NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2324175151|ref|NP_001400403|]
View 

zinc finger protein 653 isoform 1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-547 1.40e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 2324175151 522 HLRRHMIIHSGVREFTCETCGKSFKR 547
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
494-622 1.29e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2324175151 494 NHVNLVHrkgKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTC--ETCGKSFKRKNHLEVHRRT--HTGETPLQCEIC 569
Cdd:COG5048   313 NHSGESL---KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSET 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2324175151 570 GYQCRQRASlnwhMKKHTAEVQ---------YNFTCDRCGKRFEKLDSVKFHtLKSHPDHKP 622
Cdd:COG5048   390 LSNSCIRNF----KRDSNLSLHiithlsfrpYNCKNPPCSKSFNRHYNLIPH-KKIHTNHAP 446
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-547 1.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 2324175151 522 HLRRHMIIHSGVREFTCETCGKSFKR 547
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
494-622 1.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2324175151 494 NHVNLVHrkgKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTC--ETCGKSFKRKNHLEVHRRT--HTGETPLQCEIC 569
Cdd:COG5048   313 NHSGESL---KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSET 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2324175151 570 GYQCRQRASlnwhMKKHTAEVQ---------YNFTCDRCGKRFEKLDSVKFHtLKSHPDHKP 622
Cdd:COG5048   390 LSNSCIRNF----KRDSNLSLHiithlsfrpYNCKNPPCSKSFNRHYNLIPH-KKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
550-575 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 2324175151 550 HLEVHRRTHTGETPLQCEICGYQCRQ 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
536-558 6.00e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.00e-03
                           10        20
                   ....*....|....*....|...
gi 2324175151  536 FTCETCGKSFKRKNHLEVHRRTH 558
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-547 1.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 2324175151 522 HLRRHMIIHSGVREFTCETCGKSFKR 547
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 536-558 2.35e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.52  E-value: 2.35e-05
                          10        20
                  ....*....|....*....|...
gi 2324175151 536 FTCETCGKSFKRKNHLEVHRRTH 558
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
494-622 1.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2324175151 494 NHVNLVHrkgKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTC--ETCGKSFKRKNHLEVHRRT--HTGETPLQCEIC 569
Cdd:COG5048   313 NHSGESL---KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSET 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2324175151 570 GYQCRQRASlnwhMKKHTAEVQ---------YNFTCDRCGKRFEKLDSVKFHtLKSHPDHKP 622
Cdd:COG5048   390 LSNSCIRNF----KRDSNLSLHiithlsfrpYNCKNPPCSKSFNRHYNLIPH-KKIHTNHAP 446
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-559 5.41e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2324175151 497 NLVHRKGKTKVCPHPGCGKKFYLSNHLRRHM-------------------IIHSGVREFTCETCGKSFKRKNHLEVHrRT 557
Cdd:COG5189   341 MLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYH-RK 419


                  ..
gi 2324175151 558 HT 559
Cdd:COG5189   420 HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
550-575 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 2324175151 550 HLEVHRRTHTGETPLQCEICGYQCRQ 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
536-558 6.00e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.00e-03
                           10        20
                   ....*....|....*....|...
gi 2324175151  536 FTCETCGKSFKRKNHLEVHRRTH 558
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH