTNFGKVIRTLSKL 114
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 35-158 1.24e-03

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 39.14  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  35 KEDLAEWLRDLYGLDIdAANFLRVLETGLVLCRHANTVteaalaflaeAPERVQKIpmpqvgvfcNGAAQpgTFQARDNI 114
Cdd:cd21283     5 EAELRTWIEGLTGRSI-GPDFQKGLKDGVILCELMNKL----------QPGSVPKI---------NRSMQ--NWHQLENL 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1767231908 115 SNFIqwcrKEM---GIQEVLMFETEDLVLRKNVKSVVLCLLELGRRA 158
Cdd:cd21283    63 SNFI----KAMvsyGMKPVDLFEANDLFESGNMTQVQVSLLALAGMA 105
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 41-158 3.29e-03

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 38.28  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  41 WLRDLYGLDIDAANFLRVLETGLVLCRHANTVTEAALaflaeapERVQKIPMPQVGVfcngaaqpgtfqarDNISNFIQW 120
Cdd:cd21277     8 WIEAVTGKNFGNKDFRSALENGVLLCDLINKIKPGII-------KKINRLSTPIAGL--------------DNINVFLKA 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1767231908 121 CrKEMGIQEVLMF---ETEDLVLR---------KNVKSVVLCLLELGRRA 158
Cdd:cd21277    67 C-EKLGLKEAQLFhpgDLQDLSTRvtvkqeetdRRLKNVLITLYWLGRKA 115
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 278-527 5.03e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  278 SHKPGSFLKPPGPPVQHEVKVQDGPSQPQPLMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSSGPRSEfPARARTPREM 357
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS-PISASASSPA 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  358 APFLRSQEKPTLSQRMSSPGPQLSSPCRGPDLQSTLSERRVNRSPGelpRGRTPTSWVPKEADSQGAHTKAPIPQRlqip 437
Cdd:PHA03307   222 PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT---RIWEASGWNGPSSRPGPASSSSSPRER---- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  438 etTSKKTPARGPSPPPRSSSLASPHtiWLPDQGASPEISEPMSAQSSSPGKGLTKipirlSPARPPTPGRGSLGTEGGGS 517
Cdd:PHA03307   295 --SPSPSPSSPGSGPAPSSPRASSS--SSSSRESSSSSTSSSSESSRGAAVSPGP-----SPSRSPSPSRPPPPADPSSP 365

                          250
                   ....*....|
gi 1767231908  518 MQRGSLSSRA 527
Cdd:PHA03307   366 RKRPRPSRAP 375
PHA03247 PHA03247
large tegument protein UL36; Provisional
 286-520 5.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  286 KPPGPPVQHEVKVQDGPSQP-QPLMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSSGPRSEFPARARTPREMAPFLRSQ 364
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  365 EKP---TLSQRMSSPG--PQLSSPCRGP----------DLQSTLSERRVNRSPGELPRGRTPTSWVPKEADSQGAHTKAP 429
Cdd:PHA03247  2656 PAPgrvSRPRRARRLGraAQASSPPQRPrrraarptvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL 2735

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231908  430 I--------------------PQRLQIPETTSKKTPARGPSPPPRSSSLASPHTIWLPDQGASPEISEPM---------- 479
Cdd:PHA03247  2736 PaapappavpagpatpggparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAdppaavlapa 2815

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1767231908  480 ----SAQSSSPGKGLTKIPIRLSPARPPTPGRGSLGTEG----GGSMQR 520
Cdd:PHA03247  2816 aalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapGGDVRR 2864
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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