|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-405 |
1.92e-89 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 275.69 E-value: 1.92e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 13 PVLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGL 92
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 93 VLSSFAVTPGQMQLLEILVGFGIAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 173 IFAVVILCALFALPFLRSPSMATKAE------LDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFitekcg 246
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALrayddaSPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPY------ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 247 aidptglLADIGVTTTSilGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSL 326
Cdd:cd17355 237 -------LADRGISPAA--AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1232094251 327 VMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHLPI 405
Cdd:cd17355 308 LFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-409 |
2.23e-53 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 182.39 E-value: 2.23e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 13 PVLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGL 92
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 93 VLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIG-GGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 173 IFAVVILC-ALFALPFLRSPSMATKAELDESLGTVLKrAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKCGAidpt 251
Cdd:COG2223 164 ILGILLLVvAVLAWLFLRDPPAGAAAAAKASLRDQLE-ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL---- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 252 glladigvttTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSL 331
Cdd:COG2223 239 ----------SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232094251 332 WLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHLPIREKP 409
Cdd:COG2223 309 LGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-408 |
2.39e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 128.06 E-value: 2.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQLLEILVGFGIAGtGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFII 173
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAG-FFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 174 FAVVILCALFAlpflrspsmatkaeldeslgtvlkrafkdpSFTMIFVGFFSCGYQLGFITAHFPAFITEKCGAidptgl 253
Cdd:COG2271 170 LGLPGLLLALL------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 254 ladigvttTSILGAIAISVIGLANIVGSILSGWLGKRYTK--KYLLSGIYVARTVASALFIMLPiTPASVLIFSLVMGSL 331
Cdd:COG2271 214 --------SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232094251 332 WLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTgGYDTVWWIGVGVGAFSALVHLPIREK 408
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
15-405 |
2.42e-31 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 123.10 E-value: 2.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 15 LISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVL 94
Cdd:cd17353 5 VLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 95 SSFAVTPgqmqLLEILVGFGIAGTGFGVILAI-VGRAAK--PENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVF 171
Cdd:cd17353 85 SAFAISL----PLLFLGYGVLGGIGAGIGYITpVSTAVKwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 172 IIFAVVILCALFAL-------PFLRSPSMATKAELDESLGTV---LKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFI 241
Cdd:cd17353 161 LILGIIFLIIIVIGaflirdpPKGWVPPGVDPLANNAENSPRdytPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 242 TEKCGAIDPTGlladigvtttsilgAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASV 321
Cdd:cd17353 241 QEFAGLDAGIA--------------ALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 322 LIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGkFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17353 307 VLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALAL 385
|
....
gi 1232094251 402 HLPI 405
Cdd:cd17353 386 ALLL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-367 |
3.17e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.31 E-value: 3.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 1 MIQTSPKASIFTPVLISGCVILMLGFAIrasFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRA 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGI---VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 81 IIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGtGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQI 160
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGA-LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 161 MLQYYHWQTVFIIFAVVILCALFALPFLRSpsmATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAF 240
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLP---ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 241 ITEKCGAidptglladigvttTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPiTPAS 320
Cdd:COG2814 234 LQEVLGL--------------SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1232094251 321 VLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGS 367
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
20-401 |
4.30e-28 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 114.20 E-value: 4.30e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 20 VILMLGFAIrASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAV 99
Cdd:COG2807 26 VALNLRPAI-TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 100 TPGQMQLLEILVGFGIAgTGFGVILAIVGRAAkPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVIL 179
Cdd:COG2807 105 SVALLLAGTALIGAGIA-VGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 180 CALFA-LPFLRSpsmATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFitekcgaidptglLADIG 258
Cdd:COG2807 183 LALLLwLPLLRR---RPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI-------------LRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 259 VTTTsiLGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLiFSLVMGSLWLATVPL 338
Cdd:COG2807 247 LSAA--TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWL-WAVLLGLGQGGLFPL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1232094251 339 TSGLVAHIYG-LRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:COG2807 324 ALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
14-406 |
2.61e-26 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 108.79 E-value: 2.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNwprAEFSMAIAIQNLAWGVGQ---PIFGAIAERFGDRRAIIAGAILYAL 90
Cdd:cd17352 4 VVFASFLVNFFTDGILNSFGVLFVELLEEFG---ESTSDIAWIGSLLLGVSLfsgPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 91 GLVLSSFAVTpgqmqLLEILVGFGI-AGTGFGVIL----AIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYY 165
Cdd:cd17352 81 GLLLSSFATS-----LWQLYLTYGVlGGLGLGLIYspaiVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 166 HWQTVFIIFAVVILCALFAlpflrspsmatkaeldeslgTVLKRAFKDPSFTMIFVG--FFSCGYQLGFItaHFPAFite 243
Cdd:cd17352 155 GWRGALLILGGLCLNLCVC--------------------GLLLRLLKDPTFVLLALGvsFAMLGFFVPFV--YLPSY--- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 244 kcgaidptglLADIGVTTTsiLGAIAISVIGLANIVGSILSGWLG-KRYTKKYLLSGIYVARTVASALFIMLPITPASVL 322
Cdd:cd17352 210 ----------AKSLGIDES--DAAFLLSIIGISDIVGRILLGLLAdKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 323 IFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVH 402
Cdd:cd17352 278 VFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
....
gi 1232094251 403 LPIR 406
Cdd:cd17352 358 FLLP 361
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-390 |
1.96e-24 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 103.65 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 20 VILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAV 99
Cdd:cd17314 10 LLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 100 TpgqmQLLEILVGFGIAGTGFG-VILAIVGRAAK--PENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAV 176
Cdd:cd17314 90 N----SFPLSYACFVFIGAGTGiLYGSAVLVTTQyfPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 177 VILCALFALP---FLRSPSMATKAELDESLGTVLKRAFKDPSFTMIFVGFFS---CGYQLGFITAHfpafitekcgaidp 250
Cdd:cd17314 166 LAAIVLSVVSllgFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLvliGGFLFIANMAS-------------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 251 tglLADIGVTTTSILGAIAISVIGLANIVGSILSGWLGKRYTKK-YLLSGIYVARTVASALF-IMLPITPASVLIFSLVM 328
Cdd:cd17314 232 ---LVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRlSTLSILLTILGLGLCAFlFLLKMTPVGLVLTGSLL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232094251 329 GSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWI 390
Cdd:cd17314 309 GFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYI 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-401 |
5.44e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.27 E-value: 5.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 51 SMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgFGVILAIVGRA 130
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAV-WPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 131 AKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV-ILCALFALPFLR--SPSMATKAELDESLGTVL 207
Cdd:cd17325 113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALaLLALVLALLLLPepRPPPNKRAVSAARLRSGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 208 KRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKCGAidptglladigvtTTSILGaIAISVIGLANIVGSILSGWL 287
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL-------------SPAQIG-LLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 288 GKRYTKKYLlsgIYVARTVASALFIMLPITP--ASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQL 365
Cdd:cd17325 259 SDRIGRKPL---ILIGLLLSAVALLLLPLATsfWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
330 340 350
....*....|....*....|....*....|....*.
gi 1232094251 366 GSFLGVWLGGKFYDmTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17325 336 GMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-403 |
4.14e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.55 E-value: 4.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 38 PIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAG 117
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 118 TgFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALpFLRSPSMATKA 197
Cdd:cd17324 104 F-WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLL-WRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 198 ELDESLGTVLKRAFKDPsftmifVGFFSCGYQLGFITAHFPAFitekcgAIDPTGLLADIGVTTTSILGAIAisVIGLAN 277
Cdd:cd17324 182 PGSLGLLSSLLLLLRNP------RLRLAYLITFLLFGGFFALY------TYLAPFLTDVPGFSSSAIIGLLL--LFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 278 IVGSILSGWLGKRYTKKYLLSGIYVArTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHIyGLRYMGTLYG 357
Cdd:cd17324 248 VVGSPLAGRLADRGGRRALLIALLLL-AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1232094251 358 VVFFSHQLGSFLGVWLGGKFYDMtGGYDTVWWIGVGVGAFSALVHL 403
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDH-GGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-370 |
2.57e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.10 E-value: 2.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFA 98
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 99 VTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVI 178
Cdd:pfam07690 83 SSLWLLLVLRVLQGLG-AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 179 LCALFALPFLRSPSMA---TKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKcgaidptglla 255
Cdd:pfam07690 162 LLAAVLLLLPRPPPESkrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL----------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 256 digvTTTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPIT--PASVLIFSLVMGSLWL 333
Cdd:pfam07690 231 ----GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTlsSLWLLLALLLLGFGFG 306
|
330 340 350
....*....|....*....|....*....|....*..
gi 1232094251 334 ATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLG 370
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-401 |
3.58e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.42 E-value: 3.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFA 98
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 99 VTPGQMQLLEILVGFGIAGTgFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQY--YHWQTVFIIFAV 176
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLI-DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 177 VILCALFALPFL-----RSPSMATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEkcgaidpt 251
Cdd:cd06174 161 LALLAAILLLLVvpdppESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD-------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 252 glladiGVTTTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSL 331
Cdd:cd06174 233 ------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 332 WLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-405 |
2.20e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 79.92 E-value: 2.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFA 98
Cdd:cd17319 9 FLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 99 VTPGQMQLLEILVGFGIAGtGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV- 177
Cdd:cd17319 89 TSLTSLYVLRFLLGVAEAG-FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLg 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 178 ILCALFALPFLrspsmatkaeldeslgtvlkrafkdPSFTMIFVGFFSCGYQLGFITAHFPAFITEKCG-AIDPTGLLAd 256
Cdd:cd17319 168 LLLAVLWWFYL-------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLA- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 257 igvtttsilgaiaiSVIGLANIVGSILSGWLGKRYTKKY--LLSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWLA 334
Cdd:cd17319 222 --------------AIPFLAGAIGMILGGRLSDRLLRGArrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232094251 335 TVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHLPI 405
Cdd:cd17319 288 ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
14-401 |
1.78e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 74.16 E-value: 1.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIrASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:cd17365 1 LALCFLIIVLDGFDL-AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQLLEILVGFGIaGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFII 173
Cdd:cd17365 80 LTAFAQSVLQLALLRFLTGLGL-GAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 174 FAVVilcALFALPFLRspsmatkaeldeslGTVlkrafkdpsftMIFVGFFSCGYQLGFITAHFPAfitekcgaidptgL 253
Cdd:cd17365 159 GGVP---PLILLPLLR--------------GTL-----------LLWVTFFMGLLLVYLLNSWLPK-------------L 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 254 LADIGVTTTSilGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWL 333
Cdd:cd17365 198 MVEAGYSLSQ--ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVN 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232094251 334 ATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17365 276 GAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALA 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
39-401 |
1.95e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 74.14 E-value: 1.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGT 118
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFgVILAIVGRAAKPENRSLALGIATAAGSAGQVFGaPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRSPSMATKAE 198
Cdd:cd17474 105 GP-LALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 199 LDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPafitekcgaidptgLLADIGVTTTSILGAIAISVIGLANI 278
Cdd:cd17474 183 SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP--------------FLLELLYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 279 VGSILSG-WLGKRYTKKYLLSGIYVARTVASALFIMLPiTPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYG 357
Cdd:cd17474 249 LGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1232094251 358 VVFFSHQLGSFLGVWLGGKFYdMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
14-384 |
2.64e-14 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 73.97 E-value: 2.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFS----MAIAIQNLAwgvgQPIFGAIAERFGDRRAIIAGAILYA 89
Cdd:cd17423 4 VVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSwitsIGLAVQQLA----SPVGSALSTRYGARPVVMLGGLLSS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 90 LGLVLSSFAVTPGQMQL-LEILVGFGIAGTgFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQ 168
Cdd:cd17423 80 LGFLLASFATSLLHLYLcIGLLSGLGWALV-FAPTMATVSRYFS-RRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 169 TVFIIFAVVIL----C-ALFALPFLRSPSMATKAELDESLGTVLkraFKDPSFTMIFVG--FFSCGYQLGFItaHFPAFi 241
Cdd:cd17423 158 GALLLLSALSLhlvpCgALLRPLALPGDPPAPPRSLSAAFGLSL---LTHRAFLRYALAttLINTGYFIPYV--HLVAH- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 242 tekcgaidptglLADIGVTTTSilGAIAISVIGLANIVGSILSGWLGKRYTKK--YLLSgIYVARTVASALFIMLPITPA 319
Cdd:cd17423 232 ------------ARALGLGEYQ--AAFVVSVAAVADAVGRLFSGWLADLGPLRllHLLV-LWTALTGLSLLLLPLAKVYG 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1232094251 320 SVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGY 384
Cdd:cd17423 297 SLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDY 361
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-329 |
3.64e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 73.49 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 22 LMLGFAIRasfgvfqiPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTP 101
Cdd:cd17371 16 LLLGLVLP--------ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 102 GQMQLLEILVGFGIAGTgFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYH----WQTVFIIFAVV 177
Cdd:cd17371 88 WQLLILRALAGLGFGGE-WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFLLGALP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 178 ILCALFALPFLRSPSMATKAELDESLG--TVLKRAFKDPSF--TMIFVGFFSCGYQLGF--ITAHFPAFITekcgaidpt 251
Cdd:cd17371 167 ALLVLFIRRFVKEPPQWQAARAARRHFadRPSLRELFSPPLlrTTLLASLLATGALGGYygITTWLPSYLT--------- 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232094251 252 gllADIGVTTTSILGAIAISVIGlaNIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMG 329
Cdd:cd17371 238 ---GERGLSFEGSAGYLVVTILG--GFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLG 310
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
51-382 |
8.63e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 8.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 51 SMAIAIQNLAWGVGQPIFGAIAE----RFGDRRA-IIAGAILYALGLVLSSFAVT-PGQMQLLEILVGFGIAGTGFGVI- 123
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLFTAPDlSPTGKLIYALVTYLLLGLAYTLVn 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 124 ---LAIVGR-AAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYY------HWQTVFIIFAVVILcALFALPFLRSPSM 193
Cdd:COG2211 129 ipySALGAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGL-LAFLLTFFGTKER 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 194 ATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEkcgaidptglLADIGVTTTSILGAIAIsvi 273
Cdd:COG2211 208 PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY----------VLGLSAALVGLLLALYF--- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 274 gLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIML-PITPASVLIFSLVMGSLWLATVPLTSGLVAHI------ 346
Cdd:COG2211 275 -LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydew 353
|
330 340 350
....*....|....*....|....*....|....*..
gi 1232094251 347 -YGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTG 382
Cdd:COG2211 354 kTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-401 |
1.21e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.79 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 53 AIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAK 132
Cdd:cd17329 40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFG-GGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 133 PENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHwQTVFIIFAVVILCALFALPFLRSPSMATKAELDE-SLGTVLKRAF 211
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKtEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 212 KDPSFTMIFVGFFSCGYQLGFITAHFPAFitekcgaidptglLADIGVTTTSILGAiaisVIGLANIVGSILSGWLGKRY 291
Cdd:cd17329 198 RDRAFLLFLLASFLISLIYFQLESTLPVY-------------VVEILGLGESLLGL----LLALNALLIVLLQFPVARLV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 292 TKKYLLSGIYVARTVASALFIMLPI--TPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFL 369
Cdd:cd17329 261 ERFRLRKILMIGILLFAIGFAVLAFanTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAI 340
|
330 340 350
....*....|....*....|....*....|..
gi 1232094251 370 GVWLGGKFYDMtGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17329 341 GPLVGGLLLDL-LGPGLPWLILAALGLIAAAL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-189 |
1.28e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 13 PVLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGL 92
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 93 VLSSFAVTPGQMQLLEILVGFGIaGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGL-GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 1232094251 173 IFAVVILCALFALPFLR 189
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-401 |
3.64e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.21 E-value: 3.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASfgvfqIPIAAEFNWPRAEF--SMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALG 91
Cdd:cd17473 4 LLLASTLTVMAGAAIAPA-----LPAIAQHFVPNSELlvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 92 LVLSSFAVTPGQMQLLEILVGFGIAGTgFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFgAPAAQIMLQYYHWQTVF 171
Cdd:cd17473 79 GVAGLFLDSLYALLASRALLGIGVAGI-MTLATALIGDYFEGEERAKMLGLQSAAMSLGGVV-FLLLGGALAEIGWRAPF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 172 IIFAVVILCALFALPFLRSPsmATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEkcgaidpt 251
Cdd:cd17473 157 LVYLLALPVLILVLLFLPEP--ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQE-------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 252 glladIGVTTTSILGaIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVarTVASALFIM-----LPITPASVLIFSL 326
Cdd:cd17473 227 -----RGGGSAALIG-LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA--LMALGFLLLalasgLWVVLLGAILAGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1232094251 327 VMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17473 299 GFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
39-382 |
6.47e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.43 E-value: 6.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAgt 118
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA-- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFG--APAAQIMLQYYHWQTVFIIFAVVILcALFALPFLRSPSMATK 196
Cdd:cd17478 100 AFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGplIAAALVALFGGLGLLILLIIPGLAV-ALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 197 AELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAhFPAFITEKCGAIdptglladigvtttsILGAIAISVIGLA 276
Cdd:cd17478 179 KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTF-LPFYLVQRGYSL---------------VFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 277 NIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFslVMGSLWLATVPLTsGLVAHIYGLRYMGTLY 356
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLV--LAGFLLFASFPVT-VVLAQELLPGNVGLAS 319
|
330 340
....*....|....*....|....*..
gi 1232094251 357 GVVF-FSHQLGSfLGVWLGGKFYDMTG 382
Cdd:cd17478 320 GLMMgLSFGLGG-IGAPVLGALADAFG 345
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
63-401 |
6.89e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 66.43 E-value: 6.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 63 VGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgFGVILAIVGRAAKPENRSLALGI 142
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGL-FVVSESWLNALATNENRGRVLGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 143 ATAAGSAGQVFGAPAAQIMLQYYHwqTVFIIFAVVILCALFALPFLRSPSMATKAELDESLGTVLKRAFkdpsftMIFVG 222
Cdd:cd17477 125 YSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAP------LALLG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 223 FFSCGYQLGFITAHFPAFitekcgaidptglLADIGVTTTSIlgAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYV 302
Cdd:cd17477 197 AFVAGFLEGAFYSLLPLY-------------GLRLGLSVAQA--ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 303 ARTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTG 382
Cdd:cd17477 262 LGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341
|
330
....*....|....*....
gi 1232094251 383 GYDTVWWIGVGVGAFSALV 401
Cdd:cd17477 342 PHGLFLFLAAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-327 |
7.81e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.42 E-value: 7.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 6 PKASIFTPVLISGCVILMLGFAIrASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGA 85
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 86 ILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgfGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQY- 164
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLL--DVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 165 --YHWQTVFIIFAVVILCALFALPFLRSPSMATKAELDESLGTVLKRAFKDPSFTMIFVG-FFSCGYQLGFITAhFPAFI 241
Cdd:COG0738 159 lsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAiFLYVGAEGAIGDW-LPLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 242 TEKCGAidptglladigvttTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASV 321
Cdd:COG0738 238 KDVLGL--------------SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLAL 303
|
....*.
gi 1232094251 322 LIFSLV 327
Cdd:COG0738 304 IGLALV 309
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
65-383 |
1.84e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.33 E-value: 1.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 65 QPIFGAIAERFgDRRAIIAGAIL-YALGLVLSSFAVTPGQMQLLEILVGFGIAGtGFGVILAIVGRAAKPENRSLALGIA 143
Cdd:cd17328 51 SPIFGYLGDRY-NRKWILAVGILiWSAATLLSSFAPNFWQLLLFRALVGIGEAS-YSPIAPTIIADLFPKEKRTRALGVF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 144 TAAGSAGQVFGAPAAQIMLQY-YHWQTVFIIFAVV-ILCALFALPFLRSP------SMATKAELDESLGTVLKRAFKDPS 215
Cdd:cd17328 129 YFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLgVLLAILLLLFVREPprgaaeGGVMAKSTATSFLADLKALAKNPS 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 216 FTMIFVGFFSCGYQLGFITAHFPAFITEKCGAIDPTglLADIGVtttsILGAIAIsVIGLAN-IVGSILSGWLGKRYTKK 294
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLS--SADVGL----IFGAITC-IAGVLGvLLGGILADRLRRKTPRA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 295 YLLSGIYVARTVASALFIMLPITPAS-VLIFSLVMGSLWLATV--PLTSGLVAHIYGLRYMGTLYGV-VFFSHQLGSFLG 370
Cdd:cd17328 282 DPLVCAVGLLAAAPFLFLALVLALSNlLLAWVLLFLGEFLLSLnwAPVFAILLYVVIPTRRSTASAIqILLSHLLGDAGS 361
|
330
....*....|...
gi 1232094251 371 VWLGGKFYDMTGG 383
Cdd:cd17328 362 PYLIGLISDLLRQ 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
12-403 |
2.70e-11 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 64.50 E-value: 2.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 12 TPVLISGCVILmlgFAIRASFGVFQIPIAAEFNWPRAEfsMAIAIQNLAWG--VGQPIFGAIAERFGDRRAIIAGAILYA 89
Cdd:cd17380 1 VILLFLATCIC---YADRVNMPIAIVPMAKEFGWSKTD--QGLVLSSFFWGyaLTQVLGGYLADRFGGKKVLLLAVALWS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 90 LGLVLSSFAVTPGQ--MQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHW 167
Cdd:cd17380 76 LATLLTPLLAYSSLplLILSRILLGLG-EGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 168 QTVFIIFAvviLCALFALPFLRSPSMATKAeldeslgtvlkrafkdpsftmIFVGFFSCGYQLGFITAHFPAFITEKCGA 247
Cdd:cd17380 155 PSVFYFFG---LLGLLWALVWLIYLPPVWA---------------------IIVAHFCMNWGFYILLSWLPTYFHEVLVP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 248 idptglLADIGVTTTsilgaiaisVIGLANIVGSILSGWLG-----KRYTKKYLLSGIYVARTVASALFIMLPITPAS-- 320
Cdd:cd17380 211 ------LAKGWVFNV---------VPWLVMFPSSNVAGWLAdhlisRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSfs 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 321 --VLIFSLVMGSLWLAtvplTSG-LVAHI-YGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGA 396
Cdd:cd17380 276 laLLCMSVALGLSAFS----SSGvLVNHQdIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNL 351
|
....*..
gi 1232094251 397 FSALVHL 403
Cdd:cd17380 352 VGAVVFL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-401 |
3.75e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.18 E-value: 3.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTpgqmqLLEILVGFGIAGT 118
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-----YPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFGVILAIVGRAA----KPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV-ILCALFALPFLR-SPS 192
Cdd:cd17475 97 GYGSVQPGGGRAImrwfPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVsILAAVLFWLFYRePPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 193 MATKAELDESLGTVLKRAFKDPSFTMI-FVGFFSCGYQLGFITaHFPAFITEKcgaidptgllADIGVTTTSILGAIAis 271
Cdd:cd17475 177 ASAATESASTLLRSLKEVLRNRDVWLIaIAGALLVAPQFALLT-FLLLFLHDH----------LGLSVVAAGALLAVA-- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 272 viGLANIVGSILSGWL-----GKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHI 346
Cdd:cd17475 244 --QLGGALGRIGLGRVsdrvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1232094251 347 YGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
24-403 |
4.79e-11 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 63.90 E-value: 4.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 24 LGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQ 103
Cdd:TIGR00893 5 INYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 104 MQLLEILVGFGIAGTGFGVILaIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV-ILCAL 182
Cdd:TIGR00893 85 LYILRVLLGAAEAPFFPGIIL-IVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLgIIWGV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 183 FALPFLRSP------------SMATKAELDESLGTV--------LKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFIT 242
Cdd:TIGR00893 164 LWLKFIPDPpqkakwlteeekYIVVGGLLAEQQGKGpstpkkyqIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 243 EKCGaidptglladIGVTTTSILGAIAISVIGLANIVGSILSGWLGKRyTKKYLLSGIY--VARTVASALFIM---LPIT 317
Cdd:TIGR00893 244 QERG----------LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR-GKSLVFARKTaiIAGLVLSLLMFAtnyVNIP 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 318 PASVLIFSLVMGSLWLATVPLTsgLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAF 397
Cdd:TIGR00893 313 YAALALVALGFFGLGAGAIGWA--LISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALI 390
|
....*.
gi 1232094251 398 SALVHL 403
Cdd:TIGR00893 391 GALSYL 396
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
39-241 |
8.75e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.52 E-value: 8.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGT 118
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIG-AGG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRSPSMATKAE 198
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLAL 198
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1232094251 199 LDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFI 241
Cdd:COG0477 199 LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
39-401 |
8.89e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.98 E-value: 8.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGT 118
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GfGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILcALFALPFLRSPSMATKAE 198
Cdd:cd17320 105 S-VVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGL-LLLLLVLLFLPETLPEEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 199 LDESLGTVLkRAFKDPSFTMIFVGFFSCgyqLGFITAHFPAFITekcgaIDPTGLLADIGVTTTSIlgAIAISVIGLANI 278
Cdd:cd17320 183 RKPLLSSLL-RAYKRVLKNRRFLGYALA---LGLSFAGLFAYLA-----AAPFIYIEQLGLSPAQF--GLLFALNAIALI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 279 VGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPIT-----PASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRymG 353
Cdd:cd17320 252 LGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA--G 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1232094251 354 TLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17320 330 TASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-351 |
1.47e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.23 E-value: 1.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 24 LGFAIRASFGVFQIPI------AAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSF 97
Cdd:cd17489 1 ILLANFFFFLSFYLLLpvlplyAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 98 AVTPGQMQLLEILVGFGIaGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV 177
Cdd:cd17489 81 ATSVALLLVLRLIHGIGW-GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 178 ILCALFALPFLRSPSmaTKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKcgaidptgLLADI 257
Cdd:cd17489 160 ALLALLLVFLVKDPP--PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER--------GISNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 258 GvtttsilgaIAISVIGLANIVGSILSGWLGKRYTKKYLLSgiyvartvasalfimlpitpASVLIFSLVMGSLWLATVP 337
Cdd:cd17489 230 G---------LFFTVYAIALLLSRPFSGKLSDRKGPKTVII--------------------PGLLLLALGLLLLSFAGSP 280
|
330
....*....|....
gi 1232094251 338 LTSGLVAHIYGLRY 351
Cdd:cd17489 281 WMLLLAAVLYGLGF 294
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
66-390 |
2.04e-10 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 61.75 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 66 PIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQL-LEILVGFGIAgTGFGVILAIVGRAAKpENRSLALGIAT 144
Cdd:cd17424 56 PLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLtLGVLTGLGFA-LCYSPAIAMVGKYFH-KRKALAYGIAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 145 AAGSAGQVFGAPAAQIMLQYYHWQTVFIIFA--VVILCALFAlpflrspsmatkaeldeslgtvLKRAFKDPSFTMIFVG 222
Cdd:cd17424 134 SGSGIGTFILAPVVQLLIEQFSWRGALLILGgfVLNLCVCGA----------------------LMRFLLMPDFLVLAVS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 223 FFSCGYQLGfitahfPAFITekcgaIDPTGLlaDIGVTTTSilGAIAISVIGLANIVGSILSGWL-GKRYTKKYLLSGIY 301
Cdd:cd17424 192 VLFLAYGCS------PPFVY-----LVPYAL--SVGVSHQQ--AAFLMSILGVIDIIGNITFGWLtDRRCLKKYRYFCYL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 302 VARTVASALFIMLPITPASVLI--FSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYD 379
Cdd:cd17424 257 FAVGMDGLCCLFLPILKTFPLLvpFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVD 336
|
330
....*....|.
gi 1232094251 380 MTGGYDTVWWI 390
Cdd:cd17424 337 TTGTYTAAFLL 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-186 |
2.69e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.42 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGT 118
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232094251 119 gFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALP 186
Cdd:cd17321 102 -MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLAR 168
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
20-346 |
6.14e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 60.34 E-value: 6.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 20 VILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAV 99
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 100 TPGQMqLLEILVGFGIAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAG----QVFGAPAAQIMLQ---YYHWQTVFI 172
Cdd:cd17341 86 SSYWG-LLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGvavsQLLAPLIAGAIVFdggFVGWRNAFF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 173 IFAVVILCALFALPFLRSpSMATKAELDESLGTVLKRAFKDP-SFTMIFVGFFSCGYQLGFiTAHFPAFITEKCGaidpt 251
Cdd:cd17341 165 VPGILLAIAAVLVLLFGD-DLPTGKASALEFLKVQLAVLKNYrTWILSLLYGVTFGSFVGF-SNVLPTYFKTRFG----- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 252 glladIGVTTTSILGAIaisvIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSL 331
Cdd:cd17341 238 -----LPLVTAGILAAL----FPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVA 308
|
330
....*....|....*
gi 1232094251 332 WLATVPLTSGLVAHI 346
Cdd:cd17341 309 LGLGAGAGNGSVFRM 323
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
63-188 |
6.96e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.89 E-value: 6.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 63 VGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGI 142
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFG-AAFALVAGAALIADIYPPEERGVALGL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1232094251 143 ATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFL 188
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFL 137
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
50-403 |
1.53e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 50 FSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVG---FGIAGTGFGVIL-A 125
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLaflLGIASAFFGPARqA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 126 IVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRSPSMATKAELDESLGT 205
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 206 VLKRAF----KDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKCGAidptglladigvttTSILGAIAISVIGLANIVGS 281
Cdd:cd06173 196 DLREGLrylrRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG--------------GAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 282 ILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASvLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFF 361
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLL-LAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1232094251 362 SHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHL 403
Cdd:cd06173 341 LNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-198 |
3.50e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.97 E-value: 3.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGT 118
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYH-WQTVFIIFAVVILCALFALPFLRSPSMATKA 197
Cdd:COG2223 312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
.
gi 1232094251 198 E 198
Cdd:COG2223 392 A 392
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
30-401 |
4.02e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.61 E-value: 4.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 30 ASFGVFQIPIAAEFNWPRAEF--SMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLL 107
Cdd:cd17316 16 FLIGFVAPVLAAEFSLGLSLLqtGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 108 EILVGFGIAGTgFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAA----QIMLQYYHWQTVFIIFAVVILCALF 183
Cdd:cd17316 96 RFLQGIGIGGE-YPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAslliPLLSGDWGWRILFLIGALPALLALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 184 ALPFLrspsmatkaeldeslgtvlkrafkdpSFTMIFVGFFSCGYqlGFITAHFPAFITEKCGaidptglladIGVTTTS 263
Cdd:cd17316 175 LRRRT--------------------------LLLILLWFFISFGY--YGLTTFLPTYLQTVLG----------LSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 264 ILgaiaISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWLATV-PLTSGL 342
Cdd:cd17316 217 LY----LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVwGALYAY 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1232094251 343 VAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALV 401
Cdd:cd17316 293 LAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
14-401 |
7.19e-09 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 57.07 E-value: 7.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:cd17422 4 VAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQL-LEILVGFGIAGTgFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:cd17422 84 TASFASSIVEMYLtIGIISGLGYCFT-FLPTVTILSQYFK-KRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 173 IFAVVilcalfalpflrspsmatkaELDESLGTVLKRAFKDPSFtmIFVGFFSCGYQLGFITAhfPAFITEkcgaidptg 252
Cdd:cd17422 162 VVGAL--------------------QLNIVVCGALLRVLKEPGF--ICYALFGLFATLGFFAP--QLYIIP--------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 253 LLADIGVTTTsiLGAIAISVIGLANIVGSILSGWLgkryTKKYLLSGIYVARTVASALFIMLPITP-----ASVLIFSLV 327
Cdd:cd17422 209 LSLSLGIDQD--WAAYMLSAMAIAELFGRISAGWV----LNKCPIRKIYIELICVILLCVVLLLFPfaygfWSLLVCSIF 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 328 MGSLW--LATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWW---IGVGVGA-FSALV 401
Cdd:cd17422 283 YGFMFgtVAGTHIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYscaAGMALGAvFLALV 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
11-376 |
9.07e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.98 E-value: 9.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 11 FTPVLISGCVILMLGFAIRAsfgvfqipIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYAL 90
Cdd:TIGR00895 23 FLIMLMDGYDLAAMGFAAPA--------ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 91 GLVLSSFAVTPGQMQLLEILVGFGIaGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTV 170
Cdd:TIGR00895 95 FTLLCALATNVTQLLILRFLAGLGL-GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 171 FIIFAVV-ILCALFALPFLRSP-----------------SMATKAELDESLGTVLKRAFKDP---SFTMIFVG------- 222
Cdd:TIGR00895 174 FYVGGIApLLLLLLLMRFLPESidflvskrpetvrrivnAIAPQMQAEAQSALPEQKSTQGTkrsVFKALFQGktaritv 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 223 FFSCGYQLGFITAHFPAFITEKcgaidptgLLADIGVTTTsiLGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYV 302
Cdd:TIGR00895 254 LLWLLYFMLLVGVYFLTNWLPK--------LMVELGFSLS--LAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1232094251 303 ARTVASALFIMLPItPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGK 376
Cdd:TIGR00895 324 GAVFAVLVGSTLFS-PTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
39-406 |
1.53e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 56.05 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGt 118
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 gFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRSpsmatkae 198
Cdd:cd17504 101 -FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL-------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 199 ldeslgtvlkRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITekcgaiDPTGLLADIGVTTTSILgaiaISVIGLANI 278
Cdd:cd17504 172 ----------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQ------LPTPTGFGLGITEAGLL----LLPGALVML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 279 VGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMG---SLWLATVPltsGLVAHIYGLRYMGTL 355
Cdd:cd17504 232 IAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGiglGLAFASLP---NIVVESVPPDRTGIA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232094251 356 YGVVFFSHQLGSFLG------------VWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHLPIR 406
Cdd:cd17504 309 TGMNTVLRTIGSAIGpaiagailttytVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-189 |
1.78e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.68 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 3 QTSPKASIFTPVLISGCVILMLGFAIRASFGVFQIPIAAEFNWprAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAII 82
Cdd:cd17489 184 GTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVII 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 83 AGAILYALGLVLSSFAVTPGQMQLLEILVGFGIaGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIML 162
Cdd:cd17489 262 PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF-GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
170 180
....*....|....*....|....*..
gi 1232094251 163 QYYHWQTVFIIFAVVILCALFALPFLR 189
Cdd:cd17489 341 ELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
16-188 |
1.38e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.40 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 16 ISGCVILMLGFAIRASFGVFQIPIAAEFNwPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLS 95
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 96 SFAVTPGQMQLLEILVGFGIAGTGFGVilAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYH--WQTVFII 173
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGA--AVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYI 157
|
170
....*....|....*
gi 1232094251 174 FAVVILCALFALPFL 188
Cdd:cd06179 158 NAIFNALALILLFFF 172
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-406 |
2.30e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.28 E-value: 2.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 29 RASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLE 108
Cdd:cd17312 19 RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 109 ILVGFgIAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAvvILCALFALpfl 188
Cdd:cd17312 99 GLNGL-FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPG--IVGLVVAI--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 189 rspsmatkaeldeslgtVLKRAFKDPSFTMIFVGFFSCgyqlgfitahFPAFITEKCGAIDPTGLLADIGVTTTSilGAI 268
Cdd:cd17312 173 -----------------ILFFFLRDSPPYVWVLSLAYA----------FVYIVRYACLDWGPLYLYEVKGYSLID--AGW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 269 AISVIGLANIVGSILSGWLGKRY--TKKYLLSGIYVA-RTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAH 345
Cdd:cd17312 224 FSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLlMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQ 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232094251 346 IYGLRY-MGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGyDTVWWIGVGVGAFSALVHLPIR 406
Cdd:cd17312 304 DIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGW-STVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
125-403 |
2.37e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 125 AIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHW--QTVFIIFAVVILCALFALPFLRSPSMATKAELDES 202
Cdd:cd17370 111 ALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKS 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 203 LGTVLKRAFKDPSFTMIFVGFFSCGYqlgfitAHFPAFITEkcgaidptglladigVTTTSILGAIAISVIGLANIV--- 279
Cdd:cd17370 191 KKTSLKKLPKAFWLYLLAVALFALGN------FSFAFLILR---------------AQELGLSAALIPLLYALFNLVyal 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 280 GSILSGWLGKRYTKKYLLSGIYVArTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVV 359
Cdd:cd17370 250 AAYPAGRLSDRIGRKKLLILGYLS-LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF 328
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1232094251 360 FFSHQLGSFLGVWLGGKFYDMTgGYDTVWWIGVGVGAFSALVHL 403
Cdd:cd17370 329 NTVVGIGWLLASLIAGYLWDLI-SPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-189 |
2.49e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.19 E-value: 2.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 48 AEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIV 127
Cdd:cd17473 233 ALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLG-FGLLLPTLNSWA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232094251 128 GRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYH-WQTVFIIFAVVILCALFALPFLR 189
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGgLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-185 |
3.09e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.81 E-value: 3.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIPIA----AEFNWPRAEFSMAIAIQNLAWGVGQ-PIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSlflkDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFII 173
Cdd:cd17330 257 LLPFASSVPLLVLAAAILAFG-TGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
|
170
....*....|..
gi 1232094251 174 FAVVILCALFAL 185
Cdd:cd17330 336 AAGLLLIALFLL 347
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-189 |
1.81e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.50 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGT 118
Cdd:cd17503 22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG-GGV 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLR 189
Cdd:cd17503 101 LIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLD 171
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
41-406 |
1.89e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 49.61 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 41 AEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgF 120
Cdd:cd06180 27 AELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFV-F 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 121 GVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQY-YHWQTVFIIFAVV--ILCALFALPFLRSPSMATKA 197
Cdd:cd06180 106 VFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLsaVLLLLSFLLLRRGPSAPTEA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 198 ELDESlgtvlkRAFKDPSFTMIFVGFFSCGyqLGFI-TAHF-PAFITEKCGAidptglladigvtttSILGAIAISVIGL 275
Cdd:cd06180 186 SAAES------APGLNRPLWRLALAYGLFG--FGYIiTATFlPLIARETGAG---------------SLLAGLLWSLFGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 276 ANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPiTPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTL 355
Cdd:cd06180 243 AAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSP-GPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRAL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1232094251 356 yGVVFFSHQLGSFLGVWLGGKFYDMTGGYDTVWWIGVGVGAFSALVHLPIR 406
Cdd:cd06180 322 -ALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
52-383 |
2.14e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.52 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 52 MAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGqmqllEILVGFGIAGTG--FGVILAIVGR 129
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY-----GLILGRALQGSGaiSSVVMALLAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 130 AAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRsPSMATKAELDESLGTVLKR 209
Cdd:cd17472 111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFV-PDPPKIVQISEKEKKKLKK 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 210 AFKDPSF-TMIFVGFFscgyQLGFITAHFPAFitekcgaidptGLLADIGVTTTSILGAIAISVIGLANIVGSILSGWLG 288
Cdd:cd17472 190 LLKNKRLlRLDFSIFI----LHFVLMAFFYIL-----------PLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 289 KRYTKKYLLSGIYVARTVAsalFIMLPITPASVLIFSLVMGSLWLATV---PLTSGLVAHIYGLRYMGTLYGVVFFSHQL 365
Cdd:cd17472 255 KKGKMKQVFVSSILLIAVG---FLLLLFAATSLWLLIIGLIIFFIGFNlleALLPSLVSKIAPKEYRGTAMGIYNTSQFL 331
|
330
....*....|....*...
gi 1232094251 366 GSFLGVWLGGKFYDMTGG 383
Cdd:cd17472 332 GSFLGGALGGLLWGLLGY 349
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
19-401 |
2.35e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.18 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIP---IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLS 95
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVIlpiIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 96 SFAVTPGQMQLLEILVGFGIAGTGFGVIlAIVGRAAKPEN-RSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIF 174
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAM-ALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 175 AvvILCALFAlpflrspsmatkaeldeslgtVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEKCGAidptgll 254
Cdd:cd17476 160 A--ILAAIVA---------------------VAAIFWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGY------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 255 adigvttTSILGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASalfIMLPITPASVLIFSLVMGSLWLA 334
Cdd:cd17476 210 -------SPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGP---ILFATMPVHQTYWAQAFPAMIVA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 335 TV------PLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFY--------DMTGGYDTVWWIGVGVGAFSAL 400
Cdd:cd17476 280 PFgmdfsfPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVEtsvnedgaDLLKGYRAAWYLGIGLAALGLL 359
|
.
gi 1232094251 401 V 401
Cdd:cd17476 360 I 360
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
38-379 |
3.59e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.78 E-value: 3.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 38 PIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAER----FGDRRA-IIAGAILYALGLVLSSFAVTPG-----QMQLL 107
Cdd:cd17313 24 PILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRPfILVGAPLAALGLILIPNAADIGlalgdGPRTW 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 108 EILVGFGI-------AGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGApAAQIMLQYYHW---------QTVF 171
Cdd:cd17313 104 ALVLFVLGivlldfaMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY-LLGAILWDHNWfgfalggnlKVPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 172 ----IIFAVVILCALFALPFLRSPSMATKAELDESLGTVLKR-----AFKDPSFTMIFVGFFSCGYQLGFITAHFPAFIT 242
Cdd:cd17313 183 yigaIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSllkllKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 243 EKCGAIDPTGLLA-DIGVTTtsilGAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPiTPASV 321
Cdd:cd17313 263 EEVYHGTSAASSHyGAGVRM----GAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVH-NVTVA 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232094251 322 LIFSLVMGSLW--LATVPLTsgLVAHIYGLR------YMGTLYGVVFFSHQLGS-FLGVWLGGKFYD 379
Cdd:cd17313 338 LVLFALGGIGWatININPYP--LVSDYHSESgrgqgtDTGLLNLAISLAQILVSlLAGPIIDVKGYG 402
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
69-183 |
4.95e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 48.57 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 69 GAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTGFGVILAIVGRAAKPENRSLALGIATAAGS 148
Cdd:PRK14995 62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGS 141
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1232094251 149 AGQVFGAPAAQIMLQYYHWQTVF-----IIFAVVILCALF 183
Cdd:PRK14995 142 GGAAFGPLVGGILLEHFYWGSVFlinvpIVLVVMGLTARY 181
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
59-403 |
6.50e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.94 E-value: 6.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 59 LAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSL 138
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG-GGGLMSLAFIIIADLVPPRERGK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 139 ALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIfavVILCALFALPFLRSPSMAtkaeldeslgtvlkrafkdpsftm 218
Cdd:cd17502 120 YQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI---NLPIGGLALALLRTILLS------------------------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 219 IFVGFFSCGYQLGFITaHFPAFITEKCGAidptglladigvttTSILGAIAISVIGLANIVGSILSGWLGKR--YTKKYL 296
Cdd:cd17502 173 SIFGFLFGGALFGLIY-YLPLYFQLVLGD--------------SATKSGVRLLPLIIGLVIGSIISGALISKtgRYKPLI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 297 LSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWLATVpLTSGLVAHIYGL--RYMGTLYGVVFFSHQLGSFLGVWLg 374
Cdd:cd17502 238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIG-FQQPLVAVQNAVppADVGVATATNTFFRSLGGTLGVAI- 315
|
330 340
....*....|....*....|....*....
gi 1232094251 375 gkfydmtggyDTVWWIGVGVGAFSALVHL 403
Cdd:cd17502 316 ----------TDVFLVALALAALAFLLSL 334
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
59-394 |
6.55e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.96 E-value: 6.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 59 LAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILvgFGIAGTGFGVILAIVGRAAKPENRSL 138
Cdd:cd17330 45 LGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFL--DGLTGGNVSVAQAYIADITDEEERAK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 139 ALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVV-ILCALFALPFLRspsmatkaeldeslgtvlkrafkdPSFT 217
Cdd:cd17330 123 AFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALaLLNLVLVLFFLP------------------------PLRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 218 MIFVGFFSCgYQLGFITAHFPAFitekcgaidptgLLADIGVTTTSIlgAIAISVIGLANIVGSIL-SGWLGKRYTKKYL 296
Cdd:cd17330 179 LLLVYFLIA-LAFAGLESVFSLF------------LKDRFGFSPSQI--GLLLALVGIAGILAQLLlIPRLAKRLGERKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 297 LSGIYVartVASALFIMLPI--TPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLG 374
Cdd:cd17330 244 LRLGLL---LAIIGLLLLPFasSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLA 320
|
330 340
....*....|....*....|
gi 1232094251 375 GKFYDMTGGYdTVWWIGVGV 394
Cdd:cd17330 321 GPLYSFLGPG-VPFLLAAGL 339
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
26-186 |
6.62e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 6.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 26 FAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQ 105
Cdd:cd17370 212 FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 106 LLEILVGFGIAGTGfGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFAL 185
Cdd:cd17370 292 LGFILWGLYMGAQE-SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
.
gi 1232094251 186 P 186
Cdd:cd17370 371 L 371
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
129-401 |
1.46e-05 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 46.84 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 129 RAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVIL---CALFALPFLRSPSMATKAELDESLGT 205
Cdd:cd17485 119 ELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLlllLPVLFLRELELPQQPPASERGAALKA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 206 VLKRAFKDPSF--TMIFVGFFSCGYQLGFitAHFPAFitekcgaidptglLADIGVTTTSIlGAIAISVIGLANIVGSIL 283
Cdd:cd17485 199 SLRAFLRRPGTrwLLLFLLLYKLGEQGAL--AMLPPF-------------LVDRGFSLSQI-GLLSGVGGSLVSIAGSLL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 284 SGWLGKRYTKKYLLSGIYVARTVASALFIMLPITP---------ASVLIFSLVMGslwLATVPLTSgLVAHIYGLRYMGT 354
Cdd:cd17485 263 GGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGsglnwvlllASLALLHLVGG---MITTALFT-LMMDCSQQAQAGT 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1232094251 355 LYGVVFFSHQLGSFLGVWLGGKFYDMTgGYDTVWWIGVGVGAFSALV 401
Cdd:cd17485 339 DYTLLATVEVLGKLLFGSLAGFLADHL-GYAAAFLLFAILSALSVLL 384
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
125-328 |
1.54e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 46.81 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 125 AIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFA----LPFLRSPSMATKAeld 200
Cdd:PRK03545 120 SLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLliklLPLLPSEHSGSLK--- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 201 eSLGTVLKRAFKDPSFTMIFVgffscgyqlgFITAHFPAFitekcGAIDPtgLLADIGVTTTSILGAIAIsVIGLANIVG 280
Cdd:PRK03545 197 -SLPLLFRRPALVSLYLLTVV----------VVTAHFTAY-----SYIEP--FVQQVAGLSENFATLLLL-LFGGAGIIG 257
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1232094251 281 SILSGWLGKRYTKKYLLSGIYVartVASALFIMLPITPASVLIFSLVM 328
Cdd:PRK03545 258 SVLFSRLGNRHPSGFLLIAIAL---LLVCLLLLLPAANSEWHLSVLSI 302
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
53-375 |
1.76e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.49 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 53 AIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFgIAGTGFGVILAIVGRAAK 132
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 133 pENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVI-LCALFALPFLRSPSMATKAELDESLGTVLKRAF 211
Cdd:cd17391 120 -EKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLfLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 212 KDPSFTMIFVGFFSCGYQLGFITAHFPAFITEkcgaidptglLADIGVTTTSILGAIAiSVIGLANIVGSILSGWLGKRY 291
Cdd:cd17391 199 NPSLLISLFVTTFIIQLANQSIEPILTLYIRQ----------LMGDASNLAFISGLVF-SATGVSSLLSAPRLGKLGDRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 292 --TKKYLLSGIYVARTVasaLFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFL 369
Cdd:cd17391 268 ghHRILLGALLASALLY---IPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVA 344
|
....*.
gi 1232094251 370 GVWLGG 375
Cdd:cd17391 345 GPLLGS 350
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
69-208 |
2.15e-05 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 46.21 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 69 GAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiaGTGFGVI-LAIVGRAAKPENRSLALGIATAAG 147
Cdd:PRK11646 67 GAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLG--GTLFDPPrTALVIKLIRPHQRGRFFSLLMMQD 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232094251 148 SAGQVFGAPAAQIMLQyYHWQTVFIIFAVV-ILCALFALPFLRSPSMAT-KAELDESLGTVLK 208
Cdd:PRK11646 145 SAGAVIGALLGSWLLQ-YDFRLVCATGAVLfVLAAAFNAWLLPAYKLSTvRTPVREGMTRVLR 206
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
66-383 |
2.18e-05 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 46.09 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 66 PIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVT-------PGQMQLLEILVGFGIAGTGFGVILAivgrAAK--PENR 136
Cdd:cd17354 55 PLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTglisdlsFWLMCLCFFLIGNSTSSLYTAALVT----CAKnfPESR 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 137 SLALGI-ATAAGSAGQVFgapaAQIMLQYYHWQ--TVFIIFAVVILC-ALFALPFLRSPSMATKaeldeslgtvlkRAFK 212
Cdd:cd17354 131 GLAIGIpKGCYGLSGAIG----SQLYKALFFHDsaRVFLFLAVLPAVvGLLAWFSVRIVSIEEG------------EFLK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 213 DPSFTMIFVGFF-SCGYQLGFITAhfpafitekcgaidptglLADIGVTTTSILG-AIAISVIGLANIVGSILSGWLGKR 290
Cdd:cd17354 195 DIDFWLLFISLFlGVGPGEMFINN------------------LGQIGQSLTGPSNtSTLVSLFSIFSFLGRLLSGLLSDL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 291 YTKKYLLSgiYVARTVASALFIMLPITpasVLIFSLVMGSLWLATV----------PLTSGLVAHIYGLRYMGTLYGVVF 360
Cdd:cd17354 257 FVRKFRLP--RPSRMVLLLLILSLGHL---LQAFGLPSGALYVASAligfgygglfSIAPTIVSELFGLKNFGTNYGFLM 331
|
330 340
....*....|....*....|....
gi 1232094251 361 FSHQLGSFL-GVWLGGKFYDMTGG 383
Cdd:cd17354 332 LAPAIGSLIfSVIYAGVYYDNGGE 355
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
52-185 |
2.30e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 52 MAIAIQNLAWGVGQPIFGAI-AERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIaGTGFGVILAIVGRA 130
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL-GLNLPLLTTLVTEL 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1232094251 131 AKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFAL 185
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
46-187 |
3.01e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.98 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 46 PRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV--LSSFAVTPGQMQLLEILVGFGIA-GTGFGV 122
Cdd:cd17369 262 DRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFpfFWLLDTGSTWLIVLAAVVVLGVLhGMMYGP 341
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232094251 123 ILAIVGRAAKPENRSLALGIATAAGSAGQVFGAP--AAQIMLQYYHWQTVFIIFAVVILCALFALPF 187
Cdd:cd17369 342 QAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPliATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
14-202 |
3.19e-05 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 45.89 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:TIGR00892 20 VLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQL-LEILVGFGIAgTGFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:TIGR00892 100 LASFSSNVIELYLtAGFITGLGLA-FNFQPSLTMLGKYFY-RRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFL 177
|
170 180 190
....*....|....*....|....*....|
gi 1232094251 173 IFAVVILCALFALPFLRSPSMATKAELDES 202
Cdd:TIGR00892 178 ILGGLLLHCCVCGALMRPVGPSQRVSKSKS 207
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
39-191 |
3.81e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.83 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGT 118
Cdd:TIGR00711 28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG-GGP 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVF----IIFAVVILCALFALPFLRSP 191
Cdd:TIGR00711 107 LIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFlinvPIGIIVVVVAFFILPRDKPA 183
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
59-324 |
5.56e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 5.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 59 LAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIA---GTGFGVILAIVgraaKPEN 135
Cdd:cd17323 45 LGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSsplAIGAGTIADLF----TPEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 136 RSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLrspsmatkaeldeslgtvlkrafkdps 215
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLF--------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 216 FTMIFVGFFSCGYQLGFITAHFPAFITekcgaidptgLLADIGVTTTSILGAIAISvIGLANIVGSILSGWLGKRYTKKY 295
Cdd:cd17323 174 LPIVLLLGLYVGLVYAILYLFLTAFPY----------VFGEVYGFSPGEVGLMYLP-IGIGALIGSIIGGRLSDYYYRRL 242
|
250 260 270
....*....|....*....|....*....|.
gi 1232094251 296 LLS--GIYVARTVASALFIMLPITPASVLIF 324
Cdd:cd17323 243 KKKngGKPEPEARLPPAFIGAFLFPIGLFIF 273
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
66-185 |
7.24e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 7.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 66 PIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAgtgfgvILAIVG----RAAKPENRSLALG 141
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG------ITAGLGisyfQDLMPGQPGLATT 326
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1232094251 142 IATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFAL 185
Cdd:cd17471 327 LYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
31-385 |
9.85e-05 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 44.04 E-value: 9.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 31 SFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTpgqMQLLEIL 110
Cdd:cd17421 21 TFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATS---VPFLYVS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 111 VGFgIAGTGFGVIL-AIVGRAAKPENRSLALGIATAAGSAGQVFG-APAAQIMLQYYHWQTVFIIFAVVILcALFALPFL 188
Cdd:cd17421 98 MGL-LVGLGFAFLYqAAAVMTAKYFKKRLATAYAIARSGMGLTFAlAPFTQLLLDEYDWQGALLIFGGIML-NLVASGML 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 189 RSPsmatkaeLDESLgtvlkraFKDPSFTMIFVGF-FScgyQLGFITAHFPAFITEKCGAIDPTGlladigvtttsilGA 267
Cdd:cd17421 176 LRP-------IDFSL-------LKDPFFCIYTWSFvFS---QLAYFIPYFHLVARARTLGIDPMD-------------AS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 268 IAISVIGLANIVGSILSGWLGKR-YTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHI 346
Cdd:cd17421 226 FIISVAGITETVAQLASGWIADQnWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDL 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 1232094251 347 YGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGYD 385
Cdd:cd17421 306 VGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYD 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
28-382 |
2.10e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 28 IRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLL 107
Cdd:TIGR00881 10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 108 EILVGFgIAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAP-AAQIMLQYYHWQTVFIIFAVV-ILCALFAL 185
Cdd:TIGR00881 90 WALNGI-FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPlVLFGIAELYSWHWVFIVPGIIaIIVSLICF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 186 PFLRSPSMA---TKAELDESLGTVLKRAFKDPSFT-----------------MIFVGFFSCGYQLGFITaHFPAFITEKC 245
Cdd:TIGR00881 169 LLLRDSPQScglPPAEEMPNEEPDGDAEKKEEELTkkqiflqyvllnkvlwyISLGYVFVYVVRTGILD-WSPLYLTQEK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 246 GaidptglladigvtTTSILGAIAISVIGLANIVGSILSGWLGKRY--TKKYLLSGIYVARTVASAL--FIMLPITPASV 321
Cdd:TIGR00881 248 G--------------FSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLvyWLNPAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232094251 322 LIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTG 382
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
50-384 |
2.66e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.83 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 50 FSMAIAIQNLAWGVGQPIFGAIAERFGDR-RAIIAGAILYALGLVLSSFaVTPGQMQLLEILVGFGIAGTGFGVIL--AI 126
Cdd:COG2270 54 WGYALAIAGLLVALLAPVLGAIADRSGRKkPFLAFFTLLGVLATAALFF-VAPGGLWLGLLLFVLANIGFEGSLVFynAF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 127 VGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHW----------QTVFIIFAVVILcaLFALPFLR------- 189
Cdd:COG2270 133 LPDIATPEEIGRVSGLGWALGYLGGVLLLLINLALFLKPEAfglpdageavRISFLLTALWWL--LFALPLFLflperpr 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 190 SPSMATKAELDES---LGTVLKRAFKDPSFTMIFVGFFScgYQLGFITahfpafitekcgAIDPTGLLA--DIGVTTTSI 264
Cdd:COG2270 211 PGPAPPRGAVRAGfreLRRTLRELRRYRDLLRFLLAYFF--YRDGVQT------------VIAFAGIYAagVLGFSTTEL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 265 LGAIAIsvIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPiTPASVLIFSLVMGSLWLATVPLTSGLVA 344
Cdd:COG2270 277 IVFGLL--VQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLT-TALAFWILGLLIGLVMGGIQALSRSLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1232094251 345 HIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDMTGGY 384
Cdd:COG2270 354 RLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQ 393
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
253-401 |
2.78e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 253 LLADIGVTTTSIlgAIAISVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPiTPASVLIFSLVMGSLW 332
Cdd:COG2814 36 IAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP-SLWLLLAARFLQGLGA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1232094251 333 LATVPLTSGLVAHIYGLRYMGTLYGVVFFSHQLGSFLGVWLGGKFYDmTGGYDTVWWIGVGVGAFSALV 401
Cdd:COG2814 113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFGWRWVFLVNAVLALLALLL 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-189 |
3.10e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFqipiAAEFNW--PRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALG 91
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLY----YFKYVLglSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 92 LVLSSFAVTPGQMQLLEILVGFGIAGTGFGVIL-AIVGRAAKPE-------NRSLALGIATAAGSAGQVFGAPAAQIMLQ 163
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPwAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1232094251 164 YYHWQ---------------TVFIIFAVVILCALFALPFLR 189
Cdd:COG2211 388 LFGYVagaaqspsaltgirlLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-188 |
4.57e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 12 TPVLISGCVILMLGFAIRASFGVFqipIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALG 91
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLL---AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 92 LVLssFAVTPGQMQLLEILVGFGIAGTGFGVIL-AIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTV 170
Cdd:cd06173 288 LLV--LGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 1232094251 171 FIIFAVVILCALFALPFL 188
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-185 |
5.68e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 13 PVLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAII-AGAILYALG 91
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 92 LVLSSFAVTPGQMQLLEILVGFGIAGtGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIML-QYYHWQTV 170
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGG-LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGA 362
|
170
....*....|....*
gi 1232094251 171 FIIFAVVILCALFAL 185
Cdd:cd06174 363 FLVLAVLLLLAAILL 377
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
43-191 |
7.29e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.51 E-value: 7.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 43 FNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV--LSSFAVTPGQMQLLEILVGFGIAGTGF 120
Cdd:cd17367 254 AGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVplLSALDHTDSPYTAFALVLVGLVFLSGY 333
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232094251 121 GVILAIVgRAAKPENRSLALGIATAAGSAGQVFG--APAAQIMLQYYHWQTVFiIFAVVILCALFALPFLRSP 191
Cdd:cd17367 334 TSINAVV-KAELFPTHVRALGVGLPYALAVAIFGgtAPYVALWLKSIGHEWVF-FWYVAGLIAISLVVYLRMP 404
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
14-179 |
7.95e-04 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 41.30 E-value: 7.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:cd17425 4 VLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQLLEILVGFGIAGTGFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFII 173
Cdd:cd17425 84 ASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFV-RRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLV 162
|
....*.
gi 1232094251 174 FAVVIL 179
Cdd:cd17425 163 FGGVLL 168
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
52-183 |
1.59e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 52 MAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgFGVILAIVGRAA 131
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGL-LPAINSLLAKIT 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1232094251 132 KPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALF 183
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
49-343 |
1.81e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 49 EFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTGFGVILaIVG 128
Cdd:cd17327 42 QYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFIL-YLG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 129 RAAKPENRSLALGIATAAGSAGQVFG---APAAQIMLQY---YHWQTVFIIFAVV-ILCALFALPFL------------- 188
Cdd:cd17327 121 MWYKREEQAKRIAFFYAAAGLGSIFGgllAYGVFKILGVgglAGWRWLFIIEGLItIIIGLVIFFWLpdnpskawfltee 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 189 -------RSPSMATKAELDESLGTVLKRAFKDPSFTMIFVGFFSCGYQLGFITAHFPAFITEkcgaidptgllaDIGVTT 261
Cdd:cd17327 201 ekelaveRLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKS------------LGFYSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 262 TSILGAIAISVIGLANIvgsILSGWLGKRYTKKYLLSGIYVARTVASALfIMLPITPASVLIFSLVMGSLWL-ATVPLTS 340
Cdd:cd17327 269 QTNLLSVPIGALGAVSL---LIAALLSDRFKKRGLFAIFACVLALVGSI-ILLAAPNPPGAYFAAYILGGGSyAGFPILL 344
|
...
gi 1232094251 341 GLV 343
Cdd:cd17327 345 SWI 347
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
66-214 |
1.89e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 39.99 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 66 PIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTGFGVILAIVGRAAKPENRSLALGIATA 145
Cdd:cd17383 48 PFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGIALA 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 146 AGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALPFLRSP-SMATKAELDESLGTVLKRAFKDP 214
Cdd:cd17383 128 FISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPvRRETRANMPEPVGTPIHRLLMDP 197
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
43-189 |
2.36e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.93 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 43 FNWPRAEFSMAIAIQNLAWGVGQPIF-GAIAERFGDRRAIIAGAILYALGLVLSSFAvTPGQMqLLEILVGFGIAGTGFG 121
Cdd:cd17388 237 FDWSPTMVGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFA-TQGWM-VFPILILLALGGIAGP 314
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232094251 122 VILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQY--YHWQ-TVFIIFAVVILCALFALPFLR 189
Cdd:cd17388 315 ALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAspATWPgLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-155 |
2.84e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 1 MIQTSPKASIFTPVLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRA 80
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232094251 81 I---IAGAILYALGLVLSSFAVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGA 155
Cdd:pfam07690 268 LllaLLLLILAALGLLLLSLTLSSLWLLLALLLLGFG-FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-185 |
2.91e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 20 VILMLGFAIRASFgvfqIPIAA-EFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAE-RFGDRRAIIAGAILYALGLVLSSF 97
Cdd:cd17490 205 LQQMITFSTTFGF----TPLIAkQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFLIPF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 98 AVTPGQMQLLEILVGFGiAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVF-IIFAV 176
Cdd:cd17490 281 APNLTLLYLLQALNGFG-TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFfVIGVI 359
|
....*....
gi 1232094251 177 VILCALFAL 185
Cdd:cd17490 360 ALLAAILSL 368
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
63-392 |
3.00e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 63 VGQPIFGAIAERFGDRRAIIAGAILYALgLVLSSFAVTPGQMQLLEILVGFGIAGTGFGVILAIVGRAAKPENRSLALGI 142
Cdd:cd17335 47 LSAPLWGALADRFGKRKALLLLSLLAAV-LFFLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 143 ATAAGSAGQVFGAPAAQIMLQYYHWQT----VFIIFAVVILCALFALPFLRSPSMATKAELDESlgtVLKRAFKDPSFTM 218
Cdd:cd17335 126 QRLWGSIGFGIAALLVGILIDRSSTYKnytiAFYVFAVLMLLALLLALKFPFRPKHPEPNENTG---GLLALLRNPRVLA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 219 IFVGFFSCGYQLGFITAHFpafitekcgaidpTGLLADIGVTTTSILGAIAISVIglANIVGSILSGWLGKRYTKKYLLS 298
Cdd:cd17335 203 FLLVAFLMGFGHGLIYSFL-------------FWHLQDLGGSKTLIGLLWTVGVV--SEIPFFFFSSRLIQRFGHVGLLY 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 299 ---GIYVARTVASALFIMLPITPASVLIFSLVMGSLWLATVPLTSGLVAHIYGLRYMGTLYGVvffSHQLGSFLGVWLGG 375
Cdd:cd17335 268 lglLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGL---YFGLGGGLGSLIGG 344
|
330
....*....|....*..
gi 1232094251 376 KFYDMTGGYDTVWWIGV 392
Cdd:cd17335 345 YLYEAFGARTTFRFFAI 361
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
8-185 |
3.27e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 8 ASIFTPVLISGCVILMLGfairasfGVFQIPIAAEFNWPRAE----FSMAIAIQNLAWGVGQPIFGAiaeRFGDRRAIIA 83
Cdd:cd17331 210 AFLLLVKLLSGLPIGMFQ-------SMFSLVAMDFFGLTPEEngylMSYAGVLGMVVQGLLVGPLTK---RFGERSLLKL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 84 GAILYALGLVLSSFAVTPGQMQLleILVGFGIAGTGFGVIL-AIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIML 162
Cdd:cd17331 280 SVALLAIGYLLLAFVTTVWQLLV--LLLPLVIGGSVLYTVItSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
|
170 180
....*....|....*....|...
gi 1232094251 163 QYYHWQTVFIIFAVVILCALFAL 185
Cdd:cd17331 358 QAYGFPSFGLLGAAINGLLTVYL 380
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
63-331 |
4.21e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.20 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 63 VGQPIFGAIAERFGDRRAIIAGAILYALGLVLssFAVTPGQ----------MQLLEILVGFGIAGTgFGVILAIVGRAAK 132
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLV--IAVTPTYatigiwapiiLLLARLLQGLSVGGE-YGTSATYLSEVAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 133 PENRSLALGIATAAGSAGQVFGAPAAQIMLQY--------YHWQTVFIIFAVvilCALFALpFLR-----SPSMATKAEL 199
Cdd:cd17367 132 PGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTlgedqmaaWGWRIPFLLGGV---LAVVVL-WLRrgleeTESFEAIAES 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 200 DESLGTVLKRAFKDPSFTMIFVGFFSCGyqlgfiTAHFPAFITEKcgaidPTGLLADIGVTTTSILGAIAISviGLANIV 279
Cdd:cd17367 208 NEASAGTLRELRRHPRELLLVVGLTAGG------TLAFYTWTTYL-----QKFLVNTAGFSKGDATWITTAA--LLVFML 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1232094251 280 GSILSGWLGKRYTKKYLLSGIYVARTVASA-LFIMLPITPASVLIFSLVMGSL 331
Cdd:cd17367 275 LQPLGGRLSDRIGRRPLLLFFGIGGTLATVpLLSALDHTDSPYTAFALVLVGL 327
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
14-205 |
4.52e-03 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV 93
Cdd:cd17426 4 VVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 94 LSSFAVTPGQMQL-LEILVGFGIAgTGFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFI 172
Cdd:cd17426 84 AASFCNTVEGLYFcVGVVGGLGLA-FNLNPALTMIGKYFY-KKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFL 161
|
170 180 190
....*....|....*....|....*....|...
gi 1232094251 173 IFAVVILCALFALPFLRspSMATKAELDESLGT 205
Cdd:cd17426 162 ILGGLLLNCCVAGSLMR--PIGPKPFLDLTLFT 192
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-154 |
4.54e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 19 CVILMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFA 98
Cdd:cd17321 175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALL 254
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 99 VTPGQMqlLEILVGFGIAGTGFGVILAIVGRAA----KPENRSLALGIATAAGSAGQVFG 154
Cdd:cd17321 255 GADSSV--WLLLPGLVLLGLGLGLFATPLTNAAlssvPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
14-189 |
4.89e-03 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 39.03 E-value: 4.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 14 VLISGCVI-LMLGFAIRASFGVFQIPIAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGL 92
Cdd:cd17427 3 AVVFGAFIsIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLGM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 93 VLSSFAVTPGQMQL-LEILVGFGIAgTGFGVILAIVGRAAKpENRSLALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVF 171
Cdd:cd17427 83 ISASFCNSVMQLYLcIGVIGGLGLA-FNLQPALTIIGKYFY-KKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170
....*....|....*...
gi 1232094251 172 IIFAVVILCALFALPFLR 189
Cdd:cd17427 161 LILGGLLLNCCVAGSLMR 178
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
39-328 |
5.18e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 39 IAAEFNWPRAEFSMAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQmQLLEILVGFGIAGT 118
Cdd:TIGR00886 28 IKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYS-VLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 119 GFGVILAIVGRAAKPENRSLALGIATAAGSAG----QVFGAPAAQIMLQYYH--------WQTVFIIFAVVILCALFALP 186
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALGLAAGWGNMGggvaQFVMPPIIGSLIFGGGqpahlawgWAFVIVPAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 187 FLRSPSMATKAELDESLGTVLKRaFKDPSfTMIFVGFFSC--GYQLGFITAhFPAFITEKCGAIDPTglladigvtttsi 264
Cdd:TIGR00886 187 VGADTPPGKPATGKLSFKEALKV-FGNRH-TWILALLYSVtfGSFLGVSSI-FAMLFKDQFGLSKVQ------------- 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1232094251 265 LGAIAiSVIGLANIVGSILSGWLGKRYTKKYLLSGIYVARTVASALFIMLPITPASVLIFSLVM 328
Cdd:TIGR00886 251 AGAYA-SLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLF 313
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
37-216 |
5.67e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 38.65 E-value: 5.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 37 IPIAAEFNwprAEFSMAIAIQNLAWGVG---QPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMqlleiLVGF 113
Cdd:PRK15403 40 INVVRDFN---ADVSLAPASVSLYLAGGmalQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQF-----LIAR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 114 GIAGTGFGVIlAIVG----RAAKPENRSLAL-GIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALFALpFL 188
Cdd:PRK15403 112 FIQGTSICFI-ATVGyvtvQEAFGQTKGIKLmAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGL-LL 189
|
170 180 190
....*....|....*....|....*....|.
gi 1232094251 189 RSPSMATKAELDESLGTVLK---RAFKDPSF 216
Cdd:PRK15403 190 AMPETVKRGAVPFSAKSVLRdfrNVFRNRLF 220
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
58-192 |
8.28e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 37.95 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 58 NLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLV-LSSFAVTPGQMQLLEILVGFGIAGTGFGvILAIVGRAAKPENR 136
Cdd:cd17365 216 NIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLAlLGVSPASLVLLYVLVFLAGACVNGAQVG-LYALAARFYPTEVR 294
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1232094251 137 SLALGIATAAGSAGQVFGAPAAQIMLQY-YHWQTVFIIFAVVILCALFALPFLRSPS 192
Cdd:cd17365 295 ATGVGWALGVGRLGAILGPLLGGLLLAAgLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
67-183 |
8.62e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 38.14 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 67 IFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGFGIAGTgFGVILAIVGRAAKPENRSLALGIATAA 146
Cdd:PRK03893 74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGE-YGSSATYVIESWPKHLRNKASGFLISG 152
|
90 100 110
....*....|....*....|....*....|....*..
gi 1232094251 147 GSAGQVFGAPAAQIMLQYYHWQTVFIIFAVVILCALF 183
Cdd:PRK03893 153 FSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALW 189
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
23-177 |
8.82e-03 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 38.09 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 23 MLGFAIRASFGVFQIPI---------------AAEFNWPRAEFSMAIAiqNLAWG--VGQPIFGAIAERFGDRR----AI 81
Cdd:cd17382 9 CISFGIRCNLGVAIVRMvnnftdayggkvivhKAEFNWTPETVGLIES--SFFWGylVTQIPGGFIAAKFAANRvfglAI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 82 IAGAILYALglVLSSFAVTPGQMQLLEILVGFgIAGTGFGVILAIVGRAAKPENRSLALGIATAAGSAGQVFGAPAAQIM 161
Cdd:cd17382 87 FVTSTLNML--IPIAARVHYGCVIFVRILQGL-VEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGIL 163
|
170
....*....|....*.
gi 1232094251 162 LQYYHWQTVFIIFAVV 177
Cdd:cd17382 164 VQYVGWSSPFYVYGVF 179
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
52-189 |
9.74e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 37.98 E-value: 9.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232094251 52 MAIAIQNLAWGVGQPIFGAIAERFGDRRAIIAGAILYALGLVLSSFAVTPGQMQLLEILVGF--GIAGTGFGVILAIVgr 129
Cdd:PRK09874 58 LVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLlgGFVPNANALIATQV-- 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232094251 130 aakPENRS-LALGIATAAGSAGQVFGAPAAQIMLQYYHWQTVFIIFA-VVILCALFALPFLR 189
Cdd:PRK09874 136 ---PRNKSgWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITAsVLFLCFLVTLFCIR 194
|
|
| |
