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Conserved domains on  [gi|32401461|ref|NP_861435|]
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glucose-dependent insulinotropic receptor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
6-290 3.96e-141

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 405.99  E-value: 3.96e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRF 165
Cdd:cd15104  81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15104 161 LLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALA--RQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 246 IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15104 239 LVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
KLF18_N super family cl40479
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
346-453 2.91e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


The actual alignment was detected with superfamily member cd21575:

Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 39.67  E-value: 2.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 346 QTLYtcdaCDTQTLYTCDaQTLYTCdaQTLYTCDAQTLYTCDAQTLYTCdaQTLY------TCDTQTLYTCdaQTLYTCD 419
Cdd:cd21575  16 QTLY----GGQMTTPSGD-QTLYGG--QMTTSFSEQTLYGGQMTTPSGD--QTLYggqmttPNGNQTLYGG--QMTTSTG 84
                        90       100       110
                ....*....|....*....|....*....|....
gi 32401461 420 AQTLYtcDAQTLYTCDAQTLYTSSLVTGQTEQTP 453
Cdd:cd21575  85 NQTLY--GGQMTTSGSDQTLYGGQMTTSSGDQTL 116
 
Name Accession Description Interval E-value
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
6-290 3.96e-141

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 405.99  E-value: 3.96e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRF 165
Cdd:cd15104  81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15104 161 LLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALA--RQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 246 IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15104 239 LVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
22-279 1.48e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 118.94  E-value: 1.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461    22 NALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQ-HTQKTLCSLRMAFVTSSAAASVLTVMLIA 100
Cdd:pfam00001   2 NLLVILVILRNKKLRT-PTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   101 FDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL--GVSIFQQTTYHGPCTFFAVFHP----RFVLTLSCAGF 174
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlfGWTLTVPEGNVTVCFIDFPEDLskpvSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   175 FPAVLLFVFFYCDMLKiasvhsqHIRKMEHAGAMVGACRPPRpvndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKC 254
Cdd:pfam00001 161 LLPLLVILVCYTLIIR-------TLRKSASKQKSSERTQRRR-----KALKTLAVVVVVFILCWLPYHIVNLLDSLALDC 228
                         250       260
                  ....*....|....*....|....*...
gi 32401461   255 CLYQVLEK---YLWLLGVGNSLLNPLIY 279
Cdd:pfam00001 229 ELSRLLDKalsVTLWLAYVNSCLNPIIY 256
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
346-453 2.91e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 39.67  E-value: 2.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 346 QTLYtcdaCDTQTLYTCDaQTLYTCdaQTLYTCDAQTLYTCDAQTLYTCdaQTLY------TCDTQTLYTCdaQTLYTCD 419
Cdd:cd21575  16 QTLY----GGQMTTPSGD-QTLYGG--QMTTSFSEQTLYGGQMTTPSGD--QTLYggqmttPNGNQTLYGG--QMTTSTG 84
                        90       100       110
                ....*....|....*....|....*....|....
gi 32401461 420 AQTLYtcDAQTLYTCDAQTLYTSSLVTGQTEQTP 453
Cdd:cd21575  85 NQTLY--GGQMTTSGSDQTLYGGQMTTSSGDQTL 116
 
Name Accession Description Interval E-value
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
6-290 3.96e-141

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 405.99  E-value: 3.96e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15104   1 AAGVILAVLSPLIITGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRF 165
Cdd:cd15104  81 ITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15104 161 LLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALA--RQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 246 IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15104 239 LVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
7-288 5.68e-47

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 163.12  E-value: 5.68e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGV-AISGLVTDQLSSSAQHtQKTLCSLR 81
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYrnrrLRTVTN-----YFIVSLAVADLLVALlVMPFSAVYTLLGYWPF-GPVLCRFW 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVF 161
Cdd:cd14967  76 IALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd14967 156 NKIYVLVSSVISFFIPLLIMIVLYARIFRVAR-------------------------RELKAAKTLAIIVGAFLLCWLPF 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 242 LITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd14967 211 FIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
7-282 6.79e-41

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.44  E-value: 6.79e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRT-VTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL---GVSIFQQTTYHGPCTFFAVFHP 163
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLlgwGVYDYGGYCCCCLCWPDLTLSK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHagamvGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd00637 160 AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSS-----NSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32401461 244 TSIVQVAC-HKCCLYQVLEKYLWLLGVGNSLLNPLIYAYW 282
Cdd:cd00637 235 LLLLDVFGpDPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
8-287 6.87e-31

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 120.92  E-value: 6.87e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAmllsIYKNDG---VGLCFTLNLAVADTLIGVAIS--GLVTDQLSSSAqhTQKTLCSLRM 82
Cdd:cd15065   3 GIFLSLIIVLAIFGNVLVCLA----IFTDRRlrkKSNLFIVSLAVADLLVALLVMtfAVVNDLLGYWL--FGETFCNIWI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGV----------------SIF 146
Cdd:cd15065  77 SFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLgwhrlsqdeikglnhaSNP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 147 QQTTYHGPCTFFAVFHprfvltlSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAG-AMVGACRPPRP-------V 218
Cdd:cd15065 157 KPSCALDLNPTYAVVS-------SLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSeSGSKFQVPSLSskhnnqgV 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32401461 219 NDFKAVRTVSVLIGSFTLSWSPFLITSIVQVAChKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15065 230 SDHKAAVTLGIIMGVFLICWLPFFIINIIAAFC-KTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFR 297
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
22-279 1.48e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 118.94  E-value: 1.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461    22 NALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQ-HTQKTLCSLRMAFVTSSAAASVLTVMLIA 100
Cdd:pfam00001   2 NLLVILVILRNKKLRT-PTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   101 FDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL--GVSIFQQTTYHGPCTFFAVFHP----RFVLTLSCAGF 174
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlfGWTLTVPEGNVTVCFIDFPEDLskpvSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   175 FPAVLLFVFFYCDMLKiasvhsqHIRKMEHAGAMVGACRPPRpvndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKC 254
Cdd:pfam00001 161 LLPLLVILVCYTLIIR-------TLRKSASKQKSSERTQRRR-----KALKTLAVVVVVFILCWLPYHIVNLLDSLALDC 228
                         250       260
                  ....*....|....*....|....*...
gi 32401461   255 CLYQVLEK---YLWLLGVGNSLLNPLIY 279
Cdd:pfam00001 229 ELSRLLDKalsVTLWLAYVNSCLNPIIY 256
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
7-288 4.16e-30

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 118.16  E-value: 4.16e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAmllsIYKNDGVGL---CFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLcSLRMA 83
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAA----IIKNRRLHKpmyILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATW-LLRKG 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHP 163
Cdd:cd14972  76 SLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGLPK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAgFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGamvgacRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd14972 156 SYLVLILVF-FFIALVIIVFLYVRIFWCLWRHANAIAARQEAA------VPAQPSTSRKLAKTVVIVLGVFLVCWLPLLI 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 244 TSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd14972 229 LLVLDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRR 273
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
8-287 3.32e-27

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 109.75  E-value: 3.32e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVaisglVTDQLSSSAQHTQKT------LCSLR 81
Cdd:cd15067   3 GVVLSLFCLVTVAGNLLVILAVLRERYLRT-VTNYFIVSLAVADLLVGS-----IVMPFSILHEMTGGYwlfgrdWCDVW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFlPlGVSIFQQTTYHGPCTFFAVF 161
Cdd:cd15067  77 HSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF-P-AIAWWRAVDPGPSPPNQCLF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 --HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkMEHagamvgacrpprpvndfKAVRTVSVLIGSFTLSWS 239
Cdd:cd15067 155 tdDSGYLIFSSCVSFYIPLVVMLFTYYRIYRAAA--------KEQ-----------------KAAKTLGIVMGVFILCWL 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 240 PFLITSIVQVACHKCCLY---QVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15067 210 PFFVTNILIGFCPSNCVSnpdILFPLVTW-LGYINSGMNPIIYACSSRDFR 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
8-281 2.28e-25

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 105.59  E-value: 2.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAIsglvtdqLSSSAqhTQKTL--------CS 79
Cdd:cd15057   4 GCILYLLVLLTLLGNALVIAAVLRFRHLRSKVTNYFIVSLAVSDLLVAILV-------MPWAA--VNEVAgywpfgsfCD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  80 LRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGV-------SIFQQTTYH 152
Cdd:cd15057  75 VWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLgwhraddTSEALALYA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 153 GPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMvgACRPPRPVN-----DFKAVRTV 227
Cdd:cd15057 155 DPCQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALERAAQE--STNPDSSLRsslrrETKALKTL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 228 SVLIGSFTLSWSPFLITSIVQVAC------HKCCLYQVLEKYLWlLGVGNSLLNPLIYAY 281
Cdd:cd15057 233 SIIMGVFVCCWLPFFILNCVLPFCdlrtaqFPCVPDTTFIVFVW-LGWANSSLNPIIYAF 291
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
8-288 2.80e-25

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 105.11  E-value: 2.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15051   4 GVVLAVIILLTVIGNVLVCLAVAVN-RRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP--LGVSIFQQTTYHGPCTFFAVFH--P 163
Cdd:cd15051  83 LCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPihLGWNTPDGRVQNGDTPNQCRFElnP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAgamVGACRPPRP--VNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15051 163 PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPA---STANSSKSAatAREHKATVTLAAVLGAFIICWFPY 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 242 LITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15051 240 FTYFTYRGLCGDNINETALSVVLW-LGYANSALNPILYAFLNRDFRR 285
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
9-287 3.01e-25

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 104.50  E-value: 3.01e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAIsglvtdqLSSSAQHTQK-------TLCSLR 81
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNL-FIVSLACADLLVGTLV-------LPFSAVNEVLdvwifghTWCQIW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-------GVSIFQQTTYHGP 154
Cdd:cd15063  77 LAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLvgwndgkDGIMDYSGSSSLP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 155 CTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSqhirkmehagamvgacrpprpvndfKAVRTVSVLIGSF 234
Cdd:cd15063 157 CTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMET-------------------------KAAKTVAIIVGCF 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 235 TLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15063 212 IFCWLPFFTVYLVRAFCEDCIPPLLFSVFFW-LGYCNSALNPCIYALFSRDFR 263
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
8-287 4.78e-25

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 104.49  E-value: 4.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLL--SIYKNDGVglcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15056   4 STFLSLVILLTILGNLLVIVAVCTdrQLRKKTNY---FVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAI-KQPLRYfqIMNGLVAGGCIAGLWLISYLIGFLPLG-----VSIFQQTTYHGP----- 154
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAIcCQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPIMqgwnhIGIEDLIAFNCAsgsts 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 155 CTFfaVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVN---DFKAVRTVSVLI 231
Cdd:cd15056 159 CVF--MVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAGSSNHEADQHRNSRmrtETKAAKTLGIIM 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 232 GSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15056 237 GCFCVCWAPFFVTNIVDPFIGYRVPYLLWTAFLW-LGYINSGLNPFLYAFFNKSFR 291
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
6-279 5.03e-25

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 104.84  E-value: 5.03e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15058   1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQ------QTTYHGP--CTF 157
Cdd:cd15058  81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRandpeaNDCYQDPtcCDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 FAVFHprFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRK------------MEHAGAMVGAC--RPPR--PVNDF 221
Cdd:cd15058 161 RTNMA--YAIASSVVSFYIPLLIMIFVYARVFLIATRQLQLIDKrrlrfqsecpapQTTSPEGKRSSgrRPSRltVVKEH 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 222 KAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIY 279
Cdd:cd15058 239 KALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLNW-LGYINSGLNPIIY 295
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
8-279 5.33e-25

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 104.60  E-value: 5.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMA 83
Cdd:cd15959   4 GALLSLAILVIVGGNLLVIVAIAktprLQTMTN-----VFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-------GVSIFQQTTYHGP-C 155
Cdd:cd15959  79 VDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPImnqwwrdGADEEAQRCYDNPrC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 TFFAVFHPrFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKME--------HAGAMVGAC--RPPR--PVNDFKA 223
Cdd:cd15959 159 CDFVTNMP-YAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRLIRKDKvrfppeesPPAESRPACgrRPSRllAIKEHKA 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 224 VRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIY 279
Cdd:cd15959 238 LKTLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLNW-LGYANSAFNPIIY 292
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
9-281 2.75e-24

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 102.38  E-value: 2.75e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIG-VAISGLVTDQLSSSAQHTqKTLCSLRMA 83
Cdd:cd15048   1 IVLAVLISVLILVtvigNLLVILA-FIKDKKLRTVSNFFLLNLAVADFLVGlVSMPFYIPYTLTGKWPFG-KVFCKAWLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI-GFLPLGVSIFQQTT--YHGPC--TFF 158
Cdd:cd15048  79 VDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLyGPAIIGWDLWTGYSivPTGDCevEFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 159 AVFHprFVLTLSCAGFFPAVLLFVFFYCDM-LKI-----ASVHSQHIRKMEHAGAMVGACRPPRPV--NDFKAVRTVSVL 230
Cdd:cd15048 159 DHFY--FTFITSVLEFFIPFISVSFFNLLIyLNIrkrsrRRPLRSVPILPASQNPSRARSQREQVKlrRDRKAAKSLAIL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 231 IGSFTLSWSPFLITSIVQVACHKCCL-YQVLEKYLWLLGvGNSLLNPLIYAY 281
Cdd:cd15048 237 VLVFLICWAPYTILTIIRSFCSGSCVdSYLYEFTFWLLW-TNSAINPFLYAA 287
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
8-287 2.80e-24

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 101.65  E-value: 2.80e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAIS--GLVTDQLSSSAqhTQKTLCSLR 81
Cdd:cd15059   4 SSIVSVVILLIIVGNVLVIVAVLtsrkLRAPQN-----WFLVSLAVADILVGLLIMpfSLVNELMGYWY--FGSVWCEIW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQQTTYHGPCTFFAV- 160
Cdd:cd15059  77 LALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPL-FGWKDEQPWHGAEPQCELs 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLtLSCAG-FFPAVLLFVFFYCDMLKIAsvhsqhiRKMEHagamvgacrpprpvndfKAVRTVSVLIGSFTLSWS 239
Cdd:cd15059 156 DDPGYVL-FSSIGsFYIPLLIMIIVYARIYRAA-------KRKER-----------------RFTLVLGVVMGAFVLCWL 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 240 PFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15059 211 PFFFTYPLVVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFR 258
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
8-287 1.92e-23

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 99.27  E-value: 1.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLL-------SIYkndgvglcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSL 80
Cdd:cd15329   4 GIVLLIIILGTVVGNALVIIAVCLvkklrtpSNY--------LIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  81 RMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGV-----------SIFQQT 149
Cdd:cd15329  76 WISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGwknkvndpgvcQVSQDF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 150 TYHGPCTFFAVFHPRFVLtlscagffpavllfVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSV 229
Cdd:cd15329 156 GYQIYATFGAFYIPLIVM--------------LVLYYKIYRAAK-------------------------SERKAIKTLGI 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32401461 230 LIGSFTLSWSPFLITSIVQ-VACHKCCLY---QVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15329 197 IMGAFTLCWLPFFILALLRpFLKPIKCSCiplWLSRLFLW-LGYANSFLNPIIYAKFNREFR 257
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
8-288 3.99e-23

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 98.17  E-value: 3.99e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15064   4 SVLLSLIILATILGNALVIAAILLT-RKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL------------GVSIFQQTTYhgpc 155
Cdd:cd15064  83 CCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLfgwrtpdsedpsECLISQDIGY---- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 TFFAVFhprfvltlsCAGFFPAVLLFVFFYcdmlKIASVHSQhirkmEHagamvgacrpprpvndfKAVRTVSVLIGSFT 235
Cdd:cd15064 159 TIFSTF---------GAFYIPLLLMLILYW----KIYRAAAR-----ER-----------------KAAKTLGIILGAFI 203
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 236 LSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15064 204 VCWLPFFLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
8-287 5.49e-23

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 97.82  E-value: 5.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAmlLSIYKN-DGVGLCFTLNLAVADTLIGVAISGL-VTDQLSSSAQHtQKTLCSLRMAFV 85
Cdd:cd15061   3 ISFLILAIIFTIFGNLLVILA--VATTRRlRTITNCYIVSLATADLLVGVLVLPLaIIRQLLGYWPL-GSHLCDFWISLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFfaVFHPRF 165
Cdd:cd15061  80 VLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYY--TYDKGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15061 158 RIYSSMGSFFLPLLLMLFVYLRIFRVIA-------------------------KERKTAKTLAIVVGCFIVCWLPFFIMY 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 32401461 246 IVQVACHkCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15061 213 LIEPFCD-CQFSEALSTAFTWLGYFNSVINPFIYAFYNKDFR 253
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
5-288 1.21e-21

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 94.63  E-value: 1.21e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   5 FSFGVILAVLtilIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVtdQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd14968   4 IVLEVLIAVL---SVLGNVLVIWAVKLNRALRT-VTNYFIVSLAVADILVGALAIPLA--ILISLGLPTNFHGCLFMACL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-----GVSIFQQTTYHGP-CTFF 158
Cdd:cd14968  78 VLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMfgwnnGAPLESGCGEGGIqCLFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 159 AVFHPRFVLTLScagFFPAVL----LFVFFYcdmLKIASVhsqhIRKMEHAGAMVGACRPPRPV--NDFKAVRTVSVLIG 232
Cdd:cd14968 158 EVIPMDYMVYFN---FFACVLvpllIMLVIY---LRIFRV----IRKQLRQIESLLRSRRSRSTlqKEVKAAKSLAIILF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 233 SFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd14968 228 LFALCWLPLHIINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
10-288 8.00e-21

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 91.67  E-value: 8.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAV--NALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGvaisgLVTDQLSSSAQHTQK-----TLC 78
Cdd:cd15066   3 GFAMTLIILAAIfgNLLVIISVMrhrkLRVITN-----YFVVSLAMADMLVA-----LCAMTFNASVEITGRwmfgyFMC 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  79 SLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIF-------QQTTY 151
Cdd:cd15066  73 DVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYtteehlqYRKTH 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 152 HGPCTFfaVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIAsvhsqhirKMEHagamvgacrpprpvndfKAVRTVSVLI 231
Cdd:cd15066 153 PDQCEF--VVNKIYALISSSVSFWIPCIVMIFTYYRIYLEA--------KREH-----------------KAAKTLGIIM 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 232 GSFTLSWSPFLITSIVQVACHKCCLY-QVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15066 206 GAFILCWLPFFLWYVTTTLCGDACPYpPILVSILFWIGYFNSTLNPLIYAYFNRDFRE 263
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
8-279 1.28e-20

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 91.89  E-value: 1.28e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15958   4 SLLMALIVLLIVAGNVLVIVA-IGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTT------YHGP--CTFfa 159
Cdd:cd15958  83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDdqalkcYEDPgcCDF-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKME----HAGAMVGACRPPRP-----VNDFKAVRTVSVL 230
Cdd:cd15958 161 VTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEgrfhNTLTGLGRKCKRRPsrilaLREQKALKTLGII 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32401461 231 IGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIY 279
Cdd:cd15958 241 MGVFTLCWLPFFLVNVVNVFNRELVPDWLFVFFNW-LGYANSAFNPIIY 288
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
6-279 4.65e-20

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 89.41  E-value: 4.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCS--LRMA 83
Cdd:cd15050   2 PLGIALSTISLITVILNLLVLYA-VRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLfwLSMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAaaSVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQ----TTYHGPCTFFA 159
Cdd:cd15050  81 YVASTA--SIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARggerVVLEDKCETDF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqhirkmehagamvgACRPPRpvndfKAVRTVSVLIGSFTLSWS 239
Cdd:cd15050 159 HDVTWFKVLTAILNFYIPSLLMLWFYAKIFK--------------------AVNRER-----KAAKQLGFIMAAFILCWI 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32401461 240 PFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIY 279
Cdd:cd15050 214 PYFILFMVIAFCKNCCNENLHMFTIW-LGYINSTLNPFIY 252
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
8-279 6.30e-20

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 89.92  E-value: 6.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15957   4 GIVMSLIVLAIVFGNVLVITA-IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQT------TYHGP--CTFFA 159
Cdd:cd15957  83 CVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAThqeainCYAEEtcCDFFT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 vfHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKME------------HAGAMVGACRPPRPVNDFKAVRTV 227
Cdd:cd15957 163 --NQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEgrfhnqnidqngSGGGGGNRRRSKFCLKEHKALKTL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 228 SVLIGSFTLSWSPFLITSIVQVAcHKCCLYQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd15957 241 GIIMGTFTLCWLPFFIVNIVHVI-QDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
9-288 1.95e-19

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 88.04  E-value: 1.95e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15305   5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNF-FLMSLAVADMLVGILVMPVsLIAILYDYAWPLPRYLCPIWISLDVL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGF-LP-LGVSIFQQTTYHGPCtffAVFHPRF 165
Cdd:cd15305  84 FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpIPvIGLQDDEKVFVNGTC---VLNDENF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCdmLKIASVHSQHIRKmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15305 161 VLIGSFVAFFIPLIIMVITYC--LTIQVLQRQQAIN-----------------NERRASKVLGIVFFLFLIMWCPFFITN 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 246 IVQVACHKCC----LYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15305 222 ILSVLCKEACdqklMEELLNVFVW-VGYVSSGINPLVYTLFNKTYRR 267
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
8-281 3.14e-19

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 88.14  E-value: 3.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAIsgLVTDQLSSSAQHTQ-KTLCSLRMAFVT 86
Cdd:cd15320   5 GCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLV--MPWKAVAEIAGFWPfGSFCNIWVAFDI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYhGPCTFFAVFHPR-- 164
Cdd:cd15320  83 MCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWHKAKPT-SFLDLNASLRDLtm 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 ----------FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPP----------RPVNDF--- 221
Cdd:cd15320 162 dncdsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNStgnrgsgdcqQPESSFkms 241
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461 222 -----KAVRTVSVLIGSFTLSWSPFLITSIVQVACHK------CCLYQVLEKYLWlLGVGNSLLNPLIYAY 281
Cdd:cd15320 242 fkretKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPtstepfCISSTTFDVFVW-FGWANSSLNPIIYAF 311
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
42-280 6.60e-19

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 86.45  E-value: 6.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  42 CFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLV 121
Cdd:cd15055  37 LLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRR 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 122 AGGCIAGLWLISYLIGFLPLgVSIFQQTTY------HGPCTFFaVFHPRFVLTLSCAGFFPaVLLFVFFYcdmLKIASVH 195
Cdd:cd15055 117 VKICICLCWFVSALYSSVLL-YDNLNQPGLirynscYGECVVV-VNFIWGVVDLVLTFILP-CTVMIVLY---MRIFVVA 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 196 SQHIRKMEHAGAMVGACRPPRPVN---DFKAVRTVSVLIGSFTLSWSPFLITSIV-QVACHKCCLYQVLekyLWLLGVgN 271
Cdd:cd15055 191 RSQARAIRSHTAQVSLEGSSKKVSkksERKAAKTLGIVVGVFLLCWLPYYIVSLVdPYISTPSSVFDVL---IWLGYF-N 266

                ....*....
gi 32401461 272 SLLNPLIYA 280
Cdd:cd15055 267 SCLNPLIYA 275
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
8-281 8.13e-19

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 86.93  E-value: 8.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAIsgLVTDQLSSSAQHTQ-KTLCSLRMAFVT 86
Cdd:cd15319   4 GCLLSLLILWTLLGNILVCAAVVRFRHLRSKVTNIFIVSLAVSDLFVALLV--MPWKAVAEVAGYWPfGAFCDVWVAFDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIF--QQTTYHGPCTFFAVFHPR 164
Cdd:cd15319  82 MCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHkdSGDDWVGLHNSSISRQVE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 ----------FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPV------------NDFK 222
Cdd:cd15319 162 encdsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSLERAAEHAQSCRSNRIDchhhtslrtsikKETK 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32401461 223 AVRTVSVLIGSFTLSWSPFLITSIVQVACHK----------CCLYQVLEKYLWlLGVGNSLLNPLIYAY 281
Cdd:cd15319 242 VLKTLSVIMGVFVCCWLPFFILNCMVPFCDRppadpdaglpCVSETTFDVFVW-FGWANSSLNPIIYAF 309
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
9-285 1.36e-18

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 85.76  E-value: 1.36e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd15314   5 IFLGLISLVTVCGNLLVIISIAhfkqLHTPTN-----YLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGF--LPLGVSIFQQTTYHGPC-TFFAVF 161
Cdd:cd15314  80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFgiIFLELNIKGIYYNHVACeGGCLVF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFF--PAVLLFvffyCDMLKIASVHSQHIRKMEHAGAMVGACRPPRpvnDFKAVRTVSVLIGSFTLSWS 239
Cdd:cd15314 160 FSKVSSVVGSVFSFyiPAVIML----CIYLKIFLVAQRQARSIQSARTKSGASSSKM---ERKATKTLAIVMGVFLLCWT 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32401461 240 PFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAY---WQRE 285
Cdd:cd15314 233 PFFLCNIIDPFINYSIPPVLIEVLNW-LGYSNSTLNPFIYAFfysWFRK 280
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
8-287 5.76e-18

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 83.55  E-value: 5.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRM 82
Cdd:cd15053   4 ALFLLLLPLLTVFGNVLVIMSVFrersLQTATN-----YFIVSLAVADLLVAILVMPFaVYVEVNGGKWYLGPILCDIYI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLgVSIFQQTTYHGP--CTFfav 160
Cdd:cd15053  79 AMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIA-CPL-LFGLNNVPYRDPeeCRF--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLTLSCAGFF-PAVLLFVFFYCDMLKIasvhsqhirKMEHagamvgacrpprpvndfKAVRTVSVLIGSFTLSWS 239
Cdd:cd15053 154 YNPDFIIYSSISSFYiPCIVMLLLYYRIFRAL---------RREK-----------------KATKTLAIVLGVFLFCWL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461 240 PFLITSIVQVACHK-----CCL-YQVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15053 208 PFFTLNILNAICPKlqnqsCHVgPALFSLTTW-LGYVNSFLNPIIYTIFNIEFR 260
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
9-288 1.39e-17

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 83.06  E-value: 1.39e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILiiaVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGV-AIS-GLVTDQLSSSAQHTqktlCSLRMAFVT 86
Cdd:cd15068   8 LAIAVLAIL---GNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVlAIPfAITISTGFCAACHG----CLFIACFVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL----------GVSIFQQTTYHG--P 154
Cdd:cd15068  80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMlgwnncgqpkEGKNHSQGCGEGqvA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 155 CTFFAVFHPRFVLTLScagFFPAVLLFVFFYCDM-LKIASVHSQHIRKMEhAGAMVGACRPPRPVNDFKAVRTVSVLIGS 233
Cdd:cd15068 160 CLFEDVVPMNYMVYFN---FFACVLVPLLLMLGVyLRIFLAARRQLKQME-SQPLPGERARSTLQKEVHAAKSLAIIVGL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 234 FTLSWSPFLITSIVQVACHKCCLYQVLEKYLW-LLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15068 236 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAiVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
14-290 2.98e-17

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 81.39  E-value: 2.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  14 LTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASV 93
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  94 LTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-------LGVSIFQQTTYHGPCTFFAVFHPR-- 164
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPielgwheLGHERTLPNLTSGTVEGQCRLLVSlp 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAGFFPAVLLFVFFYCDMLKIAsvhsqhirkmehagamvgacrpprpVNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15054 169 YALVASCLTFFLPSGAICFTYCRILLAA-------------------------RKALKASLTLGILLGMFFVTWLPFFVA 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 245 SIVQVACHkCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15054 224 NVVQAVCD-CVSPGLFDVLTW-LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
9-288 4.65e-17

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 80.76  E-value: 4.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLS--IYKNDGVGLCftlNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15334   5 LTLSILALMTTAINSLVITAIIVTrkLHHPANYLIC---SLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQQTTYHGPCTffaVFHPRFV 166
Cdd:cd15334  82 TCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPL-FWRHQTTSREDECI---IKHDHIV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LTL--SCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15334 158 FTIysTFGAFYIPLALILILYYKIYRAAT-------------------------RERKAATTLGLILGAFVICWLPFFVK 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32401461 245 SIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15334 213 EVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKK 256
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
10-281 7.90e-17

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 80.57  E-value: 7.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSA 89
Cdd:cd15317   5 IVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  90 AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLI--SYLIGFLPLGV------SIFQQTTYHGPCtfFAVF 161
Cdd:cd15317  85 TTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVpgIYTFGLIYTGAndegleEYSSEISCVGGC--QLLF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLtLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAG-AMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15317 163 NKIWVL-LDFLTFFIPCLIMIGLYAKIFLVARRQARKIQNMEDKFrSSEENSSKASASRERKAAKTLAIVMGIFLFCWLP 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 32401461 241 FLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAY 281
Cdd:cd15317 242 YFIDTIVDEYSNFITPAIVFDAVIW-LGYFNSAFNPFIYAF 281
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
8-288 1.04e-16

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 80.01  E-value: 1.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd17790   4 VITTGILSLVTVTGNLLVLISFKVN-SELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI---GFLPLGVSIFQQTTYHGPCTFFAVFHPR 164
Cdd:cd17790  83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLwapAILFWQYLVGERTVLAGQCYIQFLSQPI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqhirkmehagamvgacrppRPVNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd17790 163 ITFGTAIAAFYLPVTIMIILYWRIYR-------------------------ETIKEKKAARTLSAILLAFILTWTPYNIM 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32401461 245 SIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYAYWQREVRQ 288
Cdd:cd17790 218 VLVSTFCKDCVPKTLWELGYWLCYV-NSTVNPMCYALCNKSFRD 260
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
14-290 1.47e-16

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 79.46  E-value: 1.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  14 LTILIIAV--NALVVVAmllsIYKNDGVG---LCFTLNLAVADTLIGVA-------ISGLVTDQLSSSAQHTQkTLCSLR 81
Cdd:cd15103   8 LTLGIVSLleNILVILA----IAKNKNLHspmYFFICSLAVADMLVSVSnaletivIILLNNGYLVPRDSFEQ-HIDNVI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLplgvsifqqttyhgpctfFAVF 161
Cdd:cd15103  83 DSMICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGIL------------------FIIY 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLF-VFFYCDMLKIASVHSQHIrkmehagAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15103 145 SDSVPVIICLISMFFAMLVLmASLYVHMFLLARSHVKKI-------AALPGQRSTRQRANMKGAVTLTILLGVFIFCWAP 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 241 FLITSIVQVACHK---CCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15103 218 FFLHLTLMISCPSnpyCACYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
9-281 2.67e-16

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 79.18  E-value: 2.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAmllsIYKN---DGVGLCFTLNLAVADTLIG-----VAISGLVTDQLSSSAqhtqkT 76
Cdd:cd14993   1 IVLIVLYVVVFLLalvgNSLVIAV----VLRNkhmRTVTNYFLVNLAVADLLVSlfcmpLTLLENVYRPWVFGE-----V 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 LCSLrMAFVTSSA-AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPLGVsIFQQTTYHGPc 155
Cdd:cd14993  72 LCKA-VPYLQGVSvSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIII-MLPLLV-VYELEEIISS- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 tffavfHPRFVLTLSCAGFFPA--------VLLFVFFYC-DMLKIASVHSQHIRKMEHAGAmVGACRPPRPVNDF----- 221
Cdd:cd14993 148 ------EPGTITIYICTEDWPSpelrkaynVALFVVLYVlPLLIISVAYSLIGRRLWRRKP-PGDRGSANSTSSRrilrs 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 222 --KAVRTVSVLIGSFTLSWSPFLITSIV-----QVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd14993 221 kkKVARMLIVVVVLFALSWLPYYVLSILldfgpLSSEESDENFLLILPFAQLLGYSNSAINPIIYCF 287
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
9-280 4.14e-16

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 78.13  E-value: 4.14e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVvvamLLSIYKN---DGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15049   5 IATGSLSLVTVGGNILV----ILSFRVNrqlRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIF--QQTTYHGPCTFFAVFH 162
Cdd:cd15049  81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAiLGWQYFvgERTVPDGQCYIQFLDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIAsvhsqhirkmehagamvgacrpprpVNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15049 161 PAITFGTAIAAFYLPVLVMTILYWRIYRET-------------------------ARERKAARTLSAILLAFIITWTPYN 215
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYA 280
Cdd:cd15049 216 ILVLVSTFCAKCIPDTLWSFGYWLCYI-NSTINPFCYA 252
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
9-287 6.37e-16

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 77.47  E-value: 6.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd15060   5 ILLSVIIAFTIVGNILVILSVFtyrpLRIVQN-----FFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQ-QTTYHGPCTFFAvfH 162
Cdd:cd15060  80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLiGWNDWPeNFTETTPCTLTE--E 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15060 158 KGYVIYSSSGSFFIPLLIMTIVYVKIFIATS-------------------------KERRAARTLGIIMGVFVVCWLPFF 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15060 213 LMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFR 257
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
10-290 6.96e-16

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 77.66  E-value: 6.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVA-ISGLVTDQLSSSaqhtqKTLCSLRMAFVTSS 88
Cdd:cd15962   5 IMLCISGTVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGlILNFVFQYVIQS-----ETISLITVGFLVAS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQttyHGPCTffaVFHP--RF 165
Cdd:cd15962  80 FTASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPvLGWNCLEE---RASCS---IVRPltKS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvgacrPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15962 154 NVTLLSASFFFIFILMLHLYIKICKIVCRHAHQIALQQHFLT------ASHYVATKKGVSTLAIILGTFGASWLPFAIYC 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 246 IvqVACHKcclYQVLEKYLWLL-GVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15962 228 V--VGDHE---YPAVYTYATLLpATYNSMINPIIYAYRNQEIQRSM 268
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
9-279 9.54e-16

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 76.91  E-value: 9.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNA--LVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15328   2 LVLTLLAMLVVATFLwnLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLsLVHELSGRRWQLGRSLCQVWISFD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSiFQQTTYHGPCTFFAVFHPRF 165
Cdd:cd15328  82 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFG-WGETYSEDSEECQVSQEPSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIAsvhsqhiRKMEHAGAMVGacrpprpvndfkavrtvsVLIGSFTLSWSPFLITS 245
Cdd:cd15328 161 TVFSTFGAFYLPLCVVLFVYWKIYKAA-------QKEKRAALMVG------------------ILIGVFVLCWIPFFLTE 215
                       250       260       270
                ....*....|....*....|....*....|....
gi 32401461 246 IVQVAChKCCLYQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd15328 216 LISPLC-SCDIPPIWKSIFLWLGYSNSFFNPLIY 248
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
13-287 1.72e-15

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 76.90  E-value: 1.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  13 VLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGV-AISGLVTDQLSSSaqhTQKTLCSLRMAFVTSSAAA 91
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNY-FLVSLAAADVAVGLfAIPFAITISLGFC---TDFHSCLFLACFVLVLTQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  92 SVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL------------GVSIFQQTTYHGPCTFFA 159
Cdd:cd15069  85 SIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFlgwnkamsatnnSTNPADHGTNHSCCLISC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPrfVLTLSCAGFF-------PAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGacrpprpvNDFKAVRTVSVLIG 232
Cdd:cd15069 165 LFEN--VVPMSYMVYFnffgcvlPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQ--------REIHAAKSLAIIVG 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 233 SFTLSWSPFLI---TSIVQVACHKCCLYQVLEKYLwLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15069 235 IFALCWLPVHIlncITLFQPEFSKSKPKWAMNVAI-LLSHANSVVNPIVYAYRNRDFR 291
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
6-288 2.72e-15

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 75.83  E-value: 2.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15300   2 TIAAVTAVVSLITIVGNVLVMISFKVN-SQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL---GVSIFQQTTYHGPCTFFAVFH 162
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIlcwQYFVGKRTVPERECQIQFLSE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqhirkmehagamvgacrppRPVNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15300 161 PTITFGTAIAAFYIPVSVMTILYCRIYK-------------------------ETIKERKAAQTLSAILLAFIITWTPYN 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYAYWQREVRQ 288
Cdd:cd15300 216 IMVLVSTFCSDCIPLTLWHLGYWLCYV-NSTVNPMCYALCNKTFRK 260
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
9-285 2.79e-15

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 75.79  E-value: 2.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd15330   5 LFLGTLILCAIFGNACVVAAIALE-RSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTYHGPCTFFAvfHPRFVL 167
Cdd:cd15330  84 CTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPmLGWRTPEDRSDPDACTISK--DPGYTI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 168 TLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLITSIV 247
Cdd:cd15330 162 YSTFGAFYIPLILMLVLYGRIFKAAA-------------------------RERKTVKTLGIIMGTFILCWLPFFIVALV 216
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32401461 248 QVAC-HKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQRE 285
Cdd:cd15330 217 LPFCeSTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKD 255
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
43-288 3.37e-15

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 75.36  E-value: 3.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVA------ISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQI 116
Cdd:cd15354  38 FVCSLAVADMLVSVSnawetiTIYLLNNRHLVIEDAFVRHIDNVFDSLICISVVASMCSLLAIAVDRYVTIFYALRYHNI 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 117 MNGLVAGGCIAGLWLISYLIGFLPLgvsIFQQTTYhgpctffavfhprfVLTLSCAGFFPAVLLFVFFYCDMLKIASVHS 196
Cdd:cd15354 118 MTVRRAGIIIACIWTFCTGCGIIFI---LYSESTY--------------VIICLITMFFAMLFLMVSLYIHMFLLARTHV 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 197 QHIRKMEHAGAMvgacrppRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHK----CCLYQVLEKYLWLLgVGNS 272
Cdd:cd15354 181 KRIAALPGYNSV-------RQRTSMKGAVTLTILLGIFIVCWAPFFLHLILMISCPQnlycVCFMSHFNMYLILI-MCNS 252
                       250
                ....*....|....*.
gi 32401461 273 LLNPLIYAYWQREVRQ 288
Cdd:cd15354 253 VIDPLIYAFRSQEMRK 268
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
10-288 5.43e-15

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 74.94  E-value: 5.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAmllsIYKNDGVG---LCFTLNLAVADTLIGVA-----ISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15353   6 VFVTLGIVSLLENILVIAA----IAKNKNLHspmYFFICSLAVADMLVSVSngsetVVITLLNGNDTDAQSFTVNIDNVI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLplgvsifqqttyhgpctFFAVF 161
Cdd:cd15353  82 DSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVL-----------------FIIYS 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIrkmehagAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15353 145 DSSVVIICLISMFFTMLALMASLYVHMFLLARLHIKRI-------AVLPGTGPIRQGANMKGAITLTILLGVFVVCWAPF 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 242 LITSIVQVACHK----CCLYQVLEKYLWLLgVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15353 218 FLHLIFYISCPRnpycVCFMSHFNMYLILI-MCNSVIDPLIYAFRSQELRK 267
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
5-290 1.02e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 74.16  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   5 FSFGVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVaISGLVTdqLSSSAQHT---QKTL 77
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLkkkkLRTPLN-----LFLLNLALADLLMSV-VGYPLS--FYSNLSGRwsfGDPG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQImNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCT 156
Cdd:cd14969  73 CVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLfGWSSYVPEGGGTSCS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 FFAVFHPR----FVLTLSCAGFFPAVLLFVFFYcdmLKIAsvhsQHIRKMEHAGAMVGACRPPRPVN--DFKAVRTVSVL 230
Cdd:cd14969 152 VDWYSKDPnslsYIVSLFVFCFFLPLAIIIFCY---YKIY----RTLRKMSKRAARRKNSAITKRTKkaEKKVAKMVLVM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 231 IGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd14969 225 IVAFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
10-288 1.58e-14

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 73.50  E-value: 1.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLvtdQLSSSAQHTQKTL-CSLRMAFVTSS 88
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAISLE-KRLQNVTNYFLMSLAIADLLVGLLVMPL---SILTELFGGVWPLpLVLCLLWVTLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 ---AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLGVSIFQQTT---YHGPCtffAVFH 162
Cdd:cd15052  82 vlfCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGIS-SPIPVLGIIDTTnvlNNGTC---VLFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15052 158 PNFVIYGSIVAFFIPLLIMVVTYALTIRLLS-------------------------NEQKASKVLGIVFAVFVICWCPFF 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32401461 243 ITSIVQVACHKCCLY---QVLEKYLWlLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15052 213 ITNILTGLCEECNCRispWLLSVFVW-LGYVSSTINPIIYTIFNKTFRR 260
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
13-290 3.29e-14

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 72.50  E-value: 3.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  13 VLTILIIAVNALVVV---AMLLSIYKNDGVG---LCFTLNLAVADTLIGVA------ISGLVTDQLSSsaqhtqkTLCSL 80
Cdd:cd15102   2 ATSVVFVAICCFIVLenlLVLIAIWRHMKFHrpmYYFLGNLALSDLLAGAAylanilLSGARTLRLSP-------AQWFL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  81 RMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGgCIAGLWLISYLIGFLP-LG---VSIFQQTTyhgpcT 156
Cdd:cd15102  75 REGSMFVALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLL-LIGACWLISLLLGGLPiLGwncLGALDACS-----T 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 FFAVFHPRFVLTlsCAGFFPAVLL-FVFFYCDMLKIasVHSQHIRkmehagamvgACRPPRPVNDFKAVRTVSVLIGSFT 235
Cdd:cd15102 149 VLPLYSKHYVLF--CVTIFAGILAaIVALYARIYCL--VRASGRK----------ATRASASPRSLALLKTVLIVLLVFI 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 236 LSWSPFLITSIVQVACH-KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15102 215 ACWGPLFILLLLDVACPvKTCPILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
14-290 6.34e-14

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 71.75  E-value: 6.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  14 LTILIIAVNALVVVAmllsIYKNDGVG---LCFTLNLAVADTLigVAISGLVTDQLSSSAQH--------TQKTLCSLRM 82
Cdd:cd15351  10 LGLVSLVENILVVVA----IAKNRNLHspmYYFICCLAVSDML--VSVSNLIETLFMLLLEHgvlvcrapMLQHMDNVID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGflplgvsifqqttyhgpcTFFAVFH 162
Cdd:cd15351  84 TMICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSS------------------TLFIVYY 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVF-FYCDMLKIASVHSQHIRKMEHAGamvgacRPPRPVNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15351 146 NSNAVILCLIVFFLFMLVLMLvLYIHMFILACRHSQSISSQQRRQ------CPHQQTASLKGAITLTILLGIFFLCWGPF 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 242 LITSIVQVACHK----CCLYQVLEKYLWLLgVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15351 220 FLHLTLIVTCPThpfcLCYFKYFNLFLILI-ICNSIIDPLIYAFRSQELRKTL 271
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
9-290 8.21e-14

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 71.35  E-value: 8.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVvAMLLSIYKNDGVGLCFTLNLAVADTLIGVaisGLVTDQLSSSAQHTQKTLCSLrMAFVTSS 88
Cdd:cd15100   5 IVLCVSGTLIACENAIVV-AIIFSTPSLRAPMFLLIGSLALADLLAGL---GLILHFVFRYCVYSEALSLVS-VGLLVAA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTyhgPCTffaVFHP--RF 165
Cdd:cd15100  80 FSASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPvLGWNCLREGS---SCS---VVRPltKN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvgacrPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15100 154 HLAVLAVAFLLVFALMLQLYAQICRIVLRHAHQIALQRHFLA------PSHYVATRKGVSTLALILGTFAACWIPFAVYC 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 246 IVQVAChkcclYQVLEKYLWLLGV-GNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15100 228 LLGDGS-----SPALYTYATLLPAtYNSMINPIIYAFRNQDIQKVL 268
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
2-288 1.22e-13

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 70.72  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   2 ESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15321   4 QATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNL-FLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVF 161
Cdd:cd15321  83 LALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHirkmehagamvgacrpprpvndFKAVrtVSVLIGSFTLSWSPF 241
Cdd:cd15321 163 EAWYILSSSIGSFFAPCLIMILVYLRIYLIAKNREKR----------------------FTFV--LAVVIGVFVLCWFPF 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 242 LITSIVQVACHKCC-LYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15321 219 FFSYSLGAICPELCkVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
9-281 1.26e-13

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 71.03  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVgLCFTLNLAVADTLIGVAISGLVTdqLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd15071   5 GIEVLIALVSVPGNVLVIWAVKVNQALRDAT-FCFIVSLAVADVAVGALVIPLAI--IINIGPQTEFYSCLMVACPVLIL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL----GVSIFQQT-----TYHGP---CT 156
Cdd:cd15071  82 TQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMfgwnNLNAVERAwaansSMGELvikCQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 FFAVFHPRFVLTLSCAGF-FPAVLLFVFFYCDMLKIasvhsqhIRKMEHAGAMVGACRPPRPVN-DFKAVRTVSVLIGSF 234
Cdd:cd15071 162 FETVISMEYMVYFNFFVWvLPPLLLMLLIYLEVFYL-------IRKQLNKKVSSSSSDPQKYYGkELKIAKSLALILFLF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 235 TLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd15071 235 ALSWLPLHILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAF 281
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
5-290 1.34e-13

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 71.20  E-value: 1.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   5 FSFGVILAVLTILIIAVNALVVVAMLL--SIYKNDGVglcFTLNLAVADtLIGVAISGLVTDQLSSSAQH--TQKTLCSL 80
Cdd:cd15337   1 YLIGIYIAIVGILGVIGNLLVIYLFSKtkSLRTPSNM---FIINLAISD-FGFSAVNGFPLKTISSFNKKwiWGKVACEL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  81 rMAFVTSS-AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCTF- 157
Cdd:cd15337  77 -YGFAGGIfGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFfGWGRYVPEGFQTSCTFd 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 FAVFHPR---FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEH--AGAMVGACRPPRPVnDFKAVRTVSVLIG 232
Cdd:cd15337 156 YLSRDLNnrlFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQTAKsgMGKDTEKNDARKKA-EIRIAKVAIILIS 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 233 SFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15337 235 LFLLSWTPYAVVALLGQFGPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
9-288 1.44e-13

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 70.28  E-value: 1.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV--NALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15324   3 IVLVVVVIILVTIvgNVLVVVAVFTSRALRAPQNL-FLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgvsifqQTTYHGPCTFFAVFHPRFV 166
Cdd:cd15324  82 LFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPL------LMTKHDEWECLLNDETWYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIrkmehagamvgacrpprpvndfkaVRTVSVLIGSFTLSWSPFLITSI 246
Cdd:cd15324 156 LSSCTVSFFAPGLIMILVYCKIYRVAKMREKRF------------------------TFVLAVVMGVFVLCWFPFFFTYS 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 247 VQVACHK-CCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15324 212 LHAVCRKrCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
6-288 2.59e-13

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 69.82  E-value: 2.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15333   6 SLAVLLALITLATTLSNAFVIATIYLT-RKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSD 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgvsIFQQTTYHGPCTFFAVFHPRF 165
Cdd:cd15333  85 ITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPF---FWRQAKAEEEVSECVVNTDHI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTL--SCAGFFPAVLLFVFFYcdmlkiasvhsqhirkmehaGAMVGACRpprpVNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd15333 162 LYTVysTVGAFYIPTLLLIALY--------------------GRIYVEAR----ARERKATKTLGIILGAFIVCWLPFFI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 244 TSIVQVACHKCCLYQ-VLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15333 218 ISLVLPICKDACWFHlAIFDFFTWLGYLNSLINPIIYTMSNEDFKQ 263
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
9-288 3.02e-13

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 69.69  E-value: 3.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSiyKN-DGVGLCFTLNLAVADTLIGVaisgLVTdQLSSSAQHTQK-----TLCSLRM 82
Cdd:cd15331   5 IILGLLILATIIGNVFVIAAILLE--RSlQGVSNYLILSLAVADLMVAV----LVM-PLSAVYEVSQHwflgpEVCDMWI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQpLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL----GVSIFQQTTYHGPCTF- 157
Cdd:cd15331  78 SMDVLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLfgwkDEDDLDRVLKTGVCLIs 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 ----FAVFHprfvltlSCAGFFPAVLLFVFFYCDMLKIAsvhsqhirKMEHagamvgacrpprpvndfKAVRTVSVLIGS 233
Cdd:cd15331 157 qdygYTIFS-------TVGAFYVPLLLMIIIYWKIYQAA--------KRER-----------------KAARTLAIITGA 204
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461 234 FTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15331 205 FVVCWLPFFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRG 259
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
6-288 3.66e-13

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 69.20  E-value: 3.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15323   2 GLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNL-FLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQQTT--YHGPCTFFAvfHP 163
Cdd:cd15323  81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL-ISMYRDPEgdVYPQCKLND--ET 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHirkmehagamvgacrpprpvndFKAVrtVSVLIGSFTLSWSPFLI 243
Cdd:cd15323 158 WYILSSCIGSFFAPCLIMILVYIRIYRVAKAREKR----------------------FTFV--LAVVMGVFVVCWFPFFF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 244 TSIVQVACHKCC-LYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15323 214 SYSLYGICREACeVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRR 259
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
13-287 3.89e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 69.59  E-value: 3.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  13 VLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAAS 92
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVN-KQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNAS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  93 VLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI---GFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTL 169
Cdd:cd15299  91 VMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLwapAILFWQYFVGKRTVPPDECFIQFLSEPIITFGT 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 170 SCAGFFPAVLLFVFFYCDMLKiasvhsqhirkmehagamvgacrppRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQV 249
Cdd:cd15299 171 AIAAFYLPVTIMTILYWRIYK-------------------------ETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNT 225
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32401461 250 ACHKCCLYQVLEKYLWLLGVgNSLLNPLIYAYWQREVR 287
Cdd:cd15299 226 FCDSCIPKTYWNLGYWLCYI-NSTVNPVCYALCNKTFR 262
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-287 5.70e-13

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 69.10  E-value: 5.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAVNALVVVAMLLSIYKNDGV----GLCFTLNLAVADTLIGV--AISGLVTDQLSssaQHTQKTLCSLRMAF 84
Cdd:cd15099   3 IAVLCFLAGPVTFLENILVLLTILSSTALrrrpSYLFIGSLALADMLASVifTISFLDFHVFH---QRDSRNLFLFKLGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgvSIFQQTTYHGPCTFFAVFHPR 164
Cdd:cd15099  80 VTMAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPL--MGWRCKTWDSPCSRLFPYIDR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLtLSCAGFFpAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15099 158 HYL-ASWTGLQ-LVLLFLIIYAYPYILWKAHRHEANMGGPKLGRQQVKGQARMRMDIRLAKTLSLILLVLAICWLPVLAF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 245 SIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15099 236 MLVDVRVTLTNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELR 278
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
9-280 7.31e-13

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 68.45  E-value: 7.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVvvamLLSIYKN---DGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15297   5 LVAGSLSLVTIIGNILV----MVSIKVNrhlQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI---GFLPLGVSIFQQTTYHGPCTFFAVFH 162
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILwapAILFWQFIVGGRTVPEGECYIQFFSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15297 161 AAVTFGTAIAAFYLPVIIMTVLYWQISRASS-------------------------REKKVTRTILAILLAFIITWTPYN 215
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYA 280
Cdd:cd15297 216 VMVLINTFCASCIPNTVWTIGYWLCYI-NSTINPACYA 252
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
46-287 1.09e-12

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 68.29  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  46 NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCsLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGgC 125
Cdd:cd15342  41 NLAAADLFAGVAYLFLMFHTGPWTAKLSLYQWF-LRQGLLDTSLTASVANLLAIAVERHQTIFTMQLHSKMSNQRVVI-L 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 126 IAGLWLISYLIGFLP-LGVSIFQQTtyhGPCTFFAVFHPRFVLTLSCAGFFPAVLLFV------FFYC--DMLKIASVHS 196
Cdd:cd15342 119 IFGIWMVALILGLIPaMGWNCLCDL---KRCSTMAPLYSRSYLVFWALSNLLTFLIMVavytriFIYVrrKSQRMSEHHS 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 197 QHIRKMEhagAMVGAcrpprpvndfkaVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNP 276
Cdd:cd15342 196 SHPRYRE---TVLGL------------MKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAYEKYFLLLAEINSLVNP 260
                       250
                ....*....|.
gi 32401461 277 LIYAYWQREVR 287
Cdd:cd15342 261 IVYSYRDKEMR 271
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
10-288 1.28e-12

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 67.99  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSiyKNDGVGLCFTL-NLAVADTLIGVA-------ISGLVTDQLSSSAQHTQKtLCSLR 81
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKN--KNLHSPMYFFLcSLAVADMLVSVSnsletimIAVLNSGYLVISDQFIQH-MDNVF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLplgvsifqqttyhgpctFFAVF 161
Cdd:cd15352  83 DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIV-----------------FIVYS 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVgacrpPRPVNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15352 146 ESKTVIVCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGA-----PQQRSCMKGAVTITILLGVFIVCWAPF 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32401461 242 LITSIVQVACHK---CCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15352 221 FLHLILIISCPHnpyCLCYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRK 270
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
6-288 1.46e-12

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 67.51  E-value: 1.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNdGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15062   2 VVGVALGAFILFAIGGNLLVILSVACNRHLR-TPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAvfHPRF 165
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVNE--EPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQhirkmehagamvgacrpprpvnDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15062 159 VLFSSLGSFYLPLAIILVMYCRVYVVAFKFSR----------------------EKKAAKTLGIVVGAFVLCWFPFFVVL 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 246 IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15062 217 PLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKR 259
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
7-282 1.48e-12

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 68.09  E-value: 1.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15390   2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGF---LPLGVSIFQQTTYHGPCTFFAVFHP 163
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALpqlLYSTTETYYYYTGSERTVCFIAWPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 R-------------FVLTLscagFFPAVLLFVFFY---CDMLKIASVHSQHIRKMEHAGAMVgacrpprpvndfKAVRTV 227
Cdd:cd15390 160 GpnslqdfvynivlFVVTY----FLPLIIMAVAYTrvgVELWGSKTIGENTPRQLESVRAKR------------KVVKMM 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32401461 228 SVLIGSFTLSWSP----FLITSIVQ-VACHKcclyQVLEKYL--WLLGVGNSLLNPLIYaYW 282
Cdd:cd15390 224 IVVVVIFAICWLPyhlyFILTYLYPdINSWK----YIQQIYLaiYWLAMSNSMYNPIIY-CW 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
9-290 1.50e-12

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 67.86  E-value: 1.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd15088   1 VIMPSVFGCICVVglvgNGIVLYVLVRCSKLRTAPDI-FIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLigfLPLGVSIF-QQTTYHGPCTFFAVFHP 163
Cdd:cd15088  80 DANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFL---SILPVWVYsSLIYFPDGTTFCYVSLP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 R------FVLTLSCAGFFpaVLLFVFFYCdmlkiasvhsqHIRKMEHAGAMVGACRPPRPVNDFKAV-RTVSVLIGSFTL 236
Cdd:cd15088 157 SpddlywFTIYHFILGFA--VPLVVITVC-----------YILILHRLARGVAPGNQSHGSSRTKRVtKMVILIVVVFIV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461 237 SWSPFLITSIVQVACHKCCL-YQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15088 224 CWLPFHVVQLVNLAMNRPTLaFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
12-287 1.59e-12

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 67.65  E-value: 1.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  12 AVLTILIIAV----NALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15304   4 ALLTVIVIILtiagNILVIMAVSLEKKLQNATNY-FLMSLAIADMLLGFLVMPVsMLTILYGYRWPLPSKLCAVWIYLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLGVSIFQQTTY---HGPCTffaVFHP 163
Cdd:cd15304  83 LFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGIS-MPIPVFGLQDDSKvfkEGSCL---LADE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYcdMLKIASVHsQHIRkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd15304 159 NFVLIGSFVAFFIPLTIMVITY--FLTIKSLQ-QSIS------------------NEQKASKVLGIVFFLFVVMWCPFFI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 244 TSIVQVACHKCC----LYQVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15304 218 TNVMAVICKESCnevvIGGLLNVFVW-IGYLSSAVNPLVYTLFNKTYR 264
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
8-288 1.78e-12

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 67.54  E-value: 1.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15301   4 VIVAAVLSLVTVGGNVMVMISFKID-KQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPLGVSI----FQQTTYHGPCTF-FAVFH 162
Cdd:cd15301  83 ASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL-WPPWIYSWpyieGKRTVPAGTCYIqFLETN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYcdmlkiASVHSQHIRKMEHAgamvgacrpprpvnDFKAVRTVSVLIGSFTLSWSPF- 241
Cdd:cd15301 162 PYVTFGTALAAFYVPVTIMCILY------WRIWRETKKRQKKQ--------------ESKAAKTLSAILLAFIVTWTPYn 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 242 LITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15301 222 VLVLIKAFFPCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
9-288 2.09e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 67.26  E-value: 2.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLS--IYKNDGVGLCftlNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15335   5 LTLALITILTTVLNSAVIAAICTTkkLHQPANYLIC---SLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTffaVFHPRFV 166
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCI---IQHDHVI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LTL--SCAGFF-PAVLLFVFFYcdmlkiasvhsqhirKMEHAGAmvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd15335 159 YTIysTFGAFYiPLTLILILYY---------------RIYHAAS-----------RERKAARILGLILGAFILSWLPFFI 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32401461 244 TSIVqVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15335 213 KELI-VGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKL 256
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
16-287 2.63e-12

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 67.15  E-value: 2.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  16 ILIIAVNALVVVAmllsIYKNDGVGLCFTL---NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCsLRMAFVTSSAAAS 92
Cdd:cd15101  12 IFIMLANLLVIAA----IYKNRRFHFPIYYllaNLAAADFFAGLAYFFLMFNTGPNTRRLTVSTWF-LRQGLLDTSLTAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  93 VLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGgCIAGLWLISYLIGFLPlgvsifqQTTYHGPCTFFAVFHPRFVLTLSCA 172
Cdd:cd15101  87 VANLLAIAVERHISVMRMQLHSRLSNRRVVV-LIVLVWTMAIVMGAIP-------SVGWNCLCAIDACSNMAPLYSRSYL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 173 GFFPAVLLFVFFYcdMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACH 252
Cdd:cd15101 159 VFWAISNLVTFLV--MVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLDGLCC 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32401461 253 KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15101 237 RQCNVLAVEKFFLLLAEFNSAVNPIIYSYRDKEMS 271
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
6-288 4.86e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 66.07  E-value: 4.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15326   2 LLGLVLGAFILFAIVGNILVILSVVcnrhLRIPTN-----YFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL--GVSIFQQTTYHGPCT--- 156
Cdd:cd15326  77 AAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLlgWKEPAPPDDKVCEITeep 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 FFAVFHprfvltlSCAGFFPAVLLFVFFYCDMLKIASVHSQhirkmehagamvgacrpprpvnDFKAVRTVSVLIGSFTL 236
Cdd:cd15326 157 FYALFS-------SLGSFYIPLIVILVMYCRVYIVALKFSR----------------------EKKAAKTLGIVVGMFIL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 237 SWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15326 208 CWLPFFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKR 259
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
6-288 5.02e-12

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 66.09  E-value: 5.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15327   2 GVGVFLAIFILMAIVGNILVILSVACNRHLQT-VTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAvfHPRF 165
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITE--EPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQhirkmehagamvgacrpprpvnDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15327 159 ALFSSLFSFYLPLMVILVMYFRVYVVALKFSR----------------------EKKAAKTLAIVVGVFILCWFPFFFVL 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 246 IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15327 217 PLGSFFPALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKR 259
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
11-288 5.50e-12

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 66.01  E-value: 5.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILII----AVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15306   3 AALLILMVIiptiGGNILVILAVSLEKKLQYATNY-FLMSLAVADLLVGLFVMPIaLLTILFEAMWPLPLVLCPIWLFLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGF-LPL-GVSIFQQTTYHGPCTFFAVFHP 163
Cdd:cd15306  82 VLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIpVPIkGIETDVDNPNNITCVLTKERFG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYcdMLKIASVHSQHIrkmehagamvgacrpprpVNDFKAVRTVSVLIGSFTLSWSPFLI 243
Cdd:cd15306 162 DFILFGSLAAFFTPLAIMIVTY--FLTIHALRKQTI------------------TNEQRASKVLGIVFFLFLLMWCPFFI 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 244 TSIVQVACHKC---CLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15306 222 TNITSVLCDSCnqtTLQMLMEIFVW-IGYVSSGVNPLVYTLFNKTFRD 268
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
9-280 6.41e-12

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 65.81  E-value: 6.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKN---DGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15298   1 VFIATVTGSLSLVTVVGNILVMLSIKVNrqlQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI---GFLPLGVSIFQQTTYHGPCTFFAVFH 162
Cdd:cd15298  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLwapAILFWQFVVGKRTVPDNQCFIQFLSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDmLKIASVHSQhirkmehagamvgacrpprpvndfKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15298 161 PAVTFGTAIAAFYLPVVIMTVLYIH-ISLASARER------------------------KVTRTIFAILLAFILTWTPYN 215
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYA 280
Cdd:cd15298 216 VMVLVNTFCQSCIPDTVWSIGYWLCYV-NSTINPACYA 252
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
44-281 1.00e-11

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 65.45  E-value: 1.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  44 TLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAG 123
Cdd:cd15312  39 ILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIK 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 124 GCIAGLWLISYLIGFlplGVsIFQQTTYHG--------PCTFFAV--FHPRFVLTLSCAGFFPAVLLFVFFYCdmlKIAS 193
Cdd:cd15312 119 VFLVISWSVPCLFAF---GV-VFSEVNLEGiedyvalvSCTGSCVliFNKLWGVIASLIAFFIPGTVMIGIYI---KIFF 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 194 VHSQHIRKMEHAGAmvgaCRPPRPVN------DFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlL 267
Cdd:cd15312 192 VARKHAKVINNRPS----VTKGDSKNklskkkERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVDLFDALVW-L 266
                       250
                ....*....|....
gi 32401461 268 GVGNSLLNPLIYAY 281
Cdd:cd15312 267 GYFNSTCNPLIYGF 280
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
9-282 1.23e-11

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 64.76  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd14964   3 IILSLLTCLGLLGNLLVLL-SLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGV--SIFQQTTYHGPCTFFAVFHprfV 166
Cdd:cd14964  82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGkgAIPRYNTLTGSCYLICTTI---Y 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LTLSCAGFFPAVLLFVFFYCdMLKIASVHSQHIRKMEHAGAmvgacrpPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSI 246
Cdd:cd14964 159 LTWGFLLVSFLLPLVAFLVI-FSRIVLRLRRRVRAIRSAAS-------LNTDKNLKATKSLLILVITFLLCWLPFSIVFI 230
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32401461 247 VQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYW 282
Cdd:cd14964 231 LHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLG 266
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
9-294 1.64e-11

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 64.43  E-value: 1.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLL-SIYKNDGVglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMA 83
Cdd:cd15296   1 VILAVLMALLVVAtvlgNALVILAFVVdSSLRTQGN--FFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYfQIMNGLVAGGCIAglWLISYLIGFLPLGVSIF-------QQTTYHGPCT 156
Cdd:cd15296  79 VDYLLCTASVFNIVLISYDRFLSVTRAVSY-RAQKGMTRQAVLK--MVLVWVLAFLLYGPAIIsweyiagGSIIPEGECY 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 FFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLkiasvhsQHIRKMEHagamvgacrppRPVNDFKAVRTVSVLIGSFTL 236
Cdd:cd15296 156 AEFFYNWYFLMTASTLEFFTPFISVTYFNLSIY-------LNIQKRRF-----------RLSRDKKVAKSLAIIVCVFGL 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 32401461 237 SWSPFLITSIVQVACHKCCLYQVL-EKYLWLLGVgNSLLNPLIYAywqrevrqqLCHMA 294
Cdd:cd15296 218 CWAPYTLLMIIRAACHGHCVPDYWyETSFWLLWV-NSAINPVLYP---------LCHMS 266
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
46-290 1.86e-11

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 64.53  E-value: 1.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  46 NLAVADTLIGVaisGLVTDQLSSSAQHTQ-KTLCSLRMafVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGG 124
Cdd:cd15960  41 SLALADLLAGL---GLIANFVAIYVMNSEaVTLCSAGL--LLAAFSASVCSLLAITVDRYLSLYNALTYHTERTLTFTYG 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 125 CIAGLWLISYLIGFLP-LGVSIFQQTTyhgPCTffaVFHPrfvLTLSCAGFFPAVLLFVF-----FYCDMLKIASVHSQH 198
Cdd:cd15960 116 LLALLWLTCIGIGLLPaMGWNCLRAPA---SCS---VLRP---VTKNNAAVLAVSFLLLFalmmqLYLQICRIAFRHAQQ 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 199 IRKMEH--AGAMVGACRpprpvndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKcclyQVLEKYLWLLGVGNSLLNP 276
Cdd:cd15960 187 IAVQHQfvNFCLASSTR--------KGVSTLSLILATFAFCWVPFAVYSMVADSSYP----MIYTYYLVLPAACNSVINP 254
                       250
                ....*....|....
gi 32401461 277 LIYAYWQREVRQQL 290
Cdd:cd15960 255 IIYAFRNPDIQKSL 268
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
9-290 3.63e-11

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 63.51  E-value: 3.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVvamlLSIYKNDGVGLCFTL---NLAVADTLIGVaisGLVTDQLSSSAQHTQKTLCsLRMAFV 85
Cdd:cd15961   5 IVLCTSGTLISCENAIVV----LIIFQNPSLRAPMFLligSLALADLLAGI---GLILNFIFAYLLQSEAAKL-VTVGLI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTyhgPCTffaVFHPr 164
Cdd:cd15961  77 VASFSASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPvMGWNCLADES---TCS---VVRP- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 fvLTLSCAGFFPAVLLFVF-----FYCDMLKIASVHSQHIRKMEHAGAMvgacrpPRPVNDFKAVRTVSVLIGSFTLSWS 239
Cdd:cd15961 150 --LTKNNAAILSVSFLLMFalmlqLYIQICKIVMRHAHQIALQHHFLAT------SHYVTTRKGVSTLAIILGTFAACWM 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 240 PFLITSIVQVAChkcclYQVLEKYLWLL-GVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15961 222 PFTLYSLIADYT-----YPSIYTYATLLpATYNSIINPVIYAFRNQEIQKAL 268
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
5-282 4.30e-11

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 63.72  E-value: 4.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   5 FSFGVILAVLTiliiavNALVVVAMLLsiYKNDGVGLCFTL-NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMA 83
Cdd:cd15316   7 LGFGAVLAVFG------NLLVMISILH--FKQLHSPTNFLIaSLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFlplgvSIFQQTTYH----------- 152
Cdd:cd15316  79 CDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSF-----SVFYTGVNDdgleelvnaln 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 153 --GPCTffAVFHPRFVLTLSCAGFFPAVLLfVFFYCdmlKIASVHSQHIRKMEHAGAMVGACRPPRPV----NDFKAVRT 226
Cdd:cd15316 154 cvGGCQ--IILNQNWVLVDFLLFFIPTFAM-IILYG---KIFLVAKQQARKIEMTSSKAESSSESYKDrvarRERKAAKT 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 227 VSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYW 282
Cdd:cd15316 228 LGITVIAFLVSWLPYLIDVLIDAFMNFITPPYIYEICCW-CAYYNSAMNPLIYALF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
9-288 4.64e-11

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 63.04  E-value: 4.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd15322   5 ILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNL-FLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQQTTYHGPCTFFAVFHPRFVLT 168
Cdd:cd15322  84 CTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-ITIEKKSGQPEGPICKINDEKWYIIS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 169 LSCAGFFPAVLLFVFFYCDMLKIASVHSQHirkmehagamvgacrpprpvndFKAVrtVSVLIGSFTLSWSPFLITSIVQ 248
Cdd:cd15322 163 SCIGSFFAPCLIMVLVYIRIYQIAKNREKR----------------------FTFV--LAVVIGVFVICWFPFFFTYTLT 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32401461 249 VAChKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15322 219 AVC-DCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 257
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
9-288 5.42e-11

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 62.97  E-value: 5.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVvvamLLSIYKNDGVG---LCFTLNLAVADTLIGVAisglVTDQLSSSAQHTQK---TLCSLRM 82
Cdd:cd15346   5 VVFIIICCFIILENIFV----LLTIWKTKKFHrpmYYFIGNLALSDLLAGVA----YTANLLLSGATTYKltpTQWFLRE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQpLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTyhGPCTFFAVF 161
Cdd:cd15346  77 GSMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSFRSFLLISACWVISLILGGLPiMGWNCISALS--SCSTVLPLY 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTlsCAGFFPAVLL-FVFFYCdmlKIASVHSQHIRKMEHAGAMVGACRppRPVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15346 154 HKHYILF--CTTVFTLLLLsIVILYC---RIYSLVRTRSRRLTFRKNIRKASR--SSEKSMALLKTVIIVLSVFIACWAP 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32401461 241 FLITSIVQVACH-KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15346 227 LFILLLLDVGCKvKTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRR 275
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
10-288 1.42e-10

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 61.74  E-value: 1.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNAL----VVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15972   1 VLIPLVYLVVCVVGLggntLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAA-QNALSYWPFGSFMCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPlgVSIFQQTTYHGPCTFFA------ 159
Cdd:cd15972  80 AINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLV-VLP--VVIFSGVPGGMGTCHIAwpepaq 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLSCAGFFPAVLlfVFFYCDMLKIASVHSqhirkmehAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWS 239
Cdd:cd15972 157 VWRAGFIIYTATLGFFCPLL--VICLCYLLIVVKVRS--------SGRRVRATSTKRRGSERKVTRMVVIVVAAFVLCWL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 240 PFLITSIVQVACH--KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15972 227 PFYALNIVNLVCPlpEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
6-250 1.56e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 61.97  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCrfksLRTPAN-----YLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCTFFAV 160
Cdd:cd15083  77 GFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLfGWSRYVLEGLLTSCSFDYL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 ---FHPR-FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKM-EHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFT 235
Cdd:cd15083 157 srdDANRsYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMaKRFSKSELSSPKARRQAEVKTAKIALLLVLLFC 236
                       250
                ....*....|....*
gi 32401461 236 LSWSPFLITSIVQVA 250
Cdd:cd15083 237 LAWTPYAVVALIGQF 251
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
12-290 1.69e-10

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 61.80  E-value: 1.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  12 AVLTILIIAVNALVVVAmlLSIYKNDGVGLCF-TLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAA 90
Cdd:cd15318   8 AIGMLIIVLGNLFVVVT--VSHFKALHTPTNFlLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  91 ASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYH--------GPCTffaVFH 162
Cdd:cd15318  86 TSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAElltsvpcvGSCQ---LLY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvGACRPPRpvndfKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15318 163 NKLWGWLNFPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTN--GASKRER-----KAAKTLGIAVGVYLLCWLPFT 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15318 236 IDTMVDSLLNFITPPLLFDIIIW-FAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
8-287 2.82e-10

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 60.95  E-value: 2.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAmllsIYKNDGVGL---CFTLNLAVADTL-----------IGVAISGLVTDQLSSsaqht 73
Cdd:cd15350   4 EEVFFTIAAVGLLENLLVLVA----VIKNKNLHSpmyFFICSLAVSDMLgslyktlenilIILADMGYLNRRGPF----- 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  74 QKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTyhg 153
Cdd:cd15350  75 ETKLDDIMDSLFCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMILFFHFVATV--- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 154 pcTFFAVFhprfvltlscagFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMvgacrppRPVNDFKAVRTVSVLIGS 233
Cdd:cd15350 152 --ICFTVL------------FFLMLVLILCLYVHMFLLARSHARKIASLPNHHAQ-------HQRSNMRGAITLTILLGV 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 234 FTLSWSPFLITSIVQVACHK---CCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15350 211 FVCCWAPFVLHLLLMMFCPMnpyCACYRSLFQVNGTLIMSHAVIDPAIYAFRSPELR 267
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
6-290 3.21e-10

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 60.60  E-value: 3.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVvvamLLSIYKND---GVGLCFTLNLAVADTLIGVA------ISGLVTDQLSSSAQHTQKT 76
Cdd:cd15347   2 VASIFIVILCCIIVLENLLV----LIAVARNKkfhSAMFFFIGNLAFSDLLAGVAfianilLSGSVTFRLTPVQWFIREG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 lcslrMAFVTSSAaaSVLTVMLIAFDRYLAIKQPLRYFQIMNG---LVAGGCiaglWLISYLIGFLP-LGVS-IFQQTTY 151
Cdd:cd15347  78 -----TAFITLSA--SVFSLLAIAIERHVAITKVKLYGSDKNCrmvLLIGAC----WVISIVLGGLPiLGWNcIGNLEDC 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 152 HGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCdmlkiasvhsqhIRKMEHAGAmvgaCRPPRpvndFKAVRTVSVLI 231
Cdd:cd15347 147 STVLPLYSKHYILFVVTIFSIILLSIVILYVRIYC------------IVRSSHAEM----AAPQT----LALLKTVTIVL 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 232 GSFTLSWSPFLITSIVQVACH-KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15347 207 GVFIVCWLPAFIILLLDTSCKvKSCPILYKADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
9-279 3.33e-10

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 60.90  E-value: 3.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAisGLVTDQL--SSSAQHTQKTLCSL--RMAF 84
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNF-FITQLAIADLCVGLI--NVLTDIIwrITVEWRAGDFACKVirYLQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIafDRYLAIKQPLRYFQimNGLVAGGCIAGLWLISYLIGfLPLGVsIFQQTTY---HGPC--TFFA 159
Cdd:cd15197  82 VVTYASTYVLVALSI--DRYDAICHPMNFSQ--SGRQARVLICVAWILSALFS-IPMLI-IFEKTGLsngEVQCwiLWPE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLSCAGFF--PAVLLFVFFYCDMLKI---ASVHSQHIRKMEHAGAMVGA-CRPPRPVNDFKAVRTVSVLIGS 233
Cdd:cd15197 156 PWYWKVYMTIVAFLVFfiPATIISICYIIIVRTIwkkSKIQVTINKAGLHDGSSRRSsSRGIIPRAKIKTIKMTFVIVTV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461 234 FTLSWSPFLITSIVQVachkcclYQVLEKYLWLLGVG---------NSLLNPLIY 279
Cdd:cd15197 236 FIICWSPYFVFDLLDV-------FGLLPRSKTKIAAAtfiqslaplNSAINPLIY 283
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
7-288 4.30e-10

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 60.18  E-value: 4.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTlNLAVADTLIGVA------ISGLVTDQLSSSaqhtqktLCSL 80
Cdd:cd15349   3 LTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLA-NIALSDLLTGTSylvnicLSGERTFRLTPA-------LWFL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  81 RMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgvsifqqTTYHGPCTFfav 160
Cdd:cd15349  75 REGLLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPL-------LGWNCLCDF--- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 fhprfvltLSCAGFFP----AVLLF--VFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSF 234
Cdd:cd15349 145 --------RSCSSLLPlyskSYILFclVIFFIILLTIIGLYFAIYCLVRASGQRVISARSRR--RSLRLLKTVLMILGAF 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461 235 TLSWSPFLITSIVQVACH-KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15349 215 MVCWGPLFILLLVDFFCSsRSCKPLFGMEWVLALAVLNSAINPLIYSFRSLEVRR 269
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
13-287 5.02e-10

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 59.85  E-value: 5.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  13 VLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGL-VTDQLSSSAQHTQKTLCSLRMAFVTSSAAA 91
Cdd:cd15308   9 LLILAIIAGNVLVCLSVCTERALKTTTNY-FIVSLAVADLLLALLVLPLyVYSEFQGGVWTLSPVLCDALMTMDVMLCTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  92 SVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGflplGVSIFQQTTYHGPCTFFAVFHPR-FVLTLS 170
Cdd:cd15308  88 SIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVA----SPVIFGLNNVPNRDPAVCKLEDNnYVVYSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 171 CAGFFPAVLLFVFFYCDMLKiasvhsqhirkmehagamvGACRpprpvnDFKAVRTVSVLIGSFTLSWSPFLITSIVQVA 250
Cdd:cd15308 164 VCSFFIPCPVMLVLYCAMFR-------------------GLGR------ERKAMRVLPVVVGAFLFCWTPFFVVHITRAL 218
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32401461 251 CHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15308 219 CESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
9-288 6.43e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 59.81  E-value: 6.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd15974   1 VLIPVIYLLVCAIglsgNTLVIY-VVLRYAKMKTVTNIYILNLAVADELFMLGLPFLAT-QNAISYWPFGSFLCRLVMTV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPLGVSIFQQTTYHgPCTF-----FA 159
Cdd:cd15974  79 DGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLV-VLPVIIFSDVQPDLN-TCNIswpepVS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLSCAGFFPAVLlfVFFYCDMLKIASVHSqhirkmehAGAMVGACRppRPVNDFKAVRTVSVLIGSFTLSWS 239
Cdd:cd15974 157 VWSTAFIIYTAVLGFFGPLL--VICLCYLLIVIKVKS--------SGLRVGSTK--RRKSERKVTRMVVIIVVVFVFCWL 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 240 PFLITSIVQ--VACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15974 225 PFYMLNIVNliVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
43-281 7.44e-10

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 59.62  E-value: 7.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSaQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd14970  38 YILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLIGFlplgvsifqqttyhgPCTFFAVFHPRFVLTLSCAGFFPA----------VLLFVF-FYCDMLKI 191
Cdd:cd14970 117 KLVSLCVWALSLVLGL---------------PVIIFARTLQEEGGTISCNLQWPDppdywgrvftIYTFVLgFAVPLLVI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 192 ASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWL--LGV 269
Cdd:cd14970 182 TVCYSLIIRRLRSSRNLSTSGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCiaLSY 261
                       250
                ....*....|..
gi 32401461 270 GNSLLNPLIYAY 281
Cdd:cd14970 262 ANSCLNPILYAF 273
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
41-281 7.92e-10

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 59.79  E-value: 7.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  41 LCFTLNLAVADTLIGVAISGL-VTDQLSSSAQ-HTQKTLCSLRMAFVTssaaASVLTVMLIAFDRYLAIKQPLRYFQIMN 118
Cdd:cd15070  36 FYFIVSLALADIAVGVLVIPLaIVVSLGVTIHfYSCLFMSCLLVVFTH----ASIMSLLAIAVDRYLRVKLTVRYRIVTT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 119 GLVAGGCIAGLWLISYLIGFLPL-----GVSIFQQTTYHGPCTFFAVFHPRFVLTLScagFF-----PAVLLFVFFYCDM 188
Cdd:cd15070 112 QRRIWLALGLCWLVSFLVGLTPMfgwnrKPSLESVNTTPLQCQFTSVMRMDYMVYFS---FFtwiliPLVIMCALYVDIF 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 189 LKIASVHSQHIRKMEHAGAMVGacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKcclyqvLEKYLWLLG 268
Cdd:cd15070 189 YIIRNKLSQNATGFRETGAFYG--------REFKTAKSLALVLFLFAVCWLPLSIINCVVYFNPK------VPKIALYLG 254
                       250
                ....*....|....*..
gi 32401461 269 V----GNSLLNPLIYAY 281
Cdd:cd15070 255 IllshANSMMNPIVYAC 271
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
89-290 8.78e-10

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 59.18  E-value: 8.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISyLIGFLP--LGVSIFQQTTYHGPCTffAVFHPRFV 166
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHS-LIGCLPplFGWSSLEFDRFKWMCV--AAWHKEAG 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LT----LSCAgFFPAVLLFVFfYCDMLKIASVhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15214 160 YTafwqVWCA-LLPFVVMLVC-YGFIFRVARA------------------------NQCKAFITILVVLGAFVTTWGPYM 213
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15214 214 VVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
9-287 1.69e-09

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 58.61  E-value: 1.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLLSIYKNDGVGLcFTLNLAVAD-----TLIGVAISGLVTDQLSSSAQhtqktLCS 79
Cdd:cd15193   1 IYIPILYLIIFFTgllgNLFVIALMSKRSTTKRLVDT-FVLNLAVADlvfvlTLPFWAASTALGGQWLFGEG-----LCK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  80 LRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFA 159
Cdd:cd15193  75 LSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCVEDSSSR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPrFVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqHIRKMEHAGAMVGACRPprpvndfKAVRTVSVLIGSFTLSWS 239
Cdd:cd15193 155 FFQG-ISLATLFLTFVLPLIVILFCYCSILV-------RLRRHFHGAKRTGRRRR-------NSLRIVFAIVTAFVLSWL 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 240 PFLITSIVQVACHK------CCLYQVLEKYLWL---LGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15193 220 PFNTLKAVRLLLELgggvlpCHTTVAIRQGLTItacLAFVNSCVNPLIYSLLDRHFR 276
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
15-288 1.73e-09

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 58.68  E-value: 1.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  15 TILIIAVNALVVV---AMLLSIYKNDGVG---LCFTLNLAVADTLIGVA------ISGLVTDQLSSsaqhtqkTLCSLRM 82
Cdd:cd15345   4 TIFFLVICSFIVLenlMVLIAIWKNNRFHnrmYFFIGNLALCDLLAGIAykvnilMSGKKTFSLSP-------TQWFLRE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNG---LVAGGCiaglWLISYLIGFLP-LGVSIFQQTtyHGPCTFF 158
Cdd:cd15345  77 GSMFVALGASTFSLLAIAIERHLTMIKMRPYDANKRYrvfLLIGTC----WLISVLLGALPiLGWNCLDNL--PDCSTIL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 159 AVFHPRFVLTlsCAGFFPAVLL-FVFFYCDMLKIASVHSQHI---RKMEHAGAMVgacrpprpvndfkavRTVSVLIGSF 234
Cdd:cd15345 151 PLYSKKYVAF--CISIFIAILVaIVILYARIYILVKSSSRRVtnhRNSERSMALL---------------RTVVIVVGVF 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 235 TLSWSPFLITSIVQVACH-KCClyQVLEKYLWL--LGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15345 214 IACWSPLFILLLIDVACEvKQC--PILYKADWFiaLAVLNSAMNPIIYTLASKEMRR 268
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
9-290 1.82e-09

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 58.79  E-value: 1.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLlsiyKND---GVGLCFTLNLAVADTLIGV------AISGLVTdqlsssAQHTQK 75
Cdd:cd15207   1 VLFIVSYSLIFLLcvvgNVLVCLVVA----KNPrmrTVTNYFILNLAVSDLLVGVfcmpftLVDNILT------GWPFGD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  76 TLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGfLPLGVsIFQQTTYHgpc 155
Cdd:cd15207  71 VMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIM-IPQAL-VLEVKEYQ--- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 tffavfHPRFVLTLSCAGFFP--------AVLLFVFFYCDMLKIASV-HSQHIRKMEHAgAMVGACRPPRPVND------ 220
Cdd:cd15207 144 ------FFRGQTVHICVEFWPsdeyrkayTTSLFVLCYVAPLLIIAVlYVRIGYRLWFK-PVPGGGSASREAQAavskkk 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 221 ---FKAVRTVSVLigsFTLSWSPFLITSIVQV-ACHKCCLYQVLEKYLW----LLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15207 217 vrvIKMLIVVVVL---FALSWLPLHTVTMLDDfGNLSPNQREVLYVYIYpiahWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
8-288 2.26e-09

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 57.98  E-value: 2.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15325   4 GVILGGFILFGVLGNILVILSVACHRHLQT-VTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMN---GLVAGGCIaglWLISYLIGFLPLgvSIFQQTTYHGPCTFFAVFHPR 164
Cdd:cd15325  83 CCTASIMSLCIISIDRYIGVSYPLRYPSIMTerrGLLALLCV---WVLSLVISIGPL--FGWKEPAPEDETICQITEEPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQhirkmehagamvgacrpprpvnDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15325 158 YALFSALGSFYLPLAIILVMYCRVYVVALKFSR----------------------EKKAAKTLGIVVGCFVLCWLPFFLV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32401461 245 SIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15325 216 MPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
16-290 3.52e-09

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 57.53  E-value: 3.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  16 ILIIAVNALVVV---AMLLSIYKNDGVGLCFTL---NLAVADTLIGVA------ISGLVTDQLSSSaqhtqktLCSLRMA 83
Cdd:cd15348   5 VAFLAVCAFIVLenlIVLLALWRNKKFHSPMFYllgSLTLSDLLAGAAyaanilMSGANTLKLTPA-------LWFLREG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGgCIAGLWLISYLIGFLP-LGVSIFqqTTYHGPCTFFAVFH 162
Cdd:cd15348  78 GVFITLTASVFSLLAIAIERHITMVRMKPYPGDKRGRMFL-LIGAAWLVSILLGVLPiLGWNCL--GNLDACSTVLPLYA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTlsCAGFFPAVLL-FVFFYCDMLKIASVHSQHIRKMEHAGAMvgACRPPRPVndfKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15348 155 KSYILF--CITVFLAILAaIVVLYARIYRIVKANSQRLGALPTRKGR--ARRSQKYL---ALLKTVTIVLGTFVACWLPL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32401461 242 LITSIVQVACH-KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15348 228 FLLLLLDVSCPaQACPVLLKADYFLGLAMINSLLNPIIYTLTSRDMRRAI 277
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
43-290 4.40e-09

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 57.27  E-value: 4.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSL-RMAFVTSsAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLV 121
Cdd:cd14982  38 YMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLtGLLFYIN-MYGSILFLTCISVDRYLAVVHPLKSRRLRRKRY 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 122 AGGCIAGLWLISyLIGFLPLGVSIFQQTTYHGPCTFFAvFHPRFVLTLSCAGFFPAVLLFVFFycdMLKIASVHSQHIRK 201
Cdd:cd14982 117 AVGVCAGVWILV-LVASVPLLLLRSTIAKENNSTTCFE-FLSEWLASAAPIVLIALVVGFLIP---LLIILVCYSLIIRA 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 202 MehagaMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSI--------VQVACHKCCLYQVLEKYLWLLGVGNSL 273
Cdd:cd14982 192 L-----RRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRIlyllvrlsFIADCSARNSLYKAYRITLCLASLNSC 266
                       250
                ....*....|....*..
gi 32401461 274 LNPLIYAYWQREVRQQL 290
Cdd:cd14982 267 LDPLIYYFLSKTFRKRL 283
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
10-281 5.11e-09

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 57.09  E-value: 5.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdQLSSSAQHTQKTLCSLRMAFVTSSA 89
Cdd:cd15093   6 IYAVVCLVGLCGNSLVIY-VVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAA-SNALRHWPFGSVLCRLVLSVDGINM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  90 AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPlgVSIFQQTTYHG----PCTF-----FAV 160
Cdd:cd15093  84 FTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLV-ILP--VVVFAGTRENQdgssACNMqwpepAAA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLTLSCAGFFPAVLLFVFFYCDMlkiasvhsqhIRKMEHAGAMVGACRppRPVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15093 161 WSAGFIIYTFVLGFLLPLLIICLCYLLI----------VIKVKSAGLRAGWQQ--RKRSERKVTRMVVMVVVVFVICWLP 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 241 FLITSIVQVACHKCC--LYQVLEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd15093 229 FYVLQLVNVFVQLPEtpALVGVYHFVVILSYANSCANPILYGF 271
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
7-288 7.36e-09

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 56.52  E-value: 7.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAML----LSIYKNdgvglCFTLNLAVADTLIG-VAISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15310   3 YALSYCALILAIVFGNVLVCMAVLreraLQTTTN-----YLVVSLAVADLLVAtLVMPWVVYLEVTGGVWNFSRICCDVF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYfqiMNGLVAGGC------IAGLWLISYLIGfLPLgvsIFQQTTYHGPc 155
Cdd:cd15310  78 VTLDVMMCTASILNLCAISIDRYTAVVMPVHY---QHGTGQSSCrrvslmITAVWVLAFAVS-CPL---LFGFNTTGDP- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 TFFAVFHPRFVLTLSCAGFF----PAVLLFVFFYCDMLKiasvhsqhirkmehagamvgacrpprpvnDFKAVRTVSVLI 231
Cdd:cd15310 150 TVCSISNPDFVIYSSVVSFYlpfgVTLLVYVRIYVVLLR-----------------------------EKKATQMLAIVL 200
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 232 GSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15310 201 GAFIVCWLPFFLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
10-290 8.23e-09

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 56.40  E-value: 8.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSA 89
Cdd:cd15194   5 ILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  90 AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFV--- 166
Cdd:cd15194  85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPSKVIfsl 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 167 LTLSCAGFFPaVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvgacrpprpvndfKAVRTVSVLIGSFTLSWSPFLITSI 246
Cdd:cd15194 165 VSLIVAFFLP-LLSILTCYCTIIWKLCHHYQKSGKHQKKLR--------------KSIKIVFIVVAAFVFSWMPFNLFKA 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 247 VQVAC-----HKCCLYQVLEKYLWL---LGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15194 230 LAIASglqveVTCLPYTLAQLGMEVsapLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
12-280 1.25e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 56.26  E-value: 1.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  12 AVLTILIIAV--NALVVVAMllsiYKNDGV---GLCFTLNLAVADTLIGVAISGLvtdqLSSSAQHTQ----KTLCSLrM 82
Cdd:cd15336   6 VILIIGITGMlgNALVIYAF----CRSKKLrtpANYFIINLAVSDFLMSLTQSPI----FFVNSLHKRwifgEKGCEL-Y 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTS-SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCTF-FA 159
Cdd:cd15336  77 AFCGAlFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLfGWSAYVPEGLLTSCTWdYM 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPR---FVLTLSCAGFFpaVLLFVFFYCDMLKIASVHS--QHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSF 234
Cdd:cd15336 157 TFTPSvraYTMLLFCFVFF--IPLGIIIYCYLFIFLAIRStgREVQKLGSQDRKEKAKQYQRMKNEWKMAKIAFVVILLF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 235 TLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYA 280
Cdd:cd15336 235 VLSWSPYACVALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYA 280
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
10-141 1.34e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 56.05  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILiiavNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGV---AISglVTDQL------SSSAQHTQKTLCSL 80
Cdd:cd15137   9 VVGIIALL----GNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVyllIIA--SVDLYyrgvyiKHDEEWRSSWLCTF 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461  81 RMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQImNGLVAGGCIAGLWLISYLIGFLPL 141
Cdd:cd15137  83 AGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVLPL 142
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
10-281 1.44e-08

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 56.01  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdQLSSSAQHTQKTLCSLRMAFVTSSA 89
Cdd:cd15971   6 IYFVVCIIGLCGNTLVIY-VILRYAKMKTVTNIYILNLAIADELFMLGLPFLAI-QVALVHWPFGKAICRVVMTVDGINQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  90 AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFF-----AVFHPR 164
Cdd:cd15971  84 FTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIwpgesSAWYTG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAGFFpaVLLFVFFYCDMLKIASVHSQHIRkmehagamVGACRppRPVNDFKAVRTVSVLIGSFTLSWSPFLI- 243
Cdd:cd15971 164 FIIYTFILGFF--VPLTIICLCYLFIIIKVKSSGIR--------VGSSK--RKKSEKKVTRMVSIVVAVFVFCWLPFYIf 231
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32401461 244 -TSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd15971 232 nVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAF 270
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
10-288 1.61e-08

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 55.35  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAV----NALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15210   2 FAAVWGIVFMVVgvpgNLLTVLA-LLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPLGVSI---FQQTTYHGPCTFFAVFH 162
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGS-FLPLWLGIwgrFGLDPKVCSCSILRDKK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PR-FVLTLSCAGFFPAVLLFVFFYcdmlkiasvhsqhirkmehagamvgACRpprpvNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15210 160 GRsPKTFLFVFGFVLPCLVIIICY-------------------------ARR-----EDRRLTRMMLVIFLCFLVCYLPI 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 242 LITSIVqvacHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15210 210 TLVNVF----DDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
9-288 1.69e-08

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 55.76  E-value: 1.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd15096   5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNI-LILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIM---NGLVAggcIAGLWLIsYLIGFLPLG-----VSIFQQTTYHGPCTFFAV 160
Cdd:cd15096  84 AYASVYTLVLMSLDRYLAVVHPITSMSIRterNTLIA---IVGIWIV-ILVANIPVLflhgvVSYGFSSEAYSYCTFLTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHP---RFVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqHIRKMehaGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLS 237
Cdd:cd15096 160 VGTaaqTFFTSFFLFSYLIPLTLICVLYMLMLR-------RLRRQ---KSPGGRRSAESQRGKRRVTRLVVVVVVVFAIC 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 238 WSPFLITSIVQVACH--KCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15096 230 WLPIHIILLLKYYGVlpETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
9-288 1.93e-08

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 55.69  E-value: 1.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILiiaVNALVVVAMLLSIYKNDGVGLCFTLNLAVADtLIGVAIsgLVTDQLSSSAQHTQKT--LCSLRMAFVT 86
Cdd:cd15340   8 LTLGTFTVL---ENLLVLCVILHSRSLRCRPSYHFIGSLAVAD-LLGSVI--FVYSFLDFHVFHRKDSpnVFLFKLGGVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgvSIFQQTTYHGPCT-FFAVFHPRF 165
Cdd:cd15340  82 ASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPL--LGWNCKKLNSVCSdIFPLIDETY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLscAGFFPAVLLFVfFYCDMLKIASVHSQHIRKMEHA-----------GAMVGACRPPRPVNDFKAVRTVSVLIGSF 234
Cdd:cd15340 160 LMFW--IGVTSVLLLFI-VYAYMYILWKAHHHAVRMLQRGtqksiivytseDGKVQTTRPDQTRMDIRLAKTLVLILVVL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461 235 TLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15340 237 IICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 290
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
11-290 2.08e-08

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 55.23  E-value: 2.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAVNALVVVAMLLSIYKNDGV----GLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCsLRMAFVT 86
Cdd:cd15341   3 IAVLCTLCGLLCILENVAVLYLILSSPKLrrkpSYLFIGSLALADFLASVVFACSFVDFHVFHGVDSSAIFL-LKLGGVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTyhgPCT-FFAVFHPR 164
Cdd:cd15341  82 MSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLmGWNCCPLNS---PCSeLFPLIPND 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCagfFPAVLLFVFFYCDMLKIASVHsQHIRKMEHAGAMVGAcRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15341 159 YLLSWLL---LVAILLSGIIYTYGHVLWKAH-KHVVYMEKHQDQQGP-GNARMRLDVRLAKTLGLVLAVLLICWSPVLAL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 245 SIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15341 234 MMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
46-286 2.40e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 55.27  E-value: 2.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  46 NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLcSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQplryFQIMNGLVAGGC 125
Cdd:cd15343  41 NLAAADFFAGIAYVFLMFNTGPVSKTLTVNRW-FLRQGLLDTSLSASLTNLLVIAVERHISIMR----MKVHSNLTKRRV 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 126 ---IAGLWLISYLIGFLP-LGVSIFQQTTyhgPCTFFAVFHPRFVLT----LSCAGFFPAVLLFVFFYCDMLKIASVHSq 197
Cdd:cd15343 116 tllIALVWAIAIFMGAVPtLGWNCICNIS---ACSSLAPIYSRSYLVfwsvSNLVVFLIMVVVYLRIYVYVQRKTNVLS- 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 198 hirkmEHAGAMVGACRPPrpvndFKAVRTVSVLIGSFTLSWSPFLITSIVQ-VACHKCCLYQVlEKYLWLLGVGNSLLNP 276
Cdd:cd15343 192 -----PHTSGSINRRRTP-----IKLMKTVMTVLGAFVICWTPGLVVLLLDgLNCTRCGVQHV-KRWFLLLALLNSVMNP 260
                       250
                ....*....|
gi 32401461 277 LIYAYWQREV 286
Cdd:cd15343 261 IIYSYKDEEM 270
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
8-290 3.28e-08

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 54.75  E-value: 3.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSiyKN-DGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHT-QKTLCSLRMAFV 85
Cdd:cd15302   4 ALITAILSIITVIGNILVLLSFYVD--RNiRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYWPlGWVLCDLWLSVD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFlplgVSIFQQTTYHG--------PCTF 157
Cdd:cd15302  82 YTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFF----ISIFGWQYFTGqgrslpegECYV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 FAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLS 237
Cdd:cd15302 158 QFMTDPYFNMGMYIGYYWTTLIVMLILYAGIYRAAN-------------------------RARKALRTITFILGAFVIC 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461 238 WSPFLITSIVQVAC-HKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15302 213 WTPYHILATIYGFCeAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
7-288 4.37e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.19  E-value: 4.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGV-----AISGLVTDQLSSSAQHTQKTLCsLR 81
Cdd:cd15307   3 WALLALVLVLGTAAGNILVCLAIAWE-RRLQNVTNYFLMSLAITDLMVAVlvmplGILTLVKGHFPLSSEHCLTWIC-LD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTssaaASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISyLIGFLPLgvSIFQQTTYH-----GPCT 156
Cdd:cd15307  81 VLFCT----ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLS-IAMSLPL--SLMYSKDHAsvlvnGTCQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 ffaVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKI-ASVHSQHIR--KMEHagamvgacrpprpvndfKAVRTVSVLIGS 233
Cdd:cd15307 154 ---IPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLlARQRSRHGRiiRLEQ-----------------KATKVLGVVFFT 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 234 FTLSWSPFLITSIVQVACHKCCLY---QVLEKYLWlLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15307 214 FVILWSPFFVLNLLPTVCAECEERishWVFDVVTW-LGYASSMVNPIFYTIFNKVFRQ 270
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
9-288 4.69e-08

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 54.29  E-value: 4.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNA-LVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGV------AISGLVTDQLSSSAqhtqkTLCSLR 81
Cdd:cd15392   3 IILMYSTIFVLAVGGnGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVfcvpfsFIALLILQYWPFGE-----FMCPVV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGF-LPLGVSIFQQTTYHGPCTFFAV 160
Cdd:cd15392  78 NYLQAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALpIAITSRLFEDSNASCGQYICTE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFV------LTLSCAGFFPAVLLFVFFYCdmlkiasvhsqhirkmeHAGAMVGACRPPRPV----------NDFKAV 224
Cdd:cd15392 156 SWPSDTnryiysLVLMILQYFVPLAVLVFTYT-----------------RIGIVVWAKRTPGEAennrdqrmaeSKRKLV 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 225 RTVSVLIGSFTLSWSPFLITSIVQVAcHKCCLYQVLEKYLWL----LGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15392 219 KMMITVVAIFALCWLPLNILNLVGDH-DESIYSWPYIPYLWLaahwLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
7-288 5.64e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 53.82  E-value: 5.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLrMAFV- 85
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNV-FLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLq 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPL--RYFQIMNGlvAGGCIAGLWLISYLIGFlPlgvSIFQQTTY-HGPCTFFAVFH 162
Cdd:cd15001  80 LLSFICSVLTLTAISIERYYVILHPMkaKSFCTIGR--ARKVALLIWILSAILAS-P---VLFGQGLVrYESENGVTVYH 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYcdMLKIASVHSQHIRKMEhagamvgacrpprpvndFKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15001 154 CQKAWPSTLYSRLYVVYLAIVIF--FIPLIVMTFAYARDTR-----------------KQVIKMLISVVVLFAVCWGPLL 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32401461 243 ITSIVQVACHKCCLYQVLEKYL----WLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15001 215 IDNLLVSFDVISTLHTQALKYMriafHLLSYANSCINPIIYAFMSKNFRS 264
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
9-292 1.01e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 53.29  E-value: 1.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLL-------SIYkndgvglcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLR 81
Cdd:cd15295   5 FLMSLLALVIVLGNALVIIAFVVdknlrhrSNY--------FFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNG-LVAGGCIAGLWLISYLIGFlPLGVSIFQQTTYHGPCTFFAV 160
Cdd:cd15295  77 LVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHG-PAILVSDSWKTEDGECEPEFF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLTLSCAGFFPAVLLFVFFycDMLKIASVHSQhirkmehagamvgacrpprpVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15295 156 SNWYILAITSVLEFLVPVILVAYF--NTQIYWSLWKR--------------------LRDRKLAKSLAIILGTFAICWAP 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 241 FLITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYAywqrevrqqLCH 292
Cdd:cd15295 214 YSLFTIIRAACEKHRGSPWYNFAFWLQWF-NSFINPFLYP---------LCH 255
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
45-290 1.16e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 53.26  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  45 LNLAVADTLigVAISGLVTDQLSSSAQH--TQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15082  53 VNLSVADFL--VSLTGGTISFLTNARGYffLGVWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAA 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGcIAGLWLISYLIGFLP-LGVSIFQQTTYHGPCT---FFAVFHPR-FVLTLSCAGFFPAVLLFVFFYCDMLkiasvhsQ 197
Cdd:cd15082 131 LG-LLFVWTFSFIWTIPPvLGWSSYTVSKIGTTCEpnwYSGNMHDHtYIITFFTTCFILPLGVIFVSYGKLL-------Q 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 198 HIRKMEHAGAMVGACRPPrpvnDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPL 277
Cdd:cd15082 203 KLRKVSNTQGRLGNARKP----ERQVTRMVVVMIVAFMVCWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPI 278
                       250
                ....*....|...
gi 32401461 278 IYAYWQREVRQQL 290
Cdd:cd15082 279 IYVFMNKQFRKCL 291
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
94-171 1.47e-07

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 52.49  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPlgVSIFQQTTYHGPCT---FFAVFHPrfVLTLS 170
Cdd:cd15911  91 LAVM--SYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTIT--VILMSQLTFCGPNEidhFFCDFAP--LLKLS 164

                .
gi 32401461 171 C 171
Cdd:cd15911 165 C 165
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
43-290 1.48e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 52.89  E-value: 1.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15338  41 FIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVA 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLigflplgvSIFqqttyhgPCTFFAVFHPRFVLTLSCAGFFPA-------VLLFVFFYCDMLKIASVH 195
Cdd:cd15338 121 VAVICLVWILSLL--------SIT-------PVWMYAGLMPLPDGSVGCALLLPNpetdtywFTLYQFFLAFALPLVVIC 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 196 SQHIRKMEHAGAMVgACRPPRP--VNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCL-YQVLEKYLWLLGVGNS 272
Cdd:cd15338 186 VVYFKILQNMASTV-APLPQRSlrVRTKKVTRMAVAICLAFFICWAPFYILQLAHLSIDRPSLaFLYAYNVAISMGYANS 264
                       250
                ....*....|....*...
gi 32401461 273 LLNPLIYAYWQREVRQQL 290
Cdd:cd15338 265 CINPFLYIMLSETFKRQF 282
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
78-172 1.86e-07

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 52.49  E-value: 1.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAA--SVLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQQtTYHGPC 155
Cdd:cd13954  73 CLTQLYFFFSLGGTecFLLAVM--AYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHT-VLISQL-PFCGSN 148
                        90       100
                ....*....|....*....|
gi 32401461 156 T---FFAVFHPrfVLTLSCA 172
Cdd:cd13954 149 VinhFFCDIPP--LLKLSCS 166
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
9-290 4.08e-07

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 51.61  E-value: 4.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLLSIyKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd14985   1 VVIPALYIAIFLVgllgNLFVVWVFLFPR-GPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPL--RYFQIMngLVAGGCIAGLWLISYLIGfLPLGVSIFQQTTYHGPCTFFAVFH 162
Cdd:cd14985  80 ISVNMFASIFLLTCMSVDRYLAIVHPVasRRLRRR--RQARVTCALIWVVACLLS-LPTFLLRSLQAIENLNKTACIMLY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PR------FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMehagamvgacrppRPVNDfKAVRTVSVLIGSFTL 236
Cdd:cd14985 157 PHeawhfgLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKN-------------GRKRR-KSLKIIFALVVAFLV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32401461 237 SWSPFLITSIVQV-----ACHKCCLYQVLE---KYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd14985 223 CWLPFHFFKFLDFlaqlgAIRPCFWELFLDlglPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
47-291 4.38e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 51.48  E-value: 4.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  47 LAVADtLIGVAISGLVTDQLSSSAQHTQ--KTLCSLrMAFV---TSSAAASVLTVMliAFDRYLAIKQPLRYFQIMNGLV 121
Cdd:cd14981  44 LAITD-LLGILLTSPVVLAVYASNFEWDggQPLCDY-FGFMmsfFGLSSLLIVCAM--AVERFLAITHPFFYNSHVKKRR 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 122 AGGCIAGLWLISYLIGFLPL-GVSIFQQttyHGPCTF-FAVFHPRFVLTLSCAGFFP---AVLLFVFFYCDMLKIASVHS 196
Cdd:cd14981 120 ARLMLGAVWAFALLIASLPLlGLGSYVL---QYPGTWcFLDFYSKNTGDAAYAYLYSilgLLILLVTLLCNLLVIITLLR 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 197 QHIRKMEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVachkccLYQVLEKYLWLL-----GVGN 271
Cdd:cd14981 197 MRRRKKRHRRSRRSARRQKR--NEIQMVVLLLAITVVFSVCWLPLMIRVLINA------TGDSEKNGKTDLlavrmASWN 268
                       250       260
                ....*....|....*....|
gi 32401461 272 SLLNPLIYAYWQREVRQQLC 291
Cdd:cd14981 269 QILDPWVYILLRKEVLRRLY 288
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
78-183 5.14e-07

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 50.91  E-value: 5.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAA--SVLTVMliAFDRYLAIKQPLRYFQIMNGlvaGGCI---AGLWLISYLIGFLplgvsifqqttyH 152
Cdd:cd15227  73 CVAQVFLFIFFAASelALLTVM--AYDRYVAICHPLHYEVIMNR---GACVqmaAASWLSGLLYGAL------------H 135
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 32401461 153 GPCTFFAVF-HPRFV----------LTLSCAGFFPA-VLLFVF 183
Cdd:cd15227 136 TANTFSLPFcGSNVIhqffcdipqlLKLSCSDTYLNeIGVLVL 178
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
11-151 5.25e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 51.09  E-value: 5.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAV--NALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGV-----AISGLVTDqlSSSAQHTQK----TLCS 79
Cdd:cd14980   5 IFIWIIGILALigNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIylliiAIADQYYR--GRYAQYSEEwlrsPPCL 82
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32401461  80 LRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQI-MNGLVAGgcIAGLWLISYLIGFLPLGVSIFQQTTY 151
Cdd:cd14980  83 LACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLsYKSAKII--LILGWLFSIIFAAIPILYSINQPGDN 153
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
9-290 1.03e-06

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 49.88  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMllsIYKNDGVGLCFTL--NLAVADTLIGVA-ISGLVTDQLSSSAQHTQKTLCSLRMAFv 85
Cdd:cd15963   5 VVLCISGTVISCENAIVVAVI---FYTPAFRAPMFLLigSLATADLLAGLGlILHFAFVYCIQSAPVNLVTVGLLAPSF- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 tssaAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTyhgPCTFFAVFHPR 164
Cdd:cd15963  81 ----TASVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPvVGWNCLKDPS---TCSVVKPLTKN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAgFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAmvgacrPPRPVNDFKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15963 154 HLVILSIS-FFMVFALMLQLYAQICRIVCRHAHQIALQRHFLP------TSHYVTTRKGIATLAVILGTFASCWLPFAVY 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32401461 245 SIVQVAChkcclYQVLEKYLWLL-GVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15963 227 CLLGDYT-----YPALYTYATLLpATYNSMINPIIYAFRNQEIQKVL 268
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
9-287 1.29e-06

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 50.12  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKND---GVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIAALARHKnlrGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGflplgvsiFQQTTYHGPCTFFAVFHP-- 163
Cdd:cd14992  81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLA--------IPQLYYATTEVLFSVKNQek 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAG------FFPAVLLFVFFYCDMLKIASVHSQHIRKM---EHAGAMVGACRPPRPVNDFKAVRTVSVLIGSF 234
Cdd:cd14992 153 IFCCQIPPVDnktyekVYFLLIFVVIFVLPLIVMTLAYARISRELwfrKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 235 TLSWSPFLITSIVQ---VACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd14992 233 VICWLPFHLFFLLRdffPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
9-288 1.45e-06

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 49.72  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVAMLLS-IYKNDGVGLCFTLNLAVADTLIGV-------AISGLVTDQLSSsaqhtqkT 76
Cdd:cd15098   1 VIVPVVFGLIFCLgvlgNSLVITVLARVkPGKRRSTTNVFILNLSIADLFFLLfcvpfqaTIYSLPEWVFGA-------F 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 LCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQI---MNGLVAGGCIaglWLISYLIGfLPLGVSIFQQTTYHG 153
Cdd:cd15098  74 MCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLrtrRNALLGVLVI---WVLSLAMA-SPVAVHQDLVHHWTA 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 154 PCTFFAVFH-------PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMvgacrpprpvndfKAVRT 226
Cdd:cd15098 150 SNQTFCWENwpekqqkPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSKK-------------KTAQT 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 227 VSVLIGSFTLSWSPFLITS---------------IVQVACHkCCLYqvlekylwllgvGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15098 217 VLVVVVVFGISWLPHHIIHlwvefgdfpltqasfVLRITAH-CLAY------------ANSCVNPIIYAFLSENFRK 280
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
43-133 1.52e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 49.56  E-value: 1.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15232  38 FLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVC 117
                        90
                ....*....|.
gi 32401461 123 GGCIAGLWLIS 133
Cdd:cd15232 118 VGLATGVWAIG 128
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
14-249 1.76e-06

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 49.37  E-value: 1.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  14 LTILIIAVNALVVVAMLLSiYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTqktLCSLRMAFVTSSAAASV 93
Cdd:cd15905   8 LSSLIIFANLFIILGIACN-RKLHNTANYFFLSLLLADLLTGVALPFIPGMSNESRRGYH---SCLFVYVAPNFLFLSFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  94 LTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLP-LGVSIFQQTTYhgpCTFFAVFHPRFVLTLSCA 172
Cdd:cd15905  84 ANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPaLGWNNWTPGSN---CSYKQVFPAAYIYLEVYG 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 173 GFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNdFKAVRTVSVLIGSFTLSWSPFLITSIVQV 249
Cdd:cd15905 161 LVLPSILAIAFMSVRVLAVARRQLQDICKLLRAVQRDGPSELEQQLN-LRYAKCIAGVSLTFLVCWVPYIAYLLMSV 236
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
9-290 1.76e-06

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 49.33  E-value: 1.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGL-CFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15002   4 ILLGVICLLGFAGNLMVIGILLNNARKGKPSLIdSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAgGCIAGLWLISYLIGfLPLGV--SIFQQT-TYHGPCTFFAVFHPR 164
Cdd:cd15002  84 CMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRIT-AVVASIWVPACLLP-LPQWLfrTVKQSEgVYLCILCIPPLAHEF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 ---FVLTLSCAGF-FPAVLLFVFFYcdmlKIAsvhsQHIRKMEHAGAMVGACRPPRPVNdfkavRTVSVLIGSFTLSWSP 240
Cdd:cd15002 162 msaFVKLYPLFVFcLPLTFALFYFW----RAY----GQCQRRGTKTQNLRNQIRSRKLT-----HMLLSVVLAFTILWLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 241 FLITS--IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15002 229 EWVAWlwLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
22-290 2.01e-06

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 49.43  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  22 NALVVVAMLLSIYKNdgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAF 101
Cdd:cd15339  18 NILVLFTIIRSRKKT--VPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTAMSL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 102 DRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFlPLGV--SIFQQTTYHGPCTFFAVfHPR----FVLTLSCAGFF 175
Cdd:cd15339  96 DRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVL-PVWVyaKVIKFRDGLESCAFNLT-SPDdvlwYTLYQTITTFF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 176 PAVLLFVFFYCDMLkiasvhsQHIRKMEHAGAMVGACRPPRP-VNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKC 254
Cdd:cd15339 174 FPLPLILICYILIL-------CYTWEMYRKNKKAGRYNTSIPrQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQP 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32401461 255 CLYQVLEKYLWL-LGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15339 247 TLAFYVSYYLSIcLSYASSSINPFLYILLSGNFRKRL 283
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
43-281 2.11e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 49.14  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGV-----AISGLVTDQLSSsaqhtqkTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQim 117
Cdd:cd14984  38 YLLNLALADLLFVLtlpfwAVYAADGWVFGS-------FLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALR-- 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 118 NGLVAGGCI--AGLWLISYLIGFLPLGVSIFQQTTYHGPCTFF----AVFHPRFVLTLS--CAGFFPAVLLFVFFYCDML 189
Cdd:cd14984 109 ARTLLHGKLtcLGVWALALLLSLPEFIFSQVSEENGSSICSYDypedTATTWKTLLRLLqnILGFLLPLLVMLFCYSRII 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 190 KIAsVHSQHIRKmehagamvgacrpprpvndFKAVRTVSVLIGSFTLSWSPFLITSIVQ------VACHKCCLYQVLEKY 263
Cdd:cd14984 189 RTL-LRARNHKK-------------------HRALRVIFAVVVVFFLCWLPYNIVLLLDtlqllgIISRSCELSKSLDYA 248
                       250       260
                ....*....|....*....|.
gi 32401461 264 LWL---LGVGNSLLNPLIYAY 281
Cdd:cd14984 249 LQVtesLAFSHCCLNPVLYAF 269
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
16-286 2.44e-06

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 48.87  E-value: 2.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  16 ILIIAVNALVVVAMLLSIYKNDGVgLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCsLRMAFVTSSAAASVLT 95
Cdd:cd15344  12 IFIMLANLLVMVAIYVNRRFHFPI-YYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL-LRQGLIDTSLTASVAN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  96 VMLIAFDRYLAIKQPLRYFQIMNGLVAGgCIAGLWLISYLIGFLP-LGVS-IFQQTTYHGPCTFFAVFHPRFVLTLSCAG 173
Cdd:cd15344  90 LLAIAIERHITVFRMQLHTRMSNRRVVV-VIVVIWTMAIVMGAIPsVGWNcICDIENCSNMAPLYSDSYLVFWAIFNLVT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 174 FFPAVLLFVFFYCDMLKIASVHSQHIRKmehagamvgacrpPRPVND--FKAVRTVSVLIGSFTLSWSPFLITSIVQVAC 251
Cdd:cd15344 169 FVVMVVLYAHIFGYVRQRTMRMSRHSSG-------------PRRNRDtmMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC 235
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32401461 252 HKCCLYqVLEKYLWLLGVGNSLLNPLIYAYWQREV 286
Cdd:cd15344 236 PQCDVL-AYEKFFLLLAEFNSAMNPIIYSYRDKEM 269
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
43-290 3.01e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 48.69  E-value: 3.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15215  37 FIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIAsvhsqhiRK 201
Cdd:cd15215 117 YLLIYGTWIVSVLQSTPPLyGWGQAAFDERNALCSVIWGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAA-------RR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 202 MEHAgamvgacrpprpvndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVgNSLLNPLIYAY 281
Cdd:cd15215 190 CYHC----------------KAAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQVPQWVISIILWLFFL-QCCIHPYIYGY 252

                ....*....
gi 32401461 282 WQREVRQQL 290
Cdd:cd15215 253 MHKSIKKEF 261
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
24-246 3.50e-06

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 48.37  E-value: 3.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  24 LVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGV-----AISGLVT-DQLSSSAQHTQK-TLCSLRMAFVTSSAAASVLTV 96
Cdd:cd15136  19 IIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIylgllAIVDAKTlGEYYNYAIDWQTgAGCKTAGFLAVFSSELSVFTL 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  97 MLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPC---TFFAVFHPRFVLTLSCA 172
Cdd:cd15136  99 TVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLvGVSSYSKTSICLPFeteTPVSKAYVIFLLLFNGL 178
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 173 GFFPAVLLFVFFYCdmlkiasvhsqhirkmehagaMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP---FLITSI 246
Cdd:cd15136 179 AFLIICGCYIKIYL---------------------SVRGSGRAANSNDTRIAKRMALLVFTDFLCWAPiafFGLTAA 234
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
78-172 3.74e-06

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 48.22  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAA--SVLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLGVSIFQQtTYHGPC 155
Cdd:cd15225  73 CATQMFFFLFLGGTecFLLAAM--AYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVS-LGQTTLIFSL-PFCGSN 148
                        90       100
                ....*....|....*....|
gi 32401461 156 T---FFAVFHPrfVLTLSCA 172
Cdd:cd15225 149 EinhFFCDIPP--VLKLACA 166
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
77-288 4.06e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 48.23  E-value: 4.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 LCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQI---MNGLVAGGCIaglWLISYLIGfLPLGVSIFQQTTYHG 153
Cdd:cd14971  72 MCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIrtpRNALAASGCI---WVVSLAVA-APVLALHRLRNYTPG 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 154 PCTFFAVFHPR------FVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqHIRKMEHAGAMVGACRPPRPvndfKAVRTV 227
Cdd:cd14971 148 NRTVCSEAWPSrahrraFALCTFLFGYLLPLLLICVCYAAMLR-------HLWRVAVRPVLSEGSRRAKR----KVTRLV 216
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32401461 228 SVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLW--LLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd14971 217 LVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWahCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
43-281 4.36e-06

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 48.21  E-value: 4.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd14991  38 YLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLIsYLIGFLPLGVSIFQQTTYHGP-C-TFFAVFHPRFVL----TLSCAGFFPAVLLFVFfyCdMLKIASVHS 196
Cdd:cd14991 118 AGVAGLLWAL-VLLLTLPLLLSTLLTVNSNKSsChSFSSYTKPSLSIrwhnALFLLEFFLPLGLIVF--C-SVRIACNLR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 197 QHIRKMEHAGAMvgacrpprpvndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVG------ 270
Cdd:cd14991 194 IRQSLGKQARVQ-------------RAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCLNSVAQLFHISlaftyl 260
                       250
                ....*....|.
gi 32401461 271 NSLLNPLIYAY 281
Cdd:cd14991 261 NSALDPVIYCF 271
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
43-281 5.11e-06

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 48.02  E-value: 5.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLigvAISGLVTdqlsSSAQHTQKT------LCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQI 116
Cdd:cd15089  38 YIFNLALADAL---ATSTLPF----QSAKYLMETwpfgelLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 117 MNGLVAGGCIAGLWLISYLIGFlPLGVSIFQQTTYHGpctffavfhprfvlTLSCAGFFPA----------VLLFVF-FY 185
Cdd:cd15089 111 RTPAKAKLINICIWVLSSGVGV-PIMVMAVTKTPRDG--------------AVVCMLQFPSpswywdtvtkICVFIFaFV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 186 CDMLKIASVHSQHIRKMEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQ--VACHKCCLYQVLEKY 263
Cdd:cd15089 176 VPILVITVCYGLMILRLRSVRLLSGSKEKDR--NLRRITRMVLVVVAAFIICWTPIHIFVIVWtlVDIDRRNPLVVAALH 253
                       250
                ....*....|....*....
gi 32401461 264 LWL-LGVGNSLLNPLIYAY 281
Cdd:cd15089 254 LCIaLGYANSSLNPVLYAF 272
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
10-248 5.15e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 47.84  E-value: 5.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAV----NALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15219   1 LLAVLLVVVLVVsllsNLLVLLCFLYSAELRKQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVF---H 162
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTLHLPReeeR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHirkmehagamvgacrpprpvndfKAVRTVSVLIGSFTLSWSPFL 242
Cdd:cd15219 161 RRFAVFTAFFHAFTFLLSLLVLCVTYLKVLKVRRRQ-----------------------RATKKISIFIGTFVLCFAPYV 217

                ....*.
gi 32401461 243 ITSIVQ 248
Cdd:cd15219 218 ITRLVE 223
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
94-171 5.67e-06

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 47.66  E-value: 5.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPlgVSIFQQTTYHGPCT---FFAVFHPrfVLTLS 170
Cdd:cd15224  91 LAVM--AYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIK--VYFISQLSFCGPNVinhFFCDISP--LLNLS 164

                .
gi 32401461 171 C 171
Cdd:cd15224 165 C 165
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
78-135 5.67e-06

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 47.71  E-value: 5.67e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15936  73 CMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFA 130
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
9-289 7.58e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 47.60  E-value: 7.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGV---GLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15401   1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLrnaGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNgLVAGGCIAGLWLISYLIGFLPlgvSIFQQTTYHGP----CTFFAVF 161
Cdd:cd15401  81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYN-MKKTCCYVCLTWVLTLAAIVP---NFFVGSLQYDPriysCTFAQTV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKmehagamvgACRPPRPVNDFKAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15401 157 SSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVRQ---------DSKQKLKANDIRNFLTMFVVFVLFAVCWGPL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461 242 LITSIVqVACHKCCLYQVLEKYLWLL----GVGNSLLNPLIYAYWQREVRQQ 289
Cdd:cd15401 228 NFIGLA-VAINPLKVAPKIPEWLFVLsyfmAYFNSCLNAVIYGVLNQNFRKE 278
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
9-281 7.76e-06

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 47.47  E-value: 7.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV----NALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQkTLCSLRMAF 84
Cdd:cd15094   1 LISAVLYGLICIVglvgNGLVIY-VVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGA-AMCKIYMVL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPlgVSIFQQTTYHGPCTFFAVFHPR 164
Cdd:cd15094  79 TSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLV-MLP--IILYASTVPDSGRYSCTIVWPD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 ---------FVLTLSCAGF-FPAVLLFVFFYCDMLKIASVHSQHIRKMEHagamvgacRPPRpvndfKAVRTVSVLIGSF 234
Cdd:cd15094 156 ssavngqkaFTLYTFLLGFaIPLLLISVFYTLVILRLRTVGPKNKSKEKR--------RSHR-----KVTRLVLTVISVY 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 235 TLSWSPFLITSIVQVACHKCCLYQVLEKYLWL----LGVGNSLLNPLIYAY 281
Cdd:cd15094 223 IICWLPYWAFQVHLIFLPPGTDMPKWEILMFLlltvLSYANSMVNPLLYAF 273
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
93-143 8.35e-06

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 47.22  E-value: 8.35e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461  93 VLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGV 143
Cdd:cd15431  90 LLAVM--AYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
9-290 9.13e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 47.50  E-value: 9.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKND---GVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQrmrTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFaVFHPRF 165
Cdd:cd15202  81 YCSVHVSAYTLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRS-LCLEDW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIrkmehaGAMVGACRPPRPV----------NDFKAVRTVSVLIGSFT 235
Cdd:cd15202 158 PERADLFWKYYDLALFILQYFLPLLVISFAYARV------GIKLWASNMPGDAtteryfalrrKKKKVIKMLMVVVVLFA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 236 LSWSPFLITSI---VQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15202 232 LCWLPFNIYVLllsSKPDYLIKTINAVYFAFHW-LAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
43-281 9.20e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 47.21  E-value: 9.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIgVAISGLVTDQLSSSAQHT-QKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLV 121
Cdd:cd15203  38 FILNLAVSDLLL-CLVSLPFTLIYTLTKNWPfGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRH 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 122 AGGCIAGLWLISYLIGfLPLGVS------IFQQTTYHGP-CT-FFAVFHPRFVLTLSCAGF---FPAVLLFvFFYcdmLK 190
Cdd:cd15203 115 ALLIIALIWILSLLLS-LPLAIFqelsdvPIEILPYCGYfCTeSWPSSSSRLIYTISVLVLqfvIPLLIIS-FCY---FR 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 191 IASVHSQHIRKMEHagamvgaCRPPRPVNDFKAV----RTVSVLI---GSFTLSWSPFLITSIVQ----VACHKCCLYQV 259
Cdd:cd15203 190 ISLKLRKRVKKKRG-------KRTLSSRRRRSELrrkrRTNRLLIamvVVFAVCWLPLNLFNLLRdfepLPQIDGRHFYL 262
                       250       260
                ....*....|....*....|..
gi 32401461 260 LEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd15203 263 IFLICHLIAMSSACVNPLLYGW 284
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
73-135 1.09e-05

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 46.98  E-value: 1.09e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461  73 TQKTL----CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15430  64 ERKTIsfsgCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFL 130
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
15-288 1.19e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.77  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  15 TILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVL 94
Cdd:cd15085  11 ATFSIFNNVLVIAVTLKNPQLRNPINI-FILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLW 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  95 TVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAgLWLISYLIGFLPL-GVSIFQQTTYHGPCTF------FAVFHPRFVL 167
Cdd:cd15085  90 SLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLF-IWLFCLFWAVAPLfGWSSYGPEGVQTSCSIgweersWSNYSYLILY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 168 TLSCagFFPAVLLFVFFYCDMLKiaSVHSQHiRKMEHAGAmvgacrPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIV 247
Cdd:cd15085 169 FLMC--FVIPVAIIGFSYGNVLR--SLHKLN-KKIEQQGG------KNCPEEEERAVIMVLAMVIAFLICWLPYTVFALI 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 32401461 248 QVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15085 238 VVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
84-135 1.37e-05

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 46.82  E-value: 1.37e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461  84 FVTSSAAASVLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15229  81 FFFAGTEAFLLSAM--AYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFL 130
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
43-281 1.64e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 46.49  E-value: 1.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQkTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15091  38 YIFNLALADALVTTTMPFQSTVYLMNSWPFGD-VLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLIGF--LPLGVSIFQQTTYHGPCTFFAVFHPrfvltLSCAGFFPAVLLFVF-FYCDMLKIASVHSQHI 199
Cdd:cd15091 117 KIINICIWLLSSSVGIsaIVLGGTKVREDVDSTECSLQFPDDD-----YSWWDTFMKICVFIFaFVIPVLIIIVCYTLMI 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 200 RKMEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVG--NSLLNPL 277
Cdd:cd15091 192 LRLKSVRLLSGSREKDR--NLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGytNSSLNPI 269

                ....
gi 32401461 278 IYAY 281
Cdd:cd15091 270 LYAF 273
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
42-279 1.78e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 46.55  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  42 CFTLNLAVADTLIgvAISGLVTDQLSSSAQHT---QKTLCSLRmAFVTS-SAAASVLTVMLIAFDRYLAIKQPLRYfQIM 117
Cdd:cd15134  37 YYLFSLAVSDLLL--LILGLPFELYTIWQQYPwvfGEVFCKLR-AFLSEmSSYASVLTITAFSVERYLAICHPLRS-HTM 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 118 NGLV-AGGCIAGLWLISYLIG------------FLPLGVSIFQQTTYHgpCTFFAVFHPRFVLT-LSCAGFF--PAVLLF 181
Cdd:cd15134 113 SKLSrAIRIIIAIWIIAFVCAlpfaiqtrivylEYPPTSGEALEESAF--CAMLNEIPPITPVFqLSTFLFFiiPMIAII 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 182 VFFYCDMLKIA-SVHSQHIRKMEHAGAMVGACRppRPVndfkaVRTVSVLIGSFTLSWSPFLITSIVQVAcHKCCLYQVL 260
Cdd:cd15134 191 VLYVLIGLQLRrSTLLRRGQRSVSGGRRSSQSR--RTV-----LRMLVAVVVAFFICWAPFHAQRLLTVY-AKNMTPPYL 262
                       250       260
                ....*....|....*....|....*
gi 32401461 261 EKYLWLLGVG------NSLLNPLIY 279
Cdd:cd15134 263 FINRILFYISgvlyyvSSTVNPILY 287
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
43-288 2.09e-05

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 46.29  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15162  38 YMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLiGFLPLGVsifQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAV--LLFVFFYCDMLKIASVHSQHIR 200
Cdd:cd15162 118 LGTCLAIWLLALL-VTLPLYL---VKQTIFLPALDITTCHDVLPEQLLVGDWFYYFlsLAIVGFLIPFILTASCYVATIR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 201 KMEHAGAMVGACRPPRpvndfkAVRTVSVLIGSFTLSWSPfliTSIVQVACHKCCLYQVLEK----YLWLLGVG--NSLL 274
Cdd:cd15162 194 TLAALEDENSEKKKKR------AIKLAATVLAIFIICFAP---SNLLLLAHYSLISSSGTGHlyfaYLLALCLStlNSCI 264
                       250
                ....*....|....
gi 32401461 275 NPLIYAYWQREVRQ 288
Cdd:cd15162 265 DPFIYYFVSKEFRD 278
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
8-136 2.39e-05

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 46.23  E-value: 2.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAV--NALVVVAmllsIYKNDG---VGLCFTLNLAVAD---TLIGVAISgLVTDQLSSsaQHTQKTLCS 79
Cdd:cd15208   2 VLIALYILVFIVGLvgNVLVCFA----VWRNHHmrtVTNYFIVNLSLADflvIIICLPAT-LLVDVTET--WFFGQVLCK 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461  80 LRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQimNGLVAGGCIAGLWLISYLI 136
Cdd:cd15208  75 IIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLI 129
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
43-279 2.40e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 46.19  E-value: 2.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAisGLVTDQLSSSAQH---TQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNG 119
Cdd:cd14979  38 YLFSLAVSDLLILLV--GLPVELYNFWWQYpwaFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 120 LVAGGCIAGLWLISYLIGfLPLGvSIFQQTTYHGPC-------------TFFAVFHPRFVLTLSCAGFFPavlLFVFFYC 186
Cdd:cd14979 116 RRVKRFILAIWLVSILCA-IPIL-FLMGIQYLNGPLpgpvpdsavctlvVDRSTFKYVFQVSTFIFFVLP---MFVISIL 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 187 DMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFK-AVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCL-YQVLEKYL 264
Cdd:cd14979 191 YFRIGVKLRSMRNIKKGTRAQGTRNVELSLSQQARRqVVKMLGAVVIAFFVCWLPFHAQRLMFSYASKEDTfLFDFYQYL 270
                       250
                ....*....|....*....
gi 32401461 265 WLL-GVG---NSLLNPLIY 279
Cdd:cd14979 271 YPIsGILfylSSAINPILY 289
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
4-280 2.46e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 45.86  E-value: 2.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   4 SFSFGVIlavlTILIIAVNALVVVAMLLSIyKNDGVGLCFTLNLAVADTLIGV-AISGLVTDQLSSSaQHTQKTLCSLRM 82
Cdd:cd15393   4 SILYGII----SLVAVVGNFLVIWVVAKNR-RMRTVTNIFIANLAVADIIIGLfSIPFQFQAALLQR-WVLPRFMCPFCP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFqiMNGLVAGGCIAGLWLISYLIGfLPLGV-------------SIFQQT 149
Cdd:cd15393  78 FVQVLSVNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVA-LPVALalrveeltdktnnGVKPFC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 150 TYHGPCtffAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKiasvhsqHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSV 229
Cdd:cd15393 155 LPVGPS---DDWWKIYNLYLVCVQYFVPLVIICYAYTRIAV-------KIWGTKAPGNAQDVRDDEILKNKKKVIKMLII 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 230 LIGSFTLSWSPFLITSIVQVachkccLYQVLEKY-----LWL----LGVGNSLLNPLIYA 280
Cdd:cd15393 225 VVALFALCWLPLQTYNLLNE------IKPEINKYkyiniIWFcshwLAMSNSCYNPFIYG 278
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
9-279 2.47e-05

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 45.89  E-value: 2.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLlSIYKNDGVGLCFTLNLAVAD------TLIGVAISGLVTDQLSSSaqhtqkTLCSLRM 82
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIY-RLRRSRRTIYSLLLHLAIADllvtffCIPSEAIWAYTVAWLAGN------TMCKLVK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQImnGLVAGGCIAGLWLISyLIGFLPLG----------VSIFQQTTYH 152
Cdd:cd15384  78 YLQVFGLYLSTYITVLISLDRCVAILYPMKRNQA--PERVRRMVTVAWILS-PIFSIPQAvifhvergpfVEDFHQCVTY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 153 GpcTFFAVFHPRFVLTLSCAGFFPAVLLfVFFYCDMLKIASVhSQHIRKMEHAGAMVGACRPPRPVNDFKA----VRTVS 228
Cdd:cd15384 155 G--FYTAEWQEQLYNMLSLVFMFPIPLV-IMVTCYVLIFITL-SKSSRDFQGLEIYTRNRGPNRQRLFHKAkvksLRMSA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 229 VLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd15384 231 VIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
7-279 2.74e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 45.70  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVV-----AMLLSIYkndgVGLCFtlnLAVADTLIGVA----ISGLVTDQLSSSAQHTQKTL 77
Cdd:cd14978   3 YGYVLPVICIFGIIGNILNLVvltrkSMRSSTN----VYLAA---LAVSDILVLLSalplFLLPYIADYSSSFLSYFYAY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSA-AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGF--------LPLGVSIFQQ 148
Cdd:cd14978  76 FLPYIYPLANTFqTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLprffeyevVECENCNNNS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 149 TTYHGPCTFFAVFHPRFVLTLSCAGFFPAVL-LFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRpvNDFKAVRTV 227
Cdd:cd14978 156 YYYVIPTLLRQNETYLLKYYFWLYAIFVVLLpFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQR--RERRTTIML 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461 228 SVLIGSFTLSWSPFLITSIVQVACHKCCL---YQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd14978 234 IAVVIVFLICNLPAGILNILEAIFGESFLspiYQLLGDISNLLVVLNSAVNFIIY 288
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
11-289 3.10e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 45.67  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAVNALVVVAMLLSIYKND---GVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15402   3 LACILIFTIVVDILGNLLVILSVYRNKklrNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVL 167
Cdd:cd15402  83 SVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSAYTI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 168 TLSCAGFFPAVLLFVFFYcdmLKIASVHSQHIRKMEHAGamvgacRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIV 247
Cdd:cd15402 163 AVVFFHFILPIIIVTFCY---LRIWILVIQVRRRVKPDN------KPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 248 qVACHKCCLYQVLEKYLWL----LGVGNSLLNPLIYAYWQREVRQQ 289
Cdd:cd15402 234 -VAVDPETIVPRIPEWLFVasyyMAYFNSCLNAIIYGLLNQNFRRE 278
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
25-281 3.12e-05

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 45.67  E-value: 3.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  25 VVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQkTLCSLRMAFVTSSAAASVLTVMLIAFDRY 104
Cdd:cd15970  20 MVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGS-LLCRLVLSVDAINMFTSIYCLTVLSIDRY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 105 LAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPlgVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFF 184
Cdd:cd15970  99 IAVVHPIKAARYRRPTVAKMVNLGVWVFSILV-ILP--IIIFSNTAPNSDGSVACNMQMPEPSQRWLAVFVVYTFLMGFL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 185 YcDMLKIASVHSQHIRKMEHAGAMVGACRppRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKccLYQVLEKYL 264
Cdd:cd15970 176 L-PVIAICLCYILIIVKMRVVALKAGWQQ--RKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQ--HDATVSQLS 250
                       250
                ....*....|....*..
gi 32401461 265 WLLGVGNSLLNPLIYAY 281
Cdd:cd15970 251 VILGYANSCANPILYGF 267
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
15-279 3.98e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 45.44  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  15 TILIIAVNALVVVAMLLSIYKNDGVGLC----FTLNLAVADTLIGVAISGL-----VTDQLSSsAQHTQKTLCSLRMafV 85
Cdd:cd15383   7 TFVLFVLSACSNLAVLWSATRNRRRKLShvriLILHLAAADLLVTFVVMPLdaawnVTVQWYA-GDLACRLLMFLKL--F 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVmlIAFDRYLAIKQPLRYFQIMNGLVAGGCIAglWLISYLIGfLPLGVsIFQQTTYHGPCTFF-AVFHPR 164
Cdd:cd15383  84 AMYSSAFVTVV--ISLDRHAAILNPLAIGSARRRNRIMLCAA--WGLSALLA-LPQLF-LFHTVTATPPVNFTqCATHGS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FV----------LTLSCAGFFPAVLLFVFFYCDMLKIASvhsQHIRKMEHAGAMVGACRPPR--PVNDFKAVRTVSVLIG 232
Cdd:cd15383 158 FPahwqetlynmFTFFCLFLLPLLIMIFCYTRILLEISR---RMKEKKDSAKNEVALRSSSDniPKARMRTLKMTIVIVS 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32401461 233 SFTLSWSPFLITSIVQVACHKCCLYQV---LEKYLWLLGVGNSLLNPLIY 279
Cdd:cd15383 235 SFIVCWTPYYLLGLWYWFSPEMLEQTVpesLSHILFLFGLLNACLDPLIY 284
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
4-287 4.12e-05

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 45.31  E-value: 4.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   4 SFSFGVILAVLTIliiavNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGvAISGLVTDQLSSSAQ-HTQKTLCSLRM 82
Cdd:cd16003   4 SLAYGFVVAVAVF-----GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMA-AFNTLINFIYALHSEwYFGEAYCRFHN 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFH 162
Cdd:cd16003  78 FFPITSVFASIYSMTAIAVDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 PRFVLTLScagffpaVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVG--------ACRPPRpvndfKAVRTVSVLIGSF 234
Cdd:cd16003 156 PDQHFTYH-------IIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGdtsdkyheQLRAKR-----KVVKMMIIVVLTF 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 235 TLSWSP----FLITSIVQVACHKCCLYQVLEKYLWlLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd16003 224 AICWLPyhiyFIVTGLYQQLNRWKYIQQVYLASFW-LAMSSTMYNPIIYCCLNKRFR 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
78-290 4.89e-05

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 45.01  E-value: 4.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVaggCIAgLWLISYLIGFLPLGVSIFQ--QTTYHGP- 154
Cdd:cd15420  73 CGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRV---CTT-LAATSWACGFLLALVHVVLllRLPFCGPn 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 155 ------CTFFAVF-------HPRFVLTLSCAGFF---PAVLLFVFFYCDMLKIASVHSQHIRKmehagamvgacrpprpv 218
Cdd:cd15420 149 evnhffCEILAVLklacadtWINEILIFAGCVFIllgPFSLILISYLHILAAILKIQSAEGRR----------------- 211
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32401461 219 ndfKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKcclyQVLEKYLWLL-GVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15420 212 ---KAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNS----AEQEKILSLFySLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
46-288 4.97e-05

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 44.79  E-value: 4.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  46 NLAVADTLIGVAISGLVTDQLSSSaqhtQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGC 125
Cdd:cd15920  41 NLALADLLLVLCLPFRVAYQNTAG----PLSFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 126 IAGLWLISyLIGFLPLGVSIFQQTTYHGPCtffavFHPR--------FVLTlSCAGFFPAVLLFVFFYcdmLKIASvhsq 197
Cdd:cd15920 117 SGGVWLLL-LACMIPFLFESRNEGPCDNKC-----FHFRskgltaggINLT-AVVIFYILSLLFLYFY---AKISH---- 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 198 hirKMEhaGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSI----VQVACHKCCLYQ----VLEKYLWLLGV 269
Cdd:cd15920 183 ---KLY--KVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIVRVpyvlAQIDVISSLPWKqtlhIANELVLCLSA 257
                       250
                ....*....|....*....
gi 32401461 270 GNSLLNPLIYAYWQREVRQ 288
Cdd:cd15920 258 LNSCLDPIIYFFLSSSFRR 276
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
40-290 5.16e-05

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 45.11  E-value: 5.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  40 GLCFtLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPL-----RYF 114
Cdd:cd15117  35 TVCF-LNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVwarnhRTP 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 115 QIMNgLVAGGciagLWLISYLIGFLPLgvsIFQQTTYHGPCTF-FAVFHP--------RFVLTLSCAGFFPAVLL-FVFF 184
Cdd:cd15117 114 ARAA-LVAVG----AWLLALALSGPHL---VFRDTRKENGCTHcYLNFDPwnetaedpVLWLETVVQRLSAQVITrFVLG 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 185 YCDMLKIASVHSQHIRKMEHAGAMVGACRPprpvndfkaVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYL 264
Cdd:cd15117 186 FLVPLVIIGGCYGLIAARLWREGWVHSSRP---------FRVLTAVVAAFFLCWFPFHLVSLLELVVILNQKEDLNPLLI 256
                       250       260       270
                ....*....|....*....|....*....|..
gi 32401461 265 WL------LGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15117 257 LLlplsssLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
9-278 5.46e-05

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 45.11  E-value: 5.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd14977   4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLGVS--IFQQTTYHG---------PCTF 157
Cdd:cd14977  84 LGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLA-VPEAVLstVARESSLDNssltvcimkPSTP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 FAVFHPRFVLtlscagffpaVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAV-RTVSVLIGSFTL 236
Cdd:cd14977 163 FAETYPKARS----------WWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRGTKKHMKQRRQLaKTVLCLVLVFAF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 237 SWSPFLITSIVQ--VACHKCCLY----QVLEKYLWLLGVGNSLLNPLI 278
Cdd:cd14977 233 CWLPEHISNILRatLYNEVLIDTrstlDILDLIGQFLSFFNSCVNPIA 280
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
11-281 5.66e-05

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 44.74  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAV--NALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTqkTLCSLRMAFVTSS 88
Cdd:cd15181   5 LAYSLVFLLGVvgNGLVLT-ILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGT--FLCKLVGAIHKLN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGfLPLGVSIFQQTTYHG---PCTFF-AVFHPR 164
Cdd:cd15181  82 FYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLS-LPNLVFLEVETSTNAnrtSCSFHqYGIHES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLS-----CAGFFpaVLLFVFFYCdmlkiasvhsqhirkmeHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWS 239
Cdd:cd15181 161 NWWLTSrflyhVVGFF--LPLLIMGYC-----------------YATIVVTLCQSSRRLQKQKAIRVAILVTLVFCLCWL 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 240 PFLITSIV------QVACHKCCLYQVLEKYLWL---LGVGNSLLNPLIYAY 281
Cdd:cd15181 222 PYNIVIFLdtlddlKAVVKNCKLNDLLDAAITVtesLGFSHCCLNPILYAF 272
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
15-290 6.02e-05

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 44.73  E-value: 6.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  15 TILIIAV--NALVVvAMLLSIYKNDGVGLCFTLNLAVADTLIgvaisgLVTDQL--SSSAQHTQ----KTLCSLRMAFVT 86
Cdd:cd15192   9 IIFVVGIfgNSLVV-IVIYCYMKLKTVANIFLLNLALADLCF------LITLPLwaAYTAMEYHwpfgNFLCKIASALVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLisyLIGFLPLGVSIFQQTTYHGPC--TFFAVFHP- 163
Cdd:cd15192  82 FNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWL---LAGVASLPAIIHRDVFFIENTniTVCAFHYPs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 -----RFVLTL--SCAGFFPAVLLFVFFYCDMLKiASVHSQHIRKmehagamvgacrpPRPVND--FKAVRTVSVLigsF 234
Cdd:cd15192 159 qnstlLVGLGLmkNLLGFLIPFLIILTCYTLIGK-ALKKAYEIQR-------------NKPRNDeiFKMIMAVVLF---F 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32401461 235 TLSWSPFLITSIVQV-----ACHKCCLYQVLEK---YLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15192 222 FFCWIPHQIFTFLDVliqlkVIQDCHIADIVDTampFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
9-290 7.01e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 44.76  E-value: 7.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAV---NALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVAisgLVTDQLSSSAQ---HTQKTLCSLRM 82
Cdd:cd15388   2 VEIAVLAIIFACAllsNSLVLLV-LWRRRKQLARMHVFMLHLCIADLVVAFF---QVLPQLVWDITdrfRGPDVLCRLVK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQ----IMNGLVaggCIAglWLISyLIGFLPlGVSIFQQT-----TYHG 153
Cdd:cd15388  78 YLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQkgraRWNGPV---CVA--WAIS-LILSLP-QVFIFSKVevapgVYEC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 154 PCTFFAVFHPR-FVLTLSCAGFF-PAVLLFVffyCDMLKIASVHSQHIRKMEHAGAMVGACRP----PRPVNDF-----K 222
Cdd:cd15388 151 WACFIEPWGLKaYVTWITLVVFVlPTLIITV---CQVLIFKEIHINIYLKSQIIVAVVKKKQLlssrASSVAEVskamiK 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 223 AVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15388 228 TVKMTLVIVLVYVLCWAPFFLVQLWSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
94-147 7.24e-05

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 44.40  E-value: 7.24e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLgVSIFQ 147
Cdd:cd15912  91 LAVM--SFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPT-ILVFQ 141
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
78-183 7.32e-05

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 44.42  E-value: 7.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAAS--VLTVMliAFDRYLAIKQPLRYFQIMNGLVaggCIaGLWLISYLIGFL---PLGVSIFQQtTYH 152
Cdd:cd15230  73 CAAQFFFFAVFGTTEcfLLAAM--AYDRYVAICNPLLYTVIMSKRV---CI-QLVAGSYLCGFVnsiVHTSSTFSL-SFC 145
                        90       100       110
                ....*....|....*....|....*....|....*
gi 32401461 153 GPCT---FFAVFHPrfVLTLSCAG-FFPAVLLFVF 183
Cdd:cd15230 146 GSNVinhFFCDIPP--LLKLSCSDtHINELVLFAF 178
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
91-280 9.16e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 44.10  E-value: 9.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  91 ASVLTVMLIAFDRYLAIKQPLRYFQIMNGLvAGGCIAGLWLISYLIGFLPL--GVSIFQQTTYHGPCTFFAV---FHPR- 164
Cdd:cd15079  85 GSIWTNAAIAYDRYNVIVKPLNGNPLTRGK-ALLLILFIWLYALPWALLPLlfGWGRYVPEGFLTSCSFDYLtrdWNTRs 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 165 FVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRkmEHAGAM-VGACRPPRPVNDFKA-VR---TVSVLIGSFTLSWS 239
Cdd:cd15079 164 FVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALR--EQAKKMnVVSLRSNADANKQSAeIRiakVALTNVFLWFIAWT 241
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32401461 240 PFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYA 280
Cdd:cd15079 242 PYAVVALIGAFGNQSLLTPLVSMIPALFAKTAACYNPIVYA 282
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
9-282 9.56e-05

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 43.89  E-value: 9.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTL---NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLllaNLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLryfQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPCTF---FAVF 161
Cdd:cd15213  81 WFFVLEGVAILLIISVDRYLIIVQRQ---DKLNPHRAKILIAVSWVLSFCVSFPPLvGWGKYEFPPRAPQCVLgytESPA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 162 HPRFVLTLSCAGFFPAVLLFVFFYCDMLkiasvhsqhirkmehagamvgacrppRPVNDFK--AVRTVSVLIGSFTLSWS 239
Cdd:cd15213 158 DRIYVVLLLVAVFFIPFLIMLYSYFCIL--------------------------NTVRSFKtrAFTTILILFIGFSVCWL 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 240 PFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYaYW 282
Cdd:cd15213 212 PYTVYSLLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIY-CW 253
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
13-288 9.73e-05

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 44.04  E-value: 9.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  13 VLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGV-AISGLVTDQLSSSAQHTQkTLCSLRMAFVTSSAAA 91
Cdd:cd15981   8 LFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIfCMPTTLVDNLITGWPFDN-AMCKMSGLVQGMSVSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  92 SVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIgFLPLGVSI-FQQTTYHGPCTFFAVFHPRFvltlS 170
Cdd:cd15981  87 SVFTLVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWVLALII-MCPSAVTLtVTREEHHFMVDDYNNSYPLY----S 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 171 CAGFFP--------AVLLFVFFYCDMLKIASVHSQHI-RKMEHAGAMVGACRPP---RPVNDFKAVRTVSVLIGS---FT 235
Cdd:cd15981 160 CWEAWPdtemrkiyTTVLFSHIYLAPLTLIVIMYARIaFKLFKSSAPIRGSQGEeeeGRRVSKRKIKVINMLIIValfFT 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 236 LSWSPF----LITSIVQVACHKCCLYQV-LEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15981 240 LSWLPLwtlmLLTDYGHLSEDQLNLVTVyVFPFAHWLAFFNSSVNPIIYGYFNENFRR 297
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
7-288 1.27e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 43.49  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15309   3 YAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNY-LIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRY-FQIMNGLVAGGCIAGLWLISYLIGfLPLGVSIfqQTTYHGPCTffaVFHPRF 165
Cdd:cd15309  82 MMCTASILNLCAISIDRYTAVAMPMLYnTRYSSKRRVTVMISVVWVLSFAIS-CPLLFGL--NNTDQNECI---IANPAF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVFFYCDMLKIASvhsqhirkmehagamvgacrpprpvNDFKAVRTVSVLIGSFTLSWSPFLITS 245
Cdd:cd15309 156 VVYSSIVSFYVPFIVTLLVYVQIYIVLQ-------------------------KEKKATQMLAIVLGVFIICWLPFFITH 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32401461 246 IVQVAChKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15309 211 ILNMHC-DCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
11-289 1.45e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 43.61  E-value: 1.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAVNALVVVAMLLSIYKNDGV---GLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLrnaGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISyLIGFLPlgvSIFQQTTYHGP----CTFFAVFHP 163
Cdd:cd15209  83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLT-VLAVLP---NFFIGSLQYDPriysCTFAQTVST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 RFVLTLSCAGFFPAVLLFVFFYcdmLKIASVHSQHIRKMEHagamvgACRPPRPVNDFKAVRTVSVLIGSFTLSWSPF-L 242
Cdd:cd15209 159 VYTITVVVIHFLLPLLIVSFCY---LRIWVLVLQVRQRVKP------DQRPKLKPADVRNFLTMFVVFVLFAVCWAPLnF 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32401461 243 ITSIVQVACHKCC--LYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQ 289
Cdd:cd15209 230 IGLAVAINPKEMApkIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
94-154 1.53e-04

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 43.46  E-value: 1.53e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPlgVSIFQQTTYHGP 154
Cdd:cd15913  91 LSVM--AFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIP--VVLISQLPFCGP 147
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
78-172 1.55e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 43.31  E-value: 1.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLplgvsifqQTTY--HGP- 154
Cdd:cd15421  73 CGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLI--------HTVYtmHFPy 144
                        90       100
                ....*....|....*....|....
gi 32401461 155 CTFFAVFHprF------VLTLSCA 172
Cdd:cd15421 145 CGSREIHH--FfcevpaLLKLSCA 166
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
94-139 1.78e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 43.35  E-value: 1.78e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVaggCIaGLWLISYLIGFL 139
Cdd:cd15226  91 LIAM--AFDRYVAICKPLHYLTIMSPRM---CI-LLVVASWIIGFI 130
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
78-171 1.86e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 43.20  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIfqQTTYHGPCT- 156
Cdd:cd15940  73 CVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTI--RLPYCGPNEi 150
                        90
                ....*....|....*..
gi 32401461 157 --FFAVFHPrfVLTLSC 171
Cdd:cd15940 151 dsFFCDVPP--VIKLAC 165
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
10-288 1.90e-04

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 43.31  E-value: 1.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVaMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdqlSSSAQHTQ--KTLCSLRMAFVTS 87
Cdd:cd15973   6 IYALVCLVGLIGNSMVIF-VILRYAKMKTATNIYILNLAIADELFMLSVPFLAA---SAALQHWPfgSAMCRTVLSVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgflPLGVSIFQQTTYHG----PCTFF---AV 160
Cdd:cd15973  82 NMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLV---ISPIIIFADTATRKgqavACNLIwphPA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLTLSCAGFFPAVLLFVFFYCDMlkiasvhsqhIRKMEHAGAMVGACRppRPVNDFKAVRTVSVLIGSFTLSWSP 240
Cdd:cd15973 159 WSAAFVIYTFLLGFLLPVLAIGLCYILI----------IGKMRAVALKAGWQQ--RRKSEKKITRMVLMVVTVFVICWMP 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 241 FLITSIVQVACHKccLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQ 288
Cdd:cd15973 227 FYVVQLLNLFLPR--LDATVNHASLILSYANSCANPILYGFLSDNFRR 272
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
9-250 2.18e-04

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 42.88  E-value: 2.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIgVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRS-VTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGF-LPLGVSIFQQTTYHGPC--TFFAVFHPRF 165
Cdd:cd15121  83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLpMPFYRTVLKKNINMKLCipYHPSVGHEAF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 -VLTLSCAGFFPAVLLFVFFYCDMLKiaSVHSQHIRKMEHAGamvgacrpprpvndfkavRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15121 163 qYLFETITGFLLPFTAIVTCYSTIGR--RLRSARFRRKRRTN------------------RLVVLIIATFALFWLPYHVV 222

                ....*.
gi 32401461 245 SIVQVA 250
Cdd:cd15121 223 NLIQVA 228
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
43-281 2.44e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 42.93  E-value: 2.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQkTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15092  38 YIFNLALADTLVLLTLPFQGTDIFLGFWPFGN-ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLIGfLPLGVSIFQQTTYHGPCTFFAVFHPRfvltlSCAGFFPAVLLFVF-FYCDMLKIASVHSQHIRK 201
Cdd:cd15092 117 KVVNVCIWALASVVG-VPVMVMGSAQVEDEEIECLVEIPTPQ-----DYWDPVFGICVFLFsFIIPVLIISVCYSLMIRR 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 202 MEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCC--LYQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd15092 191 LRGVRLLSGSKEKDR--NLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSseTAVAILRFCTALGYVNSSLNPVLY 268

                ..
gi 32401461 280 AY 281
Cdd:cd15092 269 AF 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
93-139 2.49e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 42.98  E-value: 2.49e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 32401461  93 VLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFL 139
Cdd:cd15235  91 LLAVM--AYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLL 135
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
93-139 2.50e-04

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 42.60  E-value: 2.50e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 32401461  93 VLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFL 139
Cdd:cd15918  90 LLAVM--AYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLL 134
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
77-241 3.03e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 42.48  E-value: 3.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 LCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIG---FLPLGVS--IFQQTTY 151
Cdd:cd15928  72 LCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAgpaLVLVGVEhiQGQQTPR 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 152 HGPCTFFAVFHP--RFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKmehagamVGACRppRPVNDFKAVRTVSV 229
Cdd:cd15928 152 GFECTVVNVSSGllSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRT-------AGASR--RDNNHRQTVRMLAV 222
                       170
                ....*....|..
gi 32401461 230 LIGSFTLSWSPF 241
Cdd:cd15928 223 IVLAFVLCWLPF 234
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
5-172 3.20e-04

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 42.53  E-value: 3.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   5 FSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADT-LIGVAISGLVTDQLSSSAQHTQKTLCSLRMA 83
Cdd:cd15941   1 SLFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGLPMYHFLGHLSFLDAcLSSVTVPKVLAGLLTLSGRTISFEGCVVQLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  84 FVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGflPLGVSIFQQTTYHGPCT---FFAV 160
Cdd:cd15941  81 AFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHA--AIHTSLTFRLPYCGPCQiayFFCD 158
                       170
                ....*....|..
gi 32401461 161 FHPrfVLTLSCA 172
Cdd:cd15941 159 IPP--VLKLACA 168
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
9-290 3.68e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 3.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTL-------CSLR 81
Cdd:cd15964   5 IVVWFVNLLAILGNVFVLLILLTSHYKLT-VPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIdwqtgpgCNTA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  82 MAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPL-GVSIFQQTTYHGPC---TF 157
Cdd:cd15964  84 GFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLvGVSSYAKVSICLPMdteTP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 158 FAVFHPRFVLTLSCAGFFPAVLLFVFFYCdmlkiaSVHSQHIrkmeHAGAmvgacrpprpvNDFKAVRTVSVLIGSFTLS 237
Cdd:cd15964 164 LAQAYIVFVLMLNIIAFVIICACYIKIYI------TVRNPQY----KSGD-----------KDTKIAKRMAVLIFTDFIC 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 32401461 238 WSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15964 223 MAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRRDV 275
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
11-279 4.13e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 42.36  E-value: 4.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  11 LAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAIsglVTDQLSSSAQH---TQKTLCSL--RMAFV 85
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRVNI-FILNLAIADLVVAFFT---VLTQIIWEATGewvAGDVLCRIvkYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMliAFDRYLAIKQPLRYFQimNGLVAGGCIAGLWLISYLIGFLPLGvsIFQQ-----TTYHGPCTFFAV 160
Cdd:cd14986  83 GLFASTYILVSM--SLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLV--IFVErelgdGVHQCWSSFYTP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 161 FHPRFVLTLSCAGFF--PAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVN-------DFKAVRTVSVLI 231
Cdd:cd14986 157 WQRKVYITWLATYVFviPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCRSVSCVSSRvslisraKIKTIKMTLVII 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32401461 232 GSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIY 279
Cdd:cd14986 237 LAFILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIY 284
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
76-287 5.98e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 41.61  E-value: 5.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  76 TLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAglWLISYLIGFLPLGV-----SIFQQTT 150
Cdd:cd15195  71 LMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVA--WVLSALCSIPQSFIfsvlrKMPEQPG 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 151 YHGPCTFFAVFHPR-----FVLTLSCAGFFPavlLFVFFYCDMLKIASVhsqhIRKMEHAGAMVGACRPPRPVNDF---- 221
Cdd:cd15195 149 FHQCVDFGSAPTKKqerlyYFFTMILSFVIP---LIITVTCYLLILFEI----SKMAKRARDTPISNRRRSRTNSLerar 221
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461 222 -KAVRTVSVLIGSFTLSWSPFLITSIV----QVACHKccLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15195 222 mRTLRMTALIVLTFIVCWGPYYVLGLWywfdKESIKN--LPPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
76-172 6.02e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 41.64  E-value: 6.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  76 TLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPC 155
Cdd:cd15424  71 ARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHI 150
                        90
                ....*....|....*..
gi 32401461 156 TFFaVFHPRFVLTLSCA 172
Cdd:cd15424 151 NHF-FCELPVVLKLACA 166
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
9-136 6.09e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.61  E-value: 6.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAmLLSIYKNDGVGLCFTLNLAVADTLIGVA------ISGLVTDQLSSSaqhtqkTLCSLRM 82
Cdd:cd15206   5 PLYSVIFLLAVVGNILVIVT-LVQNKRMRTVTNVFLLNLAVSDLLLAVFcmpftlVGQLLRNFIFGE------VMCKLIP 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461  83 AFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLI 136
Cdd:cd15206  78 YFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLI 131
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
12-280 8.61e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 41.29  E-value: 8.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  12 AVLTILIIAVNALVVVAMLLSIYKN---DGVGLCFTLNLAVADTLIG-VAISGLVTDQLSSSAQHTQKTLCSLRMAFVTS 87
Cdd:cd15212   4 ALVLLAIFLLSSLGNCAVIGVIVKHrqlRTVTNAFILSLSLSDLLTAlLCLPFAFLTLFSRPGWLFGDRLCLANGFFNAC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  88 SAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGF----LPLGVSIFQQTTYHGpCTFfaVFH- 162
Cdd:cd15212  84 FGIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSLpwylLASAPEYYEKLGFYH-CLY--VLHs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 163 ------PRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVgacrppRPVNDFKAVRTVSVLIGSFTL 236
Cdd:cd15212 159 gpsrlgAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLL------RFYSEMRTATTVLIMIVFIIC 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32401461 237 SWSPFLITSIVQVACHKCCLYQVLEKYLWLLGvGNSLLNPLIYA 280
Cdd:cd15212 233 CWGPYCLLGLVAAAGGYQFPPLMDTVAIWMAW-ANGAINPLIYA 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-289 1.04e-03

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 40.90  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  77 LCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISyliGFLPLGVSIFQQTTYH-GPC 155
Cdd:cd15190  83 LCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLA---ALLALPALILRTTSDLeGTN 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 156 TFFAVFHPRFV--------------LTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHagamvgacRPPRpvndf 221
Cdd:cd15190 160 KVICDMDYSGVvsnesewawiaglgLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKED--------KKKR----- 226
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 222 KAVRTVSVLIGSFTLSWSPFLITS---------IVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQ 289
Cdd:cd15190 227 RLLKIIITLVVTFALCWLPFHLVKtlyalmylgILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
78-183 1.06e-03

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 40.81  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGlwliSYLIGFLplgvsifqQTTYHGPCTF 157
Cdd:cd15943  87 CAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAG----SYLIGFV--------NALIQTICTF 154
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 32401461 158 FAVF------HPRF-----VLTLSCAG-FFPAVLLFVF 183
Cdd:cd15943 155 RLPFcgsnviNHFFcdvppLLKLSCSDtHVNEIVLFAF 192
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
98-172 1.08e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 40.89  E-value: 1.08e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461  98 LIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPlgVSIFQQTTYHGPCTFFAVF-HPRFVLTLSCA 172
Cdd:cd15916  94 LMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIH--TSLTFRLPFCGPNRIDYFFcDIPPLLKLACA 167
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
43-151 1.09e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 40.89  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15372  37 FLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFA 116
                        90       100
                ....*....|....*....|....*....
gi 32401461 123 GGCIAGLWLISyLIGFLPLgvsIFQQTTY 151
Cdd:cd15372 117 LCMCTAIWLIA-AALTLPL---TLQRQSY 141
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
42-147 1.10e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 40.78  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  42 CFTLNLAVADTLIGV-----AISGLVTDQLSSSaqhtqKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLR-YFQ 115
Cdd:cd15389  37 LFIVNLAVSDILITLlntpfTLVRFVNSTWVFG-----KIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKpRIT 111
                        90       100       110
                ....*....|....*....|....*....|..
gi 32401461 116 IMNGLVaggCIAGLWLISyliGFLPLGVSIFQ 147
Cdd:cd15389 112 PCQGVV---VIAIIWIMA---SCLSLPHAIYQ 137
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
78-139 1.12e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 40.72  E-value: 1.12e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFL 139
Cdd:cd15237  73 CAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLV 134
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
82-135 1.19e-03

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 40.71  E-value: 1.19e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 32401461  82 MAFVTSSAAasVLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15231  81 VSFVGTECL--LLAVM--AYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFL 130
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
7-281 1.34e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 40.53  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   7 FGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLcFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLrMAFVT 86
Cdd:cd15205   3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNI-FICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKM-VPFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSA-AASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIG--------------FLPLGVSIFQQTTY 151
Cdd:cd15205  81 STAvVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGspmlfvqqlevkydFLYEKRHVCCLERW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 152 HGPCTffavfhpRFVLTLscagfFPAVLLFVFFYCDMLKIAS--VHSQHIRK---------MEHAGAMVGACRPPRpvnd 220
Cdd:cd15205 161 YSPTQ-------QKIYTT-----FILVILFLLPLTTMLFLYSriGYELWIKKrvgdasvlqTIHGIEMSKISRKKK---- 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32401461 221 fKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLY-----QVLEKYLWLLGVGNSLLNPLIYAY 281
Cdd:cd15205 225 -RAVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYdgvtiKLIFAIVQLIGFSNSFNNPIVYAF 289
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
9-287 1.35e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 40.53  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLsiYKNDGVGLCFTL-NLAVADtlIGVAISGLVTDQLSSSAQHTQ--KTLCSLRMAFV 85
Cdd:cd15075   5 IIMAVFSIASVVLNATVIIVTLR--HKQLRQPLNYALvNLAVAD--LGTTVFGGLLSVVTNAVGYFNlgRVGCVLEGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGcIAGLWLISYLIGFLPL-GVSIFQQT---TYHGP------- 154
Cdd:cd15075  81 AFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAG-IASSWLWSLIWNTPPLfGWGSYQLEgvmTSCAPdwysrdp 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 155 -------CTFFAVFHPRFVLTLSCAGFfpavLLFVFFYCDMLKIASVHSqhIRKMEHagamvgacrpprpvndfKAVRTV 227
Cdd:cd15075 160 vnvsyilCYFSFCFAIPFAIILVSYGY----LLWTLRQVAKLGVAEGGS--TAKAEV-----------------QVARMV 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 228 SVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVR 287
Cdd:cd15075 217 VVMVMAFLLCWLPYAAFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
43-281 1.38e-03

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 40.36  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQkTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15090  38 YIFNLALADALATSTLPFQSVNYLMGTWPFGN-ILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 123 GGCIAGLWLISYLIGfLPLgvsIFQQTTYHGPCTffavfhprfvltLSCAGFFP----------AVLLFVF-FYCDMLKI 191
Cdd:cd15090 117 KIVNVCNWILSSAIG-LPV---MFMATTKYRQGS------------IDCTLTFShpswywenllKICVFIFaFIMPVLII 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 192 ASVHSQHIRKMEHAGAMVGACRPPRpvNDFKAVRTVSVLIGSFTLSWSPFLITSIVQ--VACHKCCLYQVLEKYLWLLGV 269
Cdd:cd15090 181 TVCYGLMILRLKSVRMLSGSKEKDR--NLRRITRMVLVVVAVFIVCWTPIHIYVIIKalVTIPETTFQTVSWHFCIALGY 258
                       250
                ....*....|..
gi 32401461 270 GNSLLNPLIYAY 281
Cdd:cd15090 259 TNSCLNPVLYAF 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
93-182 1.49e-03

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 40.27  E-value: 1.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  93 VLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIfqQTTYHGPCT---FFAVFHPrfVLTL 169
Cdd:cd15939  90 LLTVM--AYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTL--QLPFCGPNVidhFFCDLFP--LLKL 163
                        90
                ....*....|...
gi 32401461 170 SCAGFFPAVLLFV 182
Cdd:cd15939 164 ACTDTYVIGLLVV 176
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
8-137 1.58e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 40.19  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDGVGL-CFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15391   2 HLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLnYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQL 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLR-YFQIMNGLVAggcIAGLWLISYLIG 137
Cdd:cd15391  82 VSVTASVLTNTAIGIDRFFAVIFPLRsRHTKSRTKCI---IASIWAISFSLS 130
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
43-139 1.64e-03

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 40.08  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVa 122
Cdd:cd15409  38 FLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRL- 116
                        90
                ....*....|....*..
gi 32401461 123 ggCIAgLWLISYLIGFL 139
Cdd:cd15409 117 --CVQ-LITASYIGGFL 130
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
9-290 1.88e-03

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 39.98  E-value: 1.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNdgVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSS 88
Cdd:cd14974   5 VLYALIFLLGLPGNGLVIWVAGFKMKRT--VNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  89 AAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIgFLPlgVSIFQQT-TYHGP--CTFFAVFHPRF 165
Cdd:cd14974  83 MFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVL-SVP--YFVFRDTvTHHNGrsCNLTCVEDYDL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFfpaVLLFVF-FYCDMLKIASVHSQHIRKMEHAGaMVGACRPprpvndfkaVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd14974 160 RRSRHKALT---VIRFLCgFLLPLLIIAICYSVIAVKLRRKR-LAKSSKP---------LRVLLAVVVAFFLCWLPYHVF 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32401461 245 SIVQVAcHKCCLYQVLekYLWL-LGVG----NSLLNPLIYAYWQREVRQQL 290
Cdd:cd14974 227 ALLELV-AAAGLPEVV--LLGLpLATGlayfNSCLNPILYVFMGQDFRKRL 274
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
9-290 1.89e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 40.06  E-value: 1.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNAL---VVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTqkTLCSLRMAFV 85
Cdd:cd15180   1 VFLPVLYSLVFLLGLLgngLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGT--GLCKLAGAVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLR-YFQIMNGLVAGGCIAgLWLISYLIG---FLPLGV-SIFQQTTYHgpCT-FFA 159
Cdd:cd15180  79 KINFYCGIFLLACISFDRYLSIVHAVQmYSRKKPMLVHLSCLI-VWLFCLLLSipdFIFLEAtKDPRQNKTE--CVhNFP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFHPRFVLTLS----CAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMehagamvgacrpprpvndfKAVRTVSVLIGSFT 235
Cdd:cd15180 156 QSDTYWWLALRllyhIVGFLLPLAVMVYCYTSILLRLLRSSQGFQKQ-------------------RAIRVIVAVVVVFF 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32401461 236 LSWSPFLITSIV------QVACHKCCLYQVLEKYLWL---LGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15180 217 LCWTPYNIALLVdtlidlSVLDRNCGTESRLDIALSVtssLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
91-186 1.93e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 39.97  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  91 ASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGP-----C-----TFFAV 160
Cdd:cd14997  87 ASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGtpvavCrtpadTFWKV 166
                        90       100
                ....*....|....*....|....*..
gi 32401461 161 FhprFVLTLSCAGFF-PAVLLFVFFYC 186
Cdd:cd14997 167 A---YILSTIVVFFVvPLAILSGLYSV 190
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
9-290 2.23e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 39.74  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCftlNLAVADTLigVAISGLVTDQLSSSA--QHTQKTLCSLRMAFVT 86
Cdd:cd15220   4 FCMVLLDLTALVGNTAVMVVIAKTPHLRKFAFVC---HLCVVDLL--AALLLMPLGILSSSPffLGVVFGEAECRVYIFL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSA--AASVLTVMLIAFDRYLAIKQPLRYFQIMN-GLVAGGcIAGLWLISYLIGFLPL----------GVSIFQQTTYHG 153
Cdd:cd15220  79 SVClvSASILTISAISVERYYYIVHPMRYEVKMTiGLVAAV-LVGVWVKALLLGLLPVlgwpsyggpaPIAARHCSLHWS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 154 PCTFFAVFHPRFVLTLSCAgffPAVLLFVfFYCDMLKIasvhsqhirkmehagaMVGAcrpprpvndfKAVRTVSVLIGS 233
Cdd:cd15220 158 HSGHRGVFVVLFALVCFLL---PLLLILV-VYCGVFKV----------------FGGG----------KAALTLAAIVGQ 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32401461 234 FTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15220 208 FLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
6-293 2.65e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 39.85  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   6 SFGVILAVLTILIIAVNALVVVAMLLsiYKNDGVGLCFTL-NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAF 84
Cdd:cd15084  12 TVAVLMGMVVALASFVNGLVIVVSIK--YKKLRSPLNYILvNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  85 VTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCI-----AGLWLISYLIG---FLPLGVSifqqtTYHGPCT 156
Cdd:cd15084  90 VSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAftwgwSLLWTSPPLFGwssYVPEGLR-----TSCGPNW 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 157 F----------FAVFHPRFVLTLSCAGFFPAVLLFVffycdmLKIASVHSQHIRKMEHAGAMVgacrpprpvndfkaVRT 226
Cdd:cd15084 165 YtggtnnnsyiLALFVTCFALPLSTIIFSYSNLLLT------LRAVAAQQKESETTQRAEKEV--------------TRM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 227 VSVLIGSFTLSWSPFLITSIVqVACHKCCLYQ-VLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHM 293
Cdd:cd15084 225 VIAMVMAFLICWLPYATFAMV-VATNKDVVIQpTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLEL 291
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
94-135 2.91e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 39.48  E-value: 2.91e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 32401461  94 LTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15234  91 LAVM--AYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISIL 130
KLF18_N cd21575
N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like ...
346-453 2.91e-03

N-terminal domain of Kruppel-like factor 18; Kruppel-like factor 18 (KLF18), or Krueppel-like factor 18, is a product of a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF4 and non-mammalian KLF17. KLF18 has been found in the human testis, though it was previously hypothesized to be a pseudogene in extant placental mammals. Mouse KLF18 expression data indicates that it may function in early embryonic development. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF18. Some KLF18 isoforms have duplicated N-terminal domains.


Pssm-ID: 410566 [Multi-domain]  Cd Length: 276  Bit Score: 39.67  E-value: 2.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 346 QTLYtcdaCDTQTLYTCDaQTLYTCdaQTLYTCDAQTLYTCDAQTLYTCdaQTLY------TCDTQTLYTCdaQTLYTCD 419
Cdd:cd21575  16 QTLY----GGQMTTPSGD-QTLYGG--QMTTSFSEQTLYGGQMTTPSGD--QTLYggqmttPNGNQTLYGG--QMTTSTG 84
                        90       100       110
                ....*....|....*....|....*....|....
gi 32401461 420 AQTLYtcDAQTLYTCDAQTLYTSSLVTGQTEQTP 453
Cdd:cd21575  85 NQTLY--GGQMTTSGSDQTLYGGQMTTSSGDQTL 116
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
8-241 2.92e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.48  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   8 GVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTL-NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVT 86
Cdd:cd15131   2 GITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLsSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIG---FLPLGVSIFQQT----TYHGPCTFFA 159
Cdd:cd15131  82 SCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAgpiFVLVGVEHENGTnpidTNECKATEYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 160 VFhprfvltlscAGFFPAVLLF--VFFYCDMLKIASVHSQHIRKM-EHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTL 236
Cdd:cd15131 162 VR----------SGLLTIMVWVssVFFFLPVFCLTVLYSLIGRKLwRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVL 231

                ....*
gi 32401461 237 SWSPF 241
Cdd:cd15131 232 CWLPF 236
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
88-135 2.92e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 39.60  E-value: 2.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 32401461  88 SAAASVLTVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15915  85 SSEAMLLAVM--AYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFF 130
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
10-290 2.98e-03

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 39.57  E-value: 2.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  10 ILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQL---SSSAQHTQkTLCSLRMAFVT 86
Cdd:cd15204   5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYvvrQRSWTHGD-VLCAVVNYLRT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAIKQPLRyfQIMNGLVAGGCIAGLWLISYLIGF----------LPLGVSIF--------QQ 148
Cdd:cd15204  84 VSLYVSTNALLVIAIDRYLVIVHPLK--PRMKRRTACVVIALVWVVSLLLAIpsavyskttpYANQGKIFcgqiwpvdQQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 149 TTYHGpcTFFAVFHPRFVLtlscagffPAVLLFVFFYCDMLKI-----ASVHSQHIRKMEHagamvgaCRPprpvndfKA 223
Cdd:cd15204 162 AYYKA--YYLFLFVLEFVL--------PVLIMTLCYLRIVRKVwfrrvPGQQTEQIRRRLR-------RRR-------RK 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461 224 VRTVSVLIGSFTLSWSPFLITSIVQ----VACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15204 218 VRLLVVILTAFVLCWAPYYGYAIVRdffpTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
95-135 3.08e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 39.34  E-value: 3.08e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 32401461  95 TVMliAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYL 135
Cdd:cd15228  92 TVM--AYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSF 130
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
78-140 3.36e-03

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 39.28  E-value: 3.36e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMN-----GLVAGGCIAG-LWLIS--YLIGFLP 140
Cdd:cd15914  73 CLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSIMTpklctQLAAGCWLCGfLGPVPeiILISTLP 143
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
91-290 3.49e-03

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 39.34  E-value: 3.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  91 ASVLTVMLIAFDRYLAIKQPL---RYFQIMNGLVAGGCIaglWLISYLIGFLPLgvsIFQQTT--YHGPCTFFAVFHPRF 165
Cdd:cd15119  85 ASVLFLTVISLDRYISLAHPVwshRYRTLKSALILCGIV---WLSAAAISGPAL---YFRDTMelSINVTICFNNFHKHD 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 166 VLTLSCAGFFPAVLLFVF-FYCDMLKIASVHSQHIRKMEHAGAMVGAcrpprpvndfKAVRTVSVLIGSFTLSWSPFLIT 244
Cdd:cd15119 159 GDLIVMRHTILVWVRFFFgFLFPLLTMVVCYSLLAIKVKRRTLLISS----------KFFWTISAVIVAFFVCWTPYHIF 228
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 32401461 245 SIVQVACHKCC-LYQVLEKYLWL---LGVGNSLLNPLIYAYWQREVRQQL 290
Cdd:cd15119 229 SILELSIHHSSyLHNVLRAGIPLatsLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
9-290 4.35e-03

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTdqlsSSAQH--TQKTLCSLRMAFVT 86
Cdd:cd15188   5 VFYTLVFLLGLAGNLLLFVVLLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAM----YVAWHwvFGSFLCKFVSTLYT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  87 SSAAASVLTVMLIAFDRYLAI--KQPLRYF--QIMNGLVaggcIAGLWLISYLIGfLPLGVSIFQQTT----------YH 152
Cdd:cd15188  81 INFYSGIFFVSCMSLDKYLEIvhAQSPHRLrtRRKSLLV----LVAVWVLSIALS-VPDMVFVQTHHTnngvwvchadYG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 153 GPCTFFAVFHpRFVLTLscAGFFPAVLLFVFFYCdmlKIASVhsqhirkmehagamVGACRPPrpvNDFKAVRTVSVLIG 232
Cdd:cd15188 156 GHHTIWKLVF-QFQQNL--LGFLFPLLAMVFFYS---RIACV--------------LTRLRPP---GQGRALRFVAALVV 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32401461 233 SFTLSWSPFLIT----SIVQVACHKCClyQVLEKYLWLLGVGNSL------LNPLIYAYWQREVRQQL 290
Cdd:cd15188 213 VFFVLWFPYNLTlflhSLQDLHVIGNC--ERSRHLDYALQVTESLafvhccLNPLLYAFVSKRFRLYL 278
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
78-124 5.24e-03

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 38.55  E-value: 5.24e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGG 124
Cdd:cd15950  73 CFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQ 119
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
78-279 5.86e-03

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 38.40  E-value: 5.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  78 CSLRMAFVTSSAA--ASVLTVMliAFDRYLAIKQPLRYFQIMN-------GLVagGCIAGLWLI---SYLIGFLPLGVSI 145
Cdd:cd15953  73 CLTQMFFIHTLSImeSAVLVAM--AFDRYVAICNPLRYATILTnsriaklGLV--GLIRGVLLIlplPLLLSRLPFCANR 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 146 FQQTTYhgpCTFFAvfhprfVLTLSCAGFFPA-----VLLFVFFYCDMLKIASVHSQHIRKMehagamvgaCRPPRPVND 220
Cdd:cd15953 149 IIPHTY---CEHMA------VVKLACGDTTINriyglVVALLVVGLDLLLIALSYALIIRAV---------LRLSSKKAR 210
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 221 FKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLY-QVLEKYLWLLgvGNSLLNPLIY 279
Cdd:cd15953 211 QKALNTCTAHICVILMSYTPALFSFLTHRFGQGIAPHiHIILANLYLL--VPPMLNPIIY 268
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
78-139 6.13e-03

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 38.46  E-value: 6.13e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32401461  78 CSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGlwliSYLIGFL 139
Cdd:cd15408  86 CLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAG----SYLAGFL 143
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
43-141 6.64e-03

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 38.21  E-value: 6.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  43 FTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVA 122
Cdd:cd15368  38 FMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYA 117
                        90
                ....*....|....*....
gi 32401461 123 GGCIAGLWLIsYLIGFLPL 141
Cdd:cd15368 118 VAACIGMWLL-VLTALSPL 135
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
78-129 6.90e-03

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 38.43  E-value: 6.90e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32401461  78 CSLRMAFVT--SSAAASVLTVMliAFDRYLAIKQPLRYFQIMNG-LVAGGCIAGL 129
Cdd:cd15223  73 CFAQMFFIHffTAMESSILLVM--ALDRYVAICKPLRYPSIITKsFILKLVLFAL 125
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
93-129 7.73e-03

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 7.73e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 32401461  93 VLTVMliAFDRYLAIKQPLRYFQIMN-----GLVAGGCIAGL 129
Cdd:cd15947  90 LLAVM--AFDRYVAVCRPLHYTVIMHprlcvQLAALSWLSGL 129
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
9-283 9.01e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 37.90  E-value: 9.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461   9 VILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTL---NLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFV 85
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINIllaSLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461  86 TSSAAASVLTVMLIAFDRYLAIKQPLryfQIMNGLVAGGCIAGLWLISYLIGF-LPLGVSIFQQTTYHGPCTFFAVFHP- 163
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLIIVQKQ---DKLNPYRAKVLIAVSWAVSFCVAFpLAVGSPDLQIPSRAPQCVFGYTTNPg 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32401461 164 --RFVLTLSCAGFFpaVLLFVFFYCDMLKIASVHSQHIRkmehagamvgacrpprpvndfkAVRTVSVLIGSFTLSWSPF 241
Cdd:cd15404 158 yqAYVILIMLIFFF--IPFMVMLYSFMGILNTVRSFKTR----------------------AFTTILILFIVFTVCWAPF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 32401461 242 LITSIVQVAC----HKCCLYQVLEKYLWLLGVgNSLLNPLIYaYWQ 283
Cdd:cd15404 214 TTYSLVATFNshfyHKHNFFEISTWLLWLCYL-KSALNPLIY-YWR 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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