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Conserved domains on  [gi|71043716|ref|NP_001020813|]
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F-box only protein 46 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
 473-519 3.38e-28

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438948  Cd Length: 47  Bit Score: 106.54  E-value: 3.38e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRW 519
Cdd:cd22177   1 MLLLPDHILVNIFSYLPTRSLAALKCSCHHFKDIIETYGVRATDSRW 47
 
Name Accession Description Interval E-value
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
 473-519 3.38e-28

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438948  Cd Length: 47  Bit Score: 106.54  E-value: 3.38e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRW 519
Cdd:cd22177   1 MLLLPDHILVNIFSYLPTRSLAALKCSCHHFKDIIETYGVRATDSRW 47
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 473-507 5.28e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 43.63  E-value: 5.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71043716   473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGII 507
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
476-513 2.39e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.65  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71043716    476 LPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVR 513
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
 
Name Accession Description Interval E-value
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
 473-519 3.38e-28

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438948  Cd Length: 47  Bit Score: 106.54  E-value: 3.38e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRW 519
Cdd:cd22177   1 MLLLPDHILVNIFSYLPTRSLAALKCSCHHFKDIIETYGVRATDSRW 47
F-box_FBXO34-like cd22105
F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and ...
 473-519 2.39e-24

F-box domain found in F-box only protein 34 (FBXO34), F-box only protein 46 (FBXO46) and similar proteins; This family includes FBXO34 (also called FBX34) and FBXO46 (also called FBX46), both of which are substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. The SCF(FBOX46) complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438877  Cd Length: 47  Bit Score: 95.55  E-value: 2.39e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRW 519
Cdd:cd22105   1 FLLLPDHVLSKIFSHLPTRSLAALKCTCKDFKWLIEMFDVRGSDSRW 47
F-box_FBXO34 cd22176
F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called ...
 473-519 2.65e-19

F-box domain found in F-box only protein 34 (FBXO34) and similar proteins; FBXO34, also called FBX34, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438947  Cd Length: 48  Bit Score: 81.42  E-value: 2.65e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRW 519
Cdd:cd22176   1 MAFLPHHILVKIFRFLPTRTLAALKCTCHYFKFIIENYDIRPADSRW 47
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 476-508 1.10e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 45.13  E-value: 1.10e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 71043716 476 LPEHVLVKIFSFLPTRALAALKCTCHHFKGIIE 508
Cdd:cd09917   3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 473-507 5.28e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 43.63  E-value: 5.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71043716   473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGII 507
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELA 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
476-513 2.39e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.65  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71043716    476 LPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVR 513
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 473-507 3.07e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 41.37  E-value: 3.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71043716   473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGII 507
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLV 35
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 473-503 1.39e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 39.53  E-value: 1.39e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHF 503
Cdd:cd22139   1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRF 31
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 476-508 3.78e-04

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 38.38  E-value: 3.78e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 71043716 476 LPEHVLVKIFSFLPTRALAALKCTCHHFKGIIE 508
Cdd:cd22082   5 LPEEVLLHILKGLPIKDLLNMRAVHSRFKDLID 37
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 473-521 7.71e-04

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 37.79  E-value: 7.71e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 71043716 473 MLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIeafgvrATDSRWSR 521
Cdd:cd22102   1 ILDLPPELLVEIFSSLPGTDLPSLAQVCKKFREIL------NTDTIWQR 43
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 476-508 2.27e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.90  E-value: 2.27e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 71043716 476 LPEHVLVKIFSFLPTRALAALKCTCHHFKGIIE 508
Cdd:cd22157   3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 475-502 4.79e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 4.79e-03
                        10        20
                ....*....|....*....|....*...
gi 71043716 475 LLPEHVLVKIFSFLPTRALAALKCTCHH 502
Cdd:cd22132   3 LLPDSLLLHIFSYLSPKDLLAAGQVCKQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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