second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  22 SDYFRALLDDHFRESEEpvASGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLA 101
Cdd:cd18296   40 SDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLA 117

                 ....
gi 149036700 102 QLLE 105
Cdd:cd18296  118 QSLD 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  22 SDYFRALLDDHFRESEEpvASGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLA 101
Cdd:cd18296   40 SDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLA 117

                 ....
gi 149036700 102 QLLE 105
Cdd:cd18296  118 QSLD 121

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700    19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:smart00225  19 AAHSPYFKALFSSDFKESDKSE-------IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEE 91

                   ....*.
gi 149036700    99 SLAQLL 104
Cdd:smart00225  92 FLLKLL 97

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEepvasgdppvVTL-HDIspDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCG 97
Cdd:PHA03098  31 SSSSEYFKKMFKNNFKENE----------INLnIDY--DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCI 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 149036700  98 RSLAQLLEEDSVVGVWRIAKLFRLARLEDQCTEYMAKVIEKLVEREDF 145
Cdd:PHA03098  99 NYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDF 146

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  22 SDYFRALLDDHFRESEEpvASGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLA 101
Cdd:cd18296   40 SDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLA 117

                 ....
gi 149036700 102 QLLE 105
Cdd:cd18296  118 QSLD 121

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700    19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:smart00225  19 AAHSPYFKALFSSDFKESDKSE-------IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEE 91

                   ....*.
gi 149036700    99 SLAQLL 104
Cdd:smart00225  92 FLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  20 ATSDYFRALLDDHFRESEepvASGdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRS 99
Cdd:cd18352   34 ASSDAFRAMFDGGYREKE---ARD----IEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKRLCEYT 106

                         90
                 ....*....|
gi 149036700 100 LAQLLEEDSV 109
Cdd:cd18352  107 IAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFREseepvasGDPPVVTLHDISPDIFTHVLYYVYSDHTE---LPPELAYDVLSVADMYLLPGLKRL 95
Cdd:cd18297   32 VTASDRFKSMLSSGSTE-------AQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALELLRAASFFQLDGLKRH 104

                         90
                 ....*....|...
gi 149036700  96 CGRSLAQLLEEDS 108
Cdd:cd18297  105 CEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 96
Cdd:cd18314   26 CARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149036700  19 SATSDYFRALLDDHFRESeepvaSGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 96
Cdd:cd18245   34 AAASPYFRAKLNYNPPKD-----DGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149036700  20 ATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDH---TELPPELAYDVLSVADMYLLPGLK 93
Cdd:cd18287   43 ARSEYFRALLYGGMRESQQSE-------IELKDTNAEAFKALLKYIYTGRltlTDLKEDVLLDVLGLAHQYGFEELE 112

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149036700  20 ATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPEL-AYDVLSVADMYLLPGLKRLC 96
Cdd:cd18300   30 ARCDVMAAMFGGNFRESSAKE-------VELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18250   41 AAASSYFRAMFAGELRESRADR-------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCA 113

                         90
                 ....*....|.
gi 149036700  99 SLAQLLEEDSV 109
Cdd:cd18250  114 YLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149036700  20 ATSDYFRALLDDHFRESeepvasGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVA 84
Cdd:cd18329   42 ASSGYFKMLLSQNAKET------GQPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18279   38 AARSPVFSAMFEHEMEESKKNR-------VEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCED 110

                         90
                 ....*....|
gi 149036700  99 SLAQLLEEDS 108
Cdd:cd18279  111 ALCSNLSVEN 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  20 ATSDYFRALLDDHFRESEEPVAsgdppvVTLhDISPDIFTHVLYYVYSDHTELPP-----ELAYDVLSVADMYLLPGLKR 94
Cdd:cd18302   27 ARLEYFHSMLSSSWIEASSCSA------LTM-PIPSDILEIILDYLYTDEASAVKesqnvEFLCNVLVIADQLLITRLKE 99

                         90
                 ....*....|
gi 149036700  95 LCGRSLAQLL 104
Cdd:cd18302  100 ICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESeepvaSGDPpvVTLHDISPDIFTHVLYYVYsdhTELPPEL-----AYDVLSVADMYLLPGLK 93
Cdd:cd18344   43 AARSPVFRAMFEHEMEER-----LKNP--IEIHDLDPQVFKEMMGFIY---TGKAPHLhshsmACDVLAAADKYGLEGLK 112

                         90
                 ....*....|.
gi 149036700  94 RLCGRSLAQLL 104
Cdd:cd18344  113 VLCEDALCRNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18272   52 SAQSCFFRSMFTSNLKEARNRV-------IELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSR 124

                 ....*..
gi 149036700  99 SLAQLLE 105
Cdd:cd18272  125 FLARTVQ 131

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHfreSEEPVASGDPPVVTLHDISPDIFTHVLYYVYSD 68
Cdd:cd18301   38 ASRSDYFRKLFLSS---LLTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  20 ATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRS 99
Cdd:cd18268   44 SSSPYFRAMFCNNFRESSQAK-------VDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLY 116

                         90
                 ....*....|...
gi 149036700 100 LAQLLEEDSVVGV 112
Cdd:cd18268  117 LQDQLTPENCLSM 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  21 TSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSL 100
Cdd:cd18264   50 SSDYFRALFKDYTQESKA-------RVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYL 122

                 ....*...
gi 149036700 101 AQLLEEDS 108
Cdd:cd18264  123 INNLAPEN 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEepvasgdPPVVTLHDISPDIFTHVLYYVYsdhtelppelaydvlsvadmyllpglkrlcGR 98
Cdd:cd18265   43 SANSAYFRAMFGGHLKESR-------QAVVEIQKVSAAAMEVLLDYMY------------------------------GG 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149036700  99 SLaqLLEEDSVVGVWRIAKLFRLARLEDQCTEYM 132
Cdd:cd18265   86 GL--RIQEDNVESVLEASDLLQVSKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18242   41 AACSDYFCAMFTSEMSEKGKSE-------VELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCE 113

                 ....*.
gi 149036700  99 SL-AQL 103
Cdd:cd18242  114 FLeSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEPVasgdppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18342   42 AARSPVFSAMFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCED 114

                 ..
gi 149036700  99 SL 100
Cdd:cd18342  115 AL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149036700  22 SDYFRALLDDHFRESEEPVASGDppvVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCG 97
Cdd:cd18305   37 SGYFASMFSGSWKESKETVINLE---IPDDNITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDGLIQQCS 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLDDHFRESEEpvasgdpPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGR 98
Cdd:cd18253   38 SACSSYFRAMFCNDHRESRE-------MLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAK 110

                 ....*..
gi 149036700  99 SLAQLLE 105
Cdd:cd18253  111 FLEEQLD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149036700  48 VTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 108
Cdd:cd18347   67 IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  48 VTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEED 107
Cdd:cd18281   67 IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSD 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036700  19 SATSDYFRALLddhfreSEEPVASGDPPVVTLH--DISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 96
Cdd:cd18292   37 AKSSDVFRVML------SNDWWSESKQSEIELVedPECAAVFEKFLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149036700  21 TSDYFRALLDDHFRESEepvasgdPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMY 87
Cdd:cd01165   20 SSEYFRALFRGGFRESG-------QAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149036700  42 SGDPPVVTLHDISPDIFTHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSVVGV 112
Cdd:cd18306   54 GESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124