BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   6 AWLPFARAAAIGWVPIATHPLPAPPIPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFF 85
Cdd:cd18420    1 AWLPFARAAAIGWVPIANNPLPPPPVDQERRRTDDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 577729183  86 DRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKREN 144
Cdd:cd18420   81 DRDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 577729183  471 EDIFELQHHHLLRCLEKTTDREFVElEIPYN------GQPKRTgSPSPMASPAHstnsgiGLMQSCCGRCC 535
Cdd:pfam11879   2 TSLFESQHHHLLHCLEKTTNHEFVD-EQTYEqnclevSLQNRP-SRSPSLSSQD------GLTSSCCSRRA 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   6 AWLPFARAAAIGWVPIATHPLPAPPIPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFF 85
Cdd:cd18420    1 AWLPFARAAAIGWVPIANNPLPPPPVDQERRRTDDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 577729183  86 DRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKREN 144
Cdd:cd18420   81 DRDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   43 LLINVSGRRFETWRNTLEKYPDTLLGSNERE--FFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEEL 119
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 577729183  120 AFFGIMPDVIGDC 132
Cdd:pfam02214  81 EFYGLDELALELC 93

Domain of unknown function (DUF3399); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length. This domain is found associated with pfam02214, pfam00520.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 577729183  471 EDIFELQHHHLLRCLEKTTDREFVElEIPYN------GQPKRTgSPSPMASPAHstnsgiGLMQSCCGRCC 535
Cdd:pfam11879   2 TSLFESQHHHLLHCLEKTTNHEFVD-EQTYEqnclevSLQNRP-SRSPSLSSQD------GLTSSCCSRRA 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   6 AWLPFARAAAIGWVPIATHPLPAPPIPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFF 85
Cdd:cd18420    1 AWLPFARAAAIGWVPIANNPLPPPPVDQERRRTDDEKLIINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEETKEYFF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 577729183  86 DRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKREN 144
Cdd:cd18420   81 DRDPDIFRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRKREN 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   5 AAWLPFARAAAIGWVPIATHPLPAPPIPKDRRktDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYF 84
Cdd:cd18417    1 ATWLPFARAAAVGWLPLAKKPMPKPPSDKKRR--NDEILVVNVSGRRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQEYF 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  85 FDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKREN 144
Cdd:cd18417   79 FDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  43 LLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFF 122
Cdd:cd18418    2 IVLNVSGTRFQTWRNTLERYPDTLLGSSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFF 81

                         90       100
                 ....*....|....*....|..
gi 577729183 123 GIMPDVIGDCCYEDYRDRKREN 144
Cdd:cd18418   82 GIIPEIIGDCCYEEYKDRRREN 103

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183   43 LLINVSGRRFETWRNTLEKYPDTLLGSNERE--FFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEEL 119
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELecDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 577729183  120 AFFGIMPDVIGDC 132
Cdd:pfam02214  81 EFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  43 LLINVSGRRFETWRNTLEKYPDTLLGS----NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEE 118
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWltetEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80

                         90       100
                 ....*....|....*....|...
gi 577729183 119 LAFFGIMPDVIGDCCYEDYRDRK 141
Cdd:cd18379   81 LAFWGIDETQIEPCCWMTYRQHR 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  39 DDEKLLINVSGRRFETWRNTLEKYPDT-LLGSNERE----FFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLT 113
Cdd:cd18414    1 ESDRIVINVGGTRHETYRSTLRTLPGTrLAWLAEPDahsnFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 577729183 114 SYDEELAFFGIMPDVIGDCCYEDYRDRKreNAERLMD 150
Cdd:cd18414   81 LYEEELAFWGIDETDVEPCCWMTYRQHR--DAEEALD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  40 DEKLLINVSGRRFETWRNTLEKYPDT---LLGSNE-------------REFFYDEDCKEYFFDRDPDIFRHILNYYRTGK 103
Cdd:cd18415    1 NERIILNVGGTRHETYRSTLKTLPGTrlaLLASSDpqgdcltqcsqvgGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 577729183 104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRD-RKRENA 145
Cdd:cd18415   81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQhRDAEEA 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  41 EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEE 118
Cdd:cd18377    1 ERVVINVSGLRFETQLKTLAQFPNTLLGDpNKRMRFFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFLEE 80

                 ....
gi 577729183 119 LAFF 122
Cdd:cd18377   81 IRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  43 LLINVSGRRFETWRNTLEKYPDTLLG---SNEREFFYD--EDC----KEYFFDRDPDIFRHILNYYRTGKLHYPKHECLT 113
Cdd:cd18424    1 FTINVGGSRFVLSQQVLSSHPETRLGklaVSVRDSVLElcDDAnfvdNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAI 80

                         90       100
                 ....*....|....*....|....*...
gi 577729183 114 SYDEELAFFGIMPDVIGDCCYEDYRDRK 141
Cdd:cd18424   81 SFLQEIEYWGIDELSIDSCCRERYYRRK 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  43 LLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECL 112
Cdd:cd18382    1 VIINVGGARYSLPWSTLDRFPLTRLSrlkacRSEDDILrvcddYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80

                         90       100
                 ....*....|....*....|....*...
gi 577729183 113 TSYDEELAFFGIMPDVIGDCCYEDYRDR 140
Cdd:cd18382   81 LSFQEELAYWGIEEAHLERCCKRRLLRR 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  26 LPAPPIPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGS----NEREFF------YDEDCKEYFFDRDPDIFRHI 95
Cdd:cd18412    2 LPPEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKlrdcNTHESLlevcddYNLNENEYFFDRHPGAFTSI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 577729183  96 LNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRK 141
Cdd:cd18412   82 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLG---SNEREFFYDEDcKEYFFDRDPDIFRHILNYYRTGKLHYPKHE 110
Cdd:cd18316    3 LNVGGTLFTTSRSTLLKDPDSLLAalfSGRWPLPRDED-GSIFIDRDPELFRHILNFLRTGKLPLPSDF 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  42 KLLINVSGRRFETWRNTLEKYPDTLLG----SNEREFFYD--EDCK----EYFFDRDPDIFRHILNYYRTGKLHYPKHEC 111
Cdd:cd18413    3 RVVINVGGVKHEVLWRTLDRMPHTRLGklrdSNTHEAIVElcDDYSladnEYFFDRHPRSFASILNFYRTGKLHLVEEMC 82

                         90       100
                 ....*....|....*....|....*.
gi 577729183 112 LTSYDEELAFFGIMPDVIGDCCYEDY 137
Cdd:cd18413   83 VLAFSDDLEYWGVDELYLESCCQHKY 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  34 DRRKTddekLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRHILNYYRTGK 103
Cdd:cd18421    1 DRTRH----VIINVGGIKYRIPWTTLEEFPLTRLGqlkscNNFDEIMdicddYDVTCNEFFFDRNPCAFRTILTFLRAGK 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 577729183 104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDR 140
Cdd:cd18421   77 LRLLREMCALSFQEELLYWGIEEENLEWCCRRRLLQK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTS 114
Cdd:cd18426    3 INVGGLKRRLSSSTLSKFPDTRLGrllscDSEESILqicddYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCVFS 82

                         90       100
                 ....*....|....*....|...
gi 577729183 115 YDEELAFFGIMPDVIGDCCYEDY 137
Cdd:cd18426   83 FSQEIEYWGINEFFLDSCCSYRY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  41 EKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEE 118
Cdd:cd18409    1 QKVIINIAGLRFETQLKTLDQFPDTLLGDPEKRMkYFDSMRNEYFFDRNRPSFDGILYYYQSgGKIRRPANVPLDVFADE 80

                 ....
gi 577729183 119 LAFF 122
Cdd:cd18409   81 IIFY 84

Shal-type voltage-gated potassium channels, N-terminal; This family represents the short N-terminal helical domain of Shal-type voltage-gated potassium channels. The domain interacts with Kv channel-interacting proteins to modulate cell surface expression and the function of Kv4 channels. The interaction of the N-terminus of Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs.

                          10        20
                  ....*....|....*....|....*...
gi 577729183    2 ASVAAWLPFARAAAIGWVPIATHPLPAP 29
Cdd:pfam11601   1 ASVAAWLPFARAAAIGWVPVARNPLPPP 28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  41 EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEE 118
Cdd:cd18402    9 ERVVINIAGLRFETQLKTLAQFPNTLLGNpKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDMFSEE 88

                 ....
gi 577729183 119 LAFF 122
Cdd:cd18402   89 IKFY 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  41 EKLLINVSGRRFETWRNTLEKYPDTLLG-----SNEREFF-----YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHE 110
Cdd:cd18423    2 REIIINVGGIKYLMPWSTLDEFPLTRLGklkfcSSYEEIVqicddYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81

                         90       100
                 ....*....|....*....|....
gi 577729183 111 CLTSYDEELAFFGIMPDVIGDCCY 134
Cdd:cd18423   82 CALSFQEELTYWGIEEANLERCCL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  46 NVSGRRFETWRNTLEKYPDTLLG---SNEREFFYDEDcKEYFFDRDPDIFRHILNYYRTGKLHYPkHECLTSYDE---EL 119
Cdd:cd18376    4 NVGGQKFTTTLDTLTKDPDSMLAamfSGRHSLKKDED-GSYFIDRDGTHFRHILNYLRDGEVKIP-TEDRSVLKElleEA 81

                 ....*..
gi 577729183 120 AFFGIMP 126
Cdd:cd18376   82 EYYQLRG 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  43 LLINVSGRRFETWRNTLEKYPDTLL--------GSNEREFF----YDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHE 110
Cdd:cd18381    3 IVVNVGGVRQVLYGDVLNRYPETRLaellnclsGGYDAIFSlcddYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKGI 82

                         90       100
                 ....*....|....*....|...
gi 577729183 111 CLTSYDEELAFFGIMPDVIGDCC 133
Cdd:cd18381   83 CPICFKNEMDFWRVDLDFLDECC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLGS--NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHyPKHECLTSYDEELAFF 122
Cdd:cd18363    6 LNVGGKRFSTSRQTLTWIPDSFFTSllSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEID-LRNVDISSLRHEAEFY 84

                 ..
gi 577729183 123 GI 124
Cdd:cd18363   85 GI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLGS--NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYP 107
Cdd:cd18364    4 LNVGGYLYITQRQTLTKYPDSFLEGmvNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLP 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLGSNER-EFFYDEDCK-EYFFDRDPDIFRHILNYYRTGKLHYPKHecLTSYD---EEL 119
Cdd:cd18394    7 LNVGGHLYTTSLSTLTRYPDSMLGAMFRgDFPTARDSQgNYFIDRDGPLFRYILNFLRTSELTLPVD--FKEFDllrKEA 84

                 ....*..
gi 577729183 120 AFFGIMP 126
Cdd:cd18394   85 DFYQIEP 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577729183  45 INVSGRRFETWRNTLEKYPDTLLGS--NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHyPKHECLTSYDEELAFF 122
Cdd:cd18393    6 LNVGGKRFSTSRQTLTWIPDSFFSSllSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHEAQFY 84

                 ....*.
gi 577729183 123 GIMPDV 128
Cdd:cd18393   85 GITPLV 90