NCBI Conserved Domain Search

Conserved domains on [gi|47577433|ref|NP_001000629|]

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olfactory receptor Olr693 [Rattus norvegicus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

4.88e-155

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 433.95 E-value: 4.88e-155

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

4.88e-155

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 433.95 E-value: 4.88e-155

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

1.12e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 137.63 E-value: 1.12e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433    29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   189 DTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM----RPVVTY 263
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 47577433   264 PVDNIMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

4.88e-155

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 433.95 E-value: 4.88e-155

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

25-289

5.10e-127

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 363.06 E-value: 5.10e-127

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYP 264
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFP 242

                       250       260
                ....*....|....*....|....*
gi 47577433 265 VDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15226 243 VDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

24-289

2.32e-114

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 330.99 E-value: 2.32e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 47577433 263 YP--VDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd13954 242 YSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

28-289

5.23e-111

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 322.36 E-value: 5.23e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15936   6 VFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15936  86 AEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVDN 267
Cdd:cd15936 166 TDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMDK 245

                       250       260
                ....*....|....*....|..
gi 47577433 268 IMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15936 246 AVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

24-296

3.82e-109

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 317.86 E-value: 3.82e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 263 Y--PVDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15225 242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

23-289

5.47e-109

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 317.14 E-value: 5.47e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPVDN--IMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15230 241 SYSLDQdkVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

24-289

1.34e-104

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 306.29 E-value: 1.34e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15940 242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-299

6.35e-101

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 297.74 E-value: 6.35e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   9 DFILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT 88
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  89 TISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCG 168
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 169 PNIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVL 247
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577433 248 FFVPCIFLYMRPVVTYPVDN--IMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQdkVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-296

1.61e-100

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 296.10 E-value: 1.61e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577433 264 P--VDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15231 243 SldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

24-289

5.17e-99

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 292.08 E-value: 5.17e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 47577433 263 YPVD--NIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15912 242 SSLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-296

5.03e-98

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 289.89 E-value: 5.03e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  22 RTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFA 101
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFP 181
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 182 LLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPV 260
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577433 261 VTYPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15235 241 SSYSAdkDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

25-289

8.16e-98

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 288.69 E-value: 8.16e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILcsLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYP 264
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL--VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP 240

                       250       260
                ....*....|....*....|....*
gi 47577433 265 VDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15938 241 VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

28-296

2.33e-97

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 287.96 E-value: 2.33e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15229   6 VFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15229  86 TEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY--P 264
Cdd:cd15229 166 SDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASssV 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 265 VDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15229 246 LDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-299

2.59e-97

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 288.40 E-value: 2.59e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  10 FILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTT 89
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  90 ISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGP 169
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 170 NIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVIL-CSLKSRSSEGRRKALSTCSSHFTVVVLF 248
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIvTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577433 249 FVPCIFLYMRPVVTYP--VDNIMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:cd15410 241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

24-298

5.17e-97

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 287.23 E-value: 5.17e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577433 263 Y--PVDNIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15417 242 HsqDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-293

6.59e-97

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 287.30 E-value: 6.59e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  10 FILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTT 89
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  90 ISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGP 169
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 170 NIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLF 248
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 249 FVPCIFLYMRPVVTYPVDN--IMALCATIVEPMLNPLIYSLRNAEVK 293
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLdkVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

23-289

1.65e-96

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 285.53 E-value: 1.65e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPVD--NIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15911 241 NTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

27-289

4.81e-96

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 284.35 E-value: 4.81e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15227   5 VLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15227  85 ASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYP- 264
Cdd:cd15227 165 CSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPs 244

                       250       260
                ....*....|....*....|....*.
gi 47577433 265 -VDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15227 245 lLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

23-296

6.24e-95

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 282.01 E-value: 6.24e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577433 262 TYPVDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

23-289

1.06e-94

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 281.04 E-value: 1.06e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPV--DNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15918 241 SHSAskDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

28-296

3.76e-93

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 277.41 E-value: 3.76e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSEN-TTISLEGCMTQLFAEHFFG 106
Cdd:cd15916   6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15916  86 STECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15916 166 CADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEAL 245

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577433 266 DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15916 246 DGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-296

3.80e-93

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 277.12 E-value: 3.80e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15421   5 SLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15421  85 GAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY-- 263
Cdd:cd15421 165 CADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHsp 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15421 245 EQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

5.26e-93

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 276.62 E-value: 5.26e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15937 242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

23-289

5.93e-93

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 276.49 E-value: 5.93e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15915   1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15915  81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHI-LDLLVILNSGVMCVTIFLILItSYVVILCSL--KSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP 259
Cdd:cd15915 161 LKLACGDTSLnLWLLNIVTGSIALGTFILTLL-SYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRP 239

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 260 VV--TYPVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15915 240 SSgdSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

23-298

1.40e-92

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 275.83 E-value: 1.40e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 262 TYPVDNIM--ALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15409 241 LYALDQDMmdSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

23-289

4.05e-92

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 274.33 E-value: 4.05e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLR-SPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFA 101
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLLqSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFP 181
Cdd:cd15935  81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 182 LLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15935 161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                       250       260
                ....*....|....*....|....*...
gi 47577433 262 TYPVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15935 241 SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

23-298

8.04e-92

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 273.86 E-value: 8.04e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 262 TYPVD--NIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15416 241 SYSMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

23-289

4.01e-91

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 271.84 E-value: 4.01e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPV--DNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15237 241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

23-298

7.93e-91

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 271.50 E-value: 7.93e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 262 TYPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15411 241 SYSLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

28-298

1.67e-90

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 270.72 E-value: 1.67e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15419   6 LFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15419  86 TEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP--VVTYP 264
Cdd:cd15419 166 SDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgaVSSPE 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577433 265 VDNIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15419 246 QSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-296

2.89e-90

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 270.04 E-value: 2.89e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15429   5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15429  85 GTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15429 165 CVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSA 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577433 266 --DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15429 245 lqEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-298

6.39e-89

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 267.00 E-value: 6.39e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  10 FILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTT 89
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  90 ISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGP 169
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 170 NIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLF 248
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 249 FVPCIFLYMRPVVTYPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

1.16e-88

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 265.66 E-value: 1.16e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPVDN--IMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15232 241 SYSPEKdkVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

19-299

3.74e-88

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 265.00 E-value: 3.74e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  19 PELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQ 98
Cdd:cd15406   6 PELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQ 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  99 LFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICD 178
Cdd:cd15406  86 LFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 179 LFPLLQLACTDTHILDLLVILNSGV-MCVTIFLILItSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLY 256
Cdd:cd15406 166 ILPLLKLSCSSTYINELLLFIVGGFnVLATTLAILI-SYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMY 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47577433 257 MRPVVTYPVD--NIMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:cd15406 245 LKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

28-298

1.39e-86

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 260.81 E-value: 1.39e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15415   6 LFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15415  86 TEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVD 266
Cdd:cd15415 166 SDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLE 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577433 267 N--IMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15415 246 QekVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

23-289

1.79e-86

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 259.85 E-value: 1.79e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMyQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNS-GVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15431 160 LKLACSDTSLNEILMFATSiFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPV--DNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15431 240 KSSSdqDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-289

1.62e-85

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 257.60 E-value: 1.62e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15224   5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15224  85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15224 165 CTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSF 244

                       250       260
                ....*....|....*....|....*.
gi 47577433 266 D--NIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15224 245 DsnKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-296

7.77e-85

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 256.10 E-value: 7.77e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577433 264 PV--DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15420 243 SAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

23-298

1.76e-84

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 255.32 E-value: 1.76e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15413  81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15413 161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 262 TYPVDN--IMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15413 241 SHSLDTdkMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

24-304

2.95e-82

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 250.04 E-value: 2.95e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP--V 260
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPssS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47577433 261 VTYPVDNIMALCATIVEPMLNPLIYSLRNAEVKQALRKLWMKRG 304
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

24-298

3.44e-82

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 249.62 E-value: 3.44e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFaeh 103
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCY--- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGG---VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLF 180
Cdd:cd15412  79 FFIAlviTEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 181 PLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP 259
Cdd:cd15412 159 PLIKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRP 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577433 260 VVTYPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15412 239 PSEESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

29-296

6.47e-82

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 248.50 E-value: 6.47e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15942   7 FLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:cd15942  87 ECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVDN 267
Cdd:cd15942 167 DTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDG 246

                       250       260
                ....*....|....*....|....*....
gi 47577433 268 IMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15942 247 VVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

24-296

1.76e-81

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 247.84 E-value: 1.76e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRS-PMYFFLISLSFLDVIYSSITAPKLIIDSLSEN-TTISLEGCMTQLFA 101
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFP 181
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 182 LLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPV 260
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 261 VTYPVDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

23-289

2.32e-81

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 247.15 E-value: 2.32e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPVD--NIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15947 241 SYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-299

1.89e-80

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 245.46 E-value: 1.89e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  10 FILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTT 89
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  90 ISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGP 169
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 170 NIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLF 248
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577433 249 FVPCIFLYMRPVVTYPVDNIMALCA--TIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVfyTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

28-296

8.98e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 243.48 E-value: 8.98e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15405   6 LFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15405  86 SECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVD 266
Cdd:cd15405 166 TSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVN 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 267 N--IMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15405 246 QgkVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

28-289

2.40e-79

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 241.89 E-value: 2.40e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15914   6 LLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15914  86 TECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV- 265
Cdd:cd15914 166 TDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVvLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLd 245

                       250       260
                ....*....|....*....|....*
gi 47577433 266 -DNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15914 246 yDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-296

2.94e-78

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 239.28 E-value: 2.94e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 263 YPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15236 242 NSSdkDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

4.43e-78

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 239.30 E-value: 4.43e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  22 RTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFA 101
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFP 181
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 182 LLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPV 260
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577433 261 VTYPV--DNIMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:cd15418 241 SSHTPdrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

1.37e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 237.65 E-value: 1.37e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP-- 259
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPks 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 260 VVTYPVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15430 241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

24-296

4.35e-77

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 236.32 E-value: 4.35e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 263 Y-PVDNIMA-LCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15234 242 HsSRKTAVAsVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

24-296

9.51e-76

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 233.04 E-value: 9.51e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15434   2 ILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15434  82 GLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLV-ILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP--V 260
Cdd:cd15434 162 KLACVDTTAYEATIfALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPknS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 261 VTYPVDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15434 242 VSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

28-296

1.65e-75

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 232.37 E-value: 1.65e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15432   6 VFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15432  86 TECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDL-LVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVD 266
Cdd:cd15432 166 VDTTANEAeLFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHD 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 267 N--IMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15432 246 RgkMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

28-298

1.95e-75

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 232.31 E-value: 1.95e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15407   6 IFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFAT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15407  86 VENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDL-LVILNSGVMCVTIFLILItSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15407 166 SDIHISEIvLFFLASFNVFFALLVILI-SYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSM 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577433 266 DN--IMALCATIVEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15407 245 DTdkMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

27-296

5.11e-75

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 231.16 E-value: 5.11e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15424   5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15424  85 STECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15424 165 CADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTP 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577433 266 --DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15424 245 drDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

23-289

3.78e-72

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 223.73 E-value: 3.78e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15913   1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd15913  81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLV-ILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVV 261
Cdd:cd15913 161 LALSCVPAPGTELICyTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 262 TYPVD--NIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15913 241 GNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

27-296

1.59e-71

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 222.36 E-value: 1.59e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15233   5 VTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15233  85 GADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYV-VILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15233 165 CSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSS 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577433 266 --DNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15233 245 dkDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

24-289

3.69e-70

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 218.50 E-value: 3.69e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLV-ILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15946 162 KLACADTSLNEMVDfVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 47577433 263 YPV--DNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15946 242 YSPerDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

28-296

4.43e-70

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 218.50 E-value: 4.43e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15428   6 LFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15428  86 TECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLAS 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVT-IFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRP--VVTYP 264
Cdd:cd15428 166 TDTHQAEMAMFIMCVFTLVLpVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksSTSKE 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 265 VDNIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15428 246 YDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

27-296

4.25e-65

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 205.80 E-value: 4.25e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15433   5 VVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLA 186
Cdd:cd15433  85 SAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPV 265
Cdd:cd15433 165 CGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQ 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577433 266 DN--IMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15433 245 AHgkFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

25-296

1.63e-54

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 178.64 E-value: 1.63e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15223  83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFF--VPCIFLYMRPVV 261
Cdd:cd15223 163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFGK 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577433 262 TYPVD--NIMALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15223 243 TIPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

25-292

8.60e-51

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 168.75 E-value: 8.60e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15950   3 IAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCwLMVGGAWVGGFAHATIQLLFMY-QIPFCGPNIIDHVICDLFPLL 183
Cdd:cd15950  83 FTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVI-AQIGLAIVLRALLFMTPLTCLVtSLPYCGSRVVPHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIF-LYMRPV- 260
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFg 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577433 261 --VTYPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15950 242 qgVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-292

1.90e-50

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 167.85 E-value: 1.90e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DThILDLLVILNSGVMCVTIFLILI-TSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMR----PVVT 262
Cdd:cd15221 167 DI-TVNIWYGLTVALLTVGLDVVLIaVSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrfgRHIP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 263 YPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15221 246 RHVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

4.10e-50

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 167.17 E-value: 4.10e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DTHILDLLVILNSGVMCVTIFLILItSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM-----RPVVT 262
Cdd:cd15952 167 SIRINIIYGLFAISVLVLDVILIAL-SYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrfgHNIPR 245

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 263 YpVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15952 246 Y-IHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

25-292

2.08e-49

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 165.15 E-value: 2.08e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15917   3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQ 184
Cdd:cd15917  83 FTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDT---HILDLLVILNSGVMcvTIFLILItSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPV 260
Cdd:cd15917 163 LACGDTrvnSIYGLFVALLIVGF--DLLFIAL-SYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHR 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577433 261 ----VTYPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15917 240 fghhVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-292

8.92e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 150.73 E-value: 8.92e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICdLFP-LL 183
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYC-LHQdVM 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDL----LVILNSGVMCVTIFLilitSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM- 257
Cdd:cd15222 162 KLACSDTRVNSIyglfVVLSTMGLDSLLILL----SYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMv 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577433 258 ---RPVVTYPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15222 238 hrfGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-289

4.05e-43

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 149.03 E-value: 4.05e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMR----PVVTY 263
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLThrfgHNVPP 246

                       250       260
                ....*....|....*....|....*.
gi 47577433 264 PVDNIMALCATIVEPMLNPLIYSLRN 289
Cdd:cd15951 247 HVHILIANVYLLVPPMLNPIIYGVRT 272

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-292

1.37e-39

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 139.71 E-value: 1.37e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVS-PRMCWLMVGGAWVGGFAHATIQLLfMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGLIRGVLLILPLPLL-LSRLPFCANRIIPHTYCEHMAVVKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDT---HILDLLVILnsgvMCVTIFLILI-TSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM----- 257
Cdd:cd15953 166 GDTtinRIYGLVVAL----LVVGLDLLLIaLSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthrfg 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577433 258 RPVVTYpVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15953 242 QGIAPH-IHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

1.12e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 137.63 E-value: 1.12e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433    29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   189 DTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM----RPVVTY 263
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 47577433   264 PVDNIMALCATIVEPMLNPLIYSLRNAEVKQALRKL 299
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-293

2.58e-37

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 134.52 E-value: 2.58e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   8 TDFILLSISKIPELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSEN 87
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  88 TTISLEGCMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFC 167
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 168 GPNIIDHVICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVIL-CSLKSRSSEGRRKALSTCSSHFTVVV 246
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577433 247 LFFVPCIF--LYMR--PVVTYPVDNIMALCATIVEPMLNPLIYSLRNAEVK 293
Cdd:cd15949 242 AFYVPIAVssLIHRfgQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-293

7.23e-36

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 130.02 E-value: 7.23e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCwLMVGGAWVGGFAHATIQLLFMYQ-IPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVI-TKIGLAALARAVTLMTPLPFLLRrLPYCRSHVIAHCYCEHMAVVKLAC 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVIL-CSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLY----MRPVVT 262
Cdd:cd15948 167 GDTRFNNIYGIAVALFIVGLDLMFIILSYVFILrAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSStmhrFARHVA 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577433 263 YPVDNIMALCATIVEPMLNPLIYSLRNAEVK 293
Cdd:cd15948 247 PHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

26-292

1.26e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 126.90 E-value: 1.26e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15956   4 SLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQL 185
Cdd:cd15956  84 SAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 186 ACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCS-LKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM----RPV 260
Cdd:cd15956 164 ACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHS 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577433 261 VTYPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15956 244 VPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

6.91e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 116.24 E-value: 6.91e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433    39 GNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEHFFGGVEIILLIVMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   118 YDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNiidHVICDLFPLLQLACtdthiLDLLV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433   198 ILNSGVMCVTIFLILITSYVVILCSLKSRSSEG--------RRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVDN-- 267
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsr 232

                         250       260
                  ....*....|....*....|....
gi 47577433   268 ------IMALCATIVEPMLNPLIY 285
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-292

1.55e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 116.08 E-value: 1.55e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLACT 188
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSS-EGRRKALSTCSSHFTVVVLFFVPCIFLYMRPV-----VT 262
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSkEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfgghhIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 47577433 263 YPVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

25-289

1.54e-27

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 108.14 E-value: 1.54e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIdhvicdlfpllQ 184
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCC-----------C 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 185 LACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSH------------FTVVVLFFV-- 250
Cdd:cd00637 150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 251 -PCIFLYMRPVVTYPVDNI------MALCATIVEPMLNPLIYSLRN 289
Cdd:cd00637 230 lPYFILLLLDVFGPDPSPLprilyfLALLLAYLNSAINPIIYAFFN 275

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-292

1.70e-22

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 94.45 E-value: 1.70e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV-GGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPLLQLAC 187
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVrAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 188 TDTHILDLLVILNSGVMCVTIFLILITSYVVILCSL-KSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM-----RPVV 261
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahrfgHHVA 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577433 262 TYpVDNIMALCATIVEPMLNPLIYSLRNAEV 292
Cdd:cd15955 247 PY-VHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-296

5.54e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 81.46 E-value: 5.54e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAhatIQLLFMYQIPFCGPNIIDHVICDLFPll 183
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL---ISLPPLVGWRDETQPSVVDCECEFTP-- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 qlactdthilDLLVILNSGVMCVTI-FLILITSYVVILCSLKSrssegRRKALSTcsshFTVVVLFFVPC------IFLY 256
Cdd:cd14967 156 ----------NKIYVLVSSVISFFIpLLIMIVLYARIFRVARR-----ELKAAKT----LAIIVGAFLLCwlpffiIYLV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577433 257 MRPVVTYPVDNIMALCATIVE---PMLNPLIYSLRNAEVKQAL 296
Cdd:cd14967 217 SAFCPPDCVPPILYAVFFWLGylnSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

23-155

8.27e-16

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 76.09 E-value: 8.27e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIvSPRMCWLMVGGAWVGGFAHAT 155
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWAL 132

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

23-159

7.26e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 61.68 E-value: 7.26e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15073   1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTiVSPRMCWLMVGGAWVGGFAHATIQLL 159
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAAMPLV 136

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

24-148

7.36e-11

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 61.66 E-value: 7.36e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGA 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15336  82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWL 126

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

23-148

3.14e-10

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 59.81 E-value: 3.14e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAIC-KPLHYRtiVSPRMCWLMVGGAWV 148
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV 125

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-295

3.32e-10

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 59.30 E-value: 3.32e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQipfcgpniidHVICDLFpll 183
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSW----------HGRRGLG--- 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 qlACTDTHILDlLVILNSGVMCVTIFLILITSYVVILCSLKSrssegRRKALSTcsshFTVVVLFFVPC-----IFLYMR 258
Cdd:cd15061 148 --SCYYTYDKG-YRIYSSMGSFFLPLLLMLFVYLRIFRVIAK-----ERKTAKT----LAIVVGCFIVCwlpffIMYLIE 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577433 259 PVVTYPVDNIMALCATIV---EPMLNPLIYSLRNAEVKQA 295
Cdd:cd15061 216 PFCDCQFSEALSTAFTWLgyfNSVINPFIYAFYNKDFRRA 255

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

23-148

3.43e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 59.65 E-value: 3.43e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL 126

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

27-148

3.65e-10

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 59.29 E-value: 3.65e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMY-VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTI-SLEGCMTQLFAEHF 104
Cdd:cd15067   3 GVVLSLFcLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLfGRDWCDVWHSFDVL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15067  83 ASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

31-160

5.77e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 58.83 E-value: 5.77e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd17790   9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASV 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd17790  89 MNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILF 138

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

23-296

6.50e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 58.81 E-value: 6.50e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTisLEGCmtqLFAE 102
Cdd:cd14968   1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTN--FHGC---LFMA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HF---FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDL 179
Cdd:cd14968  76 CLvlvLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGIQCL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 180 FpllqlacTDTHILDLLVILN--------SGVMCV---TIFLILITSYVVILCSLKSRSSEGR-RKALSTCSSHFTVVVL 247
Cdd:cd14968 156 F-------EEVIPMDYMVYFNffacvlvpLLIMLViylRIFRVIRKQLRQIESLLRSRRSRSTlQKEVKAAKSLAIILFL 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 248 FFVPCIFLYMRPVVTY--PVDNI--MALCATIV----EPMLNPLIYSLRNAEVKQAL 296
Cdd:cd14968 229 FALCWLPLHIINCITLfcPECKVpkILTYIAILlshaNSAVNPIVYAYRIRKFRQTF 285

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

24-233

9.35e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 58.22 E-value: 9.35e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNiidHVICDLFPLL 183
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQ---DGQEEEICVL 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 184 QLACTDTHILDLLvilnSGVMCVTIFLILITSYVVILCSL--KSRSSEGRRK 233
Cdd:cd15012 158 DREMFNSKLYDTI----NFIVWYLIPLLIMTVLYSKISIVlwKSSSIEARRK 205

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

27-296

1.22e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 57.63 E-value: 1.22e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSI-TAPKLIIDslsenTTISLEG----C------ 95
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWD-----ITYRFYGgdllCrlvkyl 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  96 -MTQLFAEHFfggveiiLLIVMAYDRYVAICKPLHYRTIvSPRMCWLMVGGAWVGGFAHATIQL-LFMYQIPFCGpniid 173
Cdd:cd15196  80 qVVGMYASSY-------VLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLfIFSYQEVGSG----- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 174 hvicdlfpllQLACTDTHILDLLVILNSGVMCVTIF----LILITSYVVILCSLksrssegRRKALSTCSSHFTVVVLFF 249
Cdd:cd15196 147 ----------VYDCWATFEPPWGLRAYITWFTVAVFvvplIILAFCYGRICYVV-------WRAKIKTVKLTLVVVACYI 209

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 250 V---PCIFLYM------RPVVTYPVDNIMALCATIvEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15196 210 VcwtPFFVVQMwaawdpTAPIEGPAFVIIMLLASL-NSCTNPWIYLAFSGNLRRAL 264

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

24-289

1.35e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 57.99 E-value: 1.35e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAhATIQLLFMYQIPFCGPNIidhvicdLFPLL 183
Cdd:cd14993  82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII-IMLPLLVVYELEEIISSE-------PGTIT 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILNSGVMCVTIF----LILITSYVVILCSLKSRSSEGRRKALSTCSSH------------FTVVVL 247
Cdd:cd14993 154 IYICTEDWPSPELRKAYNVALFVVLYvlplLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRrilrskkkvarmLIVVVV 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 248 FFVPC--------IFLYMRPVVTYPVDNIM------ALCATIVEPMLNPLIYSLRN 289
Cdd:cd14993 234 LFALSwlpyyvlsILLDFGPLSSEESDENFllilpfAQLLGYSNSAINPIIYCFMS 289

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

24-160

1.66e-09

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 57.59 E-value: 1.66e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYsSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15079   2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIvSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPWALLPLLF 136

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

24-255

4.08e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 56.49 E-value: 4.08e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVtVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQL---- 99
Cdd:cd14978   2 LYGYVLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyi 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 100 -FAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICD 178
Cdd:cd14978  81 yPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 179 LFPLLQLACTDTHIldlLVILNSGVMCVTIFLILITSYVVILCSL----KSRSSEGRRKALSTCSS---HFTVVVLFFVP 251
Cdd:cd14978 161 PTLLRQNETYLLKY---YFWLYAIFVVLLPFILLLILNILLIRALrkskKRRRLLRRRRRLLSRSQrreRRTTIMLIAVV 237


                ....
gi 47577433 252 CIFL 255
Cdd:cd14978 238 IVFL 241

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

24-147

5.24e-09

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 56.10 E-value: 5.24e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15354   2 IAAEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIIL------LIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15354  82 FDSLICISVvasmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

23-177

5.26e-09

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 56.07 E-value: 5.26e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISleGCMTQLFAe 102
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFG--SILCKLVP- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 hFFGGVEI----ILLIVMAYDRYVAICKPLhyRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPN-IIDHVIC 177
Cdd:cd15203  78 -SLQGVSIfvstLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEIlPYCGYFC 154

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-148

1.24e-08

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 54.80 E-value: 1.24e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQlFAEHFFGG 107
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQ-HIDNVIDS 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 108 V-------EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15103  85 MicssllaSICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWV 132

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

24-151

1.44e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 54.81 E-value: 1.44e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15063  82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF 129

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

23-143

1.69e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 54.47 E-value: 1.69e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15085   1 SILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMV 143
Cdd:cd15085  81 NYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLL 121

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

24-152

1.78e-08

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 54.19 E-value: 1.78e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVT-ILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15210   1 YFAAVWGIVFMVVgVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFA 152
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFG 130

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

31-160

2.01e-08

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 54.18 E-value: 2.01e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASV 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15299  92 MNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILF 141

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

23-151

2.04e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 54.55 E-value: 2.04e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIidslsentTISLEGCmTQLFAE 102
Cdd:cd15069   1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFC-TDFHSC 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIIL-------LIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15069  72 LFLACFVLVLtqssifsLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAF 127

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

26-151

3.53e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 53.49 E-value: 3.53e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15300   4 AAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15300  84 SNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISF 129

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

29-296

3.94e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 53.40 E-value: 3.94e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYvvTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15323   9 FLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPfcgpniidhvICDLFPLLQLACT 188
Cdd:cd15323  87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP----------EGDVYPQCKLNDE 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 189 DTHILDlLVILNSGVMCVTIFLILITSYvvilcslksRSSEGRRKALSTCsshFTVVVLFFVPCIFLYMrpvVTYPVDNI 268
Cdd:cd15323 157 TWYILS-SCIGSFFAPCLIMILVYIRIY---------RVAKAREKRFTFV---LAVVMGVFVVCWFPFF---FSYSLYGI 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577433 269 MALCATIVEPM-------------LNPLIYSLRNAEVKQAL 296
Cdd:cd15323 221 CREACEVPEPLfkfffwigycnssLNPVIYTIFNQDFRRSF 261

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

28-148

5.17e-08

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 52.86 E-value: 5.17e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEG--------CMTQL 99
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSL 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577433 100 FAEHFFGGVEIILLIvmAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15350  86 FCLSLLGSIFSILAI--AADRYITIFHALRYHNIMTMRRTLVILAIIWT 132

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

24-294

7.20e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 52.63 E-value: 7.20e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIdsLSENTTISLEGCMTQLFAEH 103
Cdd:cd15068   2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQipfCGPNIIDHVICDLFPLL 183
Cdd:cd15068  80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN---CGQPKEGKNHSQGCGEG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLAC--TDTHILDLLVILNSGVMCVTIFLILITSYVVI---------------LCSLKSRSSEGRR----KALSTCSSHF 242
Cdd:cd15068 157 QVAClfEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIflaarrqlkqmesqpLPGERARSTLQKEvhaaKSLAIIVGLF 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 243 TV--VVLFFVPCiFLYMRPVVTYPVDNIM--ALCATIVEPMLNPLIYSLRNAEVKQ 294
Cdd:cd15068 237 ALcwLPLHIINC-FTFFCPDCSHAPLWLMylAIVLSHTNSVVNPFIYAYRIREFRQ 291

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

27-214

7.38e-08

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 52.39 E-value: 7.38e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15206   5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIidHVICDLFPLLQLA 186
Cdd:cd15206  85 SVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG--HKCREVWPNEIAE 162

                       170       180
                ....*....|....*....|....*....
gi 47577433 187 CTDTHILDLLVILNSG-VMCVTIFLILIT 214
Cdd:cd15206 163 QAWYVFLDLMLLVIPGlVMSVAYGLISWT 191

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

19-137

7.62e-08

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 52.62 E-value: 7.62e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  19 PELRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQ 98
Cdd:cd15321   3 VQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIY 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577433  99 LFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPR 137
Cdd:cd15321  83 LALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPR 121

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

24-148

8.21e-08

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 52.58 E-value: 8.21e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15352   2 IKAEVFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577433 104 FFGGVEIIL------LIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15352  82 FDSMICISLvasicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

23-256

9.16e-08

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 52.30 E-value: 9.16e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15390   1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTivSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICdlfpL 182
Cdd:cd15390  81 ITTVAASVFTLMAISIDRYIAIVHPLRPRL--SRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVC----F 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLlvILNSGVMCVTIFL---ILITSYVVILCSLKSRSSEG---RRKALSTCSSH-----FTVVVLFFVP 251
Cdd:cd15390 155 IAWPDGPNSLQDF--VYNIVLFVVTYFLpliIMAVAYTRVGVELWGSKTIGentPRQLESVRAKRkvvkmMIVVVVIFAI 232


                ....*
gi 47577433 252 CIFLY 256
Cdd:cd15390 233 CWLPY 237

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

23-296

1.03e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 52.15 E-value: 1.03e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLR-SPMYFFLISLSFLDVIYSSITAPKLIIDSL-----SENTTISLEGCM 96
Cdd:cd15341   1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVDFHVfhgvdSSAIFLLKLGGV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  97 TQLFAehffggVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVggfahatIQLLFMYqIPFCGPNI--IDH 174
Cdd:cd15341  81 TMSFT------ASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWV-------LTALIAY-LPLMGWNCcpLNS 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 175 VICDLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKA------LSTCSSHFTVVVLF 248
Cdd:cd15341 147 PCSELFPLIPNDYLLSWLLLVAILLSGIIYTYGHVLWKAHKHVVYMEKHQDQQGPGNARMrldvrlAKTLGLVLAVLLIC 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577433 249 FVPCIFLYMRPVVTYPVDNI---MALCAT--IVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15341 227 WSPVLALMMHSLFTSLSDHIkkaFAFCSTlcLVNSMVNPIIYALRSRELRSSL 279

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

27-148

1.03e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 52.22 E-value: 1.03e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15959   5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCV 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15959  85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWA 126

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

34-158

1.90e-07

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 51.40 E-value: 1.90e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQL 158
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFL 136

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

31-163

1.91e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 51.61 E-value: 1.91e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAST 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577433 111 ILLIVMAYDRYVAICKPLhyRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQ 163
Cdd:cd14986  89 YILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVE 139

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

26-295

2.32e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 51.16 E-value: 2.32e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVV-TILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEH 103
Cdd:cd15052   3 AALLLLLLVIaTIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTLDV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHAtiqllfmyqIPFCGPNIIDHVicDLFPLL 183
Cdd:cd15052  83 LFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS---------SPIPVLGIIDTT--NVLNNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHildlLVILNSGVMCVTIFLILITSYvvilcSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15052 152 TCVLFNPN----FVIYGSIVAFFIPLLIMVVTY-----ALTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGLCE 222

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 264 PVD-NIMALCATI------VEPMLNPLIYSLRNAEVKQA 295
Cdd:cd15052 223 ECNcRISPWLLSVfvwlgyVSSTINPIIYTIFNKTFRRA 261

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

23-287

2.34e-07

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 51.14 E-value: 2.34e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSiTAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWPFGEVMCKIVLSVD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKP---LHYRTivsPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGpniiDHVICdl 179
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPvksLRFRT---PRKAKLVSLCVWALSLVLGLPVIIFARTLQEEG----GTISC-- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 180 fpLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKS------RSSEGRRKALSTCSSHFTVVVLFFVPC- 252
Cdd:cd14970 151 --NLQWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSsrnlstSGAREKRRARRKVTRLVLVVVAVFVVCw 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47577433 253 ----IFLYMRPVVTYPVDNIMALCATIVEPM------LNPLIYSL 287
Cdd:cd14970 229 lpfhVFQIVRLLIDPPETLTVVGVFLFCIALsyanscLNPILYAF 273

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

31-160

2.45e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 51.12 E-value: 2.45e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15297   9 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15297  89 MNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILF 138

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

34-288

3.30e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 50.55 E-value: 3.30e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSenTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15070  12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLG--VTIHFYSCLFMSCLLVVFTHASIMSL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFahatiqllFMYQIPFCGPNIIDHVICDLFPLLQLACTDTHIL 193
Cdd:cd15070  90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSF--------LVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 194 DLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEG----------RRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTY 263
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNatgfretgafYGREFKTAKSLALVLFLFAVCWLPLSIINCVVY 241

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577433 264 PVDNI--MALCATI----VEPMLNPLIYSLR 288
Cdd:cd15070 242 FNPKVpkIALYLGIllshANSMMNPIVYACK 272

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

27-151

3.89e-07

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 50.38 E-value: 3.89e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15048   5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLC 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15048  85 TASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAF 129

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

34-148

4.08e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 50.43 E-value: 4.08e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15065  11 VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNL 90

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15065  91 CAISLDRYIHIKKPLKYERWMTTRRALVVIASVWI 125

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-147

4.18e-07

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 50.29 E-value: 4.18e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-------TISLEGCMTQLF 100
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNdtdaqsfTVNIDNVIDSVI 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 101 AEHFFGgvEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15353  86 CSSLLA--SICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

30-148

4.26e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 50.21 E-value: 4.26e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  30 LIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVE 109
Cdd:cd15301   8 AVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNAS 87

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577433 110 IILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15301  88 VLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWI 126

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

25-296

4.79e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 49.98 E-value: 4.79e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIySSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-AGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGfahatiqlLFMYQIPFCGPNII--DHVIC-DLFP 181
Cdd:cd14972  80 SLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWS--------VLLALLPVLGWNCVlcDQESCsPLGP 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 182 LLqlacTDTHILdLLVILNSGVMCVTIFLilitsYVVILCSLKSRSSEGRRKALSTCSSH--------FTVVVLF--FVP 251
Cdd:cd14972 152 GL----PKSYLV-LILVFFFIALVIIVFL-----YVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIVLgvFLV 221

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577433 252 C---IFLYMRPVVTYP-------VDNIMALCAtIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd14972 222 CwlpLLILLVLDVLCPsvcdiqaVFYYFLVLA-LLNSAINPIIYAFRLKEMRRAV 275

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

31-148

5.15e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 50.01 E-value: 5.15e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITA-PKLIIDSLSENTTISLEGCMTQLFAEHFFGGVE 109
Cdd:cd15337   9 IVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMS 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577433 110 IILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15337  89 ITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWL 127

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

23-148

5.66e-07

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 50.16 E-value: 5.66e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15205  81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWI 126

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

23-285

6.17e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 49.96 E-value: 6.17e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQ--LF 100
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTglLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 101 AEHFFGGveIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVggFAHATIQLLFMYQIPFCGPNiiDHVICDLF 180
Cdd:cd14982  81 YINMYGS--ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWI--LVLVASVPLLLLRSTIAKEN--NSTTCFEF 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 181 PLLQLACTDTHILDLLVilnsgVMCVTIFLILITSYVVILCSLKSRSSEG-----RRKALSTCSSHFTVVVLFFVP---- 251
Cdd:cd14982 155 LSEWLASAAPIVLIALV-----VGFLIPLLIILVCYSLIIRALRRRSKQSqksvrKRKALRMILIVLAVFLVCFLPyhvt 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47577433 252 ----------CIFLYMRPVVTYPVDNIMaLCATIVEPMLNPLIY 285
Cdd:cd14982 230 rilyllvrlsFIADCSARNSLYKAYRIT-LCLASLNSCLDPLIY 272

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

27-147

6.27e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 50.15 E-value: 6.27e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMyVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTI-SLEGCMTQLFAEHFF 105
Cdd:cd15005   6 TLGLIL-CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLF 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15005  85 CFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

24-147

7.07e-07

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 50.00 E-value: 7.07e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFL-IMYVVTILGNLLIVVTVMKSSNLRSPMY-FFLISLSFLDVIYSSITAPkliIDSLSENTTISLEGCMTQLFA 101
Cdd:cd15320   2 VLTGCFLsVLILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMP---WKAVAEIAGFWPFGSFCNIWV 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 102 --EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15320  79 afDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAW 126

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

28-148

7.23e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 49.68 E-value: 7.23e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKliidslseNTTISLEG------CMTQLFA 101
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTF--------NASVEITGrwmfgyFMCDVWN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577433 102 EH--FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15066  77 SLdvYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWI 125

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

24-148

7.75e-07

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 49.35 E-value: 7.75e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15060   2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHY---RTIvsPRMCwLMVGGAWV 148
Cdd:cd15060  82 LCCTASILNLCAIALDRYWAIHDPINYaqkRTL--KRVL-LMIVVVWA 126

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

26-161

9.27e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 49.21 E-value: 9.27e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEG-CMTQLFAEHF 104
Cdd:cd14997   4 SVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFmCKLVPFVELT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAhATIQLLFM 161
Cdd:cd14997  84 VAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALL-TSSPVLFI 139

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

25-128

9.48e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 49.41 E-value: 9.48e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILG---NLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFA 101
Cdd:cd15082  13 FTVLAALMFVVTSLSlaeNFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFA 92

                        90       100
                ....*....|....*....|....*..
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPL 128
Cdd:cd15082  93 VTFFGIVALWSLAVLAFERFFVICRPL 119

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

24-149

1.02e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 49.19 E-value: 1.02e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVG 149
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLL 127

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

26-154

1.18e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 48.89 E-value: 1.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIM---YVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLsenttislEGCMtqLFAE 102
Cdd:cd15312   1 VAMYLFMagaILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV--------ESCW--YFGD 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577433 103 HF----------FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHA 154
Cdd:cd15312  71 LFckihssldmmLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

25-148

1.38e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 48.78 E-value: 1.38e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSS--NLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTI-SLEGCMTQLFA 101
Cdd:cd14981   3 SPAPPALMFVFGVLGNLLALIVLARSSksHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDgGQPLCDYFGFM 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd14981  83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWA 129

7tmA_AKHR

cd15382

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...

23-240

1.42e-06

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320504 [Multi-domain] Cd Length: 298 Bit Score: 48.85 E-value: 1.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVvtilGNLLIVVTVMKSSNL-RSPMYFFLISLSFLDVIYSSITAPKLIIdslsENTTISLEG----CMT 97
Cdd:cd15382   5 IVYSVLFLIAAV----GNLTVLLILLRNRRRkRSRVNILLMHLAIADLLVTFIMMPLEIG----WAATVAWLAgdflCRL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  98 QLFAEHFFGGVEIILLIVMAYDRYVAICKPLhyRTIVSPRMCWLMVGGAWVGGFAHATIQL-LFMYQIPFCGPNIIDHVI 176
Cdd:cd15382  77 MLFFRAFGLYLSSFVLVCISLDRYFAILKPL--RLSDARRRGRIMLAVAWVISFLCSIPQSfIFHVESHPCVTWFSQCVT 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577433 177 CDLFPllqlacTDTHILdLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSS 240
Cdd:cd15382 155 FNFFP------SHDHEL-AYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSS 211

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

34-148

1.51e-06

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 48.47 E-value: 1.51e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15049  12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNL 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15049  92 LLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWV 126

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

27-164

1.54e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 48.89 E-value: 1.54e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAP---KLIIDSLSENTTISleGCMTQLFAEH 103
Cdd:cd14979   5 AIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPvelYNFWWQYPWAFGDG--GCKLYYFLFE 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHAtIQLLFMYQI 164
Cdd:cd14979  83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-IPILFLMGI 142

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

26-296

1.59e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 48.62 E-value: 1.59e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIidsLSENTTISLEgcMTQLFAEHff 105
Cdd:cd15102   4 SVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANIL---LSGARTLRLS--PAQWFLRE-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 106 GGVEIIL------LIVMAYDRYVAICKPLHYRTIVSPRMcWLMVGGAWVggfahatIQLLfMYQIPFCGPNIIDHV--IC 177
Cdd:cd15102  77 GSMFVALsasvfsLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWL-------ISLL-LGGLPILGWNCLGALdaCS 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 178 DLFPLLQLACTdthildllvilnsgVMCVTIFLILITS----YVVILCSLKSRSSEGRRKALSTCSSHF----TVVVLFF 249
Cdd:cd15102 148 TVLPLYSKHYV--------------LFCVTIFAGILAAivalYARIYCLVRASGRKATRASASPRSLALlktvLIVLLVF 213

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577433 250 VPC---IFL-----YMRPVVTYPV----DNIMALcaTIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15102 214 IACwgpLFIlllldVACPVKTCPIlykaDWFLAL--AVLNSALNPIIYTLRSRELRRAV 270

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

26-148

1.67e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 48.60 E-value: 1.67e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15058   4 LLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLC 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15058  84 VTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

31-151

1.73e-06

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 48.69 E-value: 1.73e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTtiSLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15071   9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQT--EFYSCLMVACPVLILTQSSI 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15071  87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSF 127

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

21-148

2.01e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 48.25 E-value: 2.01e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  21 LRTIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLF 100
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 101 AEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV 130

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

23-148

2.09e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 48.37 E-value: 2.09e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWV 126

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

24-160

2.50e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 47.84 E-value: 2.50e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMY-FFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-166

2.51e-06

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 48.15 E-value: 2.51e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15208   5 ALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSV 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTivSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPF 166
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIPQAIVMECSRV 142

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

31-295

2.76e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 47.81 E-value: 2.76e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15050   9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHaTIQLLFMYQIPFCGPNIIDHVICDlfpllqlacTDT 190
Cdd:cd15050  89 FSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFARGGERVVLEDKCE---------TDF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 191 HILDLLVILNSGVMCVTIFLILITSYVVILCSLKSrssegRRKALSTCSSHFTVVVLFFVPCIFLYMrpvvtypvdnIMA 270
Cdd:cd15050 159 HDVTWFKVLTAILNFYIPSLLMLWFYAKIFKAVNR-----ERKAAKQLGFIMAAFILCWIPYFILFM----------VIA 223

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 271 LCATIVEP--------------MLNPLIYSLRNAEVKQA 295
Cdd:cd15050 224 FCKNCCNEnlhmftiwlgyinsTLNPFIYPLCNENFKKT 262

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

34-148

2.91e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 47.71 E-value: 2.91e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15051  12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNL 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15051  92 FAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWV 126

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

28-296

3.01e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 47.62 E-value: 3.01e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSE-NTTISLEGCMTQLFAEHFFG 106
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWvggfahaTIQLLFMYQIPFCGpnIIDHviCDLFPLLQLA 186
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFG--LQDD--SKVFKEGSCL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDthilDLLVILNSGVMCVTIFLILITSYVVILCSLKsRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVTYPVD 266
Cdd:cd15304 155 LAD----ENFVLIGSFVAFFIPLTIMVITYFLTIKSLQ-QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKESC 229

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577433 267 NIMALCATI--------VEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15304 230 NEVVIGGLLnvfvwigyLSSAVNPLVYTLFNKTYRSAF 267

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

31-148

4.85e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 47.17 E-value: 4.85e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15324   9 VIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSI 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15324  89 VHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWV 126

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-160

5.90e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 46.71 E-value: 5.90e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQlfaeHFFGG 107
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNV 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577433 108 VEIIL----------LIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15351  82 IDTMIcssvvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

23-159

6.37e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 46.88 E-value: 6.37e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15074   1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPlHYRTIVSPRMCWLMVGGAWVGGFAHATIQLL 159
Cdd:cd15074  81 FLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLV 136

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

27-287

7.00e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 46.52 E-value: 7.00e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd15096   5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAhATIQLLFMYQIPFCGPNIIDHVICDlfpLLQLA 186
Cdd:cd15096  85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILV-ANIPVLFLHGVVSYGFSSEAYSYCT---FLTEV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 CTDTHILDLLVILNSGVMCVTIFLILitsYVVILCSL-KSRSSEGRRKALSTCSS-HFT----VVVLFFVPC-----IFL 255
Cdd:cd15096 161 GTAAQTFFTSFFLFSYLIPLTLICVL---YMLMLRRLrRQKSPGGRRSAESQRGKrRVTrlvvVVVVVFAICwlpihIIL 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577433 256 YMRPVVTYP------VDNIMALCATIVEPMLNPLIYSL 287
Cdd:cd15096 238 LLKYYGVLPetvlyvVIQILSNCLAYGNSCVNPILYAF 275

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

24-148

8.10e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 46.17 E-value: 8.10e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFL-IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15064   1 VLISVLLsLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15064  81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWT 126

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

26-160

9.14e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 46.37 E-value: 9.14e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15008   3 SLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLT 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15008  83 PGVQIYVLLSICVDRFYTIVYPLSFK--VSREKAKKMIAASWLFDAAFVSPALFF 135

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

24-287

9.48e-06

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 46.29 E-value: 9.48e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYssITAPKLIIDSLSENTTISLEGCM----TQL 99
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF--MLGMPFLIHQFAIDGQWYFGEVMckiiTAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 100 FAEHFFGGVEIilLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPF------CGPNIID 173
Cdd:cd15088  80 DANNQFTSTYI--LTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFpdgttfCYVSLPS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 174 HVICDLFPLLQLacTDTHILDLLVILnsgVMCVTIFLILITSYVvilcslKSRSSEGRRKALSTCSSHFTVVVLFFVPCI 253
Cdd:cd15088 158 PDDLYWFTIYHF--ILGFAVPLVVIT---VCYILILHRLARGVA------PGNQSHGSSRTKRVTKMVILIVVVFIVCWL 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577433 254 FLYM---------RPVVTYPVDNIMALCATIVEPMLNPLIYSL 287
Cdd:cd15088 227 PFHVvqlvnlamnRPTLAFEVAYFLSICLGYANSCLNPFVYIL 269

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

26-154

9.98e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 46.33 E-value: 9.98e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15928   4 TAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETC 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHA 154
Cdd:cd15928  84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSA 132

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

24-148

1.07e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 46.01 E-value: 1.07e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMyVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIdslsenttISLEGCMtqLFAEH 103
Cdd:cd15055   3 LYIVLSSIS-LLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMI--------RSIETCW--YFGDT 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577433 104 F----------FGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15055  72 FcklhssldyiLTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF 126

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

24-160

1.18e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 45.86 E-value: 1.18e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15393   2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15393  82 LSVNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALA 136

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

32-160

1.35e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 45.78 E-value: 1.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  32 MYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEII 111
Cdd:cd15298  10 LSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVM 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577433 112 LLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15298  90 NLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILF 138

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

31-148

1.36e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 45.71 E-value: 1.36e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEI 110
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSI 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577433 111 ILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15322  89 VHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV 126

7tmA_Mel1B

cd15400

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

23-148

1.41e-05

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320522 [Multi-domain] Cd Length: 279 Bit Score: 45.61 E-value: 1.41e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15400   1 TALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVM 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15400  81 GLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWA 126

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

23-148

1.52e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 45.52 E-value: 1.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMyVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15317   2 IIYIVLVLAM-LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_tmt_opsin

cd15086

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...

23-148

1.53e-05

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.

Pssm-ID: 320214 [Multi-domain] Cd Length: 276 Bit Score: 45.50 E-value: 1.53e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15086   1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFAN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRtIVSPRMCWLMVGGAWV 148
Cdd:cd15086  81 SLFGIVSLISLAVLSYERYCTLLRPTEAD-VSDYRKAWLGVGGSWL 125

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

23-158

1.62e-05

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 45.58 E-value: 1.62e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15391   1 PHLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVggAWVGGFAHATIQL 158
Cdd:cd15391  81 LVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIAS--IWAISFSLSSVQL 134

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

24-148

2.26e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 45.11 E-value: 2.26e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVV-TILGNLLIVVTVMKSSNLRSPMY-FFLISLSFLDVIyssitapkLIIDSLSENTTISLEG------- 94
Cdd:cd15057   1 IITGCILYLLVLlTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLL--------VAILVMPWAAVNEVAGywpfgsf 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577433  95 CMTQLFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15057  73 CDVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWT 126

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

25-287

2.55e-05

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 45.12 E-value: 2.55e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSiTAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd14999   2 IGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLL-TIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPL--HYRTIVSPRmcwLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHVICDLFPL 182
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLdtVKRSKSYRK---LLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSY--VVILCSLKSRSSEGRRKALSTCsshFTVVVLF---FVP-----C 252
Cdd:cd14999 158 EESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYwlSQAAASNSSRKRLPKQKVLKMI---FTIVLVFwacFLPfwiwqL 234

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577433 253 IFLYMRPVVTYPVD----NIMALCATIVEPMLNPLIYSL 287
Cdd:cd14999 235 LYLYSPSLSLSPRTttyvNYLLTCLTYSNSCINPFLYTL 273

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

25-152

2.67e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 44.64 E-value: 2.67e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMY-VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLD----------VIYSSITAPKLIIDSLSENTTISLE 93
Cdd:cd15053   2 YWALFLLLLpLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADllvailvmpfAVYVEVNGGKWYLGPILCDIYIAMD 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577433  94 GCMTQlfaehffggVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFA 152
Cdd:cd15053  82 VMCST---------ASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAA 131

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

29-155

2.98e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 44.57 E-value: 2.98e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd15001   6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFIC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHAT 155
Cdd:cd15001  86 SVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAS 132

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

24-230

3.81e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 44.35 E-value: 3.81e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd14992   2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPfcgpnIIDHVICDLFPLL 183
Cdd:cd14992  82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEV-----LFSVKNQEKIFCC 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 184 QLACTDTHILD-LLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEG 230
Cdd:cd14992 157 QIPPVDNKTYEkVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPG 204

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

24-166

3.90e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 44.45 E-value: 3.90e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15215   1 IRSVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMH 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPF 166
Cdd:cd15215  81 LFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAF 143

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

23-148

3.93e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 44.26 E-value: 3.93e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWI 126

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

28-188

4.52e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 44.17 E-value: 4.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAhATIQLLFMY-------------QIPFCGPNIIDH 174
Cdd:cd15307  86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIA-MSLPLSLMYskdhasvlvngtcQIPDPVYKLVGS 164

                       170
                ....*....|....
gi 47577433 175 VICDLFPLLQLACT 188
Cdd:cd15307 165 IVCFYIPLGVMLLT 178

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

27-250

4.75e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 44.13 E-value: 4.75e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYsSITAPKLIIDSLSENTTIS-LEGCMTQLFAEHFF 105
Cdd:cd14984   5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLF-VLTLPFWAVYAADGWVFGSfLCKLVSALYTINFY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 106 GGveIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFmYQIPFCGpniiDHVICDLFPLLQL 185
Cdd:cd14984  84 SG--ILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIF-SQVSEEN----GSSICSYDYPEDT 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47577433 186 ACTDTHILDLLVILNSGVMCvtiFLILITSYVVILCSLKSRSSEGRRKALSTCsshFTVVVLFFV 250
Cdd:cd14984 157 ATTWKTLLRLLQNILGFLLP---LLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFFL 215

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

34-159

4.91e-05

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 43.97 E-value: 4.91e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIySSITAPklIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15905  10 SLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLL-TGVALP--FIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANL 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLL 159
Cdd:cd15905  87 LMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPAL 132

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

23-147

5.52e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 44.18 E-value: 5.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMY-FFLISLSFLDVIYSSITAPKLIIDSLSENTTISlEGCMTQLFA 101
Cdd:cd15319   1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15319  80 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAW 125

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

24-162

5.80e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 43.99 E-value: 5.80e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPkliidslSENTTISLEGCMTQLF--- 100
Cdd:cd14971   2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVP-------FTATIYPLPGWVFGDFmck 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 101 AEHFFGGV----EIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHAtIQLLFMY 162
Cdd:cd14971  75 FVHYFQQVsmhaSIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA-APVLALH 139

7tmA_Histamine_H4R

cd15295

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...

24-132

6.52e-05

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320422 [Multi-domain] Cd Length: 267 Bit Score: 43.66 E-value: 6.52e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15295   2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDY 81

                        90       100
                ....*....|....*....|....*....
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRT 132
Cdd:cd15295  82 LLCTASVYNIVLISYDRYQSVSNAVSYRN 110

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

34-148

6.82e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 43.73 E-value: 6.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILL 113
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577433 114 IVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15326  92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWV 126

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

28-128

7.33e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 43.61 E-value: 7.33e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILG---NLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15075   3 LSIIMAVFSIASvvlNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAF 82

                        90       100
                ....*....|....*....|....
gi 47577433 105 FGGVEIILLIVMAYDRYVAICKPL 128
Cdd:cd15075  83 FGIAALCTVAVIAVDRLFVVCKPL 106

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

28-166

7.99e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 43.32 E-value: 7.99e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPF 166
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

23-157

8.94e-05

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 43.23 E-value: 8.94e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15209   1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIM 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPR-------MCWLMVGGAWVGGFAHATIQ 157
Cdd:cd15209  81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRntccylcLTWLLTVLAVLPNFFIGSLQ 142

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

24-293

1.01e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 43.26 E-value: 1.01e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTivSPRMCWLMVGGAWV----GGFAHATIQLLFMYQI------PFCGPNIID 173
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTlalaFALPHAICSKLETFKYsedivrSLCLEDWPE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 174 HvicdlfPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYV--VILCSLKSRSSEGRRKALSTCSSHFTVVVLF--- 248
Cdd:cd15202 160 R------ADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWAsnMPGDATTERYFALRRKKKKVIKMLMVVVVLFalc 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 249 FVP----CIFLYMRPVVTYPVDNIMALCA---TIVEPMLNPLIYSLRNAEVK 293
Cdd:cd15202 234 WLPfniyVLLLSSKPDYLIKTINAVYFAFhwlAMSSTCYNPFIYCWLNERFR 285

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

28-131

1.11e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 42.88 E-value: 1.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85

                        90       100
                ....*....|....*....|....
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYR 131
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSR 109

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

27-157

1.13e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 42.89 E-value: 1.13e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITA-PKLIIDslsenTTISLEG----CMTQLFA 101
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVlPQLCWD-----ITYRFYGpdflCRIVKHL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLhyRTIVSP-RMCWLMVGGAWVGGFAHATIQ 157
Cdd:cd15385  80 QVLGMFASTYMLVMMTADRYIAICHPL--KTLQQPtKRSYLMIGSAWALSFILSTPQ 134

7tmA_GnRHR_invertebrate

cd15384

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

31-240

1.16e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320506 [Multi-domain] Cd Length: 293 Bit Score: 42.81 E-value: 1.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDS-----LSENTTISLEGCMtQLFAEHff 105
Cdd:cd15384   9 VMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAytvawLAGNTMCKLVKYL-QVFGLY-- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 106 ggVEIILLIVMAYDRYVAICKPLHYRTivSPRMCWLMVGGAWVggfaHATIqllfmyqipFCGPNI-IDHVICDLFPLLQ 184
Cdd:cd15384  86 --LSTYITVLISLDRCVAILYPMKRNQ--APERVRRMVTVAWI----LSPI---------FSIPQAvIFHVERGPFVEDF 148

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577433 185 LACTDTHIL------DLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSS 240
Cdd:cd15384 149 HQCVTYGFYtaewqeQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNR 210

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

26-147

1.30e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 42.87 E-value: 1.30e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMyVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15054   5 AFLCLII-LLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMC 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15054  84 CSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

25-298

1.43e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 42.51 E-value: 1.43e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVV-TILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAE 102
Cdd:cd15306   2 WAALLILMVIIpTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVggfahatIQLLFMYQIPFCGpnIIDHVIcdlFPL 182
Cdd:cd15306  82 VLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWL-------ISIGIAIPVPIKG--IETDVD---NPN 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 183 LQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYMRPVVT 262
Cdd:cd15306 150 NITCVLTKERFGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLC 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577433 263 YPVD-NIMALCATI------VEPMLNPLIYSLRNAEVKQALRK 298
Cdd:cd15306 230 DSCNqTTLQMLMEIfvwigyVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-296

1.48e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 42.52 E-value: 1.48e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLR-SPMYFFLISLSFLDVIYSSITAPKLIIDSL-----SENTTISLEGCMTQL 99
Cdd:cd15099   4 AVLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVfhqrdSRNLFLFKLGGVTMA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 100 FAehffGGVEIILLivMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWvggfahaTIQLLFMYqIPFCGPNI--IDHVIC 177
Cdd:cd15099  84 FT----ASVGSLLL--TALDRYLCIYQPSNYKLLVTRTRAKVAILLMW-------CVTIIISF-LPLMGWRCktWDSPCS 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 178 DLFPLLQLACTDTHILDLLVILNSGVMCVTIFLILITSYVVILCSLKSRSSEGRRKA--------LSTCSSHFTVVVLFF 249
Cdd:cd15099 150 RLFPYIDRHYLASWTGLQLVLLFLIIYAYPYILWKAHRHEANMGGPKLGRQQVKGQArmrmdirlAKTLSLILLVLAICW 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 250 VPCIFLYMRPVVTYPVDNI---MALCAT--IVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15099 230 LPVLAFMLVDVRVTLTNKQkrmFAFCSMlcLVNSCVNPIIYALRSRELRGAM 281

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

36-148

1.96e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 42.09 E-value: 1.96e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  36 TILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILLIV 115
Cdd:cd15062  14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCV 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 47577433 116 MAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15062  94 ISVDRYIGVRYPLNYPTIVTARRATVALLIVWV 126

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

25-160

2.03e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 42.26 E-value: 2.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEH 103
Cdd:cd15310   3 YALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVwNFSRICCDVFVTLDV 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIV---SPRMCWLMVGGAWVGGFAhATIQLLF 160
Cdd:cd15310  83 MMCTASILNLCAISIDRYTAVVMPVHYQHGTgqsSCRRVSLMITAVWVLAFA-VSCPLLF 141

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

30-130

2.11e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 42.23 E-value: 2.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  30 LIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVE 109
Cdd:cd15214   7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSAS 86

                        90       100
                ....*....|....*....|.
gi 47577433 110 IILLIVMAYDRYVAICKPLHY 130
Cdd:cd15214  87 MLTLGAIAIDRYYAVLYPMVY 107

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

23-285

2.64e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 42.00 E-value: 2.64e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLImyvvTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIdslsENTTIS-LEG---CMTQ 98
Cdd:cd15195   5 LVTWVLFVI----SAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAV----WNYTVEwLAGdlmCRVM 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  99 LFAEHFFGGVEIILLIVMAYDRYVAICKPLHYRTivSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIDHvicd 178
Cdd:cd15195  77 MFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQ--ARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFH---- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 179 lfpllqlACTDTHILD---LLVILNSGVMCVTIFLILI---TSYVVILCSLKSRSSEGRRKALST----CSSHF------ 242
Cdd:cd15195 151 -------QCVDFGSAPtkkQERLYYFFTMILSFVIPLIitvTCYLLILFEISKMAKRARDTPISNrrrsRTNSLerarmr 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 243 -----TVVVLFFVPC------IFLY------MRPVVTYPVDNIMALCATIvEPMLNPLIY 285
Cdd:cd15195 224 tlrmtALIVLTFIVCwgpyyvLGLWywfdkeSIKNLPPALSHIMFLLGYL-NPCLHPIIY 282

7tmA_Histamine_H3R

cd15296

histamine receptor subtypes H3R and H3R-like, member of the class A family of ...

24-131

2.82e-04

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320423 [Multi-domain] Cd Length: 271 Bit Score: 41.70 E-value: 2.82e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15296   2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81

                        90       100
                ....*....|....*....|....*...
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYR 131
Cdd:cd15296  82 LLCTASVFNIVLISYDRFLSVTRAVSYR 109

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

24-177

2.83e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 41.64 E-value: 2.83e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSS--NLRSPMYFFLISLSFLDVIYSSITAP-KLIIDSLSEnttiSLEGCMTQLF 100
Cdd:cd15098   2 IVPVVFGLIFCLGVLGNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCVPfQATIYSLPE----WVFGAFMCKF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 101 AEHFFGG---VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLfmYQIPFCGPNIIDHVIC 177
Cdd:cd15098  78 VHYFFTVsmlVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAV--HQDLVHHWTASNQTFC 155

7tmA_PGE2_EP2

cd15139

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...

31-167

2.96e-04

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320267 [Multi-domain] Cd Length: 299 Bit Score: 41.68 E-value: 2.96e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  31 IMYVVTILGNL--LIVVTVMKSSNLRSPMYFFLI---SLSFLDVIYSSITAPkLIIDSLSENTTISLEG-----CMTQLF 100
Cdd:cd15139   9 LMFSAGVLGNVlaLVLLERRRRKEVGRRQSLFHVlvtSLVITDLLGTCLISP-VVLASYSRNTTLVGMSpnrlvCGYFGF 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47577433 101 AEHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMcwlmvggawvggfAHATIQLLFMYQIPFC 167
Cdd:cd15139  88 AMTFFSLATMLILLAMALERCLSIGHPYFYERYVSKRC-------------GYVTIPLIYLLCALFC 141

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

22-128

3.04e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 41.77 E-value: 3.04e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  22 RTIFSALFLIMYVVTILG---NLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQ 98
Cdd:cd15084   7 RSTYLTVAVLMGMVVALAsfvNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFE 86

                        90       100       110
                ....*....|....*....|....*....|
gi 47577433  99 LFAEHFFGGVEIILLIVMAYDRYVAICKPL 128
Cdd:cd15084  87 GFMVSLTGIVGLWSLAILAFERYLVICKPM 116

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

24-285

3.31e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 41.46 E-value: 3.31e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIdslsenttISLEGCMtqLFAEH 103
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMV--------RSVETCW--YFGDL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 F---FGGVEIIL-------LIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWvggfahaTIQLLFMYQIPFCGPNIID 173
Cdd:cd15314  72 FckiHSSFDITLctasilnLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISW-------SVSALVGFGIIFLELNIKG 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 174 HVicdlfpLLQLACTDTHILDLLVIlnSGVMCVTIF-----LILITSYVVILC-------SLKSR-------SSEGRRKA 234
Cdd:cd15314 145 IY------YNHVACEGGCLVFFSKV--SSVVGSVFSfyipaVIMLCIYLKIFLvaqrqarSIQSArtksgasSSKMERKA 216

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577433 235 LSTCSSHFTVVVLFFVPcIFLY--MRPVVTY--PVDNIMAL-CATIVEPMLNPLIY 285
Cdd:cd15314 217 TKTLAIVMGVFLLCWTP-FFLCniIDPFINYsiPPVLIEVLnWLGYSNSTLNPFIY 271

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

28-147

3.53e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 41.43 E-value: 3.53e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEHFFG 106
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAW 147
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW 126

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

34-147

3.88e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 41.32 E-value: 3.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  34 VVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITA-PKLIIDslsenTTISLEG----CMTQLFAEHFFGGV 108
Cdd:cd15386  12 VVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVlPQLIWE-----ITYRFQGpdllCRAVKYLQVLSMFA 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577433 109 EIILLIVMAYDRYVAICKPLhyRTIVSP-RMCWLMVGGAW 147
Cdd:cd15386  87 STYMLIMMTVDRYIAVCHPL--RTLQQPsRQAYLMIGATW 124

7tmA_mAChR_GAR-2-like

cd15302

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...

24-148

3.96e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320429 [Multi-domain] Cd Length: 266 Bit Score: 41.27 E-value: 3.96e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFL-IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFA 101
Cdd:cd15302   1 ILLALITaILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYwPLGWVLCDLWLSV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWI 127

7tmA_Encephalopsin

cd15078

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...

28-124

5.62e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320206 [Multi-domain] Cd Length: 279 Bit Score: 40.97 E-value: 5.62e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILG---NLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHF 104
Cdd:cd15078   3 LALLIATIGFLGvcnNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSL 82

                        90       100
                ....*....|....*....|
gi 47577433 105 FGGVEIILLIVMAYDRYVAI 124
Cdd:cd15078  83 FGIVSIMTLTVLAYERYIRV 102

7tmA_ET_R-like

cd14977

endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...

28-149

7.70e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.

Pssm-ID: 320108 [Multi-domain] Cd Length: 292 Bit Score: 40.48 E-value: 7.70e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGG 107
Cdd:cd14977   6 LSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVG 149
Cdd:cd14977  86 VTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVG 127

7tmA_BRS-3

cd15123

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...

24-227

8.88e-04

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.

Pssm-ID: 320251 [Multi-domain] Cd Length: 294 Bit Score: 40.29 E-value: 8.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNI-IDHVICDLFPL 182
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKnTTFEACAPYPV 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 47577433 183 LQLACTDTHILdllvilnsgvMCVTIFLILITSYVVILCSLKSRS 227
Cdd:cd15123 162 SEKILQEIHSL----------LCFLVFYIIPLSIISVYYFLIART 196

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

24-148

8.91e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 40.26 E-value: 8.91e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15325   2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15325  82 LCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWV 126

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

23-148

8.92e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 40.27 E-value: 8.92e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQlfae 102
Cdd:cd15402   1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQIS---- 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433 103 HFFGGVEIILLIV----MAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15402  77 GFLMGLSVIGSIFnitgIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWV 126

7tmA_CysLTR

cd15921

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...

24-276

9.56e-04

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320587 [Multi-domain] Cd Length: 283 Bit Score: 40.18 E-value: 9.56e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15921   2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWvgGFAHATIQLLFMYqipfcGPNIIDHVICDLFPLL 183
Cdd:cd15921  82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIW--ILMGLASSPLLFA-----KSKQHDEGSTRCLELA 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 184 QLACTDTHILDLLVILnsgVMCVTIFLILITSYVVILCSL------KSRSSEGRRKALSTCSSHFTVVVLFFVP-----C 252
Cdd:cd15921 155 HDAVDKLLLINYVTLP---VGFVVPFMTVIFCYIFIIKNLlkpspaLGRTRPSRRKACALIIISLGIFLVCFLPyhivrT 231

                       250       260
                ....*....|....*....|....
gi 47577433 253 IFLYMRPVVTYPVDNIMALCATIV 276
Cdd:cd15921 232 IHLITERQIKESCGYILRVRKAAV 255

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

28-148

1.17e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 39.68 E-value: 1.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISL--EGCMTQLFAEHFF 105
Cdd:cd14995   6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPDSWIYgyAGCLLITYLQYLG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47577433 106 GGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd14995  86 INASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWI 128

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

24-155

1.55e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 39.33 E-value: 1.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15000   1 IKSSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHAT 155
Cdd:cd15000  81 SLLLASVLALCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLAL 130

7tmA_S1PR1_Edg1

cd15346

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...

26-296

1.55e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320468 [Multi-domain] Cd Length: 277 Bit Score: 39.47 E-value: 1.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIidsLSENTTISL--------EGCMT 97
Cdd:cd15346   4 SVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLL---LSGATTYKLtptqwflrEGSMF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  98 QLFAEHFFGgveiilLIVMAYDRYVAICKPLHYRTIVSPRMcWLMVGGAWVGGfahatiqlLFMYQIPFCGPNIIDHV-- 175
Cdd:cd15346  81 VALSASVFS------LLAIAIERYITMLKMKLHNGSNSFRS-FLLISACWVIS--------LILGGLPIMGWNCISALss 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 176 ICDLFPLLQLActdtHILdllvilnsgvMCVTIFLILITSYVVILCSL-------------------KSRSSEGRRKALS 236
Cdd:cd15346 146 CSTVLPLYHKH----YIL----------FCTTVFTLLLLSIVILYCRIyslvrtrsrrltfrknirkASRSSEKSMALLK 211

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47577433 237 TCSSHFTVVVLFFVPCIFLYMRPV--------VTYPVDNIMALcaTIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd15346 212 TVIIVLSVFIACWAPLFILLLLDVgckvktcsILFKAEYFLVL--AVLNSATNPIIYTLTNKEMRRAF 277

7tmA_NPY2R

cd15399

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...

37-295

1.64e-03

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.

Pssm-ID: 320521 [Multi-domain] Cd Length: 285 Bit Score: 39.42 E-value: 1.64e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  37 ILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGVEIILLIVM 116
Cdd:cd15399  15 VVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 117 AYDRYVaiCKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFM-YQIPFCGPNIIDHVICDLFPLLQLACTDTHILDL 195
Cdd:cd15399  95 ALDRHR--CIVYHLESKISKKISFLIIGLTWAASALLASPLAIFReYSVIEISPDFKIQACSEKWPNGTLNDGTIYSVSM 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 196 LVILNsgvmcVTIFLILITSYVVILCSLKSRSSEG--------RRKalSTCSSHFTVVVLFFVPCIFLYMRPVVT----- 262
Cdd:cd15399 173 LLIQY-----VLPLAIISYAYIRIWTKLKNHVSPGggndhyhqRRR--KTTKMLVCVVVVFAVSWLPFHAFQLASdidsk 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577433 263 ----------YPVDNIMALCATIVepmlNPLIYSLRNAEVKQA 295
Cdd:cd15399 246 vldlkeykliYTIFHVIAMCSTFA----NPLLYGWMNNNYRTA 284

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

25-148

1.81e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 39.28 E-value: 1.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  25 FSALFLIMYVVTILGNLLIVVTVMKSSNLR-SPMYFFLISLSFLD----VIYSSITAPKLIIDSLSENTTI-SLEGCMTQ 98
Cdd:cd15104   2 AGVILAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADflvgLAIPGLATDELLSDGENTQKVLcLLRMCFVI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577433  99 LFAehffgGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWV 148
Cdd:cd15104  82 TSC-----AASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWL 126

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

28-154

2.08e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 39.16 E-value: 2.08e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEHFFG 106
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHA 154
Cdd:cd15217  86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMA 133

7tmA_MCHR1

cd15338

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...

24-285

2.14e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320460 [Multi-domain] Cd Length: 282 Bit Score: 39.02 E-value: 2.14e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMY---FFLISLSFLDVIYssITAPKLIIDSLSENTTISLEGCM---- 96
Cdd:cd15338   2 IMPSVFGVICFLGIIGNSIVIYTIVKKSKFRCQQTvpdIFIFNLSIVDLLF--LLGMPFLIHQLLGNGVWHFGETMctli 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  97 TQLFAEHFFGGVEIilLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNiidhVI 176
Cdd:cd15338  80 TALDTNSQITSTYI--LTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGS----VG 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 177 CDLfpLLQLACTDTHILDLL-----VILNSGVMCVTIFLIL--ITSYVVILC--SLKSRSSEGRRKALSTCSSHFTVVVL 247
Cdd:cd15338 154 CAL--LLPNPETDTYWFTLYqfflaFALPLVVICVVYFKILqnMASTVAPLPqrSLRVRTKKVTRMAVAICLAFFICWAP 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577433 248 FFVPCI--FLYMRPVVTYPVDNIMALCATIVEPMLNPLIY 285
Cdd:cd15338 232 FYILQLahLSIDRPSLAFLYAYNVAISMGYANSCINPFLY 271

7tmA_MWS_opsin

cd15080

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...

26-128

2.15e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 381742 [Multi-domain] Cd Length: 280 Bit Score: 39.05 E-value: 2.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILG---NLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15080   1 SALAAYMFLLILLGfpiNFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFA 80

                        90       100
                ....*....|....*....|....*.
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPL 128
Cdd:cd15080  81 TLGGEIALWSLVVLAIERYVVVCKPM 106

7tmA_Delta_opioid_R

cd15089

opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...

26-132

2.54e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320217 [Multi-domain] Cd Length: 281 Bit Score: 38.78 E-value: 2.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSiTAPKLIIDSLSENTTISLEGCMTQLFAEHFF 105
Cdd:cd15089   4 TALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATS-TLPFQSAKYLMETWPFGELLCKAVLSIDYYN 82

                        90       100       110
                ....*....|....*....|....*....|
gi 47577433 106 GGVEIILLIVMAYDRYVAICKP---LHYRT 132
Cdd:cd15089  83 MFTSIFTLTMMSVDRYIAVCHPvkaLDFRT 112

7tmA_Angiotensin_R-like

cd14985

angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...

27-296

2.78e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.

Pssm-ID: 341320 [Multi-domain] Cd Length: 284 Bit Score: 38.90 E-value: 2.78e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSsITAPkLIIDSLSENTTISLEGCMTQLFAEHFFG 106
Cdd:cd14985   5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFV-LTLP-LWATYTANQYDWPFGAFLCKVSSYVISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 107 G--VEIILLIVMAYDRYVAICKPLHYRTIVSPR-------MCWLMVGGAWVGGFAHATIQLLFMYQIPFCGpniidhvic 177
Cdd:cd14985  83 NmfASIFLLTCMSVDRYLAIVHPVASRRLRRRRqarvtcaLIWVVACLLSLPTFLLRSLQAIENLNKTACI--------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 178 dlfpllqLACTDTHILDLLVILNSGVMCVTIFLILITSYVVI---LCSLKSRSSEGRRKALSTCSSHFTVVVLFFVPCI- 253
Cdd:cd14985 154 -------MLYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIarsLRKRYERTGKNGRKRRKSLKIIFALVVAFLVCWLp 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577433 254 -----FLY----MRPVVTYPVDNIM------ALCATIVEPMLNPLIYSLRNAEVKQAL 296
Cdd:cd14985 227 fhffkFLDflaqLGAIRPCFWELFLdlglpiATCLAFTNSCLNPFIYVFVDRRFRQKV 284

7tmA_S1PR2_Edg5

cd15347

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...

26-148

3.11e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320469 [Multi-domain] Cd Length: 266 Bit Score: 38.64 E-value: 3.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  26 SALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIidsLSENTTISLEGcmTQLFAEHFF 105
Cdd:cd15347   4 SIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANIL---LSGSVTFRLTP--VQWFIREGT 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577433 106 G----GVEIILLIVMAYDRYVAICKPLHYRTIVSPRMcWLMVGGAWV 148
Cdd:cd15347  79 AfitlSASVFSLLAIAIERHVAITKVKLYGSDKNCRM-VLLIGACWV 124

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

24-294

3.18e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 38.40 E-value: 3.18e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSiTAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISIDY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKP---LHYRTIVSPRM----CWLMVGGAWVGGFAHATIQLLFMYQIPFCGpniidhvi 176
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPvkaLDFRTPLKAKIinicIWLLSSSVGISAIVLGGTKVREDVDSTECS-------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 177 cdlfplLQLACTDTHILDLLVilnsgVMCVTIF------LILITSYVVILCSLKS----RSSEGRRKALSTCSSHFTVVV 246
Cdd:cd15091 153 ------LQFPDDDYSWWDTFM-----KICVFIFafvipvLIIIVCYTLMILRLKSvrllSGSREKDRNLRRITRLVLVVV 221

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577433 247 LFFVPC-----IFLYMRPVVTYP----VDNIMALCATI--VEPMLNPLIYSLRNAEVKQ 294
Cdd:cd15091 222 AVFVVCwtpihIFILVEALGSVShstaAVSSYYFCIALgyTNSSLNPILYAFLDENFKR 280

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

30-171

3.44e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 38.28 E-value: 3.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  30 LIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEHFFGGV 108
Cdd:cd15308   8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVwTLSPVLCDALMTMDVMLCTA 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577433 109 EIILLIVMAYDRYVAICKPLHY-RTIVSPRMCwLMVGGAWVGGFAHATIQLLFMYQIPFCGPNI 171
Cdd:cd15308  88 SIFNLCAISVDRFIAVSVPLNYnRRQGSVRQL-LLISATWILSFAVASPVIFGLNNVPNRDPAV 150

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

24-151

4.04e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 38.04 E-value: 4.04e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFL-IMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAE 102
Cdd:cd15330   1 IITSLFLgTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGF 151
Cdd:cd15330  81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGF 129

7tmA_Mu_opioid_R

cd15090

opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...

24-137

4.31e-03

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320218 [Multi-domain] Cd Length: 279 Bit Score: 38.05 E-value: 4.31e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSiTAPKLIIDSLSENTTISLEGCMTQLFAEH 103
Cdd:cd15090   2 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGNILCKIVISIDY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 47577433 104 FFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPR 137
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPR 114

7tmA_SKR_NK2R

cd16004

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-160

4.70e-03

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.

Pssm-ID: 320670 [Multi-domain] Cd Length: 285 Bit Score: 37.90 E-value: 4.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  29 FLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGCMTQLFAEHFFGGV 108
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 109 EIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHPFKPR--LSAGSTKVVIAGIWLVALALAFPQCFY 136

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

28-154

4.70e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 38.11 E-value: 4.70e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  28 LFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENT-TISLEGCMTQLFAEHFFG 106
Cdd:cd15392   6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYwPFGEFMCPVVNYLQAVSV 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577433 107 GVEIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHA 154
Cdd:cd15392  86 FVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATA 131

7tmA_GPR25

cd15193

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...

24-160

5.10e-03

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.

Pssm-ID: 320321 [Multi-domain] Cd Length: 279 Bit Score: 37.81 E-value: 5.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  24 IFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSsITAPKLIIDSLSENTTISLEG-CMTQLFAE 102
Cdd:cd15193   2 YIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFV-LTLPFWAASTALGGQWLFGEGlCKLSSFII 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577433 103 HFFGGVEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLF 160
Cdd:cd15193  81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVY 138

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

23-180

6.87e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 37.41 E-value: 6.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  23 TIFSALFLIMYVVTILGNLLIVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEG-CMTQLFA 101
Cdd:cd15394   1 PLIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFmCYFVFLM 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47577433 102 EHFFGGVEIILLIVMAYDRYVAICKPLHYRtiVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGpniIDHVICDLF 180
Cdd:cd15394  81 QPVTVYVSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG---LDFSICEEF 154

7tmA_Relaxin_R

cd15137

relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...

108-296

8.02e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.

Pssm-ID: 320265 [Multi-domain] Cd Length: 284 Bit Score: 37.18 E-value: 8.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 108 VEIILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGaWVGGFAHATIQLLFM-YQIPFCGPNiidhVICdlFPLlqla 186
Cdd:cd15137  93 VSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACI-WLIGLLLAVLPLLPWdYFGNFYGRS----GVC--LPL---- 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 187 ctdtHILD-----------LLVILNSgvmcvTIFLILITSYVVILCSLK-SRSSEGRRKALSTCS--SHFTVVVL--FF- 249
Cdd:cd15137 162 ----HITDerpagweysvfVFLGLNF-----LAFVFILLSYIAMFISIRrTRKAAASRKSKRDMAvaKRFFLIVLtdFLc 232

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577433 250 -VPCIFLYMRPVVTYPV-DNIMALCATIVEPM---LNPLIYSLRNAEVKQAL 296
Cdd:cd15137 233 wIPIIVIGILALSGVPIpGEVYAWVAVFVLPInsaLNPILYTLSTPKFRKKL 284

7tmA_PAR4

cd15372

protease-activated receptor 4, member of the class A family of seven-transmembrane G ...

27-257

9.90e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 320494 [Multi-domain] Cd Length: 274 Bit Score: 37.03 E-value: 9.90e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433  27 ALFLIMYVVTILGNLLiVVTVMKSSNLRSPMYFFLISLSFLDVIYSSITAPKLIIDSLSENTTISLEGC--MTQLFAEHF 104
Cdd:cd15372   5 SLYTLVFLVGLPANGL-ALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCrvVTAFFYGNM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577433 105 FGGVeiILLIVMAYDRYVAICKPLHYRTIVSPRMCWLMVGGAWVGGFAHATIQLLFMYQIPFCGPNIIdhVICDLFPLLQ 184
Cdd:cd15372  84 YCSV--LLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNIT--LCHDVLPLDE 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577433 185 LACTDTHILDLLVILNsgvmCVTIFLILITSYVVILCSLkSRSSEGRRKALSTCSSHFTVVVLFFVPCIFLYM 257
Cdd:cd15372 160 QDTYLFYYFACLAVLG----FLLPLVVILFCYGSVLHTL-LRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLL 227

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01