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Conserved domains on  [gi|205360936|ref|NP_001127968|]
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CSC1-like protein 1 [Rattus norvegicus]

Protein Classification

OSCA/TMEM63 family ion channel( domain architecture ID 10342091)

OSCA/TMEM63 family ion channel is an an osmosensitive calcium-permeable cation channel that converts mechanical stimuli into electric signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-655 6.77e-62

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


:

Pssm-ID: 460661  Cd Length: 273  Bit Score: 209.68  E-value: 6.77e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  420 QCLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPIHALNNP----------VISQFFPTLLLWSFSALLPTIVYYSTLLE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  490 SHWTRSGENRIMVSKVYIFLIFMVLILPSLGLTSLDFffrWLFDKTSSDTSIRLECVFLPDQGAFFVNYVIASAFIGSGM 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  570 ELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNL 649
Cdd:pfam02714 158 ELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQL 237

                  ....*.
gi 205360936  650 YFAYLP 655
Cdd:pfam02714 238 LYVYVT 243
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-409 2.56e-46

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


:

Pssm-ID: 464272  Cd Length: 164  Bit Score: 162.88  E-value: 2.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  228 TLFITGLPREAR-KETVESHFRDAYPTCEVVDVQLCYSVAKLINLCKERKKTEKSLTYYTNLQVKTGRRtlINPKPCGQF 306
Cdd:pfam14703   3 TVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  307 CCCEVQGcEREDAISYYTRMNDSLTERITAEECRVQDQPLGMAFVTFREKSMATFILKdfnackcqglrckgepqpSSYS 386
Cdd:pfam14703  81 GFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QINP 141
                         170       180
                  ....*....|....*....|...
gi 205360936  387 RELCVSKWSVTFASYPEDICWKN 409
Cdd:pfam14703 142 QLMHPKGWTVELAPEPRDVIWEN 164
RSN1_TM super family cl16507
Late exocytosis, associated with Golgi transport; This family represents the first three ...
61-213 5.26e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


The actual alignment was detected with superfamily member pfam13967:

Pssm-ID: 433613  Cd Length: 158  Bit Score: 70.30  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936   61 FLVLILVFSIIRRKFwdygrialvseagseARF---RRLSSSSSGQQDFESELGCCSWLSAIFRLHDDQILEWCGEDAIH 137
Cdd:pfam13967  13 ALVFLLLFSILRPKN---------------KRVyapRTYLAPEEERTPPLPGTGLFGWIPPLLKIPDEEILQHAGLDAYV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  138 YLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTVFSVIYLFLTVGFMWH 212
Cdd:pfam13967  78 FLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTGFVLYLLYR 157

                  .
gi 205360936  213 H 213
Cdd:pfam13967 158 E 158
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-655 6.77e-62

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 209.68  E-value: 6.77e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  420 QCLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPIHALNNP----------VISQFFPTLLLWSFSALLPTIVYYSTLLE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  490 SHWTRSGENRIMVSKVYIFLIFMVLILPSLGLTSLDFffrWLFDKTSSDTSIRLECVFLPDQGAFFVNYVIASAFIGSGM 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  570 ELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNL 649
Cdd:pfam02714 158 ELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQL 237

                  ....*.
gi 205360936  650 YFAYLP 655
Cdd:pfam02714 238 LYVYVT 243
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-409 2.56e-46

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 162.88  E-value: 2.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  228 TLFITGLPREAR-KETVESHFRDAYPTCEVVDVQLCYSVAKLINLCKERKKTEKSLTYYTNLQVKTGRRtlINPKPCGQF 306
Cdd:pfam14703   3 TVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  307 CCCEVQGcEREDAISYYTRMNDSLTERITAEECRVQDQPLGMAFVTFREKSMATFILKdfnackcqglrckgepqpSSYS 386
Cdd:pfam14703  81 GFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QINP 141
                         170       180
                  ....*....|....*....|...
gi 205360936  387 RELCVSKWSVTFASYPEDICWKN 409
Cdd:pfam14703 142 QLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
114-653 1.65e-29

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 125.61  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 114 SWLSAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVN---LSGDLLDKDPYS-FGRTTIANLQTDN 189
Cdd:COG5594   76 GWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhfQKATNGNSDSESgLDKLSISNVSPSN 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 190 D---------LLWLHTVFSV-IYLFLTVGFMWHHTRSIRYKEESLVRQ------TLFITGLPREARKETVESHFRDAYPT 253
Cdd:COG5594  156 RlyahvflswFFFGYVLFIIfRELRFYVVLRQAYLRSPLYQQSLLTLQnnlssrTVLISGLPSELRSDEELKELFDKLKV 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 254 CEVVDVQLCYSVAKLINLCKER----KKTEKSLTYYTNLQVK-TGRRTLINPKPCGQFCCCEVQGCERE----------- 317
Cdd:COG5594  236 GEIDSDVLCRDLGTLQELYKERdkilKKLEKALNELLNKLLKkSHLKTNKKSGKLTPSRKKEFEILPEYvpdkkrpkhri 315
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 318 ------------DAISYYTRMNDSLTERI-TAEECRVQDQPLGMAFVTFreKSMATFilkdfNACKcqglrckgepQPSS 384
Cdd:COG5594  316 kklnkgifgkkvDAIDYYSAKLTKLDAEIeNARKSLYENTPTKSGFITF--KSQASA-----QIAA----------QSQI 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 385 YSRELCVSKwsVTFASYPEDICWKNLSIQgvRWWLQCLGINFSLFVVLF--FLTTPSIIMSTMDKFN-VTKPIHALN--- 458
Cdd:COG5594  379 YSRVLGKLK--VEIAPAPNDIIWDNLRLS--RKERLFKRISANILFILLiiLWAFPVAFVGTISNLNtLSSLWPFLKfil 454
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 459 ------NPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTRSGENRIMVSKVYIFL---IFMVLILPSLGLTSLDfffR 529
Cdd:COG5594  455 kdppflAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLfvnLFLVVTLASSFSSIVW---S 531
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 530 WLFDKTSSDTSIRLEcvfLPDQGAFFVNYVIASAFIGSGMELLRLPGLILYTFRM-IMAKTAADRRNvKQNQAFEYEFGA 608
Cdd:COG5594  532 LLKEPTSIMTLLANN---LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGkFKDSTPRQKWN-RLETPPSFQFGT 607
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 205360936 609 MYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAY 653
Cdd:COG5594  608 VLPQPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVS 652
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
61-213 5.26e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 70.30  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936   61 FLVLILVFSIIRRKFwdygrialvseagseARF---RRLSSSSSGQQDFESELGCCSWLSAIFRLHDDQILEWCGEDAIH 137
Cdd:pfam13967  13 ALVFLLLFSILRPKN---------------KRVyapRTYLAPEEERTPPLPGTGLFGWIPPLLKIPDEEILQHAGLDAYV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  138 YLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTVFSVIYLFLTVGFMWH 212
Cdd:pfam13967  78 FLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTGFVLYLLYR 157

                  .
gi 205360936  213 H 213
Cdd:pfam13967 158 E 158
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-655 6.77e-62

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 209.68  E-value: 6.77e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  420 QCLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPIHALNNP----------VISQFFPTLLLWSFSALLPTIVYYSTLLE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWilelppkllgLVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  490 SHWTRSGENRIMVSKVYIFLIFMVLILPSLGLTSLDFffrWLFDKTSSDTSIRLECVFLPDQGAFFVNYVIASAFIGSGM 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  570 ELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNL 649
Cdd:pfam02714 158 ELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQL 237

                  ....*.
gi 205360936  650 YFAYLP 655
Cdd:pfam02714 238 LYVYVT 243
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-409 2.56e-46

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 162.88  E-value: 2.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  228 TLFITGLPREAR-KETVESHFRDAYPTCEVVDVQLCYSVAKLINLCKERKKTEKSLTYYTNLQVKTGRRtlINPKPCGQF 306
Cdd:pfam14703   3 TVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  307 CCCEVQGcEREDAISYYTRMNDSLTERITAEECRVQDQPLGMAFVTFREKSMATFILKdfnackcqglrckgepqpSSYS 386
Cdd:pfam14703  81 GFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QINP 141
                         170       180
                  ....*....|....*....|...
gi 205360936  387 RELCVSKWSVTFASYPEDICWKN 409
Cdd:pfam14703 142 QLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
114-653 1.65e-29

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 125.61  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 114 SWLSAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVN---LSGDLLDKDPYS-FGRTTIANLQTDN 189
Cdd:COG5594   76 GWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhfQKATNGNSDSESgLDKLSISNVSPSN 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 190 D---------LLWLHTVFSV-IYLFLTVGFMWHHTRSIRYKEESLVRQ------TLFITGLPREARKETVESHFRDAYPT 253
Cdd:COG5594  156 RlyahvflswFFFGYVLFIIfRELRFYVVLRQAYLRSPLYQQSLLTLQnnlssrTVLISGLPSELRSDEELKELFDKLKV 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 254 CEVVDVQLCYSVAKLINLCKER----KKTEKSLTYYTNLQVK-TGRRTLINPKPCGQFCCCEVQGCERE----------- 317
Cdd:COG5594  236 GEIDSDVLCRDLGTLQELYKERdkilKKLEKALNELLNKLLKkSHLKTNKKSGKLTPSRKKEFEILPEYvpdkkrpkhri 315
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 318 ------------DAISYYTRMNDSLTERI-TAEECRVQDQPLGMAFVTFreKSMATFilkdfNACKcqglrckgepQPSS 384
Cdd:COG5594  316 kklnkgifgkkvDAIDYYSAKLTKLDAEIeNARKSLYENTPTKSGFITF--KSQASA-----QIAA----------QSQI 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 385 YSRELCVSKwsVTFASYPEDICWKNLSIQgvRWWLQCLGINFSLFVVLF--FLTTPSIIMSTMDKFN-VTKPIHALN--- 458
Cdd:COG5594  379 YSRVLGKLK--VEIAPAPNDIIWDNLRLS--RKERLFKRISANILFILLiiLWAFPVAFVGTISNLNtLSSLWPFLKfil 454
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 459 ------NPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTRSGENRIMVSKVYIFL---IFMVLILPSLGLTSLDfffR 529
Cdd:COG5594  455 kdppflAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLfvnLFLVVTLASSFSSIVW---S 531
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936 530 WLFDKTSSDTSIRLEcvfLPDQGAFFVNYVIASAFIGSGMELLRLPGLILYTFRM-IMAKTAADRRNvKQNQAFEYEFGA 608
Cdd:COG5594  532 LLKEPTSIMTLLANN---LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGkFKDSTPRQKWN-RLETPPSFQFGT 607
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 205360936 609 MYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAY 653
Cdd:COG5594  608 VLPQPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVS 652
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
61-213 5.26e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 70.30  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936   61 FLVLILVFSIIRRKFwdygrialvseagseARF---RRLSSSSSGQQDFESELGCCSWLSAIFRLHDDQILEWCGEDAIH 137
Cdd:pfam13967  13 ALVFLLLFSILRPKN---------------KRVyapRTYLAPEEERTPPLPGTGLFGWIPPLLKIPDEEILQHAGLDAYV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360936  138 YLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTVFSVIYLFLTVGFMWH 212
Cdd:pfam13967  78 FLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTGFVLYLLYR 157

                  .
gi 205360936  213 H 213
Cdd:pfam13967 158 E 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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