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Conserved domains on  [gi|149040747|gb|EDL94704|]
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immunoglobulin superfamily, member 8, isoform CRA_a [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-147 1.01e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747   40 GTAVSISCNVSDYEGPSQQDFEWFMYRPEAPATSLGIISTKDSQFSyaVFGPRVASGDLQVQrlkgDSVVLKIARLQAQD 119
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRFSGRGDPSN----GDGSLTIQNLTLSD 84

                          90       100
                  ....*....|....*....|....*...
gi 149040747  120 SGFYECYTPSTDTQYLGNysaKVELRVL 147
Cdd:pfam07686  85 SGTYTCAVIPSGEGVFGK---GTRLTVL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 449-543 6.60e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 449 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPeegelSSGPaQLVGGVGQDGVAELGVRPGGspVSVELVGPRSHRLR 528
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKP-----GQGP-EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                         90
                 ....*....|....*
gi 149040747 529 LHSLGPEDEGIYHCA 543
Cdd:cd00099   77 ISNLQPEDSGTYYCA 91
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 316-417 1.40e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 316 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGiGSLGPGYEDRHIAmEKVASRTYRLRLEAA 394
Cdd:cd00099   12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                         90       100
                 ....*....|....*....|....*....
gi 149040747 395 RPADAGTYRCLAKA------YVRGSGTRL 417
Cdd:cd00099   81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-147 1.01e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747   40 GTAVSISCNVSDYEGPSQQDFEWFMYRPEAPATSLGIISTKDSQFSyaVFGPRVASGDLQVQrlkgDSVVLKIARLQAQD 119
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRFSGRGDPSN----GDGSLTIQNLTLSD 84

                          90       100
                  ....*....|....*....|....*...
gi 149040747  120 SGFYECYTPSTDTQYLGNysaKVELRVL 147
Cdd:pfam07686  85 SGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 449-543 6.60e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 449 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPeegelSSGPaQLVGGVGQDGVAELGVRPGGspVSVELVGPRSHRLR 528
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKP-----GQGP-EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                         90
                 ....*....|....*
gi 149040747 529 LHSLGPEDEGIYHCA 543
Cdd:cd00099   77 ISNLQPEDSGTYYCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-146 4.20e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 4.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747    33 GPLYRVAGTAVSISCNVSdyeGPSQQDFEWFMYRPEAPATSLGIISTKDsqfsyavfgprvasgdlqvqrlkGDSVVLKI 112
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLAESGRFSVSRS-----------------------GSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 149040747   113 ARLQAQDSGFYECYTpstdTQYLGNYSAKVELRV 146
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 316-417 1.40e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 316 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGiGSLGPGYEDRHIAmEKVASRTYRLRLEAA 394
Cdd:cd00099   12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                         90       100
                 ....*....|....*....|....*....
gi 149040747 395 RPADAGTYRCLAKA------YVRGSGTRL 417
Cdd:cd00099   81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 39-136 4.16e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.01  E-value: 4.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747  39 AGTAVSISCNVSDYEGPSQqdFEWFMYRPEAPATSLGIISTKDSQFSYAVFGPRVASGDlqvqrlKGDSVVLKIARLQAQ 118
Cdd:cd00099   12 EGESVTLSCEVSSSFSSTY--IYWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGSRD------GTSSFSLTISNLQPE 83

                         90       100
                 ....*....|....*....|.
gi 149040747 119 DSGFYEC---YTPSTDTQYLG 136
Cdd:cd00099   84 DSGTYYCavsESGGTDKLTFG 104
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-147 1.01e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747   40 GTAVSISCNVSDYEGPSQQDFEWFMYRPEAPATSLGIISTKDSQFSyaVFGPRVASGDLQVQrlkgDSVVLKIARLQAQD 119
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEG--VKKGRFSGRGDPSN----GDGSLTIQNLTLSD 84

                          90       100
                  ....*....|....*....|....*...
gi 149040747  120 SGFYECYTPSTDTQYLGNysaKVELRVL 147
Cdd:pfam07686  85 SGTYTCAVIPSGEGVFGK---GTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 449-543 6.60e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 449 TVYRGETASLLCNISVRGGPPGLrlaaSWWVERPeegelSSGPaQLVGGVGQDGVAELGVRPGGspVSVELVGPRSHRLR 528
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYI----YWYRQKP-----GQGP-EFLIYLSSSKGKTKGGVPGR--FSGSRDGTSSFSLT 76

                         90
                 ....*....|....*
gi 149040747 529 LHSLGPEDEGIYHCA 543
Cdd:cd00099   77 ISNLQPEDSGTYYCA 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-146 4.20e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 4.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747    33 GPLYRVAGTAVSISCNVSdyeGPSQQDFEWFMYRPEAPATSLGIISTKDsqfsyavfgprvasgdlqvqrlkGDSVVLKI 112
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKLLAESGRFSVSRS-----------------------GSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|....
gi 149040747   113 ARLQAQDSGFYECYTpstdTQYLGNYSAKVELRV 146
Cdd:smart00410  56 SNVTPEDSGTYTCAA----TNSSGSASSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
43-125 1.03e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.21  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747    43 VSISCNVSDYEGPSQQdFEWFMYRPEAPATSLGIISTKDSQFSYAVFGPRVA-SGDLQvqrlkGDSVVLKIARLQAQDSG 121
Cdd:smart00406   2 VTLSCKFSGSTFSSYY-VSWVRQPPGKGLEWLGYIGSNGSSYYQESYKGRFTiSKDTS-----KNDVSLTISNLRVEDTG 75


                   ....
gi 149040747   122 FYEC 125
Cdd:smart00406  76 TYYC 79
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 316-417 1.40e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.55  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747 316 PGEPLELLCNVSGALPPagrhaaYSVGW-EMAPAGAPgpgRLVAQLDTEGiGSLGPGYEDRHIAmEKVASRTYRLRLEAA 394
Cdd:cd00099   12 EGESVTLSCEVSSSFSS------TYIYWyRQKPGQGP---EFLIYLSSSK-GKTKGGVPGRFSG-SRDGTSSFSLTISNL 80

                         90       100
                 ....*....|....*....|....*....
gi 149040747 395 RPADAGTYRCLAKA------YVRGSGTRL 417
Cdd:cd00099   81 QPEDSGTYYCAVSEsggtdkLTFGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 39-136 4.16e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.01  E-value: 4.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747  39 AGTAVSISCNVSDYEGPSQqdFEWFMYRPEAPATSLGIISTKDSQFSYAVFGPRVASGDlqvqrlKGDSVVLKIARLQAQ 118
Cdd:cd00099   12 EGESVTLSCEVSSSFSSTY--IYWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGSRD------GTSSFSLTISNLQPE 83

                         90       100
                 ....*....|....*....|.
gi 149040747 119 DSGFYEC---YTPSTDTQYLG 136
Cdd:cd00099   84 DSGTYYCavsESGGTDKLTFG 104
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 27-125 2.69e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747   27 QVHVPKGPLYRVAGTAVSISCNVsdyEGPSQQDFEWFmyrpeapatslgiistKDsqfsyavfGPRVASGDLQVQRLKGD 106
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEA---TGSPPPTITWY----------------KN--------GEPISSGSTRSRSLSGS 55

                          90
                  ....*....|....*....
gi 149040747  107 SVVLKIARLQAQDSGFYEC 125
Cdd:pfam13927  56 NSTLTISNVTRSDAGTYTC 74
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 34-137 5.10e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 36.88  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149040747  34 PLYRVA--GTAVSISCNVSDyegpsqqDFEW-FMYRpEAPATSLGIISTKDSQFSYAVFGprVASGDLQVQRLKGDSVVL 110
Cdd:cd05899    5 PRYLIKrrGQSVTLRCSQKS-------GHDNmYWYR-QDPGKGLQLLFYSYGGGLNEEGD--LPGDRFSASRPSLTRSSL 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 149040747 111 KIARLQAQDSGFYEC---YTPSTDTQYLGN 137
Cdd:cd05899   75 TIKSAEPEDSAVYLCassLGGGADEAYFGP 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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