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RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; Short=IDH1; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=IDPc; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 850.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 1 MSR KI H - GGS VVE MQ GDEMTRIIW EL IKEKLILPY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLILPY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV T GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP K 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 160 DGS QKVTYL V H DF E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK S KF 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK A KF 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 320 QKG Q ETSTN P IASIFAW S RGLAHRAKLDNN T EL SF F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAW T RGLAHRAKLDNN Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 1170478 400 K LG E N LK A KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 850.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 1 MSR KI H - GGS VVE MQ GDEMTRIIW EL IKEKLILPY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLILPY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV T GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP K 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 160 DGS QKVTYL V H DF E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK S KF 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK A KF 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 320 QKG Q ETSTN P IASIFAW S RGLAHRAKLDNN T EL SF F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAW T RGLAHRAKLDNN Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 1170478 400 K LG E N LK A KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 805.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 3 R KI HGGS - VVEM Q GDEMTRIIWELIK E KLILPYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKKYNVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLILPYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKKYNVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV T GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IT Y T PKDG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 162 S QKVT YL V H DFEEGGGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKSKFEA 241
Cdd:TIGR00127 161 T QKVT LK V Y DFEEGGGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKSKFEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVLICPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVLICPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 322 GQETSTN P IASIFAWSRGLAHRAKLDNN T ELS F FAN A LE EV CI E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAWSRGLAHRAKLDNN P ELS K FAN I LE SA CI N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 1170478 402 G E N LK A K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-407
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 516.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 VVEMQ GD ---- E M TR I IW EL I KEKLILP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK K Y N VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK E Y G VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V TGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEITYTPK D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 161 GS qkv TYL V HD F E E GG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKS KF 239
Cdd:COG0538 172 EM --- GVT V IR F P E DS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGD KF 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVL I CP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGAN I GD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAWSRG L A HR AK L DN ntelsff A NAL E EVCIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSGTMM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|..
gi 1170478 386 vqrsd Y L N T F EF M D KLG ENL KA 407
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL DK 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
1.06e-89
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 274.94
E-value: 1.06e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 11 VEMQ G D E MTRIIWELI K EK L ILPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK YNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVTGW V K p I I I G R HAY G DQ Y RATDFVVP G P G kveitytpkdgsqkvt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G ---------------- 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 167 ylvhdfe EGGG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K skfeaq KIW 245
Cdd:pfam00180 147 ------- NEVA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLICPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1170478 325 ts T NPIA S I FAWSRG L AHRAK L DNN telsff A NAL E EVCIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 850.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 1 MSR KI H - GGS VVE MQ GDEMTRIIW EL IKEKLILPY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKK YN VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLILPY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKK HK VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV T GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP K 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 160 DGS QKVTYL V H DF E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK S KF 239
Cdd:PTZ00435 162 DGS EPQRVD V F DF K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK A KF 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVL I CPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVL V CPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 320 QKG Q ETSTN P IASIFAW S RGLAHRAKLDNN T EL SF F AN ALE EV CIETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAW T RGLAHRAKLDNN Q EL VK F CQ ALE RS CIETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 1170478 400 K LG E N LK A KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
10-409
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 821.41
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 VVE MQ GDEMTRIIW EL IK E KLILPY VEL DL HS YDLGIENRDAT N DQVT K DAA E AIKKY N VGVKCATITPDE K RV E EF K LK 89
Cdd:PRK08299 10 VVE LD GDEMTRIIW KF IK D KLILPY LDI DL EY YDLGIENRDAT D DQVT I DAA N AIKKY G VGVKCATITPDE A RV K EF N LK 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 90 Q MWKSPNGTIRNILGGTVFRE A IICKN I PRLV T GW V KPI I IGRHAYGDQYRATDF V VPG P GK VEITY T PK DG s QKVTYL V 169
Cdd:PRK08299 90 K MWKSPNGTIRNILGGTVFRE P IICKN V PRLV P GW T KPI V IGRHAYGDQYRATDF K VPG K GK LTLVF T GE DG - EPIEHE V 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 170 HDF E e G G GVAMGMYN Q D K SI E DFA HS SF QMA L SKGW P L YLSTKNTILK K YDGRFKDIFQE I Y DKQY K S KFEA QK I W YEHR 249
Cdd:PRK08299 169 HDF P - G A GVAMGMYN L D E SI R DFA RA SF NYG L DRKY P V YLSTKNTILK A YDGRFKDIFQE V Y EAEF K E KFEA AG I T YEHR 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 250 LIDDMVA Q A M K S EGG FI WACKNYDGDVQSD S VAQG Y GSLG M MTSVL IC PDGKTVEAEAAHGTVTRHYR MY QKG Q ETSTNP 329
Cdd:PRK08299 248 LIDDMVA S A L K W EGG YV WACKNYDGDVQSD T VAQG F GSLG L MTSVL MT PDGKTVEAEAAHGTVTRHYR QH QKG E ETSTNP 327
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 330 IASIFAW S RGLAHR A KLD N N T EL SF FA NA LE E VCIET I E A GFMTKDLA ACIK gl P NVQ rsd Y L N T F EF M D KLG ENL KAK L 409
Cdd:PRK08299 328 IASIFAW T RGLAHR G KLD G N P EL VK FA DT LE K VCIET V E S GFMTKDLA LLVG -- P DQK --- W L T T E EF L D AID ENL EKA L 402
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 805.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 3 R KI HGGS - VVEM Q GDEMTRIIWELIK E KLILPYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKKYNVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLILPYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKKYNVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV T GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IT Y T PKDG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K PKDG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 162 S QKVT YL V H DFEEGGGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKSKFEA 241
Cdd:TIGR00127 161 T QKVT LK V Y DFEEGGGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKSKFEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVLICPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVLICPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 322 GQETSTN P IASIFAWSRGLAHRAKLDNN T ELS F FAN A LE EV CI E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAWSRGLAHRAKLDNN P ELS K FAN I LE SA CI N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 1170478 402 G E N LK A K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
10-414
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 726.29
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 V VEM Q GDEMTR I IW EL IK E KLI L PY VE LD LHSY DLGI E NRDAT N D Q VT KDA AEA IK KYNV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN03065 80 I VEM D GDEMTR V IW QM IK D KLI F PY LD LD IKYF DLGI L NRDAT D D K VT VES AEA TL KYNV AI KCATITPDE A RV K EF G LK 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 90 Q MW K SPNGTIRNIL G GTVFRE A I I CKNIPRLV T GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEITYT P K DG SQK V TYL V 169
Cdd:PLN03065 160 S MW R SPNGTIRNIL N GTVFRE P I L CKNIPRLV P GW K KPI C IGRHA F GDQYRATD T V IK GPGK LKMVFV P E DG NAP V ELD V 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 170 H DF E e G G GVA MG MYN Q D K SI ED FA H SS FQ MAL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y K S KFE AQK IWYEHR 249
Cdd:PLN03065 240 Y DF K - G P GVA LA MYN V D E SI RA FA E SS MA MAL Q K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EE Q W K Q KFE EHS IWYEHR 318
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVL ICP DGKT V EAEAAHGTVTRH Y R MY QKGQETSTN P 329
Cdd:PLN03065 319 LIDDMVA Y A V KSEGG YV WACKNYDGDVQSD LL AQG F GSLG L MTSVL LSS DGKT L EAEAAHGTVTRH F R LH QKGQETSTN S 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 330 IASIFAW S RGL A HRAKLD N N T EL SF F ANA LE EV CIET I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLGEN L KA K L 409
Cdd:PLN03065 399 IASIFAW T RGL E HRAKLD K N E EL LD F VHK LE SA CIET V E S G K MTKDLA IL I H G - P K V S R EF YLNT E EF I D AVAQT L AT K R 477
....*
gi 1170478 410 AQAKL 414
Cdd:PLN03065 478 GEPAV 482
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
10-409
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 701.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 V VEM Q GDEMTR I IW EL IK E KLI L P YVE LD LHSY DLG IE NRDAT N D Q VT KDA AEA IK KYNV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN00103 12 I VEM D GDEMTR V IW KS IK D KLI F P FLD LD IKYF DLG LP NRDAT D D K VT VES AEA TL KYNV AI KCATITPDE A RV K EF G LK 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 90 QMWKSPNGTIRNIL G GTVFRE A IICKNIPRLV T GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEITYT P KDGSQ K VTYL V 169
Cdd:PLN00103 92 QMWKSPNGTIRNIL N GTVFRE P IICKNIPRLV P GW T KPI C IGRHA F GDQYRATD A V IK GPGK LKLVFV P EGKDE K TELE V 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 170 HD F EEG GGVA MG MYN Q D K SI ED FA HS S FQM A LS K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y KSKFEA QK IWYEHR 249
Cdd:PLN00103 172 YN F TGA GGVA LS MYN T D E SI RA FA EA S MNT A YQ K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA Q W KSKFEA AG IWYEHR 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVL I CPDGKT V EAEAAHGTVTRHYR MY QKG Q ETSTN P 329
Cdd:PLN00103 252 LIDDMVA Y A L KSEGG YV WACKNYDGDVQSD FL AQG F GSLG L MTSVL V CPDGKT I EAEAAHGTVTRHYR VH QKG G ETSTN S 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 330 IASIFAWSRGLAHRAKLD N N TE L SF F ANA LE EV C IE T I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLG E N LKA K L 409
Cdd:PLN00103 332 IASIFAWSRGLAHRAKLD G N AR L LD F TEK LE AA C VG T V E S G K MTKDLA LL I H G - P K V S R DQ YLNT E EF I D AVA E E LKA R L 410
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-407
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 516.97
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 VVEMQ GD ---- E M TR I IW EL I KEKLILP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK K Y N VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK E Y G VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V TGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEITYTPK D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 161 GS qkv TYL V HD F E E GG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKS KF 239
Cdd:COG0538 172 EM --- GVT V IR F P E DS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGD KF 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVL I CP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGAN I GD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAWSRG L A HR AK L DN ntelsff A NAL E EVCIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSGTMM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|..
gi 1170478 386 vqrsd Y L N T F EF M D KLG ENL KA 407
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL DK 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
1.06e-89
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 274.94
E-value: 1.06e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 11 VEMQ G D E MTRIIWELI K EK L ILPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK YNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVTGW V K p I I I G R HAY G DQ Y RATDFVVP G P G kveitytpkdgsqkvt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G ---------------- 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 167 ylvhdfe EGGG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K skfeaq KIW 245
Cdd:pfam00180 147 ------- NEVA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLICPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1170478 325 ts T NPIA S I FAWSRG L AHRAK L DNN telsff A NAL E EVCIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
10-405
1.74e-53
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 182.93
E-value: 1.74e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 10 V V EMQ G D EMTR IIWE LI KE K L I L P Y V ELD - LHSY DL GIE NRD A T N DQV TK D AA EA IKKYNVGV K CA TITP DEKR V EEFK L 88
Cdd:PLN00096 1 M V YVA G E EMTR YTMD LI LA K W I E P H V DTS a WEFF DL RAK NRD D T E DQV LR D VI EA GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 89 K QM W K SPNG TI R NILG G - T VF R EA I ick N I PRLVT G WV KP IIIG RHA Y G DQ Y R A t DFVVP G P G KVEI T YT P KD G SQKVTY 167
Cdd:PLN00096 81 K KA W G SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A - GYKIV G K G TLVT T FV P EE G GKPIVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 168 LVHDFEEGGGVAMGMY N QDKSIEDF A HSS F QMA L SK G WPL Y LS TK N T IL k K YDGR F KD I FQEIY D KQY KSKF EAQKIWYE 247
Cdd:PLN00096 157 DDRTITDDLNAVVTYH N PLDNVHHL A RIF F GRC L DA G IVP Y VV TK K T VF - K WQEP F WE I MKKVF D EEF KSKF VDKGVMKS 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 248 ----- H R L I D dmv A QA MK ---- SE GGF IW A CK NYDGDV QS D SV AQ GYG S L G MM TS V L ICP D GKTV --- E A EA A HGTVT RH 315
Cdd:PLN00096 236 gdelv H L L S D --- A AT MK lvvw TD GGF GM A AH NYDGDV LT D EL AQ VHK S P G FI TS N L VGV D ENGT lik E F EA S HGTVT DM 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 316 YRMYQK G Q ETS T NP IASIFAWSRGLA H R A KLDNNT E LSF - F ANA L EE V CIETIEA G FM T K DL AA cikglpnvqr SDY L N T 394
Cdd:PLN00096 313 DEARLR G E ETS L NP LGMVEGLIGAMN H A A DVHGGK E RVH p F TAK L RA V IHKLFRE G RG T R DL CG ---------- AGG L T T 382
410
....*....|.
gi 1170478 395 FE F M D KLG E N L 405
Cdd:PLN00096 383 EQ F I D AVA E E L 393
PRK06451
PRK06451 NADP-dependent isocitrate dehydrogenase;
52-401
5.83e-05
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803
Cd Length: 412
Bit Score: 44.82
E-value: 5.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 52 T NDQVT K DAA E A I K KY N V GV K CATI TP dekrveefk LKQM WKS P N GT IR NI L gg TVFREAIIC K N IP RLVTGWVK P ---- 127
Cdd:PRK06451 75 T GNRFP K ESE E L I E KY R V LL K GPLE TP --------- IGKG WKS I N VA IR LM L -- DLYANIRPV K Y IP GIESPLKN P ekid 143
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 128 I II G R HAYG D Q YR A tdfvvpgpgk V E IT Y TPKDGSQKVTY L VHDF ---- E EGG G VAMGMYNQD K S i EDF A HSSFQM A LSK 203
Cdd:PRK06451 144 L II F R ENTD D L YR G ---------- I E YP Y DSEEAKKIRDF L RKEL gvev E DDT G IGIKLISKF K T - QRI A RMAIKY A IDH 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 204 GW - PLYLST K NTIL K KYD G R F KD -------------- IFQ E IYD K Q Y KSKFEAQ K IWYEH R LI D D M VA Q AM -- KS E GGF I 266
Cdd:PRK06451 213 KR k KVTIMH K GNVM K YTE G A F RE wayevalkefrdyv VTE E EVT K N Y NGVPPSG K VIIND R IA D N M FQ Q II ir PD E YDI I 292
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170478 267 W A c K N YD GD VQ SD SVAQGY G SL GM MTSVL I CPD G KTV ea EA A HGT VTRH yrmyq K G QETS t NP IAS I faws R G LAHRAKL 346
Cdd:PRK06451 293 L A - P N VN GD YI SD AAGALV G NI GM LGGAN I GDT G GMF -- EA I HGT APKY ----- A G KNVA - NP TGI I ---- K G GELMLRF 359
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1170478 347 DNNTEL sff A NALEEVCI E T I EAGFM T K DLA -- ACIKG L PNVQRS D Y L nt FEFM D K L 401
Cdd:PRK06451 360 MGWDKA --- A DLIDKAIM E S I KQKKV T Q DLA rf MGVRA L STTEYT D E L -- ISII D M L 411
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
