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Conserved domains on  [gi|157821705|ref|NP_001099801|]
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tRNA 2'-phosphotransferase 1 [Rattus norvegicus]

Protein Classification

tRNA 2'-phosphotransferase( domain architecture ID 10487098)

tRNA 2'-phosphotransferase catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate

EC:  2.7.1.160
Gene Ontology:  GO:0006388|GO:0000215
PubMed:  37334830

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTS_2-RNA pfam01885
RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing ...
26-198 1.75e-81

RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.


:

Pssm-ID: 460371  Cd Length: 168  Bit Score: 241.29  E-value: 1.75e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705   26 LSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQF--HSFSIEDVQLVVDTNEKQRFTLqpgePSTGPLIRANQGHSL 103
Cdd:pfam01885   1 ISKALSYLLRHGAEKEGLKLDPDGYVSVDDLLAHPRLksLKVTLEDLQRVVATNDKKRFEL----KEDGWLIRANQGHSI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  104 QVPELElmPLETPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLPGDsGVISGIRPNCEVAVFINGALALTDG 183
Cdd:pfam01885  77 PVDVLE--PITPADPLPTVLVHGTYFQAWPLILSGGLKRMGRNHIHLATGLPGE-AVISGMRHSSPVLIYIDVRKALADG 153
                         170
                  ....*....|....*
gi 157821705  184 IPFFCSVNGVILTPG 198
Cdd:pfam01885 154 IKFYRSENGVILTEG 168
 
Name Accession Description Interval E-value
PTS_2-RNA pfam01885
RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing ...
26-198 1.75e-81

RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.


Pssm-ID: 460371  Cd Length: 168  Bit Score: 241.29  E-value: 1.75e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705   26 LSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQF--HSFSIEDVQLVVDTNEKQRFTLqpgePSTGPLIRANQGHSL 103
Cdd:pfam01885   1 ISKALSYLLRHGAEKEGLKLDPDGYVSVDDLLAHPRLksLKVTLEDLQRVVATNDKKRFEL----KEDGWLIRANQGHSI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  104 QVPELElmPLETPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLPGDsGVISGIRPNCEVAVFINGALALTDG 183
Cdd:pfam01885  77 PVDVLE--PITPADPLPTVLVHGTYFQAWPLILSGGLKRMGRNHIHLATGLPGE-AVISGMRHSSPVLIYIDVRKALADG 153
                         170
                  ....*....|....*
gi 157821705  184 IPFFCSVNGVILTPG 198
Cdd:pfam01885 154 IKFYRSENGVILTEG 168
PTZ00315 PTZ00315
2'-phosphotransferase; Provisional
19-208 2.95e-46

2'-phosphotransferase; Provisional


Pssm-ID: 240356 [Multi-domain]  Cd Length: 582  Bit Score: 161.98  E-value: 2.95e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  19 EQDRNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQFHS--FSIEDVQLVVDTNEKQRFTLQPGEPSTGPLIR 96
Cdd:PTZ00315 374 DEEKLVTYSKFMSRLLRHKADQWRVPITSNGYVLLDDILRQPPMRNdpVSVQDVARVVRDSDKQRFKLAYGAADGRLYIR 453
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  97 ANQGHSLQVPELELMPLETPQALPSTlVHGTFWKHWPSILLNG-LSRQGRTHIHLASGLPGDSGVISGIRPNCEVAVFIN 175
Cdd:PTZ00315 454 ANQGHSIDGVEPELRTLTSVEEVPVA-VHGTYWSAWKAIQRCGyLSTMTRQHIHFAKGLINDEQVISGMRNNVQLFLYLD 532
                        170       180       190
                 ....*....|....*....|....*....|....
gi 157821705 176 GALALTDGIPFFCSVNGVILTPGNADGFLLP-KY 208
Cdd:PTZ00315 533 VAAVLADGVALYESSNGVILTPGVGHTRQLPlKY 566
KptA COG1859
RNA:NAD 2'-phosphotransferase, TPT1/KptA family [Translation, ribosomal structure and ...
20-196 1.66e-38

RNA:NAD 2'-phosphotransferase, TPT1/KptA family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441464  Cd Length: 181  Bit Score: 132.22  E-value: 1.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  20 QDRNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQL--PQFHSFSIEDVQLVVDTNEKQRFTLQPGepstgpLIRA 97
Cdd:COG1859    3 DKRLERLSKFLSYILRHFPEEIGLELDEEGWVDVDELLAAlrRRGRWLTREHLEAVVATNDKGRFEISGD------RIRA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  98 NQGHSLQVpELELmpleTPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLpgDSGVISGIRPNcEVAVF-ING 176
Cdd:COG1859   77 NQGHSVPV-DLDL----PPAEPPEVLYHGTAPRFLDSILEEGLKPMSRHHVHLSADR--ETARKVGSRHG-KPVVLeVDA 148
                        170       180
                 ....*....|....*....|
gi 157821705 177 ALALTDGIPFFCSVNGVILT 196
Cdd:COG1859  149 AAMRAAGHKFYRSGNGVWLT 168
 
Name Accession Description Interval E-value
PTS_2-RNA pfam01885
RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing ...
26-198 1.75e-81

RNA 2'-phosphotransferase, Tpt1 / KptA family; Tpt1 catalyzes the last step of tRNA splicing in yeast. It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate. This is presumed to be followed by a transesterification step to release the RNA. The first step of this reaction is similar to that catalyzed by some bacterial toxins. E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism.


Pssm-ID: 460371  Cd Length: 168  Bit Score: 241.29  E-value: 1.75e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705   26 LSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQF--HSFSIEDVQLVVDTNEKQRFTLqpgePSTGPLIRANQGHSL 103
Cdd:pfam01885   1 ISKALSYLLRHGAEKEGLKLDPDGYVSVDDLLAHPRLksLKVTLEDLQRVVATNDKKRFEL----KEDGWLIRANQGHSI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  104 QVPELElmPLETPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLPGDsGVISGIRPNCEVAVFINGALALTDG 183
Cdd:pfam01885  77 PVDVLE--PITPADPLPTVLVHGTYFQAWPLILSGGLKRMGRNHIHLATGLPGE-AVISGMRHSSPVLIYIDVRKALADG 153
                         170
                  ....*....|....*
gi 157821705  184 IPFFCSVNGVILTPG 198
Cdd:pfam01885 154 IKFYRSENGVILTEG 168
PTZ00315 PTZ00315
2'-phosphotransferase; Provisional
19-208 2.95e-46

2'-phosphotransferase; Provisional


Pssm-ID: 240356 [Multi-domain]  Cd Length: 582  Bit Score: 161.98  E-value: 2.95e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  19 EQDRNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQFHS--FSIEDVQLVVDTNEKQRFTLQPGEPSTGPLIR 96
Cdd:PTZ00315 374 DEEKLVTYSKFMSRLLRHKADQWRVPITSNGYVLLDDILRQPPMRNdpVSVQDVARVVRDSDKQRFKLAYGAADGRLYIR 453
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  97 ANQGHSLQVPELELMPLETPQALPSTlVHGTFWKHWPSILLNG-LSRQGRTHIHLASGLPGDSGVISGIRPNCEVAVFIN 175
Cdd:PTZ00315 454 ANQGHSIDGVEPELRTLTSVEEVPVA-VHGTYWSAWKAIQRCGyLSTMTRQHIHFAKGLINDEQVISGMRNNVQLFLYLD 532
                        170       180       190
                 ....*....|....*....|....*....|....
gi 157821705 176 GALALTDGIPFFCSVNGVILTPGNADGFLLP-KY 208
Cdd:PTZ00315 533 VAAVLADGVALYESSNGVILTPGVGHTRQLPlKY 566
KptA COG1859
RNA:NAD 2'-phosphotransferase, TPT1/KptA family [Translation, ribosomal structure and ...
20-196 1.66e-38

RNA:NAD 2'-phosphotransferase, TPT1/KptA family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441464  Cd Length: 181  Bit Score: 132.22  E-value: 1.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  20 QDRNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQL--PQFHSFSIEDVQLVVDTNEKQRFTLQPGepstgpLIRA 97
Cdd:COG1859    3 DKRLERLSKFLSYILRHFPEEIGLELDEEGWVDVDELLAAlrRRGRWLTREHLEAVVATNDKGRFEISGD------RIRA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  98 NQGHSLQVpELELmpleTPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLpgDSGVISGIRPNcEVAVF-ING 176
Cdd:COG1859   77 NQGHSVPV-DLDL----PPAEPPEVLYHGTAPRFLDSILEEGLKPMSRHHVHLSADR--ETARKVGSRHG-KPVVLeVDA 148
                        170       180
                 ....*....|....*....|
gi 157821705 177 ALALTDGIPFFCSVNGVILT 196
Cdd:COG1859  149 AAMRAAGHKFYRSGNGVWLT 168
PRK00819 PRK00819
RNA 2'-phosphotransferase; Reviewed
22-196 1.97e-31

RNA 2'-phosphotransferase; Reviewed


Pssm-ID: 179136  Cd Length: 179  Bit Score: 113.79  E-value: 1.97e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705  22 RNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQ--FHSFSIEDVQLVVDTNEKQRFTLQpgepstGPLIRANQ 99
Cdd:PRK00819   5 RLEKLSKFLSGVLRHKPEAIGLTLDEEGWVDIDALIEALAkaYKWVTRELLEAVVESDDKGRFEIS------GDRIRARQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821705 100 GHSLQVpELELmpleTPQALPSTLVHGTFWKHWPSILLNGLSRQGRTHIHLASGLpgDSGVISGIRPNCEVAVFINGALA 179
Cdd:PRK00819  79 GHSVDV-DLDL----EEDTPPAVLYHGTSSEELDSILEEGLKPMKRHYVHLSTDI--ETAREVGARHGSPVILEVDAECM 151
                        170
                 ....*....|....*..
gi 157821705 180 LTDGIPFFCSVNGVILT 196
Cdd:PRK00819 152 RKRGIKFYKAENGVWLT 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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