BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128   145 SEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYGEPAIDEDTIEGILH 224
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 86562128   225 LAHMYDMPFPTRKCEEFLIDFS 246
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128   145 SEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYGEPAIDEDTIEGILH 224
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 86562128   225 LAHMYDMPFPTRKCEEFLIDFS 246
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128     12 HTYKNVSKLEDEGTLLSPSEEHFNVQWYMAVSHKKEDMAVYLHCNILGQTEETWCINAEFEFTLKNSCGKRSTEKTTVKF 91
Cdd:smart00061   4 HTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLSKKDKHVF 83

                           90
                   ....*....|....
gi 86562128     92 TNleNIVYGWKKFI 105
Cdd:smart00061  84 EK--PSGWGFSKFI 95

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128  10 LFHTYKNVSKLEDEGT-LLSPSEEHFNVQWYMAVSHKKED-----MAVYLHCNILGQTEETWCINAEFEFTLKNSC-GKR 82
Cdd:cd00121   1 GKHTWKIVNFSELEGEsIYSPPFEVGGYKWRIRIYPNGDGesgdyLSLYLELDKGESDLEKWSVRAEFTLKLVNQNgGKS 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 86562128  83 STEKTTVKFTNLENIVYGWKKFISWEMLAKDY 114
Cdd:cd00121  81 LSKSFTHVFFSEKGSGWGFPKFISWDDLEDSY 112

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128   145 SEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYGEPAIDEDTIEGILH 224
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 86562128   225 LAHMYDMPFPTRKCEEFLIDFS 246
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128     12 HTYKNVSKLEDEGTLLSPSEEHFNVQWYMAVSHKKEDMAVYLHCNILGQTEETWCINAEFEFTLKNSCGKRSTEKTTVKF 91
Cdd:smart00061   4 HTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLSKKDKHVF 83

                           90
                   ....*....|....
gi 86562128     92 TNleNIVYGWKKFI 105
Cdd:smart00061  84 EK--PSGWGFSKFI 95

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128  10 LFHTYKNVSKLEDEGT-LLSPSEEHFNVQWYMAVSHKKED-----MAVYLHCNILGQTEETWCINAEFEFTLKNSC-GKR 82
Cdd:cd00121   1 GKHTWKIVNFSELEGEsIYSPPFEVGGYKWRIRIYPNGDGesgdyLSLYLELDKGESDLEKWSVRAEFTLKLVNQNgGKS 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 86562128  83 STEKTTVKFTNLENIVYGWKKFISWEMLAKDY 114
Cdd:cd00121  81 LSKSFTHVFFSEKGSGWGFPKFISWDDLEDSY 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 149 FSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILHLAH 227
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYtGELELSEENVEELLAAAD 80

                ..
gi 86562128 228 MY 229
Cdd:cd18186  81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18257  13 RQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYtGTVFISQATVESL 92

                        90       100
                ....*....|....*....|
gi 86562128 223 LHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18257  93 LPAANLLQIKLVLKECCDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 148 EFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILHLA 226
Cdd:cd18256  19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYtGVVEVTVSNVQELLVAA 98

                        90
                ....*....|....*.
gi 86562128 227 HMYDMPFPTRKCEEFL 242
Cdd:cd18256  99 DMLQLTEVVEICCEFL 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 149 FSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYGEP-AIDEDTIEGILHLAH 227
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGlRIQEDNVESVLEASD 102

                        90
                ....*....|....*
gi 86562128 228 MYDMPFPTRKCEEFL 242
Cdd:cd18265 103 LLQVSKLREACVRFL 117

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKE-----AEISEVALKDIDSTDFQNLLEVLYGEPA-IDEDTI 219
Cdd:cd18296  14 ELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTdLPPENA 93

                        90       100
                ....*....|....*....|....
gi 86562128 220 EGILHLAHMYDMPFPTRKCEEFLI 243
Cdd:cd18296  94 YDVLYVADMYLLPGLKRLCGTVLA 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 137 KKLRSFeKSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAID 215
Cdd:cd18238   4 KVLHQF-YENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYtGKLTLT 82

                        90       100
                ....*....|....*....|....*..
gi 86562128 216 EDTIEGILHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18238  83 VDNVQSLLYAASLLQVEEVAKACCEFM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18250  16 RAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYtGRVTVTQDNVEAL 95

                        90       100
                ....*....|....*....|
gi 86562128 223 LHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18250  96 LRAADLFQFPSVKEACCAYL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 151 DVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILHLAHMY 229
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYsGRIAIDTSNVQSLLVGASFL 100

                        90
                ....*....|....*
gi 86562128 230 DMPFPTRKCEEFLID 244
Cdd:cd18247 101 QLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18259  27 RSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYtGKLTINQGNVEAL 106

                        90       100
                ....*....|....*....|
gi 86562128 223 LHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18259 107 IRTSNRLQFPTVRKVCSRYL 126

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYGePAIDEDTIEGILHL 225
Cdd:cd18286  14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYG-GVLDLPDDVNLGEL 92

                ....*.
gi 86562128 226 AHMYDM 231
Cdd:cd18286  93 LSLADM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILH 224
Cdd:cd18270  23 QQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYtGNLAINDSTVEQLYE 102

                        90
                ....*....|....*....
gi 86562128 225 LAHMYDMPFPTRKCEEFLI 243
Cdd:cd18270 103 TACFLQVEDVLQRCREYLI 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18235  16 RKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYtAEIQVTEENVQVL 95

                        90       100
                ....*....|....*....|
gi 86562128 223 LHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18235  96 LPAANLLQLTDVRDACCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYgepaidedtiegilhl 225
Cdd:cd18297   9 NPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLY---------------- 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 86562128 226 ahmydmpfpTRKCEEFLIDFSEkpIKEKLKVAKKYQLENLKKSC 269
Cdd:cd18297  73 ---------TGGVESLDVAQDD--ALELLRAASFFQLDGLKRHC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18276  16 KELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYsSDLHLTNSNVQGV 95

                        90       100
                ....*....|....*....|..
gi 86562128 223 LHLAHMYDMPFPTRKCEEFLID 244
Cdd:cd18276  96 ATAAFFLQMEDIFSVCQKYMMD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18338  16 RSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYtAEIQVTEENVQVL 95

                        90       100
                ....*....|....*....|.
gi 86562128 223 LHLAHMYDMPFPTRKCEEFLI 243
Cdd:cd18338  96 LPAAGLLQLQDVKKTCCEFLE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILH 224
Cdd:cd18269  24 ENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYtSEIDLNDQNVQDIFA 103

                        90
                ....*....|....*...
gi 86562128 225 LAHMYDMPFPTRKCEEFL 242
Cdd:cd18269 104 LASRFQIPSIFTVCVSYL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 144 KSEEEFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGI 222
Cdd:cd18339  16 RSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYtAEIEVTEENVQVL 95

                        90       100
                ....*....|....*....|
gi 86562128 223 LHLAHMYDMPFPTRKCEEFL 242
Cdd:cd18339  96 LPAASLLQLMDVRQNCCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 146 EEEFSDVVLAVEDEKFHVLKKFLaSHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYG-----EPAIDEDTIE 220
Cdd:cd18305  12 NGENSDITICALGREWKLHKIYL-CQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGslyrdEIEIKPSRVV 90

                        90       100
                ....*....|....*....|....
gi 86562128 221 GILHLAHMYDMPFPTRKCEEFLID 244
Cdd:cd18305  91 SILAAATLLQLDGLIQQCSEVMKE 114

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 86562128 151 DVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYgepaidedtiEGILHL 225
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAY----------SGILHL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 149 FSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKD-IDSTDFQNLLEVLYGEPA-IDEDTIEGILHLA 226
Cdd:cd18267  40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDYAYSSRViINEENAESLLEAG 119

                        90
                ....*....|....*.
gi 86562128 227 HMYDMPFPTRKCEEFL 242
Cdd:cd18267 120 DMLEFQDIRDACAEFL 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 151 DVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLYG-----EPAIDEDTIEGILHL 225
Cdd:cd18261  30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTgqillEPGVIQDVLAAGSHL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 149 FSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIEGILHLAH 227
Cdd:cd18253  18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYtGKVKITTENVQYLFETSS 97

                        90
                ....*....|....*
gi 86562128 228 MYDMPFPTRKCEEFL 242
Cdd:cd18253  98 LFQISPLRDACAKFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86562128 142 FEKSEeeFSDVVLAVEDEKFHVLKKFLASHSTYFNALLLGNFKEAEISEVALKDIDSTDFQNLLEVLY-GEPAIDEDTIE 220
Cdd:cd18345  13 FERSA--FSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYtGKAPNLDKMAD 90