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Conserved domains on  [gi|20301990|ref|NP_620203|]
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podocalyxin precursor [Rattus norvegicus]

Protein Classification

Dcp1 family protein; LCP family protein( domain architecture ID 13557104)

Dcp1 (mRNA-decapping enzyme subunit 1) family protein similar to Arabidopsis thaliana mRNA-decapping enzyme-like protein that acts as a component of the decapping complex and is involved in the degradation of mRNAs| LytR-CpsA-Psr (LCP) family protein is implicated in the attachment of anionic polymers to cell wall peptidoglycan in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 285-485 3.79e-81

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 250.82  E-value: 3.79e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   285 ILNLTRDSFCKGSPP--NERFLELLCHSAKASFKPAEDSCALELAPILDNQAVAVKRIVIETKLSPKAVFELLKDKWDDL 362
Cdd:pfam06365   1 ILNLNETSDCEDFKKekGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   363 TEAGVIDIHLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 438
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 20301990   439 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKEDLD-EEEDTHL 485
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 26-266 2.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    26 DNGNKTDTSDITSIDQNQDKPATN----QPSNATPKSSVQPPT-----PTSiSTSSPDPKATQSSNSSVTTTSDSttdrt 96
Cdd:pfam05109 496 DNGTESKAPDMTSPTSAVTTPTPNatspTPAVTTPTPNATSPTlgktsPTS-AVTTPTPNATSPTPAVTTPTPNA----- 569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    97 ssststvpttsnsgqTVSSGGKSS--DKITTALPTTLGPVNASSQPTDLNTSTKLPSTPTTNSTASPHQPVSH--SEGQH 172
Cdd:pfam05109 570 ---------------TIPTLGKTSptSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSavTTGQH 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   173 --------------TTVQSSSASVSSSDNTTLLWILTTSKPTGTSEGTQ--PIAISTPGITTPVSTPLQPTGSPG---GT 233
Cdd:pfam05109 635 nitssstssmslrpSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQvtPASTSTHHVSTSSPAPRPGTTSQAsgpGN 714

                         250       260       270
                  ....*....|....*....|....*....|...
gi 20301990   234 ESVPTTEEFTHSTSSWTPVVSQGPSTPSSTWTS 266
Cdd:pfam05109 715 SSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTA 747
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 285-485 3.79e-81

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 250.82  E-value: 3.79e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   285 ILNLTRDSFCKGSPP--NERFLELLCHSAKASFKPAEDSCALELAPILDNQAVAVKRIVIETKLSPKAVFELLKDKWDDL 362
Cdd:pfam06365   1 ILNLNETSDCEDFKKekGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   363 TEAGVIDIHLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 438
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 20301990   439 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKEDLD-EEEDTHL 485
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 26-266 2.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    26 DNGNKTDTSDITSIDQNQDKPATN----QPSNATPKSSVQPPT-----PTSiSTSSPDPKATQSSNSSVTTTSDSttdrt 96
Cdd:pfam05109 496 DNGTESKAPDMTSPTSAVTTPTPNatspTPAVTTPTPNATSPTlgktsPTS-AVTTPTPNATSPTPAVTTPTPNA----- 569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    97 ssststvpttsnsgqTVSSGGKSS--DKITTALPTTLGPVNASSQPTDLNTSTKLPSTPTTNSTASPHQPVSH--SEGQH 172
Cdd:pfam05109 570 ---------------TIPTLGKTSptSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSavTTGQH 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   173 --------------TTVQSSSASVSSSDNTTLLWILTTSKPTGTSEGTQ--PIAISTPGITTPVSTPLQPTGSPG---GT 233
Cdd:pfam05109 635 nitssstssmslrpSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQvtPASTSTHHVSTSSPAPRPGTTSQAsgpGN 714

                         250       260       270
                  ....*....|....*....|....*....|...
gi 20301990   234 ESVPTTEEFTHSTSSWTPVVSQGPSTPSSTWTS 266
Cdd:pfam05109 715 SSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTA 747
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 285-485 3.79e-81

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 250.82  E-value: 3.79e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   285 ILNLTRDSFCKGSPP--NERFLELLCHSAKASFKPAEDSCALELAPILDNQAVAVKRIVIETKLSPKAVFELLKDKWDDL 362
Cdd:pfam06365   1 ILNLNETSDCEDFKKekGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   363 TEAGVIDIHLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 438
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 20301990   439 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKEDLD-EEEDTHL 485
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 26-266 2.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    26 DNGNKTDTSDITSIDQNQDKPATN----QPSNATPKSSVQPPT-----PTSiSTSSPDPKATQSSNSSVTTTSDSttdrt 96
Cdd:pfam05109 496 DNGTESKAPDMTSPTSAVTTPTPNatspTPAVTTPTPNATSPTlgktsPTS-AVTTPTPNATSPTPAVTTPTPNA----- 569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990    97 ssststvpttsnsgqTVSSGGKSS--DKITTALPTTLGPVNASSQPTDLNTSTKLPSTPTTNSTASPHQPVSH--SEGQH 172
Cdd:pfam05109 570 ---------------TIPTLGKTSptSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSavTTGQH 634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   173 --------------TTVQSSSASVSSSDNTTLLWILTTSKPTGTSEGTQ--PIAISTPGITTPVSTPLQPTGSPG---GT 233
Cdd:pfam05109 635 nitssstssmslrpSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQvtPASTSTHHVSTSSPAPRPGTTSQAsgpGN 714

                         250       260       270
                  ....*....|....*....|....*....|...
gi 20301990   234 ESVPTTEEFTHSTSSWTPVVSQGPSTPSSTWTS 266
Cdd:pfam05109 715 SSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTA 747
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 104-271 6.77e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.13  E-value: 6.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   104 PTTSNSGQTVSSGGKSSDKITTA---LPTTLG------PVNASSQPTDLNTSTKLPSTPTTNSTASPHQPVSHSEGQHTT 174
Cdd:pfam05109 449 PSSTHVPTNLTAPASTGPTVSTAdvtSPTPAGttsgasPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVT 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20301990   175 VQSSSASVSSSDNTTLLWILTTSKPTGTSEgTQPIAISTPGITTP----------VSTPLQPTGSPGGTESVPTTEEFTH 244
Cdd:pfam05109 529 TPTPNATSPTLGKTSPTSAVTTPTPNATSP-TPAVTTPTPNATIPtlgktsptsaVTTPTPNATSPTVGETSPQANTTNH 607

                         170       180
                  ....*....|....*....|....*....
gi 20301990   245 ST--SSWTPVVSQGPSTPSSTWTSGSYKL 271
Cdd:pfam05109 608 TLggTSSTPVVTSPPKNATSAVTTGQHNI 636
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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