NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2277053488|gb|KAI5559750|]
View 

hypothetical protein BDE02_17G134200 [Populus trichocarpa]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-243 6.86e-40

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 136.31  E-value: 6.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488  88 GSVMWDSGVVLGKFLEHAVDSGLLL--LHGKKVVELGSGCGLVGCIAALL--GAQVTLTDLPDRLRLLKKNIETNlrhgN 163
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKIFKELGAnnLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLEEALELLKKNIELN----A 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488 164 VRGSAVVRELIWGDDPDQDLIVPFP-DYVLGSDVVYSEGAVVDLLDTLVQLCGAQTTIFLAGELRNDAVLEYFldAAMKE 242
Cdd:pfam10294  94 LSSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYKKRREAEKKFF--KLLER 171


                  .
gi 2277053488 243 F 243
Cdd:pfam10294 172 F 172
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 88-243 6.86e-40

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 136.31  E-value: 6.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488  88 GSVMWDSGVVLGKFLEHAVDSGLLL--LHGKKVVELGSGCGLVGCIAALL--GAQVTLTDLPDRLRLLKKNIETNlrhgN 163
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKIFKELGAnnLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLEEALELLKKNIELN----A 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488 164 VRGSAVVRELIWGDDPDQDLIVPFP-DYVLGSDVVYSEGAVVDLLDTLVQLCGAQTTIFLAGELRNDAVLEYFldAAMKE 242
Cdd:pfam10294  94 LSSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYKKRREAEKKFF--KLLER 171


                  .
gi 2277053488 243 F 243
Cdd:pfam10294 172 F 172
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
113-156 8.20e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 48.36  E-value: 8.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2277053488 113 LHGKKVVELGSGCGLVGCIAALLGAQ-VTLTDL-PDRLRLLKKNIE 156
Cdd:COG2263    44 IEGKTVLDLGCGTGMLAIGAALLGAKkVVGVDIdPEALEIARENAE 89
PRK14968 PRK14968
putative methyltransferase; Provisional
 103-158 1.46e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 1.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277053488 103 EHAVDSGLLL-----LHGKKVVELGSGCGLVGCIAALLGAQVTLTDL-PDRLRLLKKNIETN 158
Cdd:PRK14968    7 EPAEDSFLLAenavdKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDInPYAVECAKCNAKLN 68
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 88-243 6.86e-40

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 136.31  E-value: 6.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488  88 GSVMWDSGVVLGKFLEHAVDSGLLL--LHGKKVVELGSGCGLVGCIAALL--GAQVTLTDLPDRLRLLKKNIETNlrhgN 163
Cdd:pfam10294  18 GGHVWDAAVVLSKYLEMKIFKELGAnnLSGLNVLELGSGTGLVGIAVALLlpGASVTITDLEEALELLKKNIELN----A 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488 164 VRGSAVVRELIWGDDPDQDLIVPFP-DYVLGSDVVYSEGAVVDLLDTLVQLCGAQTTIFLAGELRNDAVLEYFldAAMKE 242
Cdd:pfam10294  94 LSSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESVILVAYKKRREAEKKFF--KLLER 171


                  .
gi 2277053488 243 F 243
Cdd:pfam10294 172 F 172
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
113-156 8.20e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 48.36  E-value: 8.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2277053488 113 LHGKKVVELGSGCGLVGCIAALLGAQ-VTLTDL-PDRLRLLKKNIE 156
Cdd:COG2263    44 IEGKTVLDLGCGTGMLAIGAALLGAKkVVGVDIdPEALEIARENAE 89
PRK14968 PRK14968
putative methyltransferase; Provisional
 103-158 1.46e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 1.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277053488 103 EHAVDSGLLL-----LHGKKVVELGSGCGLVGCIAALLGAQVTLTDL-PDRLRLLKKNIETN 158
Cdd:PRK14968    7 EPAEDSFLLAenavdKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDInPYAVECAKCNAKLN 68
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
102-200 2.34e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.48  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277053488 102 LEHAVDSGllllhgKKVVELGSGCGLVGCIAALLGAQ--VTLTDLPDRLRLLKKNIETNLRHGNVrgsavvrELIWGDDP 179
Cdd:COG4076    29 IERVVKPG------DVVLDIGTGSGLLSMLAARAGAKkvYAVEVNPDIAAVARRIIAANGLSDRI-------TVINADAT 95

                          90       100
                  ....*....|....*....|.
gi 2277053488 180 DqdliVPFPDYVlgsDVVYSE 200
Cdd:COG4076    96 D----LDLPEKA---DVIISE 109
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 95-158 6.00e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 37.05  E-value: 6.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277053488  95 GVVLGKFLEhavdsgllLLHGKKVVELGSGCGLVG-CIAA-LLGAQVTLTDL-PDRLRLLKKNIETN 158
Cdd:COG4123    26 AVLLAAFAP--------VKKGGRVLDLGTGTGVIAlMLAQrSPGARITGVEIqPEAAELARRNVALN 84
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 111-165 9.12e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 35.38  E-value: 9.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2277053488 111 LLLHGKKVVELGSGCGLVGCIAALLGAQVTLTDL-PDRLRLLKKNIET---NLRHGNVR 165
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALALARRGADVTGVDIsPEALEIARERAAElnvDFVQGDLE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH