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Conserved domains on  [gi|2004852568|ref|NP_001380731|]
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Rhox homeobox family member 7 [Rattus norvegicus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 810-863 1.58e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 1.58e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRREQ 863
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 249-645 5.21e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.90  E-value: 5.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  249 PVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHV-QPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHV 327
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  328 QPVPVTAPLSQGMPVRVPHVQPVP-VSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRL-PHAQPVPVTPA 405
Cdd:PHA03247  2691 TVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  406 PPQTMPVRVPHVQPLPRTAPLSQAIPI----RVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMP 481
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  482 IPWHYVQP-------MPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVTVPHVQPMPFPVPQALSMPFPVPQALSMPFPV 554
Cdd:PHA03247  2851 PLGGSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  555 PQALSMPFPVHQA--LSMPVPVPVPQVQPVPVTVPHTQRIRGPVPRVQTLPPSVTQSESIPVTVSSIQPKPTTVPRAHRI 632
Cdd:PHA03247  2931 PPPPPPPRPQPPLapTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010

                          410
                   ....*....|...
gi 2004852568  633 CVPHVQILPPPVT 645
Cdd:PHA03247  3011 LALHEETDPPPVS 3023
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 590-799 3.12e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 590 QRIRGPVPRVQTLPPSVTQSeSIPVTVSSIQPKPTTVPRAHRICVPHVQILPPPVTQSESMADTVSPLQPMPVTvpHAQR 669
Cdd:pfam03154 165 QILQTQPPVLQAQSGAASPP-SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL--HPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 670 IRGPVPCVQTLPNSVPQSESMAVTVPTAQTMPPTVPHKERMPGPGPHVQSLLPPVPHEHPMPFTVHQAQPMP-----VSV 744
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPspaapGQS 321

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 745 SNAQHIPAKESSTPHVPVPREQTSPvgmncvrPIPNAAPRIRPVAVSATTVQPEP 799
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLP-------PAPLSMPHIKPPPTTPIPQLPNP 369
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 810-863 1.58e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 1.58e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRREQ 863
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
810-861 1.22e-15

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.76  E-value: 1.22e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRR 861
Cdd:pfam00046   6 TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 804-856 1.02e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.20  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2004852568  804 RRHLHDRFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRR 856
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRR 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 249-645 5.21e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.90  E-value: 5.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  249 PVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHV-QPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHV 327
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  328 QPVPVTAPLSQGMPVRVPHVQPVP-VSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRL-PHAQPVPVTPA 405
Cdd:PHA03247  2691 TVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  406 PPQTMPVRVPHVQPLPRTAPLSQAIPI----RVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMP 481
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  482 IPWHYVQP-------MPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVTVPHVQPMPFPVPQALSMPFPVPQALSMPFPV 554
Cdd:PHA03247  2851 PLGGSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  555 PQALSMPFPVHQA--LSMPVPVPVPQVQPVPVTVPHTQRIRGPVPRVQTLPPSVTQSESIPVTVSSIQPKPTTVPRAHRI 632
Cdd:PHA03247  2931 PPPPPPPRPQPPLapTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010

                          410
                   ....*....|...
gi 2004852568  633 CVPHVQILPPPVT 645
Cdd:PHA03247  3011 LALHEETDPPPVS 3023
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 208-556 9.22e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 9.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 208 QPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHV 287
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 288 QPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRvphV 367
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRI---H 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 368 QPVPVTALPPQPVPLTAPTPWAvPTRLPHAQPVPVTPAPPQTMPVRVPH----VQPLPRTAPLSQAIPIRVPHVQPVPVT 443
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPA-PLSMPHIKPPPTTPIPQLPNPQSHKHpphlSGPSPFQMNSNLPPPPALKPLSSLSTH 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 444 TPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPMPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVT 523
Cdd:pfam03154 406 HPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST 485

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2004852568 524 VPHVQPMPFPVPQALSMPFPVPQALSMPFPVPQ 556
Cdd:pfam03154 486 SSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQ 518
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
810-864 2.63e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.20  E-value: 2.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRREQS 864
Cdd:COG5576    57 RTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 590-799 3.12e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 590 QRIRGPVPRVQTLPPSVTQSeSIPVTVSSIQPKPTTVPRAHRICVPHVQILPPPVTQSESMADTVSPLQPMPVTvpHAQR 669
Cdd:pfam03154 165 QILQTQPPVLQAQSGAASPP-SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL--HPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 670 IRGPVPCVQTLPNSVPQSESMAVTVPTAQTMPPTVPHKERMPGPGPHVQSLLPPVPHEHPMPFTVHQAQPMP-----VSV 744
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPspaapGQS 321

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 745 SNAQHIPAKESSTPHVPVPREQTSPvgmncvrPIPNAAPRIRPVAVSATTVQPEP 799
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLP-------PAPLSMPHIKPPPTTPIPQLPNP 369
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 810-863 1.58e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 1.58e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRREQ 863
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
810-861 1.22e-15

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.76  E-value: 1.22e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRR 861
Cdd:pfam00046   6 TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 804-856 1.02e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.20  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2004852568  804 RRHLHDRFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRR 856
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRR 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 249-645 5.21e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.90  E-value: 5.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  249 PVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHV-QPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHV 327
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPeRPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  328 QPVPVTAPLSQGMPVRVPHVQPVP-VSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRL-PHAQPVPVTPA 405
Cdd:PHA03247  2691 TVGSLTSLADPPPPPPTPEPAPHAlVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPA 2770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  406 PPQTMPVRVPHVQPLPRTAPLSQAIPI----RVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMP 481
Cdd:PHA03247  2771 PPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  482 IPWHYVQP-------MPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVTVPHVQPMPFPVPQALSMPFPVPQALSMPFPV 554
Cdd:PHA03247  2851 PLGGSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  555 PQALSMPFPVHQA--LSMPVPVPVPQVQPVPVTVPHTQRIRGPVPRVQTLPPSVTQSESIPVTVSSIQPKPTTVPRAHRI 632
Cdd:PHA03247  2931 PPPPPPPRPQPPLapTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010

                          410
                   ....*....|...
gi 2004852568  633 CVPHVQILPPPVT 645
Cdd:PHA03247  3011 LALHEETDPPPVS 3023
PHA03247 PHA03247
large tegument protein UL36; Provisional
 376-815 1.18e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 1.18e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  376 PPQPVPLTAPTPwAVPTRLPHAQPVPVTPAPPQTMPVRVPHVQPLPrTAPLSQAIPIRVPHVQPVPVTTPPSQTM---AL 452
Cdd:PHA03247  2551 PPPPLPPAAPPA-APDRSVPPPRPAPRPSEPAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHApdpPP 2628

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  453 TAPRSQAMPITVPHVQPVPiSLPHVRPMPIPWHYVQPMPDSVPHVQPMALTVPHARHMPVPVPHVHPM------PVTVPH 526
Cdd:PHA03247  2629 PSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLtsladpPPPPPT 2707

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  527 VQPMPFPVPQALSMPfPVPQALSMPFPVPQALSMPFPVHQALSMPVPVPVPQVQPVPVTVPHTQRIRGPV---PRVQTLP 603
Cdd:PHA03247  2708 PEPAPHALVSATPLP-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRP 2786

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  604 PSVTQSESIPVTVSSIQPKPTTVPrahricvphvqiLPPPVTQSESMADTVSPLQPMPVTVPHAqrirgPVPCVQTLPNS 683
Cdd:PHA03247  2787 AVASLSESRESLPSPWDPADPPAA------------VLAPAAALPPAASPAGPLPPPTSAQPTA-----PPPPPGPPPPS 2849

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  684 VPQSESMAVTVPTAQTMPPTVPHKERMPGPGPHVQSLLPPVPHEHPMPFTVHQAQPMPVSVSNAQHIPAKESSTPHVPVP 763
Cdd:PHA03247  2850 LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2004852568  764 REQTSPVGmncvRPIPNAAPRIRPVAVS-ATTVQPEP---VLVPRRHLHDRFTDPE 815
Cdd:PHA03247  2930 QPPPPPPP----RPQPPLAPTTDPAGAGePSGAVPQPwlgALVPGRVAVPRFRVPQ 2981
PHA03247 PHA03247
large tegument protein UL36; Provisional
 102-526 4.01e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.19  E-value: 4.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  102 RPQKPVPECRWGMEDVQPVPVLiPRVQRIQLVQSRVQSVPLKVPV-VRPVPIPALSVQPIPISVPKVQPMPITVPQVQAI 180
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPdTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRD 2654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  181 PPAVPPAQPVPTTVSQDPTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAM 260
Cdd:PHA03247  2655 DPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA 2734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  261 PIRVPhVQPVPVTTPPSQAMPIRVPhvQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGM 340
Cdd:PHA03247  2735 LPAAP-APPAVPAGPATPGGPARPA--RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  341 PVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQTMPVRvphvqPL 420
Cdd:PHA03247  2812 LAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVR-----RL 2886

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  421 PRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPMPDS----VPH 496
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVpqpwLGA 2966

                          410       420       430
                   ....*....|....*....|....*....|
gi 2004852568  497 VQPMALTVPHARhMPVPVPHVhPMPVTVPH 526
Cdd:PHA03247  2967 LVPGRVAVPRFR-VPQPAPSR-EAPASSTP 2994
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 208-556 9.22e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 9.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 208 QPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHV 287
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 288 QPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRvphV 367
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRI---H 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 368 QPVPVTALPPQPVPLTAPTPWAvPTRLPHAQPVPVTPAPPQTMPVRVPH----VQPLPRTAPLSQAIPIRVPHVQPVPVT 443
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPA-PLSMPHIKPPPTTPIPQLPNPQSHKHpphlSGPSPFQMNSNLPPPPALKPLSSLSTH 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 444 TPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPMPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVT 523
Cdd:pfam03154 406 HPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST 485

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2004852568 524 VPHVQPMPFPVPQALSMPFPVPQALSMPFPVPQ 556
Cdd:pfam03154 486 SSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQ 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 249-764 1.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  249 PVPVTAPPSqAMPIRVPHVQPVPVTTPPSQAMPIRVPhvqpvpvSAPPSQAMPiRVPQVQPVSVTAPLSQGMSIRVPHVQ 328
Cdd:PHA03247  2554 PLPPAAPPA-APDRSVPPPRPAPRPSEPAVTSRARRP-------DAPPQSARP-RAPVDDRGDPRGPAPPSPLPPDTHAP 2624

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  329 PVPVTAPLSQGMPVRVPHVQPVP-------VSAPLSQAMPIRVPHVQPVPVTALPPQ-PVPLTAPTPWAVPTRL--PHAQ 398
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPpperprdDPAPGRVSRPRRARRLGRAAQASSPPQrPRRRAARPTVGSLTSLadPPPP 2704

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  399 PVPVTPAPPQTMPVrvphvQPLPrTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVR 478
Cdd:PHA03247  2705 PPTPEPAPHALVSA-----TPLP-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG 2778

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  479 PmpipwhyvqPMPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVTVPHVQPMPFPVPQALSMPFPVPQALSMPF-PVPQA 557
Cdd:PHA03247  2779 P---------PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPgPPPPS 2849

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  558 LSMPFPVHQAlsmpvpvpvpqvqpvpvtvphtqrirGPVPRvqtLPPSvtqsesipvtvSSIQPKPTTVPRahricvPHV 637
Cdd:PHA03247  2850 LPLGGSVAPG--------------------------GDVRR---RPPS-----------RSPAAKPAAPAR------PPV 2883

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  638 QILPPPVTQSESMADTVSPLQPMPVTVPHAQRIRGPVPCVQTLPNSVPQSESMAVtvPTAQTMPPTVPHKERMPGPGPHV 717
Cdd:PHA03247  2884 RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR--PQPPLAPTTDPAGAGEPSGAVPQ 2961

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 2004852568  718 QSLLPPVPHEHPMPFTvhqaqpmpVSVSNAQHIPAKESSTP---HVPVPR 764
Cdd:PHA03247  2962 PWLGALVPGRVAVPRF--------RVPQPAPSREAPASSTPpltGHSLSR 3003
PHA03378 PHA03378
EBNA-3B; Provisional
 246-491 3.50e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.30  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 246 HVQPVPVTAP-PSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHVQ-----PVPVSAPPSQAMPIRVPQVQPVSVTAPLSQG 319
Cdd:PHA03378  560 HDQLLPAPGLgPLQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSqtpepPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQ 639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 320 MSIRVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQP 399
Cdd:PHA03378  640 PITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAA 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 400 VPVTPAPPQTMPVRVPHVQPLPRTAPLSQAIPIRVPHVQPVPVTTPPSQtmaltAPRSQAMPITVPHVQPVPISLPHVRP 479
Cdd:PHA03378  720 ATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA-----AAPGAPTPQPPPQAPPAPQQRPRGAP 794

                         250
                  ....*....|..
gi 2004852568 480 MPIPWHYVQPMP 491
Cdd:PHA03378  795 TPQPPPQAGPTS 806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
269-459 6.29e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 269 PVPVTTPPSQAMPIRVPhvqPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMPVRVPHVQ 348
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAA---PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 349 PVPVSAPLSQAMPiRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVT---PAPPQTMPVRVPHVQ------- 418
Cdd:PRK12323  452 PAPAAAPAAAARP-AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEfasPAPAQPDAAPAGWVAesipdpa 530

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2004852568 419 --------PLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQA 459
Cdd:PRK12323  531 tadpddafETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
810-864 2.63e-06

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.20  E-value: 2.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 810 RFTDPELQELERVFQRNHYLSAEERKELARVMGVSEAKVQRWFKKRREHFRREQS 864
Cdd:COG5576    57 RTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
335-541 2.71e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 51.03  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 335 PLSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPW---AVPTRLPHAQPVPVTPAPPQTMP 411
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAvaaAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 412 VRVPHVQPLPRTAPLSQAIPiRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPMP 491
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARP-AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2004852568 492 DSVPhvQPMALTVPHARHMPVPVPHVHPMPVTVPHVQPMPFPVPQALSMP 541
Cdd:PRK12323  524 ESIP--DPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
PHA03247 PHA03247
large tegument protein UL36; Provisional
 103-514 2.28e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  103 PQKPVPEcrwgmedvQPVPVLIPRVQRIQLVQSRVQSVPLKVPVVRPVPIPALSVQPIPISVPKVQPMPITVPqvqaipp 182
Cdd:PHA03247  2703 PPPPTPE--------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP------- 2767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  183 avppaqpVPTTVSQDPTGPipePHVQPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAMPI 262
Cdd:PHA03247  2768 -------APAPPAAPAAGP---PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT 2837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  263 RVPHVQ-PVPVTTPPSQAMPIRVPHVQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMP 341
Cdd:PHA03247  2838 APPPPPgPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  342 VRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPlTAPTPW---AVPTRLPHAQPVPVTPAPPQTMPVRVPHVQ 418
Cdd:PHA03247  2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG-AVPQPWlgaLVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  419 PLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPMPDSVPHVQ 498
Cdd:PHA03247  2997 TGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPE 3076

                          410
                   ....*....|....*.
gi 2004852568  499 PMALTVPHARHMPVPV 514
Cdd:PHA03247  3077 AGARESPSSQFGPPPL 3092
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 369-503 2.43e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.94  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 369 PVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVT----PAPPQTMPVRVPHVQPLPRTAPLSQAIPiRVPHVQPVPVTT 444
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQapavPPPPASAPQQAPAVPLPETTSQLLAARQ-QLQRAQGATKAK 439

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2004852568 445 PPSQTMALTAPRSQAMPITVPHVQPVPISLP--HVRPMPIPWHYVQP-MPDSVPHVQPMALT 503
Cdd:PRK07994  440 KSEPAAASRARPVNSALERLASVRPAPSALEkaPAKKEAYRWKATNPvEVKKEPVATPKALK 501
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 248-453 4.43e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 248 QPVPVTAP-PSQAMPIRVPHVQPVPvTTPPSQAMPIR-----------VPHVQP------VPvSAPPSQAMPIRVPQVQP 309
Cdd:pfam09770 106 QPAARAAQsSAQPPASSLPQYQYAS-QQSQQPSKPVRtgyekykepepIPDLQVdaslwgVA-PKKAAAPAPAPQPAAQP 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 310 VSVTAPLSQGMSI-------------RVPHVQPVPVTAPlSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALP 376
Cdd:pfam09770 184 ASLPAPSRKMMSLeeveaamraqakkPAQQPAPAPAQPP-AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHP 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 377 PQPV--PLTAPTPWAVPTRLPHAQPVPVTPAPPQTMPVRV---PHVQPLPRTA------PLSQAIPIRVPHVQ------P 439
Cdd:pfam09770 263 VTILqrPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGypqnpqPGVQPAPAHQAHRQqgsfgrQ 342

                         250
                  ....*....|....
gi 2004852568 440 VPVTTPPSQTMALT 453
Cdd:pfam09770 343 APIITHPQQLAQLS 356
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 335-563 4.83e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.39  E-value: 4.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  335 PLSQGMPVrvphVQPVPVSAPLSQAMPIRVPHVQPV-PVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQTMPVR 413
Cdd:PRK10263   309 PLLNGAPI----TEPVAVAAAATTATQSWAAPVEPVtQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQS 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  414 VPHVQPLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHV-QPVPISLPHVRPMPIPWHYVQPMPD 492
Cdd:PRK10263   385 QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPeQPVAGNAWQAEEQQSTFAPQSTYQT 464

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  493 SVPHVQPMALTVPHARHMPV-PVPHVHPMPV---TVPHVQPMPF----------PVPQALSMPFPVPQALSMPFPVPQAL 558
Cdd:PRK10263   465 EQTYQQPAAQEPLYQQPQPVeQQPVVEPEPVveeTKPARPPLYYfeeveekrarEREQLAAWYQPIPEPVKEPEPIKSSL 544


                   ....*
gi 2004852568  559 SMPFP 563
Cdd:PRK10263   545 KAPSV 549
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
193-407 8.25e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 8.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 193 TVSQDPTGPIPEPHVQPVPVTAPPPQPVPLTTPPPqpvpvtapppqgmsirvphvQPVPVTAPPSQAMPIRVPHVQPVPV 272
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAP--------------------AAAAAARAVAAAPARRSPAPEALAA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 273 TTPPSQAMPIRVPHVQPVPVSAPPSQAMPiRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMPVRVPHVQPVPV 352
Cdd:PRK12323  436 ARQASARGPGGAPAPAPAPAAAPAAAARP-AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQP 514

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 353 SAplsqAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPP 407
Cdd:PRK12323  515 DA----APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 256-408 1.44e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.63  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 256 PSQAMPI-RVPHVQPVPVTTPPSQAMPIRVPHVQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMsirvPHVQPVPVTA 334
Cdd:PRK07994  361 PAAPLPEpEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAAR----QQLQRAQGAT 436

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2004852568 335 PLSQGMPVrvPHVQPVPVSAPLSqampiRVPHVQPVPVTA----LPPQPVPLTAPTPWAVPTrLPHAQPVPVTPAPPQ 408
Cdd:PRK07994  437 KAKKSEPA--AASRARPVNSALE-----RLASVRPAPSALekapAKKEAYRWKATNPVEVKK-EPVATPKALKKALEH 506
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 294-415 2.02e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 294 APPSQAMPIRVPQVQPVSVTAPlsqgmSIRVPHVQPVPVTAPlsqgmpvrvPHVQPVPVSAPLSQAmPIRVPHVQPVPVT 373
Cdd:PRK14951  382 ARPEAAAPAAAPVAQAAAAPAP-----AAAPAAAASAPAAPP---------AAAPPAPVAAPAAAA-PAAAPAAAPAAVA 446

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2004852568 374 ALPPQPVPLtAPTPWAVPTRLPHAQPVPVTPAPPQTMPVRVP 415
Cdd:PRK14951  447 LAPAPPAQA-APETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 259-409 2.80e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.47  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 259 AMPIRVPHVQPVPVTTPPSQAMPiRVPHVQPVPVSAPPSQAMPIRVPQVQPVsvtaplsqgmsirvphVQPVPVTAPLSQ 338
Cdd:PRK07994  362 AAPLPEPEVPPQSAAPAASAQAT-AAPTAAVAPPQAPAVPPPPASAPQQAPA----------------VPLPETTSQLLA 424

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2004852568 339 GMP--VRVPHVQPVPVSAPLSQAMPIRVPHVQPvPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQT 409
Cdd:PRK07994  425 ARQqlQRAQGATKAKKSEPAAASRARPVNSALE-RLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVAT 496
PHA03378 PHA03378
EBNA-3B; Provisional
 192-681 2.99e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 192 TTVSQdptgpipEPHVQPVPVTAPPPQPVPLTTPPPQPVPvtapppqgmsirvPHVQPVPVTAPPSQAMPIrvpHVQPVP 271
Cdd:PHA03378  451 TVVLH-------RPPTQPLEGPTGPLSVQAPLEPWQPLPH-------------PQVTPVILHQPPAQGVQA---HGSMLD 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 272 VTTPPSQAMPIRVPHVQPVPVsaPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLS-QGMPVRVPHVQPV 350
Cdd:PHA03378  508 LLEKDDEDMEQRVMATLLPPS--PPQPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPGLGPlQIQPLTSPTTSQL 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 351 PVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLT-APTPWAVPTRlphaqPVPVTPAPPQTMPVRVPhVQPLPRTAPLSQA 429
Cdd:PHA03378  586 ASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETsAPRQWPMPLR-----PIPMRPLRMQPITFNVL-VFPTPHQPPQVEI 659

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 430 IPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITV--PHVQPVPISLPHVRPMPIPWHYVQPMPDSVPHVQPMALTVPHA 507
Cdd:PHA03378  660 TPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMqpPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAA 739

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 508 RHMPVPVPHVHPMPVTVPHVQPMPFPVPQAL---SMPFPVPQALSMPFPVPQALSMPFPVHQALSMPVPVPVPQVQPVPV 584
Cdd:PHA03378  740 APGRARPPAAAPGRARPPAAAPGRARPPAAApgaPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQG 819

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 585 TVPHTQRIRGPVPRVQTLPPSVTQSESIPVTVSSIQPKPTTVPRAHRICVPhvqILPPPVTQSESMADTVSPLQPM---- 660
Cdd:PHA03378  820 PTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAP---VFYPPVLQPIQVMRQLGSVRAAaast 896

                         490       500
                  ....*....|....*....|....*
gi 2004852568 661 ----PVTVPHAQRIRGPVPCVQTLP 681
Cdd:PHA03378  897 vtqaPTEYTGERRGVGPMHPTDIPP 921
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
322-429 3.40e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.38  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 322 IRVPHVQPVPVTAPLSQGmpvRVPHVQPV---PVSAPLSQAMPIRVPHVQPVPVTALP--PQPVPLTAPTPWAVPTRLPH 396
Cdd:PRK14971  357 IQLAQLTQKGDDASGGRG---PKQHIKPVftqPAAAPQPSAAAAASPSPSQSSAAAQPsaPQSATQPAGTPPTVSVDPPA 433

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2004852568 397 AQPVPvtpaPPQTMPVRV-PHVQPLPRTAPLSQA 429
Cdd:PRK14971  434 AVPVN----PPSTAPQAVrPAQFKEEKKIPVSKV 463
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 270-402 3.68e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 270 VPVTTPPSQAMPIRVPhvQPVPVSAPPSQAMPIRVPQVQPVSVTAPlsqgMSIRVPHVQPVPVTAPLsQGMPVRVPHVQP 349
Cdd:PRK14951  370 AEAAAPAEKKTPARPE--AAAPAAAPVAQAAAAPAPAAAPAAAASA----PAAPPAAAPPAPVAAPA-AAAPAAAPAAAP 442

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 350 VPVS-APLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPV 402
Cdd:PRK14951  443 AAVAlAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
PHA03378 PHA03378
EBNA-3B; Provisional
 155-429 5.02e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 155 LSVQPIPISVPkVQPMPITVPQVQAIPPAVPPAQPVPTTVSQDPTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQPVPVTA 234
Cdd:PHA03378  636 LRMQPITFNVL-VFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRA 714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 235 PPPQGMSIRVPHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPhvqpvPVSAPPSQAMPIRVPQVQPVSVTA 314
Cdd:PHA03378  715 QRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR-----PPAAAPGAPTPQPPPQAPPAPQQR 789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 315 PLSqgmsirVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRL 394
Cdd:PHA03378  790 PRG------APTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTS 863

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2004852568 395 PHAQPVPVTpAPPQTMPVRVPHVQPLPRTAPLSQA 429
Cdd:PHA03378  864 DKIVQAPVF-YPPVLQPIQVMRQLGSVRAAAASTV 897
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 331-449 5.64e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 331 PVTAPLSQGMPVRVPHVQPV---PVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAP-----TPWAVPTRLPHAQPVPV 402
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEaaaPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPapvaaPAAAAPAAAPAAAPAAV 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2004852568 403 TPAPPQTMPVRVPHVQPLPRTAPlSQAIPIRVPHVQPVPVTTPPSQT 449
Cdd:PRK14951  446 ALAPAPPAQAAPETVAIPVRVAP-EPAVASAAPAPAAAPAAARLTPT 491
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
259-387 6.74e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.23  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 259 AMPIRVPHVQPVPVTTPPSQAMPirvPHVQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSIRVPHVQPV--PVTAPL 336
Cdd:PRK14971  369 ASGGRGPKQHIKPVFTQPAAAPQ---PSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVnpPSTAPQ 445

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2004852568 337 SQGMPVRVPHvQPVPVSAPLSQAMPIRvphvQPVPVTALPPQPVPLTAPTP 387
Cdd:PRK14971  446 AVRPAQFKEE-KKIPVSKVSSLGPSTL----RPIQEKAEQATGNIKEAPTG 491
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
245-459 7.43e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 43.05  E-value: 7.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 245 PHVQPVPVTAPPSQAmpirVPHVQPVPVTTPPSQAMPIRVPHVQPVPVSAppsQAMPIRVPQVQPVSVTAPLSQGMSIRV 324
Cdd:PRK12727   60 SDTPATAAAPAPAPQ----APTKPAAPVHAPLKLSANANMSQRQRVASAA---EDMIAAMALRQPVSVPRQAPAAAPVRA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 325 PHVqPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQ---AMPIRVPhvqpVPVTALPPQPVPLTAPTPwAVPTRLPhAQPVP 401
Cdd:PRK12727  133 ASI-PSPAAQALAHAAAVRTAPRQEHALSAVPEQlfaDFLTTAP----VPRAPVQAPVVAAPAPVP-AIAAALA-AHAAY 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2004852568 402 VTPAPPQTMPVRVPHVQPLPRTAPLSQAIPIRVPHVQPVpvtTPPSQTMALTAPRSQA 459
Cdd:PRK12727  206 AQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAAPA---ALAAVAAAAPAPQNDE 260
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 347-446 8.08e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 8.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 347 VQPVPVSAPLSQAMPIRvphvqpvpvTALPPQPVPLTAPTPwAVPTRLPHAQPVPvTPAPPQTMPVRvPHVQPLPRTAPL 426
Cdd:PRK14950  360 LVPVPAPQPAKPTAAAP---------SPVRPTPAPSTRPKA-AAAANIPPKEPVR-ETATPPPVPPR-PVAPPVPHTPES 427

                          90       100
                  ....*....|....*....|
gi 2004852568 427 SQAIPIRVPHVQPVPVTTPP 446
Cdd:PRK14950  428 APKLTRAAIPVDEKPKYTPP 447
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 303-460 8.28e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 303 RVPQVQPVSVTAPLSQGMSIRVPHVQPVPVTAPLSQGMPvrvPHVQPVPVSAPLSQampirvPHVQPVPVTALPPQPVPL 382
Cdd:PRK07994  362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVP---PPPASAPQQAPAVP------LPETTSQLLAARQQLQRA 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 383 TAPTPWAVPTRLPHAQPVPVTPAPPQTMPVRvPHVQPLPRTAPLSQAIPIR---VPHVQPVPVTTPPSQTMALTAPRSQA 459
Cdd:PRK07994  433 QGATKAKKSEPAAASRARPVNSALERLASVR-PAPSALEKAPAKKEAYRWKatnPVEVKKEPVATPKALKKALEHEKTPE 511


                  .
gi 2004852568 460 M 460
Cdd:PRK07994  512 L 512
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 254-541 1.18e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 42.64  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 254 APPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHVQPVPVSAPPSQAmpirvpqvqpvsVTAPLSQGMSIRVPHVQPVPVT 333
Cdd:pfam17823 116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAA------------IAAASAPHAASPAPRTAASSTT 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 334 APLSQGMPVRVPHVQPVPVSAPLSQAMPI---RVPHVQPVPVTALPPQPVPLTAPtpwavptRLPHAQPVPVTPAPPQTM 410
Cdd:pfam17823 184 AASSTTAASSAPTTAASSAPATLTPARGIstaATATGHPAAGTALAAVGNSSPAA-------GTVTAAVGTVTPAALATL 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 411 PVRVPHVQPLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPVPISLPHVRPMPIPWHYVQPM 490
Cdd:pfam17823 257 AAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNT 336

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2004852568 491 PDSVPHVQPMALTVPHARHM-----PVPVPHVHPMP---VTVPHVQPMPFPVPQALSMP 541
Cdd:pfam17823 337 PKSVASTNLAVVTTTKAQAKepsasPVPVLHTSMIPeveATSPTTQPSPLLPTQGAAGP 395
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 343-472 1.23e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.55  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 343 RVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQTMPVRVPHVQPLPR 422
Cdd:PRK07994  369 EVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAAASR 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2004852568 423 TAPLSQAIPiRVPHVQPVPVTTPPSQTMALT---APRSQAMPITVPHVQPVPI 472
Cdd:PRK07994  449 ARPVNSALE-RLASVRPAPSALEKAPAKKEAyrwKATNPVEVKKEPVATPKAL 500
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 198-458 1.40e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  198 PTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPS 277
Cdd:PRK10263   349 VDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQP 428

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  278 QAMPirvphvQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMSirvPHVQPVPVTAPLSQGMPVRVP-HVQPVPVsapL 356
Cdd:PRK10263   429 AQQP------YYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQ---TYQQPAAQEPLYQQPQPVEQQpVVEPEPV---V 496

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  357 SQAMPIRVPHVQPVPVTALPPQPVPLTAptPWAVPTRLPHAQPVPVTPAPPQTMPVRVPHVQPLPRTAPLSQAIPIRVPH 436
Cdd:PRK10263   497 EETKPARPPLYYFEEVEEKRAREREQLA--AWYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLA 574

                          250       260
                   ....*....|....*....|...
gi 2004852568  437 VQPVPVTTPPSQTMALT-APRSQ 458
Cdd:PRK10263   575 TGAAATVAAPVFSLANSgGPRPQ 597
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 360-461 1.50e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 360 MPIRVPHVQPVPVTALPPQPVPLTAPTPWAV-PTRLPHAQPVPVTPAPPQTMPVrVPHVQPLPRTAPLSQAIPirVPHVQ 438
Cdd:PRK14950  349 LPLELAVIEALLVPVPAPQPAKPTAAAPSPVrPTPAPSTRPKAAAAANIPPKEP-VRETATPPPVPPRPVAPP--VPHTP 425

                          90       100
                  ....*....|....*....|...
gi 2004852568 439 PVPVTTPPSQTMALTAPRSQAMP 461
Cdd:PRK14950  426 ESAPKLTRAAIPVDEKPKYTPPA 448
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 378-608 1.57e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 378 QPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQTMPVR-----------VPHVQP---LPRTAPLSQAIPIRVPHVQPVPVT 443
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRtgyekykepepIPDLQVdasLWGVAPKKAAAPAPAPQPAAQPAS 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 444 TPPSQ-----------TMALTAPRSQAMPITVPHVQPVPIslPHVRPMPIPWHYVQPMPDSVPHVQPMALTVPHARHMPV 512
Cdd:pfam09770 186 LPAPSrkmmsleeveaAMRAQAKKPAQQPAPAPAQPPAAP--PAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPV 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 513 PV---PHVHPMPVTVPHVQPMPFPVPQalsMPFPVPQALSMPFPVPQALSMPFPVHQALSMPVPVPvpqvqPVPVTVPHT 589
Cdd:pfam09770 264 TIlqrPQSPQPDPAQPSIQPQAQQFHQ---QPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP-----APAHQAHRQ 335

                         250
                  ....*....|....*....
gi 2004852568 590 QRIRGPVPRVQTLPPSVTQ 608
Cdd:pfam09770 336 QGSFGRQAPIITHPQQLAQ 354
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 327-411 1.64e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 327 VQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTA-----PTPWAVPTRLPHAQPVP 401
Cdd:PRK14950  360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVappvpHTPESAPKLTRAAIPVD 439

                          90
                  ....*....|
gi 2004852568 402 VTPAPPQTMP 411
Cdd:PRK14950  440 EKPKYTPPAP 449
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 351-483 2.18e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 351 PVSAPLSQAMPIRVPHVQPVPVTALP-PQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPqtmpvrvphvqplPRTAPLSQA 429
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPP-------------APVAAPAAA 432

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 430 IPIRVPHVQPVPVTTPPSQTmALTAPRSQAMPITVPHVQPVPISLPHVRPMPIP 483
Cdd:PRK14951  433 APAAAPAAAPAAVALAPAPP-AQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 249-387 2.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 249 PVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAmpirvphvqpVPVSAPPSQAMPIRVPQVQPVSVTAPlsqgmsirvPHVQ 328
Cdd:PRK14951  381 PARPEAAAPAAAPVAQAAAAPAPAAAPAAAA----------SAPAAPPAAAPPAPVAAPAAAAPAAA---------PAAA 441

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2004852568 329 PVPVTAPLSqgmpvrvphvqPVPVSAPLSQAMPIRV---PHVQPVPVTALPPQPVPLTAPTP 387
Cdd:PRK14951  442 PAAVALAPA-----------PPAQAAPETVAIPVRVapePAVASAAPAPAAAPAAARLTPTE 492
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
364-546 2.32e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 41.51  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 364 VPHVQPVPVTALP-PQPVPLTAPTPWAVPTRLPHAQPV-----PVTPAPPQTMPVRVPHVQPLP-RTAPLSQAIPIRVPH 436
Cdd:PRK12727   64 ATAAAPAPAPQAPtKPAAPVHAPLKLSANANMSQRQRVasaaeDMIAAMALRQPVSVPRQAPAAaPVRAASIPSPAAQAL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 437 VQPVPVTTPPSQTMALTAPRSQ---AMPITVPHVQPVPISLPHVRPMPIPWHYVQ-PMPDSVPHVQPMALTVPHARHMPV 512
Cdd:PRK12727  144 AHAAAVRTAPRQEHALSAVPEQlfaDFLTTAPVPRAPVQAPVVAAPAPVPAIAAAlAAHAAYAQDDDEQLDDDGFDLDDA 223

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2004852568 513 PVPHVHPMPVTVPHVQPMPFPVPQALSMPFPVPQ 546
Cdd:PRK12727  224 LPQILPPAALPPIVVAPAAPAALAAVAAAAPAPQ 257
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 590-799 3.12e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 590 QRIRGPVPRVQTLPPSVTQSeSIPVTVSSIQPKPTTVPRAHRICVPHVQILPPPVTQSESMADTVSPLQPMPVTvpHAQR 669
Cdd:pfam03154 165 QILQTQPPVLQAQSGAASPP-SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTL--HPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 670 IRGPVPCVQTLPNSVPQSESMAVTVPTAQTMPPTVPHKERMPGPGPHVQSLLPPVPHEHPMPFTVHQAQPMP-----VSV 744
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPspaapGQS 321

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2004852568 745 SNAQHIPAKESSTPHVPVPREQTSPvgmncvrPIPNAAPRIRPVAVSATTVQPEP 799
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLP-------PAPLSMPHIKPPPTTPIPQLPNP 369
PHA03379 PHA03379
EBNA-3A; Provisional
 247-458 4.55e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.81  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 247 VQPVPVTAPPSQAMPIRVPHVQPVPVTTP------PSQAMPIRVPHVQPVPVSAPPSQAMPI----RVPQVQPVSVTAPL 316
Cdd:PHA03379  583 PSQMSVRDRLARLRAEAQPYQASVEVQPPqltqvsPQQPMEYPLEPEQQMFPGSPFSQVADVmragGVPAMQPQYFDLPL 662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 317 SQGMSIRVPhvqpvpvTAPLSQGMPVR--VPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRl 394
Cdd:PHA03379  663 QQPISQGAP-------LAPLRASMGPVppVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVPERWMFQGATLSQ- 734

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2004852568 395 phaqpvPVTPAPPQTMPVRVPHVQPLPRTAPLSQAipirvPHVQPVPVTTPPSQTMALTAPRSQ 458
Cdd:PHA03379  735 ------SVRPGVAQSQYFDLPLTQPINHGAPAAHF-----LHQPPMEGPWVPEQWMFQGAPPSQ 787
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
248-345 4.70e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 248 QPVPVTAPPSQAmpirVPHVQPVPVTTP--PSQAMPIRVPHVQPVPVSAPPSQAMPirvpqVQPvSVTAPLSQGMSIRVP 325
Cdd:PRK14971  385 QPAAAPQPSAAA----AASPSPSQSSAAaqPSAPQSATQPAGTPPTVSVDPPAAVP-----VNP-PSTAPQAVRPAQFKE 454

                          90       100
                  ....*....|....*....|
gi 2004852568 326 HvQPVPVTAPLSQGMPVRVP 345
Cdd:PRK14971  455 E-KKIPVSKVSSLGPSTLRP 473
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 159-491 4.73e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 159 PIPISVPKVQPMPITVPQVQAIPPAVPPAQPVPTTVSQDPTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQpvpvtapppq 238
Cdd:pfam03154 201 PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPS---------- 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 239 gmsirvpHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIRVPHVQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQ 318
Cdd:pfam03154 271 -------LHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQ 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 319 GM---SIRVPHVQPvPVTAPLSQgMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPV-PVTALPPQPVPLTAPTPWAVPTRL 394
Cdd:pfam03154 344 PLppaPLSMPHIKP-PPTTPIPQ-LPNPQSHKHPPHLSGPSPFQMNSNLPPPPALkPLSSLSTHHPPSAHPPPLQLMPQS 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 395 PHAQPVPVTPAPPQTMPVRVPHVQPLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSqaMPITVPHVQPvPISL 474
Cdd:pfam03154 422 QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTS--TSSAMPGIQP-PSSA 498

                         330
                  ....*....|....*..
gi 2004852568 475 PHVRPMPIPWHYVQPMP 491
Cdd:pfam03154 499 SVSSSGPVPAAVSCPLP 515
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
244-325 5.29e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 244 VPHVQP--VPVTAPPSQAMPIRVPHVQPVPVTTPPSQAMPIrvphvqpVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGMS 321
Cdd:PRK14971  397 AASPSPsqSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPV-------NPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPS 469


                  ....
gi 2004852568 322 IRVP 325
Cdd:PRK14971  470 TLRP 473
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 198-432 7.44e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.94  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 198 PTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGMSIRVPHVQPVPVTAPPSQAMPIRVPHVQPVPVTTPPS 277
Cdd:pfam17823 145 PRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 278 QAMPIRVPHVQPVP--VSAPPSQAMPIRVPQVQPVSVTAPLSQGMsirVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAP 355
Cdd:pfam17823 225 GTALAAVGNSSPAAgtVTAAVGTVTPAALATLAAAAGTVASAAGT---INMGDPHARRLSPAKHMPSDTMARNPAAPMGA 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 356 LSQAMPIRVPHVQPVPVTALPPQPVPLTAPTPWAVPTRLPHAQPVPVTPAPPQTM-----PVRVPHVQPLPR---TAPLS 427
Cdd:pfam17823 302 QAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKepsasPVPVLHTSMIPEveaTSPTT 381


                  ....*
gi 2004852568 428 QAIPI 432
Cdd:pfam17823 382 QPSPL 386
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 404-538 7.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 404 PAPPQTMPVRVPHVQPLPRTAPLSQAIPIRVPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPV-PISLPHVRPMPI 482
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAaPAAAPAAAPAAV 445

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2004852568 483 PWHYVQPMPDSVPHVQPMALTVPharhmpvpvphvhPMPVTVPHVQPMPFPVPQAL 538
Cdd:PRK14951  446 ALAPAPPAQAAPETVAIPVRVAP-------------EPAVASAAPAPAAAPAAARL 488
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 400-525 7.92e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 7.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568 400 VPVTPAPPQTMPVRVPhvQPLPRTAPLSQaipirvPHVQPVPVTTPPSQTMALTAPRSQAMPITVPHVQPV-PISLPHVR 478
Cdd:PRK14951  370 AEAAAPAEKKTPARPE--AAAPAAAPVAQ------AAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAaPAAAPAAA 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2004852568 479 PMPIPwhyVQPMPDSVPHVQPMALTVPHARHMPVPVPHVHPMPVTVP 525
Cdd:PRK14951  442 PAAVA---LAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 161-376 8.85e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 8.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  161 PISVPKVQPMPITVPQVQAIPPAVPPAQPVPTTVSQDPTGPIPEPHVQPVPVTAPPPQPVPLTTPPPQPVPVTAPPPQGM 240
Cdd:PRK10263   352 PPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2004852568  241 SIRVPHVQPvPVTAPPSQAMPiRVPHVQPVPVTTPPSqamPIRVPHVQPVPVSAPPSQAMPIRVPQVQPVSVTAPLSQGM 320
Cdd:PRK10263   432 PYYAPAPEQ-PVAGNAWQAEE-QQSTFAPQSTYQTEQ---TYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPL 506

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2004852568  321 ----------------------SIRVPHVQPVPVTAPLSQGMPVRVPHVQPVPVSAPLSQAMPIRVPHVQPVPVTALP 376
Cdd:PRK10263   507 yyfeeveekrarereqlaawyqPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAP 584
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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