DNA replication complex GINS protein PSF1 [Rattus norvegicus]
DNA replication complex GINS protein PSF1( domain architecture ID 16826181)
DNA replication complex GINS protein PSF1 is a component of the heterotetrameric GINS complex, which is essential for both the initiation and elongation stages of eukaryotic DNA replication
List of domain hits
Name | Accession | Description | Interval | E-value | |||
GINS_A_psf1 | cd11710 | Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric ... |
3-130 | 3.75e-56 | |||
Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric protein complex. Psf1 is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. : Pssm-ID: 212548 Cd Length: 129 Bit Score: 173.60 E-value: 3.75e-56
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GINS_B_Psf1 | cd21696 | beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component ... |
146-194 | 4.31e-27 | |||
beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, and is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Psf1 has been reported to be a prognostic biomarker in breast cancer, prostate cancer, hepatocellular carcinoma, and non-small cell lung cancer (NSCLC) patients treated with surgery following preoperative chemotherapy or chemoradiotherapy. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) and is involved in both the initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Psf1. : Pssm-ID: 412032 Cd Length: 49 Bit Score: 97.21 E-value: 4.31e-27
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Name | Accession | Description | Interval | E-value | ||||
GINS_A_psf1 | cd11710 | Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric ... |
3-130 | 3.75e-56 | ||||
Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric protein complex. Psf1 is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212548 Cd Length: 129 Bit Score: 173.60 E-value: 3.75e-56
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GINS_B_Psf1 | cd21696 | beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component ... |
146-194 | 4.31e-27 | ||||
beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, and is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Psf1 has been reported to be a prognostic biomarker in breast cancer, prostate cancer, hepatocellular carcinoma, and non-small cell lung cancer (NSCLC) patients treated with surgery following preoperative chemotherapy or chemoradiotherapy. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) and is involved in both the initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Psf1. Pssm-ID: 412032 Cd Length: 49 Bit Score: 97.21 E-value: 4.31e-27
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COG5230 | COG5230 | Uncharacterized conserved protein [Function unknown]; |
1-191 | 5.75e-22 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227555 [Multi-domain] Cd Length: 194 Bit Score: 88.08 E-value: 5.75e-22
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Sld5 | pfam05916 | GINS complex protein; The eukaryotic GINS complex is essential for the initiation and ... |
20-111 | 1.02e-04 | ||||
GINS complex protein; The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase. Pssm-ID: 399129 Cd Length: 105 Bit Score: 40.17 E-value: 1.02e-04
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Name | Accession | Description | Interval | E-value | ||||
GINS_A_psf1 | cd11710 | Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric ... |
3-130 | 3.75e-56 | ||||
Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric protein complex. Psf1 is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212548 Cd Length: 129 Bit Score: 173.60 E-value: 3.75e-56
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GINS_B_Psf1 | cd21696 | beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component ... |
146-194 | 4.31e-27 | ||||
beta-strand (B) domain of GINS complex protein Psf1; Psf1 (partner of Sld5 1) is a component of the GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) tetrameric protein complex, and is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Psf1 has been reported to be a prognostic biomarker in breast cancer, prostate cancer, hepatocellular carcinoma, and non-small cell lung cancer (NSCLC) patients treated with surgery following preoperative chemotherapy or chemoradiotherapy. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) and is involved in both the initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits Sld5, Psf1, Psf2 and Psf3 are homologous, and homologs are also found in archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. This model represents the B-domain of GINS subunit Psf1. Pssm-ID: 412032 Cd Length: 49 Bit Score: 97.21 E-value: 4.31e-27
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GINS_A | cd11581 | Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is ... |
3-123 | 9.45e-25 | ||||
Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; The GINS complex is involved in both initiation and elongation stages of eukaryotic chromosome replication, with GINS being the component that most likely serves as the replicative helicase that unwinds duplex DNA ahead of the moving replication fork. In eukaryotes, GINS is a tetrameric arrangement of four subunits Sld5, Psf1, Psf2 and Psf3. The GINS complex has been found in eukaryotes and archaea, but not in bacteria. The four subunits of the complex are homologous and consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3. Pssm-ID: 212547 Cd Length: 103 Bit Score: 92.94 E-value: 9.45e-25
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COG5230 | COG5230 | Uncharacterized conserved protein [Function unknown]; |
1-191 | 5.75e-22 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227555 [Multi-domain] Cd Length: 194 Bit Score: 88.08 E-value: 5.75e-22
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Sld5 | pfam05916 | GINS complex protein; The eukaryotic GINS complex is essential for the initiation and ... |
20-111 | 1.02e-04 | ||||
GINS complex protein; The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase. Pssm-ID: 399129 Cd Length: 105 Bit Score: 40.17 E-value: 1.02e-04
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Blast search parameters | ||||
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