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Conserved domains on  [gi|1232144728|gb|OYU78620|]
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galactokinase [Alphaproteobacteria bacterium PA3]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  3.30.70.890|3.30.230.10
EC:  2.7.1.6
Gene Ontology:  GO:0005524|GO:0004335|GO:0005534|GO:0006012|GO:0046835
PubMed:  26862196|15526155
SCOP:  4001389|4000959

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
10-371 2.92e-158

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 449.22  E-value: 2.92e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  10 ALARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGDLPLD----HFVK 84
Cdd:COG0153     5 LIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDlddlEPGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  85 QGDWRDYVGGVAFALRDAGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYVGM 161
Cdd:COG0153    85 EDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNdlfGLGLDPVELAKIGQRAENEFVGV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 162 ACGIMDQFASACGVEGHALMLDCATLAYKPIPLP-ATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT- 239
Cdd:COG0153   165 PCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSLRDVTl 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 240 -DLSALDQLSGSP--LKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVY 316
Cdd:COG0153   245 eDLEAARARLGDEvlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1232144728 317 GARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:COG0153   325 GARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
10-371 2.92e-158

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 449.22  E-value: 2.92e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  10 ALARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGDLPLD----HFVK 84
Cdd:COG0153     5 LIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDlddlEPGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  85 QGDWRDYVGGVAFALRDAGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYVGM 161
Cdd:COG0153    85 EDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNdlfGLGLDPVELAKIGQRAENEFVGV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 162 ACGIMDQFASACGVEGHALMLDCATLAYKPIPLP-ATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT- 239
Cdd:COG0153   165 PCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSLRDVTl 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 240 -DLSALDQLSGSP--LKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVY 316
Cdd:COG0153   245 eDLEAARARLGDEvlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1232144728 317 GARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:COG0153   325 GARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 14-371 7.38e-112

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 331.50  E-value: 7.38e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  14 FKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRV-SSDLG--QGDLPLDH---FVKQG 86
Cdd:PRK05101   11 FAQQFGYPPtHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViAADYDnqQDEFSLDApivPHPEQ 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  87 DWRDYVGGVAFALRDAGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLA---LSGGAATGKDLALIAQAAENNYVGMAC 163
Cdd:PRK05101   91 QWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTfqqLYHLPLSGAEIALNGQEAENQFVGCNC 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 164 GIMDQFASACGVEGHALMLDCATLAYKPIPLPATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVTdLSA 243
Cdd:PRK05101  171 GIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVKALRDVT-LEQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 244 L----DQLSGSPLKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVY-GA 318
Cdd:PRK05101  250 FnavaAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDQgGV 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232144728 319 RMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:PRK05101  330 RMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 14-370 2.55e-94

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 286.72  E-value: 2.55e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  14 FKDAFDGTPRL-FRAPGRINIIGEHVDYAGGKVMPAAIDF--ACWVAARPNG-----LDVLRVSSDLGQGDLPLD-HFVK 84
Cdd:TIGR00131   8 FASAFGAKPDFtARAPGRVNLIGEHTDYNDGSVLPCAIDFgtLCAVAVRDDKnvriyLANADNKFAERSLDLPLDgSEVS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  85 qgDWRDYVGGVAFALRDAGHAV-QGYDLAIASDVPMGAGVSSSAALEVAIGLALSG---GAATGKDLALIAQAAENNYVG 160
Cdd:TIGR00131  88 --DWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNmghLPLDSKQILLRIQVAENHFVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 161 MACGIMDQFASACGVEGHALMLDCATLAYKPIPLPATA-CFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT 239
Cdd:TIGR00131 166 VNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGiAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATDKGALR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 240 D------------LSALDQLSGsplKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTA 307
Cdd:TIGR00131 246 DfmneyfaryiarLTKMLPLVE---ERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVC 322

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232144728 308 LAQATEGVYGARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGE 370
Cdd:TIGR00131 323 SAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 12-60 3.33e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.49  E-value: 3.33e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1232144728  12 ARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARP 60
Cdd:pfam10509   1 EAFEELFGKEPvGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
10-371 2.92e-158

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 449.22  E-value: 2.92e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  10 ALARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGDLPLD----HFVK 84
Cdd:COG0153     5 LIEAFEEAFGEEPeGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDlddlEPGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  85 QGDWRDYVGGVAFALRDAGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYVGM 161
Cdd:COG0153    85 EDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNdlfGLGLDPVELAKIGQRAENEFVGV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 162 ACGIMDQFASACGVEGHALMLDCATLAYKPIPLP-ATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT- 239
Cdd:COG0153   165 PCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGVKSLRDVTl 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 240 -DLSALDQLSGSP--LKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVY 316
Cdd:COG0153   245 eDLEAARARLGDEvlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAGVL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1232144728 317 GARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:COG0153   325 GARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 14-371 7.38e-112

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 331.50  E-value: 7.38e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  14 FKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRV-SSDLG--QGDLPLDH---FVKQG 86
Cdd:PRK05101   11 FAQQFGYPPtHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRViAADYDnqQDEFSLDApivPHPEQ 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  87 DWRDYVGGVAFALRDAGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLA---LSGGAATGKDLALIAQAAENNYVGMAC 163
Cdd:PRK05101   91 QWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTfqqLYHLPLSGAEIALNGQEAENQFVGCNC 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 164 GIMDQFASACGVEGHALMLDCATLAYKPIPLPATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVTdLSA 243
Cdd:PRK05101  171 GIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVKALRDVT-LEQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 244 L----DQLSGSPLKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVY-GA 318
Cdd:PRK05101  250 FnavaAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDQgGV 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232144728 319 RMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:PRK05101  330 RMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
PRK03817 PRK03817
galactokinase; Provisional
 25-369 9.79e-106

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 314.63  E-value: 9.79e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  25 FRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGlDVLRVSSDLGQGD-LPLDHFVKQGDWRDYVGGVAFALRDAG 103
Cdd:PRK03817    3 VKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSE-KFIFYSENFNEEKtFELDKLEKLNSWADYIKGVIWVLEKRG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 104 HAVQGYDLAIASDVPMGAGVSSSAALEVAIGLALSGGAATG---KDLALIAQAAENNYVGMACGIMDQFASACGVEGHAL 180
Cdd:PRK03817   82 YEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNlskLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHAI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 181 MLDCATLAYKPIPLPATACFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT--DLSALDQLSgspLKRARHV 258
Cdd:PRK03817  162 FLDTMTLEYEYVPFPEDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTeeDLSKLPPLL---RKRAGYV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 259 LTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLtaLAQATE-GVYGARMMGGGFGGSIIALVEPDL 337
Cdd:PRK03817  239 LRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFF--VEFALElGAYGARLTGAGFGGSAIALVDKGK 316

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1232144728 338 AATALEAILETYSAYLGGRPGAFVVRAAAGAG 369
Cdd:PRK03817  317 FESIGEELLEEYKKRFGIDPKYFVVESSDGVR 348
PRK05322 PRK05322
galactokinase; Provisional
 11-371 2.51e-96

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 291.76  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  11 LARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSS----DLGQGDLPLDH--FV 83
Cdd:PRK05322    7 KKKFAEVFGEEAeDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSanfeDLGIIEFDLDDlsFD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  84 KQGDWRDYVGGVAFALRDAGHAV-QGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYV 159
Cdd:PRK05322   87 KEDDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKdlfNLDLDRLELVKLGQKTENEFI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 160 GMACGIMDQFASACGVEGHALMLDCATLAYKPIPLPATACFLII-DSGVKHQHTSGGYASRRADCEAAartlgVALLAEV 238
Cdd:PRK05322  167 GVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVImNTNKRRELADSKYNERRAECEKA-----LEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 239 TDLSALDQLSGSP-------------LKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRL 305
Cdd:PRK05322  242 LDIKSLGELTEEEfdeysylikdetlLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1232144728 306 TALAQATEGVYGARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:PRK05322  322 VEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 14-370 2.55e-94

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 286.72  E-value: 2.55e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  14 FKDAFDGTPRL-FRAPGRINIIGEHVDYAGGKVMPAAIDF--ACWVAARPNG-----LDVLRVSSDLGQGDLPLD-HFVK 84
Cdd:TIGR00131   8 FASAFGAKPDFtARAPGRVNLIGEHTDYNDGSVLPCAIDFgtLCAVAVRDDKnvriyLANADNKFAERSLDLPLDgSEVS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  85 qgDWRDYVGGVAFALRDAGHAV-QGYDLAIASDVPMGAGVSSSAALEVAIGLALSG---GAATGKDLALIAQAAENNYVG 160
Cdd:TIGR00131  88 --DWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNmghLPLDSKQILLRIQVAENHFVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 161 MACGIMDQFASACGVEGHALMLDCATLAYKPIPLPATA-CFLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVT 239
Cdd:TIGR00131 166 VNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGiAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAATDKGALR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 240 D------------LSALDQLSGsplKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDRLTA 307
Cdd:TIGR00131 246 DfmneyfaryiarLTKMLPLVE---ERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDELVC 322

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232144728 308 LAQATEGVYGARMMGGGFGGSIIALVEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGE 370
Cdd:TIGR00131 323 SAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
PRK00555 PRK00555
galactokinase; Provisional
 27-371 3.48e-78

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 244.77  E-value: 3.48e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  27 APGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGD--LPLDhfVKQGD---WRDYVGGVAFALRD 101
Cdd:PRK00555    7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSarIPLD--TTPGQvtgWAAYAAGVIWALRG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 102 AGHAVQGYDLAIASDVPMGAGVSSSAALEVAIGLALSGGAATGKD---LALIAQAAENNYVGMACGIMDQFASACGVEGH 178
Cdd:PRK00555   85 AGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDrleQARLAQRAENEYVGAPTGLLDQLAALFGAPKT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 179 ALMLDCATLAYKPIPLPATAC---FLIIDSGVKHQHTSGGYASRRADCEAAARTLGVALLAEVTD--LSALDQLSGS-PL 252
Cdd:PRK00555  165 ALLIDFRDLTVRPVAFDPDAAgvvLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDrgLAALGAIADPiDA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 253 KRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPEVDrLTALAQATEGVYGARMMGGGFGGSIIAL 332
Cdd:PRK00555  245 RRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERID-LIADSAVRAGALGARMTGGGFGGCVIAL 323

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1232144728 333 VEPDLAATALEAILETYSAYLGGRPGAFVVRAAAGAGEV 371
Cdd:PRK00555  324 VPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGAGEC 362
PTZ00290 PTZ00290
galactokinase; Provisional
 23-368 3.41e-49

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 171.93  E-value: 3.41e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  23 RLFR-APGRINIIGEHVDYAGGKVMPAAIDFACWV-AARPNGL--DVLRVSSDLGQgDLPLDHF---VKQGDWRDYV-GG 94
Cdd:PTZ00290   37 LLFTfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHIlVGRVKHFcdHKLRFATETDE-HFVLDHLggaKHNKAWTTFVrGA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  95 VAFALRDAGHAV-----QGYDLAIASDVPMGAGVSSSAALEVAIGLALSgGAATGK------------------------ 145
Cdd:PTZ00290  116 ATLRLNRLGVAIdapslQGVCMVVHGTLPMGAGMSASASFGVALLNAIN-TVVTRRykgcptspgrrysilppmskeeli 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 146 DLALIAQAAENNYVGMACGIMDQFASACGVEGHALMLDCATLAYKPIPL-PAT---ACFLIIDSGVKHQ---HTSGGYAS 218
Cdd:PTZ00290  195 ELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMtPLLgdgACFLLIDSMIKHDllgGTAGMYNT 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 219 RRADCEAAARTLG----------VALLAEVTDLSALD------------QLSGSPLKRARHVLTEIDRT------QRAEV 270
Cdd:PTZ00290  275 VRSDQEGAQKKIGkhryrgkpftFSDLVRNPKKYTFDgdvvafmesckpLMTPGEFERGTYNIMEQIRTlefiklNDPEL 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 271 ALVQGDLIH-LGRLLNASHASLSTDMEVSTPEVDRLTALAQATEGVYGARMMGGGFGGSIIALVEPDLAATALEAILETY 349
Cdd:PTZ00290  355 PLSREERFRkAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKF 434

                         410
                  ....*....|....*....
gi 1232144728 350 SAYLGGRPGAFVVRAAAGA 368
Cdd:PTZ00290  435 KARFGVENDVYPVVAGDGA 453
PLN02865 PLN02865
galactokinase
 23-349 4.21e-37

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 138.78  E-value: 4.21e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  23 RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGD-------------LPLDHFVKQGDWR 89
Cdd:PLN02865   31 RVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEvrfrvdeiqhpiaNVSSDSKEESNWG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  90 DYVGGVAFALRDAGHAVQGYDLAIASDVP--MGAGVSSSAALEVAIGLALSggaaTGKDLAL-------IAQAAENNYVG 160
Cdd:PLN02865  111 DYARGAVYALQSRGHALSQGITGYISGSEglDSSGLSSSAAVGVAYLLALE----NANNLTVspednieLDRLIENEYLG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 161 MACGIMDQFASACGVEGHALMLDCATLAYKPIPLPATAC-------FLIIDSGVKHQHTSG-GYASRRADCEAAARTLGV 232
Cdd:PLN02865  187 LRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKpGYNLRVSECQEAARFLLE 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 233 A--------LLAEVTDLSALDQ---LSGSPLKRARHVLTEIDRTQRAEVALVQGDLIHLGRLLNASHASLSTDMEVSTPE 301
Cdd:PLN02865  267 AsgndelepLLCNVEPEVYEAHkckLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGCEP 346

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1232144728 302 VDRLTALAQATEGVYGARMMGGGFGGSIIALVEPDLAATALEAILETY 349
Cdd:PLN02865  347 LIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEY 394
PLN02521 PLN02521
galactokinase
 12-349 4.95e-35

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 134.06  E-value: 4.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  12 ARFKDAFDGTPRLF-RAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARPN-GLDVLRVS---SDLGQGDLPLDHF---- 82
Cdd:PLN02521   37 AAFVEVYGAKPDLFaRSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAeGSKKLRIAnvnDKYTTCTFPADPDqevd 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  83 VKQGDWRDYV----GGVAFALRDAGHAVQ---GYDLAIASDVPMGAGVSSSAAL----EVAIgLALSGGAATGKDLALIA 151
Cdd:PLN02521  117 LANHKWGNYFicgyKGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALvcsaAIAI-MAALGLNFTKKEVAQFT 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 152 QAAEnNYVGMACGIMDQFASACGVEGHALMLDCATLAYKPIPLPATACFLIIDS---GVKHQHTSGGYASRRADCEAAAR 228
Cdd:PLN02521  196 CKCE-RHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSlaeSNKAVTAATNYNNRVVECRLAAI 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 229 TLGVAL-------LAEVTDLSALDQL-------------------------------------------SGSP------- 251
Cdd:PLN02521  275 VLAVKLgmsaeeaISKVKTLSDVEGLcvsfagshgssdpavavkellhegpytaeeieeilgesltsifKNSPtslavlk 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 252 -------LKRARHVLTEIDRTQ--RAEVALVQGD---LIHLGRLLNASHASLSTDMEVSTPEVDRLTALAQATeGVYGAR 319
Cdd:PLN02521  355 aakhfklHQRAVHVYSEAKRVHafRDTVSSSLSEeekLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN-GALGAR 433

                         410       420       430
                  ....*....|....*....|....*....|
gi 1232144728 320 MMGGGFGGSIIALVEPDLAATALEAILETY 349
Cdd:PLN02521  434 LTGAGWGGCAVALVKEAIVPQFILALKEKF 463
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 27-333 9.68e-32

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 120.72  E-value: 9.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  27 APGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGLDVLRVSSDLGQGDLPLDHFVKQgDWRDYVGGVAFALRDAGHAV 106
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLADA-ALRYIKAAIEAALEYLGLPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 107 QGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAEnNYVGMACGIMDQFASACGveghalmld 183
Cdd:COG1577    80 KGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAafyGVELSKEELFKLALEAE-KIVHGNPSGLDTAASTYG--------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 184 cATLAY------KPIPLPATACFLIIDSGVKHQhTSggyasrradceaaartlgvALLAEVTDLSAldqlsgSPLKRARH 257
Cdd:COG1577   150 -GPIYYqrgdraEPLELPKNLPLVVGDTGVPAS-TK-------------------ELVAKVRKLKE------RNPELYEA 202

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232144728 258 VLTEIDR-TQRAEVALVQGDLIHLGRLLNASHASLSTdMEVSTPEVDRLTALAQATeGVYGARMMGGGFGGSIIALV 333
Cdd:COG1577   203 FLEEIGDlVEEAIEALEEGDLEALGELMNENHGLLRA-LGVSTPELDRLVEAARKA-GALGAKLTGAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 27-332 5.01e-20

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 88.50  E-value: 5.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  27 APGRINIIGEH-VDYaGGKVMPAAIDFACWVAARPNGlDVLRVSSDLGQG--DLPLDHFvkQGDWRDYVGGVAFALRDAG 103
Cdd:TIGR00549   1 APGKIILFGEHaVVY-GEPAIAAPIPLRTTVTVIESS-DGSFIESDLGRGslDDAPDEL--DGLKYVLAEFLSRFSELNP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 104 HAVqgyDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYVGMACGImDQFASacgVEGHAL 180
Cdd:TIGR00549  77 PPL---EITIESEIPPGRGLGSSAAVAVALIRALAdyfGSELSKEELAELANEAEKIAHGKPSGI-DTATS---TSGGPV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 181 MLDC-ATLAYKPIPLPATacFLIIDSGVKHqHTSggyasrradcEAAARtlgVALLAEvtdlsALDQLSGSPLKRarhvL 259
Cdd:TIGR00549 150 YFEKgEGEFTKLISLDGY--FVIADTGVSG-STK----------EAVAR---VRQLLE-----RFPELIDSIMDA----I 204

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232144728 260 TEIdrTQRAEVALVQGDLIHLGRLLNASHASLStDMEVSTPEVDRLTALAQaTEGVYGARMMGGGFGGSIIAL 332
Cdd:TIGR00549 205 GEL--TLEAKAALQDGDVESLGELMNINQGLLK-ALGVSHPKLDQLVEIAR-KAGALGAKLTGAGGGGCMIAL 273
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 12-60 3.33e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.49  E-value: 3.33e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1232144728  12 ARFKDAFDGTP-RLFRAPGRINIIGEHVDYAGGKVMPAAIDFACWVAARP 60
Cdd:pfam10509   1 EAFEELFGKEPvGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK03926 PRK03926
mevalonate kinase; Provisional
 27-345 1.56e-16

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 79.33  E-value: 1.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728  27 APGRINIIGEHVDYAGGKVMPAAIDFACWVAARPNGlDVLRVSSDLGqgdlpldhfvKQGDWRDYVGGVAFALRDAGhAV 106
Cdd:PRK03926    6 APGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFND-DSIYIESDYG----------KTGEKHPYVSAAIEKMREEA-DK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 107 QGYDLAIASDVPMGAGVSSSAALEVAIGLALS---GGAATGKDLALIAQAAENNYVGMACGImDQFASACGveghalmld 183
Cdd:PRK03926   74 DGVTVSITSQIPVGSGLGSSAAVTVATIGALNrllGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTMG--------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 184 cATLAY-KPIPLPATACFLII-DSGVkhqhtsggYASRRadceaaartlgvALLAEVTDLSaldqlsgsplKRARHVLTE 261
Cdd:PRK03926  144 -GFVTIpDRKKLPFPECGIVVgYTGS--------SGSTK------------ELVANVRKLK----------EEYPELIEP 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 262 I-----DRTQRAEVALVQGDLIHLGRLLNASHASLSTdMEVSTPEVDRLTALAQaTEGVYGARMMGGGFGGSIIALVEPD 336
Cdd:PRK03926  193 IlssigKISEKGEELILSGDYVSLGELMNINQGLLDA-LGVSTKELSELIYAAR-TAGALGAKITGAGGGGCMVALAAPE 270


                  ....*....
gi 1232144728 337 LAATALEAI 345
Cdd:PRK03926  271 KQSEVATAI 279
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 110-174 7.37e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 57.17  E-value: 7.37e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1232144728 110 DLAIASDVPMGAGVSSSAALEVAIGLALSggAATGKDLALIAQAAENNYVGMACGIMDQFASACG 174
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALN--ELFGLPLAKLALEAEELAGGGRGGGMDVAASLYG 63
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 268-351 7.99e-07

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 46.69  E-value: 7.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232144728 268 AEVALVQGDLIHLGRLLNASHASLSTDMEV--STPEVDRLtaLAQATEGVYGARMMGGGFGGSIIALVE-PDLAATALEA 344
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLEPLLVVgiLPPELDEL--LEALLELGLGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*..
gi 1232144728 345 ILETYSA 351
Cdd:pfam08544  79 LREAGKK 85
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 268-332 1.71e-04

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 42.92  E-value: 1.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1232144728 268 AEVALVQGDLIHLGRLLNASHaSLSTDMEVSTPEVDRLTALAQaTEGVYGARMMGGGFGGSIIAL 332
Cdd:PTZ00298  230 AKEALQKGNLFRVGELMNANH-DLCQKLTVSCRELDSIVQTCR-TYGALGAKMSGTGRGGLVVAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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