DNA-directed RNA polymerase III subunit RPC3 [Myotis davidii]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| IgC2_CD160 | cd21392 | Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ... |
24-142 | 1.15e-68 | |||||
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs. : Pssm-ID: 409621 Cd Length: 119 Bit Score: 223.05 E-value: 1.15e-68
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| RNA_pol_Rpc82 | pfam05645 | RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase ... |
346-545 | 7.01e-48 | |||||
RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. : Pssm-ID: 398977 Cd Length: 233 Bit Score: 169.96 E-value: 7.01e-48
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| HTH_9 | pfam08221 | RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several ... |
207-265 | 1.64e-21 | |||||
RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. This region is a probably DNA-binding helix-turn-helix. : Pssm-ID: 400500 Cd Length: 62 Bit Score: 88.44 E-value: 1.64e-21
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| NUDIX_Hydrolase super family | cl00447 | NUDIX hydrolase superfamily; NUDIX hydrolase is a superfamily of enzymes found in all three ... |
702-747 | 4.32e-06 | |||||
NUDIX hydrolase superfamily; NUDIX hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue NUDIX motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of NUDIX hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the NUDIX hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase. The actual alignment was detected with superfamily member cd04694: Pssm-ID: 469772 [Multi-domain] Cd Length: 135 Bit Score: 46.90 E-value: 4.32e-06
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| Name | Accession | Description | Interval | E-value | |||||
| IgC2_CD160 | cd21392 | Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ... |
24-142 | 1.15e-68 | |||||
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs. Pssm-ID: 409621 Cd Length: 119 Bit Score: 223.05 E-value: 1.15e-68
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| RNA_pol_Rpc82 | pfam05645 | RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase ... |
346-545 | 7.01e-48 | |||||
RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. Pssm-ID: 398977 Cd Length: 233 Bit Score: 169.96 E-value: 7.01e-48
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| HTH_9 | pfam08221 | RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several ... |
207-265 | 1.64e-21 | |||||
RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. This region is a probably DNA-binding helix-turn-helix. Pssm-ID: 400500 Cd Length: 62 Bit Score: 88.44 E-value: 1.64e-21
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| NUDIX_Nudt17 | cd04694 | nucleoside diphosphate-linked moiety X)) motif 17; Nucleoside diphosphate-linked moiety X)) ... |
702-747 | 4.32e-06 | |||||
nucleoside diphosphate-linked moiety X)) motif 17; Nucleoside diphosphate-linked moiety X)) motif 17 (EC 3.6.1.-) encoded by the NUDT17 gene on chromosome 1q21.1 and encodes an enzyme thought to hydrolyse some nucleoside diphosphate derivatives. Members of the NUDIX hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue NUDIX motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of NUDIX hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the NUDIX hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance _ "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. Pssm-ID: 467576 [Multi-domain] Cd Length: 135 Bit Score: 46.90 E-value: 4.32e-06
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| Name | Accession | Description | Interval | E-value | |||||
| IgC2_CD160 | cd21392 | Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ... |
24-142 | 1.15e-68 | |||||
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs. Pssm-ID: 409621 Cd Length: 119 Bit Score: 223.05 E-value: 1.15e-68
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| RNA_pol_Rpc82 | pfam05645 | RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase ... |
346-545 | 7.01e-48 | |||||
RNA polymerase III subunit RPC82; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. Pssm-ID: 398977 Cd Length: 233 Bit Score: 169.96 E-value: 7.01e-48
|
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| HTH_9 | pfam08221 | RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several ... |
207-265 | 1.64e-21 | |||||
RNA polymerase III subunit RPC82 helix-turn-helix domain; This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa. This region is a probably DNA-binding helix-turn-helix. Pssm-ID: 400500 Cd Length: 62 Bit Score: 88.44 E-value: 1.64e-21
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| NUDIX_Nudt17 | cd04694 | nucleoside diphosphate-linked moiety X)) motif 17; Nucleoside diphosphate-linked moiety X)) ... |
702-747 | 4.32e-06 | |||||
nucleoside diphosphate-linked moiety X)) motif 17; Nucleoside diphosphate-linked moiety X)) motif 17 (EC 3.6.1.-) encoded by the NUDT17 gene on chromosome 1q21.1 and encodes an enzyme thought to hydrolyse some nucleoside diphosphate derivatives. Members of the NUDIX hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue NUDIX motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of NUDIX hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the NUDIX hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance _ "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. Pssm-ID: 467576 [Multi-domain] Cd Length: 135 Bit Score: 46.90 E-value: 4.32e-06
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