NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|149060023|gb|EDM10839|]
View 

nuclear NF-kappaB activating protein [Rattus norvegicus]

Protein Classification

NKAP family protein( domain architecture ID 7381)

NKAP (NF-kappa-B-activating protein) family protein, similar to human NKAP-like protein (NKAPL) that functions as a transcriptional repressor of Notch-mediated signaling

Gene Ontology:  GO:0003682|GO:0003676

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nkap_C super family cl05538
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 308-355 9.23e-22

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


The actual alignment was detected with superfamily member pfam06047:

Pssm-ID: 461812  Cd Length: 102  Bit Score: 88.46  E-value: 9.23e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149060023  308 KHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMV 355
Cdd:pfam06047  53 RHRRMNAVRIRKENQVYSAEEKRALALLNKEERAKRENEIISQFRELV 100
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 308-355 9.23e-22

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 88.46  E-value: 9.23e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149060023  308 KHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMV 355
Cdd:pfam06047  53 RHRRMNAVRIRKENQVYSAEEKRALALLNKEERAKRENEIISQFRELV 100
 
Name Accession Description Interval E-value
Nkap_C pfam06047
NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in ...
 308-355 9.23e-22

NF-kappa-B-activating protein C-terminal domain; This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency.


Pssm-ID: 461812  Cd Length: 102  Bit Score: 88.46  E-value: 9.23e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149060023  308 KHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMV 355
Cdd:pfam06047  53 RHRRMNAVRIRKENQVYSAEEKRALALLNKEERAKRENEIISQFRELV 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH