NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|149030411|gb|EDL85448|]
View 

suppression of tumorigenicity 7-like, isoform CRA_a [Rattus norvegicus]

Protein Classification

suppressor of tumorigenicity 7 family protein( domain architecture ID 10184005)

suppressor of tumorigenicity 7 protein negatively regulates apoptotic process through regulation of genes maintaining the cellular architecture

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
75-542 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


:

Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 935.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  75 FLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLMGGTESSisePGSPANSRESetlrhhhLS 154
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLS---NGGSNSSDQS-------VP 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 155 ECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFLRPSDTVMQKAWRERNPPARIKAAYQALE 234
Cdd:cd11557   71 ECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 235 LNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIR 314
Cdd:cd11557  151 LNPECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTNVLVYIKRRLAMCARKLGRLK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 315 EAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPKSAAICYTAALLKTRTVSDKFSPETAFRK 394
Cdd:cd11557  231 EAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVADKFSPEVASRR 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 395 GLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMI 474
Cdd:cd11557  311 GLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRVEGALNLLHCTWEGTFRMI 390
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149030411 475 PYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSSTAMIALLTHQFPEVMG 542
Cdd:cd11557  391 PYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQFPEPMG 458
 
Name Accession Description Interval E-value
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
75-542 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 935.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  75 FLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLMGGTESSisePGSPANSRESetlrhhhLS 154
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLS---NGGSNSSDQS-------VP 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 155 ECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFLRPSDTVMQKAWRERNPPARIKAAYQALE 234
Cdd:cd11557   71 ECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 235 LNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIR 314
Cdd:cd11557  151 LNPECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTNVLVYIKRRLAMCARKLGRLK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 315 EAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPKSAAICYTAALLKTRTVSDKFSPETAFRK 394
Cdd:cd11557  231 EAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVADKFSPEVASRR 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 395 GLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMI 474
Cdd:cd11557  311 GLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRVEGALNLLHCTWEGTFRMI 390
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149030411 475 PYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSSTAMIALLTHQFPEVMG 542
Cdd:cd11557  391 PYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQFPEPMG 458
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
47-559 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 922.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411   47 LWFLAGLGLLYALRVPLRLCDNVTAVTGFLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLM 126
Cdd:pfam04184  10 IWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHLSPLI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  127 GGTESSISEPGSPANSREsetlrhhhLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFL 206
Cdd:pfam04184  90 GGGDNASDNGENEENRQS--------VPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFTCDTDSG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  207 RPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHE 286
Cdd:pfam04184 162 RPADEIMQKAWRERNPQARIKAAHQALEINPDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQHLSSNHE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  287 AQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPK 366
Cdd:pfam04184 242 AQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  367 SAAICYTAALLKTRTVSDKFSPETAFRKGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYA 446
Cdd:pfam04184 322 SATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  447 FFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSS 526
Cdd:pfam04184 402 FFHLQHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSF 481
                         490       500       510
                  ....*....|....*....|....*....|...
gi 149030411  527 TAMIALLTHQFPEVMGVFAKAVSMISRTCVEYL 559
Cdd:pfam04184 482 TAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFM 514
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
214-334 9.81e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 214 QKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEAttivdAERLFKQALRAGEIIYRrsqqcqhQSPQHeaqlrrdt 293
Cdd:COG2956  152 ELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL-----EQGDYEEAIAALERALE-------QDPDY-------- 211
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 149030411 294 nvlVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLN 334
Cdd:COG2956  212 ---LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL 249
 
Name Accession Description Interval E-value
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
75-542 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 935.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  75 FLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLMGGTESSisePGSPANSRESetlrhhhLS 154
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLS---NGGSNSSDQS-------VP 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 155 ECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFLRPSDTVMQKAWRERNPPARIKAAYQALE 234
Cdd:cd11557   71 ECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 235 LNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIR 314
Cdd:cd11557  151 LNPECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTNVLVYIKRRLAMCARKLGRLK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 315 EAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPKSAAICYTAALLKTRTVSDKFSPETAFRK 394
Cdd:cd11557  231 EAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVADKFSPEVASRR 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 395 GLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMI 474
Cdd:cd11557  311 GLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRVEGALNLLHCTWEGTFRMI 390
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149030411 475 PYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSSTAMIALLTHQFPEVMG 542
Cdd:cd11557  391 PYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLTHQFPEPMG 458
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
47-559 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 922.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411   47 LWFLAGLGLLYALRVPLRLCDNVTAVTGFLSSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSISHLRPLM 126
Cdd:pfam04184  10 IWLLLVAVLLYYLRGPLRLSENLNAVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHLSPLI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  127 GGTESSISEPGSPANSREsetlrhhhLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCETDFL 206
Cdd:pfam04184  90 GGGDNASDNGENEENRQS--------VPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFTCDTDSG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  207 RPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALRAGEIIYRRSQQCQHQSPQHE 286
Cdd:pfam04184 162 RPADEIMQKAWRERNPQARIKAAHQALEINPDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQHLSSNHE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  287 AQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYADVQAVLAKYDDISLPK 366
Cdd:pfam04184 242 AQHRRDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  367 SAAICYTAALLKTRTVSDKFSPETAFRKGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYA 446
Cdd:pfam04184 322 SATICYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411  447 FFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPFFIHFTAGLCSS 526
Cdd:pfam04184 402 FFHLQHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSF 481
                         490       500       510
                  ....*....|....*....|....*....|...
gi 149030411  527 TAMIALLTHQFPEVMGVFAKAVSMISRTCVEYL 559
Cdd:pfam04184 482 TAMLALLTHQFPEPMGAFAKTFLGWLSAPFSFM 514
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
214-334 9.81e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149030411 214 QKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEAttivdAERLFKQALRAGEIIYRrsqqcqhQSPQHeaqlrrdt 293
Cdd:COG2956  152 ELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL-----EQGDYEEAIAALERALE-------QDPDY-------- 211
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 149030411 294 nvlVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLN 334
Cdd:COG2956  212 ---LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH