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Conserved domains on  [gi|149064342|gb|EDM14545|]
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dynactin 4, isoform CRA_c [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dynactin_p62 super family cl20296
Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or ...
 23-122 2.07e-20

Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin.


The actual alignment was detected with superfamily member pfam05502:

Pssm-ID: 428497  Cd Length: 474  Bit Score: 85.09  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149064342   23 PLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCA-NCFDCPGCMHTLSTRATSISTQLPDDPAKT 101
Cdd:pfam05502   1 PLEHLLYCEDCHQIRCPRCVTEEIVTWYCPNCLFEVPSSNVKSEGNRCTrSCFQCPICISPLAVTSLENPPDPLGGAGAS 80

                          90       100
                  ....*....|....*....|.
gi 149064342  102 TmKKAYYLACGFCRWTSRDVG 122
Cdd:pfam05502  81 H-GGPYILSCSYCMWSSLEIG 100
 
Name Accession Description Interval E-value
Dynactin_p62 pfam05502
Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or ...
 23-122 2.07e-20

Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin.


Pssm-ID: 428497  Cd Length: 474  Bit Score: 85.09  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149064342   23 PLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCA-NCFDCPGCMHTLSTRATSISTQLPDDPAKT 101
Cdd:pfam05502   1 PLEHLLYCEDCHQIRCPRCVTEEIVTWYCPNCLFEVPSSNVKSEGNRCTrSCFQCPICISPLAVTSLENPPDPLGGAGAS 80

                          90       100
                  ....*....|....*....|.
gi 149064342  102 TmKKAYYLACGFCRWTSRDVG 122
Cdd:pfam05502  81 H-GGPYILSCSYCMWSSLEIG 100
 
Name Accession Description Interval E-value
Dynactin_p62 pfam05502
Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or ...
 23-122 2.07e-20

Dynactin p62 family; Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin.


Pssm-ID: 428497  Cd Length: 474  Bit Score: 85.09  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149064342   23 PLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCA-NCFDCPGCMHTLSTRATSISTQLPDDPAKT 101
Cdd:pfam05502   1 PLEHLLYCEDCHQIRCPRCVTEEIVTWYCPNCLFEVPSSNVKSEGNRCTrSCFQCPICISPLAVTSLENPPDPLGGAGAS 80

                          90       100
                  ....*....|....*....|.
gi 149064342  102 TmKKAYYLACGFCRWTSRDVG 122
Cdd:pfam05502  81 H-GGPYILSCSYCMWSSLEIG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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