|
Name |
Accession |
Description |
Interval |
E-value |
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
18-394 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 582.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATT-TI 96
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITaAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 97 THLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVH 176
Cdd:pfam01053 80 LALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 177 KHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCR 256
Cdd:pfam01053 160 KHG-ILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 257 GLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFAL 336
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1705789 337 AESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALK 394
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
15-396 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 577.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 15 QHFATQAIHVGPEPEqWSSRAVVLPISLATTFKQDSPGQ--------SSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTF 86
Cdd:COG0626 1 MGPATRAVHAGRDPD-PQTGAVSPPIYLTSTFVFPSAEAlaarfageEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 87 ARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:COG0626 80 ASGMAAiSAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAV 245
Cdd:COG0626 160 VDIAAIAAIAHAA-GALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 246 PSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQ 325
Cdd:COG0626 239 LSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 326 VFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
35-394 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 549.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 35 AVVLPISLATTFKQDSP--------GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTITHLLKAGDE 105
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPaeaadlfaLREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAiSTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 106 VICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVV 185
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEH-GALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 186 DNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRM 265
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 266 EKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYES 345
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1705789 346 LAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALK 394
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
12-395 |
5.33e-168 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 475.29 E-value: 5.33e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 12 PSFQHFATQAIHVGPEPEQWSSrAVVLPISLATTFKQDSPGQ-SSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGL 90
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATG-AVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 91 AAT-TTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIK 169
Cdd:PRK07811 87 AATdCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 170 ACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPF 249
Cdd:PRK07811 167 ALAELAHDA-GAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 250 DCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLK 329
Cdd:PRK07811 246 DAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1705789 330 NIKLFALAESLGGYESLAELPAIMTHASVPEkdrATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHPSAMTHASTAG---SQLEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
19-394 |
1.56e-155 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 443.40 E-value: 1.56e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 19 TQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITH 98
Cdd:PRK07671 5 TKLIHGGIIGDP-STGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 99 LLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKH 178
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 179 kDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGL 258
Cdd:PRK07671 164 -GLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 259 KTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIkGTLQHAQVFLKNIKLFALAE 338
Cdd:PRK07671 243 KTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1705789 339 SLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALK 394
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
16-395 |
6.90e-142 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 408.90 E-value: 6.90e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEpEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTT 95
Cdd:PRK06176 2 RMQTKLIHGGIS-EDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIV 175
Cdd:PRK06176 81 VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 176 HKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCC 255
Cdd:PRK06176 161 KDH-GLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 256 RGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQhAQVFLKNIKLFA 335
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 336 LAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK06176 319 LGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
18-396 |
5.38e-132 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 383.80 E-value: 5.38e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEPEQWSsrAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTIT 97
Cdd:TIGR01329 2 STLLVNTDNKNDPYD--ASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 98 HLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHK 177
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 178 HkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRG 257
Cdd:TIGR01329 160 Q-NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 258 LKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGcPGMVSFYIKGTLQHAQVFLKNIKLFALA 337
Cdd:TIGR01329 239 IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSIT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1705789 338 ESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:TIGR01329 318 VSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
17-393 |
1.45e-129 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 378.40 E-value: 1.45e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 17 FATQAIHVGPEPE-QWSSRAVvlPISLATTFKQDSP--------GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFA 87
Cdd:PRK06234 9 FATKAIHGGHIGDkQFGSLAT--PIYQTSTFIFDSAeqggrrfaGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 88 RGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK06234 87 SGMGAiSSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 167 DIKACAQIVHKH-KDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVTSDDLNERLRF--LQNSLG 243
Cdd:PRK06234 167 DIKAISNIAHENnKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLfgIKDMTG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 244 AVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQH 323
Cdd:PRK06234 246 SVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEE 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 324 AQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQAL 393
Cdd:PRK06234 326 GKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
35-396 |
1.25e-126 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 370.28 E-value: 1.25e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 35 AVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTI-THLLKAGDEVICMDEVY 113
Cdd:TIGR02080 21 CVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTALLGPDDLLVAPHDCY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 114 GGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKhKDIILVVDNTFMSAY 193
Cdd:TIGR02080 101 GGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKA-VGAVVVVDNTFLSPA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 194 FQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGM 273
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 274 AVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIM 353
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1705789 354 THASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
15-395 |
1.63e-124 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 364.98 E-value: 1.63e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 15 QHFATQAIHVGPEPEQwSSRAVVLPISLATTFKQDS--------PGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTF 86
Cdd:TIGR01328 2 MTFATRAIHAGYPPKD-QFGALTPPIYQTSTFVFDSceqggnrfAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 87 ARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:TIGR01328 81 SSGMGAiAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQIVHKhKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNE-RLRFLQNSLGA 244
Cdd:TIGR01328 161 IDMERVCRDAHS-QGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 245 VPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHA 324
Cdd:TIGR01328 240 VISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 325 QVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
35-396 |
4.74e-123 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 360.56 E-value: 4.74e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 35 AVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYG 114
Cdd:PRK08247 22 TVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVMSLFRSGDELIVSSDLYG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVVDNTFMSAYF 194
Cdd:PRK08247 102 GTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKH-GLLLIVDNTFYTPVL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMA 274
Cdd:PRK08247 181 QRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 275 VARFLESNPRVEKVIYPGlpshpqhelakrqcTGcpGMVSFYIKgtlQHAQV--FLKNIKLFALAESLGGYESLAELPAI 352
Cdd:PRK08247 261 IAAFLNEQPGVTDVLYPG--------------RG--GMLSFRLQ---DEEWVnpFLKSLKLITFAESLGGVESFITYPAT 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1705789 353 MTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08247 322 QTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
12-396 |
5.16e-123 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 362.43 E-value: 5.16e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 12 PSFQHFATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSP--------GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHC 83
Cdd:COG2873 3 EKKYGFETLALHAGQEPDP-TTGARAVPIYQTTSYVFDDAehaadlfaLKEPGNIYTRIMNPTTDVLEKRIAALEGGVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 84 LTFARGLAATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPT 162
Cdd:COG2873 82 LATASGQAAITlAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 163 LKLADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVTS-----------DDL 231
Cdd:COG2873 162 LDVLDIEAIAEIAHEH-GVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVI-VDGgnfdwaangkfPEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 232 NE-----------------------RLRFLQNsLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKV 288
Cdd:COG2873 240 TEpdpsyhglvyteafgnaafitkaRVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 289 IYPGLPSHPQHELAKRQCT-GCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLG 367
Cdd:COG2873 319 NYPGLPSHPYHELAQKYLPkGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAG 398
|
410 420
....*....|....*....|....*....
gi 1705789 368 ISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:COG2873 399 VTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
35-398 |
3.95e-122 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 359.08 E-value: 3.95e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 35 AVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYG 114
Cdd:PRK08064 24 AVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFLLLSKGDHVLISEDVYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVVDNTFMSAYF 194
Cdd:PRK08064 104 GTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAI-GCLTFVDNTFLTPLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMA 274
Cdd:PRK08064 183 QKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 275 VARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIkGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMT 354
Cdd:PRK08064 263 IALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMS 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1705789 355 HASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP 398
Cdd:PRK08064 342 HAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEE 385
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
17-397 |
1.68e-121 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 357.96 E-value: 1.68e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 17 FATQAIHVGPEPEQwSSRAVVLPISLATTFKQDS--------PGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFAR 88
Cdd:PRK07503 10 FSTRAIHHGYDPLD-HGGALVPPVYLTATFAFPTaeygaecfAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALAS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 89 GLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK07503 89 GMGAiTATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 168 IKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVTSDDLNERLRF--LQNSLGAV 245
Cdd:PRK07503 169 IAAVAEIAHGA-GAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGGKALADRIRLegLKDMTGAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 246 PSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQ 325
Cdd:PRK07503 247 MSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGR 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1705789 326 VFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAH 397
Cdd:PRK07503 327 RFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACA 398
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
35-398 |
8.43e-119 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 353.18 E-value: 8.43e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 35 AVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYG 114
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVvDNTFMSAYF 194
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLV-DNSIMSPVL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMA 274
Cdd:PLN02509 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 275 VARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFyIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMT 354
Cdd:PLN02509 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1705789 355 HASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP 398
Cdd:PLN02509 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFRTGPL 464
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
15-394 |
7.70e-114 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 337.58 E-value: 7.70e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 15 QHFATQAIHVGPEPEQWSSrAVVLPISLATTFKQDS--------PGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTF 86
Cdd:PRK06767 4 KHMETALIHHGYTSEEHKG-SLTPPLFQTSTFTFETaqqgeasfAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 87 ARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:PRK06767 83 GSGMAAiSATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQiVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAV 245
Cdd:PRK06767 163 IDLKQVIR-VAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 246 PSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYpglpshPQHELAKRQCTGCPGMVSFYIKGTLQHAQ 325
Cdd:PRK06767 242 MAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQ 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1705789 326 VFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALK 394
Cdd:PRK06767 316 AFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
34-395 |
3.90e-110 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 328.18 E-value: 3.90e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 34 RAVVLPISLATTFKQDSPGQSS--GFV--YSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTI-THLLKAGDEVIC 108
Cdd:PRK08574 18 GSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLfFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 109 MDEVYGGTNRYFRRVaSEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD----IKACaqivhKHKDIILV 184
Cdd:PRK08574 98 PMEAYGTTLRLLKSL-EKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDvpevAKAA-----KELGAILV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 185 VDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIR 264
Cdd:PRK08574 172 VDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 265 MEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRqCTGCP---GMVSFYIKGTLQHAQVFLKNIKLFALAESLG 341
Cdd:PRK08574 252 FERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKR-LFGKDlygGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1705789 342 GYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK08574 331 GVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
16-395 |
3.53e-109 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 325.80 E-value: 3.53e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPE--PEQWSSRAVVLPISL--------ATTFKqdspGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLT 85
Cdd:PRK08133 6 GFDTLAVRAGQLrsPFGEHSEALFLTSSFvfesaaeaAARFA----GEEPGNIYSRFTNPTVTMFQERLAALEGAEACVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 86 FARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLK 164
Cdd:PRK08133 82 TASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 165 LADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQnSLGA 244
Cdd:PRK08133 162 LADIAALAEIAHAA-GALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLR-TAGP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 245 VPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHA 324
Cdd:PRK08133 240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 325 QVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK08133 320 WRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
16-396 |
4.95e-107 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 320.53 E-value: 4.95e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGpEPEQWSSRAVVLPISLATTFKQD--------SPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFA 87
Cdd:PRK08249 8 GVGTKAVWAG-EKEYLPYGATQVPVVLSVAYGYDdidewydvALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 88 RGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK08249 87 TGMAAiSNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 167 DIKACAQIVHKHKDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVvMGLVSVTSDDLNERLRFLQNSLGAVP 246
Cdd:PRK08249 167 DIERLAAAAKKVGALV-VVDNTFATPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKELMEQVYHYREINGATM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 247 SPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQV 326
Cdd:PRK08249 245 DPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKR 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 327 FLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08249 325 LLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
16-396 |
1.01e-105 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 317.70 E-value: 1.01e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTT 95
Cdd:PRK08776 12 SAATAAVRAGIDRDT-AYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITH-LLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQI 174
Cdd:PRK08776 91 VLNaLLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 175 VHKhKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLC 254
Cdd:PRK08776 171 AHK-VGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 255 CRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLF 334
Cdd:PRK08776 250 LRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1705789 335 ALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08776 330 TLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
18-396 |
1.22e-104 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 314.14 E-value: 1.22e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTT-I 96
Cdd:PRK08861 7 ATIAVRTGIESDS-QYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 97 THLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIkacAQIVH 176
Cdd:PRK08861 86 SALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDI---AELCQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 177 KHKDI--ILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLC 254
Cdd:PRK08861 163 KAKAVgaLVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 255 CRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLF 334
Cdd:PRK08861 243 LRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1705789 335 ALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08861 323 SLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKA 384
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
16-394 |
3.40e-104 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 314.30 E-value: 3.40e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEPE-QWSSRAVvlPISLATTFKQDSPGQSS--------GFVYSRSGNPTRNCLEKAVAALDGAKHCLTF 86
Cdd:TIGR01326 1 HFETLQLHAGQEPDpTTGSRAV--PIYQTTSYVFDSTEHAAalfglqepGNIYSRLMNPTTDVLEQRIAALEGGVAALAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 87 ARGLAATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:TIGR01326 79 ASGQAAITyAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQIVHKHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS---------------VTSDD 230
Cdd:TIGR01326 159 LDIEAIAEVAHRHG-IPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnngrfplfTTPDP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 231 ------LNE-----------RLRFLQNsLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGL 293
Cdd:TIGR01326 238 syhglvFTEtlgnpafilkaRVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 294 PSHPQHELAKRQCTGCPGMV-SFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTL 372
Cdd:TIGR01326 317 ASHPHHALAKKYLPKGFGAVlSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGL 396
|
410 420
....*....|....*....|..
gi 1705789 373 IRLSVGLEDEKDLLEDLGQALK 394
Cdd:TIGR01326 397 IRLSVGIENIDDIIADLEQALE 418
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
18-396 |
2.35e-101 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 305.67 E-value: 2.35e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVG-PEPEQWSsrAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTI 96
Cdd:PRK08045 6 ATIAVRSGlNDDEQYG--CVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 97 -THLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIV 175
Cdd:PRK08045 84 tTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 176 HKhKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCC 255
Cdd:PRK08045 164 RE-AGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 256 RGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFA 335
Cdd:PRK08045 243 RGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFT 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 336 LAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08045 323 LAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
14-395 |
6.69e-101 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 304.52 E-value: 6.69e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 14 FQHFATQAIHVGP--EPEQWSsraVVLPISLATTF------KQDSPGQSSG--FVYSRSGNPTRNCLEKAVAALDGAKHC 83
Cdd:PRK06434 6 LNGFNTRAVQSGElrDPRFGN---VTTPIFETSTFvypnseKEAYMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 84 LTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEaaITPQT-KLVWIETPTNP 161
Cdd:PRK06434 83 LSFSSGMGAiTSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 162 TLKLADIKACAQIVHKHKdiiLVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNS 241
Cdd:PRK06434 161 TLKVPDIKNVSSFCHEND---VIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 242 LGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLpshpqhELAKRQCTGCPGMVSFYIKgTL 321
Cdd:PRK06434 238 LGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELR-SM 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1705789 322 QHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK06434 311 EDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
52-393 |
8.67e-101 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 304.08 E-value: 8.67e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 52 GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAAT-TTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLK 130
Cdd:TIGR01325 41 GELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIfAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 131 ISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKhKDIILVVDNTFMSAYFQRPLALGADICMCSAT 210
Cdd:TIGR01325 121 TVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAVAELAHA-AGAKVVVDNVFATPLLQQPLKLGADVVVYSAT 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 211 KYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIY 290
Cdd:TIGR01325 200 KHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYY 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 291 PGLPSHPQHELAKRQCTGCPGMVSFYIKGTlQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISD 370
Cdd:TIGR01325 280 PGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGD 358
|
330 340
....*....|....*....|...
gi 1705789 371 TLIRLSVGLEDEKDLLEDLGQAL 393
Cdd:TIGR01325 359 GLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
16-395 |
1.07e-98 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 298.27 E-value: 1.07e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTT 95
Cdd:PRK07269 6 HINTILAQAGIKSDE-ATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITHLLKAGDEVICMDEVYGGTNRYFRRVASEFglKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIV 175
Cdd:PRK07269 85 AFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 176 HKhKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCC 255
Cdd:PRK07269 163 HA-KGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 256 RGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLpshpqhelakrqctgcPGMVSFYI--KGTLQHaqvFLKNIKL 333
Cdd:PRK07269 242 RGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILNSLKV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1705789 334 FALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK07269 303 FTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
16-396 |
5.31e-94 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 288.11 E-value: 5.31e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEPEqWSSRAVVLPISLATTF------------------KQDSPGQSSGFVYSRSGNPTRNCLEKAVAAL 77
Cdd:PRK07049 17 HPETQMLNYGYDPE-LSEGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 78 DGAKHCLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLK-ISFVDCSKTKLLEAAITP-----QT 150
Cdd:PRK07049 96 EGAESAALFSSGMSAiATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAAEAaaakgRV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 151 KLVWIETPTNPTLKLADIKACAQIV------HKHKDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV 224
Cdd:PRK07049 176 SLILIETPANPTNSLVDVAAVRRVAdaiearQGHRPII-ACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 225 sVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGL--PSHPQHELA 302
Cdd:PRK07049 255 -LGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 303 KRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDE 382
Cdd:PRK07049 334 KRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHP 413
|
410
....*....|....
gi 1705789 383 KDLLEDLGQALKAA 396
Cdd:PRK07049 414 DDLIADLAQALDAA 427
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
18-393 |
2.41e-90 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 277.10 E-value: 2.41e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEPEqwsSRAVVLPISLATTFkqDSPGqSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTI 96
Cdd:PRK06460 4 ATRTVREDIDEA---TGAITTPIYQTTAY--HYPE-GEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAiSTTA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 97 THLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVh 176
Cdd:PRK06460 78 LALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 177 KHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNeRLRFLQNSLGAVPSPFDCYLCCR 256
Cdd:PRK06460 157 KENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLN-VIDQMRRTLGTSLDPHAAYLTLR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 257 GLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFAL 336
Cdd:PRK06460 236 GIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIP 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1705789 337 AESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQAL 393
Cdd:PRK06460 316 AQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
19-396 |
4.26e-89 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 275.95 E-value: 4.26e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 19 TQAIHVGPEPEQWS-SRAVVLPISLATTFKQDSPG------QSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLA 91
Cdd:PRK08248 11 TLAIHAGQEIDPTTgSRAVPIYQTTSYGFRDSEHAanlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 92 ATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKA 170
Cdd:PRK08248 91 AITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 171 CAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV---------------SVTSDD----- 230
Cdd:PRK08248 171 VAAIAHEH-GIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIvdsgkfdwkgsgkfpGLTEPDpsyhg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 231 -------------LNERLRFLQNsLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHP 297
Cdd:PRK08248 250 lvytdavgeaayiTKARVQLLRD-LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 298 QHELAKRQC-TGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLS 376
Cdd:PRK08248 329 SYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLS 408
|
410 420
....*....|....*....|
gi 1705789 377 VGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08248 409 VGTEAIDDILDDLRQAIRQS 428
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
18-396 |
2.65e-88 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 271.48 E-value: 2.65e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIH-VGPEPEQWSSraVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAkHCLTFARGLAA-TTT 95
Cdd:PRK07582 5 GTRSVHaGGPEAVPGEP--VLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAiTAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKtkLLEAAITPqTKLVWIETPTNPTLKLADIKACAQIV 175
Cdd:PRK07582 82 LRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAG--MAEAALAG-ADLVLAETPSNPGLDVCDLAALAAAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 176 HKHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCC 255
Cdd:PRK07582 159 HAAG-ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAH 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 256 RGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIkGTLQHAQVFLKNIKLFA 335
Cdd:PRK07582 238 RSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1705789 336 LAESLGGYESLAElpaimthasvpekDRATLG--ISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK07582 317 AATSFGGVHTSAD-------------RRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
46-396 |
5.65e-88 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 272.01 E-value: 5.65e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 46 FKQDSPGqssgFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVA 124
Cdd:PRK07504 50 FKGEDPG----FIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAvTAAILCQVKAGDHVVAARALFGSCRYVVETLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 125 SEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADI 204
Cdd:PRK07504 126 PRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQA-GAKLVVDNVFATPLFQKPLELGAHI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 205 CMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPR 284
Cdd:PRK07504 205 VVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPK 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 285 VEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRA 364
Cdd:PRK07504 285 VARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARA 364
|
330 340 350
....*....|....*....|....*....|..
gi 1705789 365 TLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK07504 365 ELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-396 |
7.36e-86 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 267.76 E-value: 7.36e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 12 PSFQHFATQAIHVGPEPEQWS-SRAVvlPISLATTFKQDSPGQSS--------GFVYSRSGNPTRNCLEKAVAALDGAKH 82
Cdd:PRK08134 4 MSPPGFDTLALHAGAAPDPATgARAV--PIHLTTSFVFRDSDHAAalfnleraGHVYSRISNPTVAVLEERVAALEGGVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 83 CLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNP 161
Cdd:PRK08134 82 AIATASGQAAlHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 162 TLKLADIKACAQIVHKHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV----------------- 224
Cdd:PRK08134 162 GLEVLDIPTVAAIAHEAG-VPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweasgkfpel 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 225 ----------------SVTSDDLNERLRFLQNsLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKV 288
Cdd:PRK08134 241 tepyagfhgmvfaeesTVAAFLLRARREGLRD-FGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 289 IYPGLPSHPQHELAKRQC-TGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLG 367
Cdd:PRK08134 320 AHPELESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAG 399
|
410 420
....*....|....*....|....*....
gi 1705789 368 ISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK08134 400 IGEGTIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
42-396 |
1.98e-83 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 260.01 E-value: 1.98e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 42 LATTFKqdspGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYF 120
Cdd:PRK05939 28 LIDVFQ----GKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLRAGDHLVSSQFLFGNTNSLF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 121 RRVAsEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKdIILVVDNTFMSAYFQRPLAL 200
Cdd:PRK05939 104 GTLR-GLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG-LLYVVDNTMTSPWLFRPKDV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 201 GADICMCSATKYMNGHSDVVMGLVSVTS-------DDLNERLR--------FLQ------NSLGAVPSPFDCYLCCRGLK 259
Cdd:PRK05939 182 GASLVINSLSKYIAGHGNALGGAVTDTGlfdwsayPNIFPAYRkgdpqqwgLTQirkkglRDMGATLSSEAAHRIAIGAE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 260 TLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQvFLKNIKLFALAES 339
Cdd:PRK05939 262 TLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFD-FLNRLKLVIKATH 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1705789 340 LGGYESLAeLPAIMT--HASVPEKdRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK05939 341 LGDTRTLV-IPVAPTiyYEMGAER-RASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-396 |
2.09e-82 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 258.29 E-value: 2.09e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 19 TQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSS--------GFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGL 90
Cdd:PRK06084 5 TLAIHAGYSPDP-TTKAVAVPIYQTTSYAFDDTQHGAdlfdlkvpGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 91 AATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIK 169
Cdd:PRK06084 84 AAITyAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 170 ACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSD----DLNERLRFLQN----- 240
Cdd:PRK06084 164 ALADAAHRH-GVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKfpwaEHKERFALLNTpdpsy 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 241 ------------------------SLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSH 296
Cdd:PRK06084 243 hgvtyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 297 PQHELAKRQCTGCP-GMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRL 375
Cdd:PRK06084 323 PEHELARRYMGGKPaSILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRL 402
|
410 420
....*....|....*....|.
gi 1705789 376 SVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK06084 403 SIGIEHIDDIIADLAQALDAS 423
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
17-396 |
2.05e-81 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 254.62 E-value: 2.05e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 17 FATQAIHVGPEPEQWSSRAVVLPISLATTFKQDS--------PGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFAR 88
Cdd:PRK05968 7 PFDLAALITAHDEGNAFDAVVPPIFQTSLFTFDSydemedvyAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 89 GLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAItPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK05968 87 GMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 168 IKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVTSDDLNERLRFLQNS-LGAVP 246
Cdd:PRK05968 166 VAALAALAKRH-GVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVV-AGSKEHIARINAEAYPyLGAKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 247 SPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELakrqcTGCPGMVSFYIKGTLqHAQV 326
Cdd:PRK05968 244 SPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSFIFREGI-DVRA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 327 FLKNIKLFALAESLGGYESLAeLPAIMTHASVPEKDR-ATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK05968 318 FADALKLFRLGVSWGGHESLV-VPAEVVLQQKAQPNSaARFGVSPRSVRLHVGLEGTEALWADLEQALAAA 387
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
17-396 |
2.66e-81 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 255.79 E-value: 2.66e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 17 FATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPG--------QSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFAR 88
Cdd:PRK05994 8 FATLAVHAGAQPDP-TTGARATPIYQTTSFVFNDADhaaslfglQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 89 GLAATTTITH-LLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK05994 87 GHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 168 IKACAQIVHKHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV------SVTSDD----------- 230
Cdd:PRK05994 167 IAAIAEVAHRAG-LPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIvdggtfDWSKSGkypmlseprpe 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 231 -----LNERL---------RFLQ-NSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPS 295
Cdd:PRK05994 246 yhglvLHETFgnfafaiaaRVLGlRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 296 HPQHELAKRQCTGCPGMV-SFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIR 374
Cdd:PRK05994 326 DPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVR 405
|
410 420
....*....|....*....|..
gi 1705789 375 LSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK05994 406 LSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
16-398 |
6.55e-81 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 255.06 E-value: 6.55e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSS--------GFVYSRSGNPTRNCLEKAVAALDGAKHCLTFA 87
Cdd:PRK07812 13 SFETKQIHAGQTPDP-ATNARALPIYQTTSYTFDDTDHAAalfglaepGNIYTRIMNPTQDVVEQRIAALEGGVAALLLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 88 RGLAATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFV-DCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:PRK07812 92 SGQAAETfAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--------------SVTSDD- 230
Cdd:PRK07812 172 LDIPGVAEVAHEA-GVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpGFTTPDp 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 231 ----------------LNERLRFLQNsLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLP 294
Cdd:PRK07812 251 syhgvvfaelgppayaLKARVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 295 SHPQHELAKRQC-TGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLI 373
Cdd:PRK07812 330 SSPWYERAKRLApKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLV 409
|
410 420
....*....|....*....|....*
gi 1705789 374 RLSVGLEDEKDLLEDLGQALKAAHP 398
Cdd:PRK07812 410 RLAVGIEGIDDILADLEAGFAAAKA 434
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
52-394 |
3.25e-78 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 246.95 E-value: 3.25e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 52 GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAAT-TTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLK 130
Cdd:PRK07810 57 GELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVE 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 131 ISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIIlVVDNTFMSAYFQRPLALGADICMCSAT 210
Cdd:PRK07810 137 TVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKV-VLDNVFATPLLQRGLPLGADVVVYSGT 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 211 KYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIY 290
Cdd:PRK07810 216 KHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRY 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 291 PGLPSHPQHELAKRQCTGCPGMVSFYIKGTL----QHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATL 366
Cdd:PRK07810 296 PFLPSHPQYDLAKRQMSGGGTVVTFELDAPEdaakKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAI 375
|
330 340
....*....|....*....|....*...
gi 1705789 367 GISDTLIRLSVGLEDEKDLLEDLGQALK 394
Cdd:PRK07810 376 GLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
19-396 |
1.20e-76 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 242.09 E-value: 1.20e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 19 TQAIHVGPEPEQwSSRAVVLPISLATTFKQDSPGQSSG----FVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATT 94
Cdd:TIGR01324 1 TRLIHSGRQPRF-SQGSVNPPLQRASTVLFDSHAAQRRakgeLTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 95 -TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQ 173
Cdd:TIGR01324 80 nSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 174 IVHKhKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSvTSDDLNERLRFLQNSLGAVPSPFDCYL 253
Cdd:TIGR01324 160 AARN-PGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVV-ANARTWDQLREHSYLMGQMVDADDAYT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 254 CCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQ-VFLKNIK 332
Cdd:TIGR01324 238 TLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVhAFLDHLQ 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1705789 333 LFALAESLGGYESLAeLPAIMTHASVPEKDRATLGisdTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:TIGR01324 318 LFGLGYSWGGYESLA-LCNQPELGHRPNIKRNLEG---PLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
16-396 |
1.32e-76 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 242.32 E-value: 1.32e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 16 HFATQAIHVGPE-PEQWSS------RA--VVLPiSLATTFKQDSpGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTF 86
Cdd:PRK07050 9 ALQTRIVQPDDQiPPGFRSfvtpvaRAstVVFP-DLATMRALDW-RQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 87 ARGLAATTTITH-LLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:PRK07050 87 PSGLAAISLVYFgLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 166 ADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAV 245
Cdd:PRK07050 167 PDVPAITAAARAR-GVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 246 PSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQ 325
Cdd:PRK07050 246 VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERYSPAQ 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1705789 326 V--FLKNIKLFALAESLGGYESLAeLPaimthASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK07050 326 VdaFVEALELFAIGWSWGGACSLA-MP-----YDVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
52-396 |
3.86e-74 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 236.24 E-value: 3.86e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 52 GQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTT-ITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLK 130
Cdd:PRK05967 51 TRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 131 ISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSAT 210
Cdd:PRK05967 131 VEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRH-GAIVMMDNTWATPLYFRPLDFGVDISIHAAT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 211 KYMNGHSDVVMGLVSVTSDDLnERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIY 290
Cdd:PRK05967 210 KYPSGHSDILLGTVSANEKCW-PQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLH 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 291 PGLPSHPQHELAKRQCTGCPGMVSFYIKGTL----QHAQVFLKNIKLFALAESLGGYESLAelpaimTHASVPEKDRATL 366
Cdd:PRK05967 289 PALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAFLDALEIFGLGYSWGGYESLA------LHVKLGDRTVAKA 362
|
330 340 350
....*....|....*....|....*....|
gi 1705789 367 GISDTLIRLSVGLEDEKDLLEDLGQALKAA 396
Cdd:PRK05967 363 PYAGPVIRLQIGLEDVPDLKADLERGFAAA 392
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
17-395 |
2.33e-71 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 230.14 E-value: 2.33e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 17 FATQAIHVGpEPEQWSSRAVVLPISLATTFKQDSPGQSS--------GFVYSRSGNPTRNCLEKAVAALDGAKHCLTFAR 88
Cdd:PRK05613 14 FETRSIHAG-QSVDSDTSARNLPIYQTTSYVFDSAEHAKqrfaledlGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 89 GLAATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFV-DCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK05613 93 GQAAETaAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 167 DIKACAQIVHKHKdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS--------------------V 226
Cdd:PRK05613 173 DIPAVAEVAHRNQ-VPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 227 TSD---------DLNE-------RLRFLQNSlGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIY 290
Cdd:PRK05613 252 TPDpayhglkyaDLGApafglkaRAGLLRDT-GATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 291 PGLPSHPQHELAKRQCTGCPGMV-SFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGIS 369
Cdd:PRK05613 331 AGLKDSPWYATKEKLGLKYTGSVlSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGIT 410
|
410 420
....*....|....*....|....*.
gi 1705789 370 DTLIRLSVGLEDEKDLLEDLGQALKA 395
Cdd:PRK05613 411 QATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
18-389 |
1.82e-67 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 218.83 E-value: 1.82e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEpEQWSSRAVVLPISLATTFKQDSPGQ---------SSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFAR 88
Cdd:PRK09028 6 ATKIVSAGRD-KKWTKGVINPPVFRASTVVFDTVAEmrhaaknraNGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 89 GLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK09028 85 GAAAiSNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 168 IKACAQIVHKHkDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGlVSVTSDDLNERLRFLQNSLGAVPS 247
Cdd:PRK09028 165 VPTLSRIAHEH-DIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLG-TATANEKHWDQLREHSYLMGQCTS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 248 PFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIK-GTLQHAQV 326
Cdd:PRK09028 243 PDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKAVTA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1705789 327 FLKNIKLFALAESLGGYESLaelpaIMTHASVPEKDRAT-LGISDTLIRLSVGLEDEKDLLEDL 389
Cdd:PRK09028 323 LVEGMQHFKMGFSWGGFESL-----ILGVFGINKLRTATnWDFSKPLIRLHIGLEDVDDLIADL 381
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
59-389 |
4.47e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 199.54 E-value: 4.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 59 YSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCS 137
Cdd:PRK08114 56 YGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAvANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 138 KTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVH-KHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGH 216
Cdd:PRK08114 136 IGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRsVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGH 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 217 SDVVMGlVSVTSDDLNERLRflQNS--LGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLP 294
Cdd:PRK08114 216 SDAMIG-TAVANARCWEQLR--ENSylMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALP 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 295 SHPQHELAKRQCTGCPGMVSFYIKGTLQHAQV--FLKNIKLFALAESLGGYESLaelpaIMthASVPEKDRA-----TLG 367
Cdd:PRK08114 293 GCKGHEFWKRDFTGSSGLFSFVLKKKLTDEQLanYLDNFSLFSMAYSWGGFESL-----IL--ANQPEEIAAirpagEVD 365
|
330 340
....*....|....*....|..
gi 1705789 368 ISDTLIRLSVGLEDEKDLLEDL 389
Cdd:PRK08114 366 FTGTLIRLHIGLEDVDDLIADL 387
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
18-393 |
6.34e-56 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 189.88 E-value: 6.34e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 18 ATQAIHVGPEPEQWSSRavVLPISLATTFKQDSPG--------QSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARG 89
Cdd:PRK06702 8 GTICVQGGYTPKNGEPR--VLPLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 90 LAATT-TITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKT-KLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK06702 86 QAAIMlAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTaDEIVALANDKTKLVYAESLGNPAMNVLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 168 IKACAQIVhKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS---------------VTSDDLN 232
Cdd:PRK06702 166 FKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 233 ERLRFLQN----------------SLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSH 296
Cdd:PRK06702 245 HGVSYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 297 PQHELAKRQCT-GCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRL 375
Cdd:PRK06702 325 ENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRL 404
|
410
....*....|....*...
gi 1705789 376 SVGLEDEKDLLEDLGQAL 393
Cdd:PRK06702 405 SVGIEDVSDIIADLEAAL 422
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
57-394 |
9.66e-54 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 183.81 E-value: 9.66e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 57 FVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAA-TTTITHLLKAGDEVICMDEVYGGTNRYFRR-VASEFGLKISFV 134
Cdd:PLN02242 68 YIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAiSSVLLQLCSSGGHVVASNTLYGGTHALLAHfLPRKCNITTTFV 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 135 DCSKTKLLEAAITP-QTKLVWIETPTNPTLKLADIKACAQIVHKhKDIILVVDNTFmSAYFQRPLALGADICMCSATKYM 213
Cdd:PLN02242 148 DITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHE-KGVTVVVDNTF-APMVLSPARLGADVVVHSISKFI 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 214 NGHSDVVMGLVSVTSDDLNERLRFLQNS---LGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRveKVIY 290
Cdd:PLN02242 226 SGGADIIAGAVCGPAELVNSMMDLHHGAlmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIY 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 291 PGLPSHPQHELAKRQ---CTGCPGMVSFYIkGTLQHAQVF---LKNIKLFAL-AESLGGYESLAELPAIMTHASVPEKDR 363
Cdd:PLN02242 304 PGLEDHPQHALLKSMankGYGFGGLLCLDM-DTEERANRLmryLQNSTQFGFmAVSLGYYETLMSCSGSSTSSELDPEEK 382
|
330 340 350
....*....|....*....|....*....|....*
gi 1705789 364 ATLGISDTLIRLSVG----LEDEKDLLEDLGQALK 394
Cdd:PLN02242 383 AAAGISPGLVRMSVGytgtLEQRWSQFEKALSAMK 417
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
70-215 |
1.52e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 65.48 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 70 LEKAVAAL--DGAKHCLTFARGLAATTTITH-LLKAGDEVICMDEVYGGTNRyfrRVASEFGLKISFVD--------CSK 138
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPvddagyggLDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 139 TKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHkDIILVVDNTF----MSAYFQRPLALGADICMCSATKYMN 214
Cdd:cd01494 82 AILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEY-GILLLVDAASaggaSPAPGVLIPEGGADVVTFSLHKNLG 160
|
.
gi 1705789 215 G 215
Cdd:cd01494 161 G 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
99-306 |
1.09e-09 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 59.28 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 99 LLKAGDEVICMDEVYGGtnryFRRVASEFGLKISFVDCSK-------TKLLEAAITPQTKLVWIETPTNPT---LKLADI 168
Cdd:cd00609 79 LLNPGDEVLVPDPTYPG----YEAAARLAGAEVVPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPTgavLSEEEL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 169 KACAQIVHKHkDIILVVDNT---FMSAYFQRPLALGAD-----ICMCSATKYMNghsdvVMGL----VSVTSDDLNERLR 236
Cdd:cd00609 155 EELAELAKKH-GILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG-----LPGLrigyLIAPPEELLERLK 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 237 FLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHF----RNGMAVARFLESNPRVEKV-------IYPGLPSHPQHELAKRQ 305
Cdd:cd00609 229 KLLPYTTSGPSTLSQAAAAAALDDGEEHLEELReryrRRRDALLEALKELGPLVVVkpsggffLWLDLPEGDDEEFLERL 308
|
.
gi 1705789 306 C 306
Cdd:cd00609 309 L 309
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
74-187 |
4.35e-09 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 57.83 E-value: 4.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 74 VAALDGAKHCLTFArgLAAtttithLLKAGDEVICMDEVYGgTNRYFRRVAsefGLKISFVDCSKT-------KLLEAAI 146
Cdd:COG0436 93 ILVTNGAKEALALA--LLA------LLNPGDEVLVPDPGYP-SYRAAVRLA---GGKPVPVPLDEEngflpdpEALEAAI 160
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1705789 147 TPQTKLVWIETPTNPT---LKLADIKACAQIVHKHkDIILVVDN 187
Cdd:COG0436 161 TPRTKAIVLNSPNNPTgavYSREELEALAELAREH-DLLVISDE 203
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
94-186 |
1.92e-08 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 55.69 E-value: 1.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 94 TTITHLLKAGDEVICMDEVY----------GGTnryFRRVASEFGlkiSF-VDCSKtklLEAAITPQTKLVWIETPTNPT 162
Cdd:PRK09082 106 AAILALVRPGDEVIVFDPSYdsyapaielaGGR---AVRVALQPP---DFrVDWQR---FAAAISPRTRLIILNTPHNPS 176
|
90 100
....*....|....*....|....*..
gi 1705789 163 ---LKLADIKACAQIVHKHkDIILVVD 186
Cdd:PRK09082 177 gtvWSAADMRALWQLIAGT-DIYVLSD 202
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
70-240 |
6.17e-08 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 53.92 E-value: 6.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 70 LEKAVAALDGAKHCLTFARGLAATTTITHLL--KAGDEVICmdevyggTNRYFrrVAS-----EFGLKISFVDCSK---- 138
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSGTAALHLALRALgiGPGDEVIT-------PAFTF--VATanailYVGATPVFVDIDPdtyn 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 139 --TKLLEAAITPQTKLVwIetPT----NPtlklADIKACAQIVHKHkDIILVVDN--TFMSAYFQRPLALGADICMCS-- 208
Cdd:COG0399 106 idPEALEAAITPRTKAI-I--PVhlygQP----ADMDAIMAIAKKH-GLKVIEDAaqALGATYKGKKVGTFGDAGCFSfy 177
|
170 180 190
....*....|....*....|....*....|....*.
gi 1705789 209 ATK---YMNGhsdvvmGLVsVTSDD-LNERLRFLQN 240
Cdd:COG0399 178 PTKnltTGEG------GAV-VTNDEeLAERARSLRN 206
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
70-240 |
3.34e-07 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 51.77 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 70 LEKAVAALDGAKHCLTFARGLAATTTITHLL--KAGDEVICmdevyggTNRYFrrVAS-----EFGLKISFVDCSKT--- 139
Cdd:cd00616 23 FEKAFAEYLGVKYAVAVSSGTAALHLALRALgiGPGDEVIV-------PSFTF--VATanailLLGATPVFVDIDPDtyn 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 140 ---KLLEAAITPQTKLVwieTPTNPTLKLADIKACAQIVHKHkDIILVVDN--TFMSAYFQRPLALGADICMCS--ATK- 211
Cdd:cd00616 94 idpELIEAAITPRTKAI---IPVHLYGNPADMDAIMAIAKRH-GLPVIEDAaqALGATYKGRKVGTFGDAGAFSfhPTKn 169
|
170 180 190
....*....|....*....|....*....|..
gi 1705789 212 --YMNGhsdvvmGLVsVTSDD-LNERLRFLQN 240
Cdd:cd00616 170 ltTGEG------GAV-VTNDEeLAERARLLRN 194
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
70-186 |
5.26e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 51.15 E-value: 5.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 70 LEKAVAALDGAKHCLTFARGLAATTT----------ITHLLKAGDEVICMDEVYGGTNRYFRRVasefGLKISFVDCSKT 139
Cdd:pfam00155 44 LREALAKFLGRSPVLKLDREAAVVFGsgaganiealIFLLANPGDAILVPAPTYASYIRIARLA----GGEVVRYPLYDS 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1705789 140 KL-------LEAAITPQTKLVWIETPTNPT---LKLADIKACAQIVHKHKdIILVVD 186
Cdd:pfam00155 120 NDfhldfdaLEAALKEKPKVVLHTSPHNPTgtvATLEELEKLLDLAKEHN-ILLLVD 175
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
54-205 |
5.51e-07 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 51.26 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 54 SSGFVYSRSGnptRNCLEKAVAALDGAKHCL---TFARGL-AATTTITHLLKAGDEVIC--------MDEVYGGTNRYfr 121
Cdd:COG4100 49 TTGYGYDDIG---RDTLERVYADVFGAEDALvrpQIVSGThAIALALFGVLRPGDELLSitgkpydtLEEVIGIRGEG-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 122 rVAS--EFGLKISFVDCSKT-----KLLEAAITPQTKLVWIETPT----NPTLKLADIKACAQIVHKHK-DIILVVDNtf 189
Cdd:COG4100 124 -QGSlkEFGISYRQVPLTEDgkidlEAIKKAINEKTKMVLIQRSRgyswRPSLTIEEIGEIIKFVKSINpDVICFVDN-- 200
|
170 180
....*....|....*....|.
gi 1705789 190 msAY--F---QRPLALGADIC 205
Cdd:COG4100 201 --CYgeFvetREPTEVGADLM 219
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
79-186 |
1.31e-06 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 50.12 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 79 GAKHCLTFArgLAAtttithLLKAGDEVI-------CMDEV---YGGTNRyFRRVASEFGLKISFVDcsktklLEAAITP 148
Cdd:PRK05764 99 GAKQALYNA--FMA------LLDPGDEVIipapywvSYPEMvklAGGVPV-FVPTGEENGFKLTVEQ------LEAAITP 163
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1705789 149 QTKLVWIETPTNPT---LKLADIKACAQIVHKHkDIILVVD 186
Cdd:PRK05764 164 KTKALILNSPSNPTgavYSPEELEAIADVAVEH-DIWVLSD 203
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
70-240 |
1.78e-06 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 49.59 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 70 LEKAVAALDGAKHCLTFARGLAATTTITHLLKA--GDEVICMDEVYGGTNryfrRVASEFGLKISFVD------CSKTKL 141
Cdd:pfam01041 29 FERAFAAYLGVKHAIAVSSGTAALHLALRALGVgpGDEVITPSFTFVATA----NAALRLGAKPVFVDidpdtyNIDPEA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 142 LEAAITPQTKLVwieTPTNPTLKLADIKACAQIVHKHkDIILVVD--NTFMSAYFQRPLALGADICMCS--ATKYM---N 214
Cdd:pfam01041 105 IEAAITPRTKAI---IPVHLYGQPADMDAIRAIAARH-GLPVIEDaaHALGATYQGKKVGTLGDAATFSfhPTKNLttgE 180
|
170 180
....*....|....*....|....*.
gi 1705789 215 GhsdvvmGLVSVTSDDLNERLRFLQN 240
Cdd:pfam01041 181 G------GAVVTNDPELAEKARVLRN 200
|
|
| PRK15407 |
PRK15407 |
lipopolysaccharide biosynthesis protein RfbH; Provisional |
71-187 |
8.05e-06 |
|
lipopolysaccharide biosynthesis protein RfbH; Provisional
Pssm-ID: 237960 Cd Length: 438 Bit Score: 47.57 E-value: 8.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 71 EKAVAALDGAKHCLTFARG----LAATTTIT-HLL-----KAGDEVICmdevyggtnryfrrVASEF----------GLK 130
Cdd:PRK15407 69 EKKLAEFLGVRYALLVNSGssanLLAFSALTsPKLgdralKPGDEVIT--------------VAAGFpttvnpiiqnGLV 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1705789 131 ISFVDCS------KTKLLEAAITPQTKLVWI-ETPTNPTlklaDIKACAQIVHKHkDIILVVDN 187
Cdd:PRK15407 135 PVFVDVElptyniDASLLEAAVSPKTKAIMIaHTLGNPF----DLAAVKAFCDKH-NLWLIEDN 193
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
91-199 |
1.05e-05 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 47.34 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 91 AATTTITHLLKAGDEVICMDEVY----------GGTNRYFRRVASEFGLKISfVDCsktklLEAAITPQTKLVWIETPTN 160
Cdd:PRK07777 97 AIAAAVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD-LDA-----LRAAVTPRTRALIVNSPHN 170
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1705789 161 PT---LKLADIKACAQIVHKHkDIILVVDNTFMSAYF----QRPLA 199
Cdd:PRK07777 171 PTgtvLTAAELAAIAELAVEH-DLLVITDEVYEHLVFdgarHLPLA 215
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
96-190 |
2.78e-05 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 45.89 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITHLLKA----GDEVICMD---EVYggtnryfRRVASEFGLKISFVDCSKT-----KLLEAAITPQTKLVWIETPTNPT- 162
Cdd:COG0079 78 IQLLARAflgpGDEVLVPEptfSEY-------PIAARAAGAEVVEVPLDEDfsldlDALLAAITERTDLVFLCNPNNPTg 150
|
90 100 110
....*....|....*....|....*....|
gi 1705789 163 --LKLADIKACAQIVhkHKDIILVVDNTFM 190
Cdd:COG0079 151 tlLPREELEALLEAL--PADGLVVVDEAYA 178
|
|
| PRK07683 |
PRK07683 |
aminotransferase A; Validated |
99-197 |
6.67e-05 |
|
aminotransferase A; Validated
Pssm-ID: 236075 Cd Length: 387 Bit Score: 44.71 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 99 LLKAGDEVICMDEVYGGTNRYFRRVasefGLKISFVDCSKT------KLLEAAITPQTKLVWIETPTNPTLKLADIKACA 172
Cdd:PRK07683 109 ILEPGTEVILPAPIYPGYEPIIRLC----GAKPVFIDTRSTgfrltaEALENAITEKTRCVVLPYPSNPTGVTLSKEELQ 184
|
90 100
....*....|....*....|....*..
gi 1705789 173 QIVH--KHKDIILVVDNTFMSAYFQRP 197
Cdd:PRK07683 185 DIADvlKDKNIFVLSDEIYSELVYEQP 211
|
|
| PRK06107 |
PRK06107 |
aspartate transaminase; |
79-189 |
1.14e-04 |
|
aspartate transaminase;
Pssm-ID: 180403 Cd Length: 402 Bit Score: 43.96 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 79 GAKHCLTFArgLAATttithlLKAGDEVIC----------MDEVYGGTNryfrrvasefglkiSFVDCSKT---KL---- 141
Cdd:PRK06107 101 GAKQAIFLA--LMAT------LEAGDEVIIpapywvsypdMVLANDGTP--------------VIVACPEEqgfKLtpea 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1705789 142 LEAAITPQTKLVWIETPTNPT---LKLADIKACAQIVHKHKDIILVVDNTF 189
Cdd:PRK06107 159 LEAAITPRTRWLILNAPSNPTgavYSRAELRALADVLLRHPHVLVLTDDIY 209
|
|
| PRK07309 |
PRK07309 |
pyridoxal phosphate-dependent aminotransferase; |
91-186 |
1.30e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235985 Cd Length: 391 Bit Score: 43.94 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 91 AATTTITHLLKAGDEVICMDEVYGGtnryFRRVASEFGLKISFVDCSKT------KLLEAAITPQ---TKLVWIETPTNP 161
Cdd:PRK07309 103 ALSASLTAILEPGDKVLLPAPAYPG----YEPIVNLVGAEIVEIDTTENdfvltpEMLEKAILEQgdkLKAVILNYPANP 178
|
90 100
....*....|....*....|....*...
gi 1705789 162 T---LKLADIKACAQIVHKHkDIILVVD 186
Cdd:PRK07309 179 TgvtYSREQIKALADVLKKY-DIFVISD 205
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
91-186 |
4.16e-04 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 42.27 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 91 AATTTITHLLKAGDEVICMDEVY----------GGTNRYFRRVASEFGLKisfvdcskTKLLEAAITPQTKLVWIETPTN 160
Cdd:PRK08912 99 ALAAALLALVEPGDEVVLFQPLYdaylplirraGGVPRLVRLEPPHWRLP--------RAALAAAFSPRTKAVLLNNPLN 170
|
90 100
....*....|....*....|....*....
gi 1705789 161 PTLKL---ADIKACAQIVHKHkDIILVVD 186
Cdd:PRK08912 171 PAGKVfprEELALLAEFCQRH-DAVAICD 198
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
96-186 |
4.81e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 42.10 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 96 ITHLLKA----GDEVICMD----------EVYGGTNRYFRRVASEFGLKIsfvdcsktKLLEAAITPQTKLVWIETPTNP 161
Cdd:PRK06836 109 LNVALKAilnpGDEVIVFApyfveyrfyvDNHGGKLVVVPTDTDTFQPDL--------DALEAAITPKTKAVIINSPNNP 180
|
90 100 110
....*....|....*....|....*....|....
gi 1705789 162 T--------LK-LADIKACAQIVHKHkDIILVVD 186
Cdd:PRK06836 181 TgvvyseetLKaLAALLEEKSKEYGR-PIYLISD 213
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
142-186 |
6.34e-04 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 6.34e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1705789 142 LEAAITPQTKLVWIETPTNPT---LKLADIKACAQIVHKHkDIILVVD 186
Cdd:PRK07682 147 IEAAITAKTKAILLCSPNNPTgavLNKSELEEIAVIVEKH-DLIVLSD 193
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
140-197 |
1.02e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 40.86 E-value: 1.02e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705789 140 KLLEAAITPQTKLVWIETPTNPT---LKLADIKACAQIVHKHkDIILVVDNTFMSAYFQRP 197
Cdd:PRK06348 153 KKLEALITSKTKAIILNSPNNPTgavFSKETLEEIAKIAIEY-DLFIISDEVYDGFSFYED 212
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
95-189 |
1.44e-03 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 40.54 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 95 TITHLLKAGDEVICMDEVYGGTNRYFR-RVASEFGLKISF----VDCSKtklLEAAITPQTKLVWIETPTNPT---LKLA 166
Cdd:PRK12414 106 AISALVHPGDEVIYFEPSFDSYAPIVRlQGATPVAIKLSPedfrVNWDE---VAAAITPRTRMIIVNTPHNPSatvFSAA 182
|
90 100
....*....|....*....|...
gi 1705789 167 DIKACAQIVhKHKDIILVVDNTF 189
Cdd:PRK12414 183 DLARLAQLT-RNTDIVILSDEVY 204
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
142-194 |
2.77e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 39.54 E-value: 2.77e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1705789 142 LEAAITPQTKLVWIETPTNPT---LKLADIKACAQIVHKHkDIILVVDNTFMSAYF 194
Cdd:PRK06108 151 LLAAITPRTRALFINSPNNPTgwtASRDDLRAILAHCRRH-GLWIVADEVYERLYY 205
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
72-186 |
5.46e-03 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 38.58 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 72 KAVAALDGAK--HCLTFARGlaaTTTITHL-------LKAGDEVIcmdevyggTNRY--------FRRVASEFGLKISFV 134
Cdd:COG0520 66 EKVARFIGAAspDEIIFTRG---TTEAINLvayglgrLKPGDEIL--------ITEMehhsnivpWQELAERTGAEVRVI 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705789 135 DCSKT-----KLLEAAITPQTKLV---WIetpTNPTLKLADIKACAQIVHKHkDIILVVD 186
Cdd:COG0520 135 PLDEDgeldlEALEALLTPRTKLVavtHV---SNVTGTVNPVKEIAALAHAH-GALVLVD 190
|
|
| |
