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Concise Results
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RecName: Full=Nardilysin; AltName: Full=N-arginine dibasic convertase; Short=NRD convertase; Short=NRD-C; AltName: Full=Nardilysin convertase; Flags: Precursor
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
99-1116
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 702.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 99 E IIKSP S DP K QYR Y I K L Q NGL QA LL I SD lsnvegktgnatdeeeeeeeeeeegeeeeeeeedddddddedsgaeiqddde 178
Cdd:COG1025 34 T IIKSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 179 egfddeeefdddehddddldneeneleeleerveark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP 258
Cdd:COG1025 62 ------------------------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP 103
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 259 DENGFDA F LK KHGGS D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KE 338
Cdd:COG1025 104 EPGEYQE F IS KHGGS H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IY 183
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 339 MLFGSLAR P G HP MGK F FW GN A ETL K hep K K NNIDTHAR L RE F WM RYYSA HY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG 418
Cdd:COG1025 184 QVHKETLN P A HP FSR F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYSA NL M K LV LY S NQS LD E LEK LARQT F GA IPN RN 260
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 419 L PK P nfshltd P FDT P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SY L R K KCW 493
Cdd:COG1025 261 L SV P ------- P ITV P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 494 A LA L FG G N G ET G feqn STYSV FSIS IT LTD E G YE H FY E VAHT VF Q Y LKMLQKL G PEKRV F E E IQKIEDNE F HY QE Q T D P V 573
Cdd:COG1025 334 A ES L SA G G G IS G ---- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P M 409
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 574 E YV ENMCE NM QL YP RQ D F L TG D Q L LFEYK P EV I AEA L N QL V P QK A NLV L L S GANEG rc D LKEK W FG T Q YS IED I ENSWTE 653
Cdd:COG1025 410 D YV SWLSD NM LR YP VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLA 487
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 654 L W K s NFDL N SD L H LP AE N K YI AT DF T L KAF D c P E TEY P AKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V 733
Cdd:COG1025 488 K W Q - QASQ N PA L S LP EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q 565
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 734 VL FDIFVNI L THN L A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y L TE F SS T PAV F TMITE QL KKTY 813
Cdd:COG1025 566 VL TRLLDYL L NDA L N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q L AS F EP T EER F AQAKS QL LRQL 645
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 814 F N ilikp ETL AK DVRL L ILEY SR WSMIDKY ----- R A LMDGLS L ES L LN F VKDFKS QL FV E G LV Q GN VTSTESMDFLRYV 888
Cdd:COG1025 646 D N ----- AEK AK PYSQ L FSPL SR LLQPPYF ereel L A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSL 720
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 889 VDK L N f VPLER E M P VQ f QVV E L PSGHH L CKVR A LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT 968
Cdd:COG1025 721 KKQ L A - PNGTG E E P RR - QVV D L DKSGS L NLEK A CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ 796
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 969 LGY H V --- Y PTCRNTS G I l GF S V tvgt Q ATKYNSETVDKK I EE FL SS FEE KIEN L T E DA F NTQVTA LI K - L K E c E D TH L G 1044
Cdd:COG1025 797 LGY V V gag Y MPLGRQP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S E EE F AQYKQG LI N q L L E - P D QN L S 870
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352519 1045 EE VD R N W NEVVTQQYL FD RLAHE I E A L K SFSKS DL VSW F KAHRGP -- G SKM LS VHVVGYGKYEL E ED G APVCE D 1116
Cdd:COG1025 871 EE AQ R L W VDIGNGDFE FD TREKL I A A V K KLTRA DL IDF F QQAVIA pq G LRL LS QSQGTKHSKAD E LK G WKTIT D 944
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
99-1116
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 702.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 99 E IIKSP S DP K QYR Y I K L Q NGL QA LL I SD lsnvegktgnatdeeeeeeeeeeegeeeeeeeedddddddedsgaeiqddde 178
Cdd:COG1025 34 T IIKSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 179 egfddeeefdddehddddldneeneleeleerveark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP 258
Cdd:COG1025 62 ------------------------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP 103
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 259 DENGFDA F LK KHGGS D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KE 338
Cdd:COG1025 104 EPGEYQE F IS KHGGS H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IY 183
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 339 MLFGSLAR P G HP MGK F FW GN A ETL K hep K K NNIDTHAR L RE F WM RYYSA HY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG 418
Cdd:COG1025 184 QVHKETLN P A HP FSR F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYSA NL M K LV LY S NQS LD E LEK LARQT F GA IPN RN 260
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 419 L PK P nfshltd P FDT P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SY L R K KCW 493
Cdd:COG1025 261 L SV P ------- P ITV P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 494 A LA L FG G N G ET G feqn STYSV FSIS IT LTD E G YE H FY E VAHT VF Q Y LKMLQKL G PEKRV F E E IQKIEDNE F HY QE Q T D P V 573
Cdd:COG1025 334 A ES L SA G G G IS G ---- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P M 409
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 574 E YV ENMCE NM QL YP RQ D F L TG D Q L LFEYK P EV I AEA L N QL V P QK A NLV L L S GANEG rc D LKEK W FG T Q YS IED I ENSWTE 653
Cdd:COG1025 410 D YV SWLSD NM LR YP VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLA 487
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 654 L W K s NFDL N SD L H LP AE N K YI AT DF T L KAF D c P E TEY P AKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V 733
Cdd:COG1025 488 K W Q - QASQ N PA L S LP EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q 565
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 734 VL FDIFVNI L THN L A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y L TE F SS T PAV F TMITE QL KKTY 813
Cdd:COG1025 566 VL TRLLDYL L NDA L N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q L AS F EP T EER F AQAKS QL LRQL 645
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 814 F N ilikp ETL AK DVRL L ILEY SR WSMIDKY ----- R A LMDGLS L ES L LN F VKDFKS QL FV E G LV Q GN VTSTESMDFLRYV 888
Cdd:COG1025 646 D N ----- AEK AK PYSQ L FSPL SR LLQPPYF ereel L A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSL 720
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 889 VDK L N f VPLER E M P VQ f QVV E L PSGHH L CKVR A LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT 968
Cdd:COG1025 721 KKQ L A - PNGTG E E P RR - QVV D L DKSGS L NLEK A CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ 796
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 969 LGY H V --- Y PTCRNTS G I l GF S V tvgt Q ATKYNSETVDKK I EE FL SS FEE KIEN L T E DA F NTQVTA LI K - L K E c E D TH L G 1044
Cdd:COG1025 797 LGY V V gag Y MPLGRQP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S E EE F AQYKQG LI N q L L E - P D QN L S 870
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352519 1045 EE VD R N W NEVVTQQYL FD RLAHE I E A L K SFSKS DL VSW F KAHRGP -- G SKM LS VHVVGYGKYEL E ED G APVCE D 1116
Cdd:COG1025 871 EE AQ R L W VDIGNGDFE FD TREKL I A A V K KLTRA DL IDF F QQAVIA pq G LRL LS QSQGTKHSKAD E LK G WKTIT D 944
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
564-845
3.25e-121
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 374.98
E-value: 3.25e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 564 F HY QE QTD P VE YV ENMCE NMQ L YP RQ D F L T GD Q LL F EY K PE V I A E A L NQ L V P QK A NLV L L S GAN EG RC D L KE K W F GT Q YS 643
Cdd:pfam16187 1 F RF QE KSP P SD YV SSLAS NMQ P YP PE D I L S GD Y LL R EY D PE L I Q E L L DY L T P EN A RIT L V S KEF EG ET D Q KE P W Y GT E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 644 I E D I ENSWTEL WK SNFDL N SD LHLP AE N KY I A TDF T LK AFDCP E - TE YP AK I VN TP QGC LWYKKD NK F KI PKA Y I RFH L I 722
Cdd:pfam16187 81 V E P I PEELLKK WK NAPEP N PE LHLP EP N PF I P TDF D LK KKEVK E p AK YP VL I RD TP LSR LWYKKD DT F WV PKA N I YLS L R 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 723 SPL IQK S AA N V VL FDIF V NI L THN L A E P AY E A DV A Q L E Y K L V A G E H GL IIR V K G F N H KLP L L FQL I IDY L TE F SST P AV F 802
Cdd:pfam16187 161 SPL AYS S PR N A VL TRLY V EL L KDS L N E Y AY D A EL A G L S Y S L S A T E R GL TLS V S G Y N D KLP V L LEK I LEK L RD F EID P DR F 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1352519 803 TM I T EQL KKT Y F N - I L IK P ETL A K D VR L LI LE YSR W SMID K YR A 845
Cdd:pfam16187 241 EI I K EQL LRS Y K N f A L EQ P YQQ A F D YL L YL LE ERS W TPEE K LE A 284
PRK15101
PRK15101 protease3; Provisional
98-1084
4.06e-105
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 353.90
E-value: 4.06e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 98 P E I I - KS PS DP K QY RY I K L Q NG LQA LL I SD lsnvegktgnatdeeeeeeeeeeegeeeeeeeedddddddedsgaeiqdd 176
Cdd:PRK15101 31 Q E T I r KS EK DP R QY QA I R L D NG MTV LL V SD -------------------------------------------------- 60
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 177 deegfddeeefdddehddddldneeneleeleer VE A R K kttekq S A AAL CVG VGS FA DPD DLP GLAH F LEHMV F MGS L K 256
Cdd:PRK15101 61 ---------------------------------- PQ A V K ------ S L AAL ALP VGS LE DPD AQQ GLAH Y LEHMV L MGS K K 100
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 257 YP DENGFDA FLKKHGGS D NAST DCE RT V F QFD V QRKYFKE A L DR W A QFFIH PL MIRDAI DRE VE AV DS E YQL AR PS D AN R 336
Cdd:PRK15101 101 YP QPDSLAE FLKKHGGS H NAST ASY RT A F YLE V ENDALPP A V DR L A DAIAE PL LDPKNA DRE RN AV NA E LTM AR SR D GM R 180
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 337 KEMLFGSLAR P G HP MGK F FW GN A ETL KHE P kkn NIDTHAR L RE F WM RYYSA HY M TL V VQ S KET L DT L E K WVTEI F SQI PN 416
Cdd:PRK15101 181 MAQVSAETIN P A HP GSR F SG GN L ETL SDK P --- GSKLQDA L VD F YQ RYYSA NL M KA V IY S NQP L PE L A K LAADT F GRV PN 257
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 417 NGLPK P N fsh L T D P FD T P A f N K -- LYRV VP IRKIHA L TITWALPPQQQHY R V K PLH YIS W L V G HEGK G SILSY L R K KCW A 494
Cdd:PRK15101 258 KNASV P E --- I T V P VV T D A - Q K gi IIHY VP AQPRKV L RVEFRIDNNSAKF R S K TDE YIS Y L I G NRSP G TLSDW L Q K QGL A 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 495 LALFG G n GETGFEQ NS ty S VF S IS IT LTD E G YEHFYE V AHTV F Q YL KM L QKL G PE K RV F E E IQKIE D NE F H Y QEQ T DPVE 574
Cdd:PRK15101 334 EGISA G - ADPMVDR NS -- G VF A IS VS LTD K G LAQRDQ V VAAI F S YL NL L REK G ID K SY F D E LAHVL D LD F R Y PSI T RDMD 410
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 575 Y V E NMCEN M QLY P RQDF L TGDQLLFE Y K P EV I AEA L NQLV PQ K A NLVLL S ga NEGRCDLKEKWFGTQ Y SIED I ENSWTEL 654
Cdd:PRK15101 411 Y I E WLADT M LRV P VEHT L DAPYIADR Y D P KA I KAR L AEMT PQ N A RIWYI S -- PQEPHNKTAYFVDAP Y QVDK I SEQTFAD 488
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 655 W K s NFDL N SD L H LP AE N K YI AT DF T L KAF D c PETEY P AK IV NT P QGCLW Y KKDNK F - KI PKA Y I RFH L IS P LIQK SA A N V 733
Cdd:PRK15101 489 W Q - QKAQ N IA L S LP EL N P YI PD DF S L IKA D - KAYKH P EL IV DE P GLRVV Y MPSQY F a DE PKA D I SLV L RN P KAMD SA R N Q 566
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 734 VLF --- D IFVNI lth N L AEPAYE A D V AQLEYKLV A GE h GL IIRVK G FNHK LP L L F Q LIIDYLTE F SS T PAVF tmit E Q L K 810
Cdd:PRK15101 567 VLF aln D YLAGL --- A L DQLSNQ A S V GGISFSTN A NN - GL MVNAN G YTQR LP Q L L Q ALLEGYFS F TP T EEQL ---- A Q A K 638
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 811 KT Y FNI L IKP E T l A K DVRLL I LEYSRW S MI ----- D KY R A L MDGLS L ESL L NFVKDFK S QLFV E G LV Q GN V T STESMDFL 885
Cdd:PRK15101 639 SW Y REQ L DSA E K - G K AYEQA I MPAQML S QV pyfer D ER R K L LPSIT L KDV L AYRDALL S GATP E F LV V GN L T EEQVTTLA 717
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 886 R Y V VDK L N ---------- F V PLEREMP V Q F Q vvelpsghhlckv R A LNKG D - A NSE V T V --- Y -- YQS GTR S lreytlme 949
Cdd:PRK15101 718 R D V QKQ L G adgtewwrgk D V VVDKKQS V N F E ------------- K A GSST D s A LAA V Y V ptg Y de YQS SAY S -------- 776
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 950 L L VMHMEE P C F - DF LRT KQT LGY H V YPT cr NT S ----- G I l GF SVTVGTQATK Y nset VDKKIEE F LSSF E E K IENLTED 1023
Cdd:PRK15101 777 S L LGQIIQ P W F y NQ LRT EEQ LGY A V FAF -- PM S vgrqw G M - GF LLQSNDKQPA Y ---- LWQRYQA F FPQA E A K LRAMKPE 849
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352519 1024 A F NTQVT ALI - K L KECED T h LGEE VD R NWNEVVTQQYL FD RLAHE I EAL K SFSKSD L VSW F K 1084
Cdd:PRK15101 850 E F AQYQQ ALI n Q L LQAPQ T - LGEE AS R LSKDFDRGNMR FD SRDKI I AQI K LLTPQK L ADF F H 910
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
220-404
1.19e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 136.15
E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 220 K QS AA A L C V GV GS FAD P DDL PGLAHFLEH MV F M G SLKYPDENGFDAFLKKH GG SD NA S T DCER T V F Q F DVQRKYFKEA L D 299
Cdd:TIGR02110 20 K RA AA L L R V AA GS HDE P SAW PGLAHFLEH LL F L G GERFQGDDRLMPWVQRQ GG QV NA T T LERT T A F F F ELPAAALAAG L A 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 300 R WAQFFIH PL MIRDAID RE V E AVDS EY QLARPSDANRK E MLFGSLARP GHP MGK F FW G NAET L khep KKN N IDTHAR LR E 379
Cdd:TIGR02110 100 R LCDMLAR PL LTAEDQQ RE R E VLEA EY IAWQNDADTLR E AALLDALQA GHP LRR F HA G SRDS L ---- ALP N TAFQQA LR D 175
170 180
....*....|....*....|....*
gi 1352519 380 F WM R Y Y S A HY M T L VV Q SKET LD T LE 404
Cdd:TIGR02110 176 F HR R H Y Q A GN M Q L WL Q GPQS LD E LE 200
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
99-1116
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 702.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 99 E IIKSP S DP K QYR Y I K L Q NGL QA LL I SD lsnvegktgnatdeeeeeeeeeeegeeeeeeeedddddddedsgaeiqddde 178
Cdd:COG1025 34 T IIKSP N DP R QYR A I T L D NGL KV LL V SD ---------------------------------------------------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 179 egfddeeefdddehddddldneeneleeleerveark KTTE K q SAAAL C V G VGSF A DPDD LP GLAHFLEHM V F M G SL KYP 258
Cdd:COG1025 62 ------------------------------------- PQAD K - SAAAL A V P VGSF D DPDD QQ GLAHFLEHM L F L G TK KYP 103
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 259 DENGFDA F LK KHGGS D NAST DC ERT VFQ F D V QRKYFK EALDR W A Q FF IH PL MIRDAI DRE VE AV DS EY Q L A R PS D AN R KE 338
Cdd:COG1025 104 EPGEYQE F IS KHGGS H NAST AT ERT NYY F E V ENDALE EALDR F A D FF AA PL FDPEYV DRE RN AV NA EY T L K R SD D GR R IY 183
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 339 MLFGSLAR P G HP MGK F FW GN A ETL K hep K K NNIDTHAR L RE F WM RYYSA HY M T LV VQ S KET LD T LEK WVTEI F SQ IPN NG 418
Cdd:COG1025 184 QVHKETLN P A HP FSR F SV GN L ETL S --- D K PGSKLRDE L LA F YQ RYYSA NL M K LV LY S NQS LD E LEK LARQT F GA IPN RN 260
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 419 L PK P nfshltd P FDT P AF ----- NKLYRV VP IRKIHA L TITWAL P PQ Q QH YR V KPL H YIS W L V G H EG K GS I L SY L R K KCW 493
Cdd:COG1025 261 L SV P ------- P ITV P LY tpeql GIIIHI VP LKPRRQ L RLEFPI P NN Q AY YR S KPL T YIS Y L L G N EG E GS L L DW L K K QGL 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 494 A LA L FG G N G ET G feqn STYSV FSIS IT LTD E G YE H FY E VAHT VF Q Y LKMLQKL G PEKRV F E E IQKIEDNE F HY QE Q T D P V 573
Cdd:COG1025 334 A ES L SA G G G IS G ---- RNFGD FSIS VS LTD K G LA H RD E IIAA VF A Y IELIRQQ G IQEWY F D E QAQLLELA F RF QE K T R P M 409
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 574 E YV ENMCE NM QL YP RQ D F L TG D Q L LFEYK P EV I AEA L N QL V P QK A NLV L L S GANEG rc D LKEK W FG T Q YS IED I ENSWTE 653
Cdd:COG1025 410 D YV SWLSD NM LR YP VE D V L DA D Y L MDGFD P AA I RAR L A QL T P EN A RIW L I S PDVPT -- D KTAY W YD T P YS VDP I TQEQLA 487
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 654 L W K s NFDL N SD L H LP AE N K YI AT DF T L KAF D c P E TEY P AKI V NT P QGC LWY KK D NK F KI PKA Y I RFH L IS P LIQK SA A N V 733
Cdd:COG1025 488 K W Q - QASQ N PA L S LP EL N P YI PD DF S L IKL D - K E SAK P ELL V DE P GLR LWY MP D QY F AE PKA D I YLS L RN P QAVD SA R N Q 565
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 734 VL FDIFVNI L THN L A E PA Y E A D VA Q L E Y K L V A GEH GL IIRVK GF NH K L P L L FQLII D Y L TE F SS T PAV F TMITE QL KKTY 813
Cdd:COG1025 566 VL TRLLDYL L NDA L N E LS Y Q A S VA G L S Y S L Y A HQG GL TLSAS GF TQ K Q P K L LEALL D Q L AS F EP T EER F AQAKS QL LRQL 645
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 814 F N ilikp ETL AK DVRL L ILEY SR WSMIDKY ----- R A LMDGLS L ES L LN F VKDFKS QL FV E G LV Q GN VTSTESMDFLRYV 888
Cdd:COG1025 646 D N ----- AEK AK PYSQ L FSPL SR LLQPPYF ereel L A ALESIT L QD L RA F REQLLQ QL HL E M LV V GN LSEEQAKQLADSL 720
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 889 VDK L N f VPLER E M P VQ f QVV E L PSGHH L CKVR A LNKG D an S EVTV YYQSG TR SL REYT L ME LL VMHMEEPC F DF LRT KQT 968
Cdd:COG1025 721 KKQ L A - PNGTG E E P RR - QVV D L DKSGS L NLEK A CDHT D -- S ALLI YYQSG YD SL ASMA L SS LL GQIISPWF F NQ LRT EEQ 796
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 969 LGY H V --- Y PTCRNTS G I l GF S V tvgt Q ATKYNSETVDKK I EE FL SS FEE KIEN L T E DA F NTQVTA LI K - L K E c E D TH L G 1044
Cdd:COG1025 797 LGY V V gag Y MPLGRQP G L - GF Y V ---- Q SPVASPAYLLER I DD FL KQ FEE RLLA L S E EE F AQYKQG LI N q L L E - P D QN L S 870
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1352519 1045 EE VD R N W NEVVTQQYL FD RLAHE I E A L K SFSKS DL VSW F KAHRGP -- G SKM LS VHVVGYGKYEL E ED G APVCE D 1116
Cdd:COG1025 871 EE AQ R L W VDIGNGDFE FD TREKL I A A V K KLTRA DL IDF F QQAVIA pq G LRL LS QSQGTKHSKAD E LK G WKTIT D 944
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
564-845
3.25e-121
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 374.98
E-value: 3.25e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 564 F HY QE QTD P VE YV ENMCE NMQ L YP RQ D F L T GD Q LL F EY K PE V I A E A L NQ L V P QK A NLV L L S GAN EG RC D L KE K W F GT Q YS 643
Cdd:pfam16187 1 F RF QE KSP P SD YV SSLAS NMQ P YP PE D I L S GD Y LL R EY D PE L I Q E L L DY L T P EN A RIT L V S KEF EG ET D Q KE P W Y GT E YS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 644 I E D I ENSWTEL WK SNFDL N SD LHLP AE N KY I A TDF T LK AFDCP E - TE YP AK I VN TP QGC LWYKKD NK F KI PKA Y I RFH L I 722
Cdd:pfam16187 81 V E P I PEELLKK WK NAPEP N PE LHLP EP N PF I P TDF D LK KKEVK E p AK YP VL I RD TP LSR LWYKKD DT F WV PKA N I YLS L R 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 723 SPL IQK S AA N V VL FDIF V NI L THN L A E P AY E A DV A Q L E Y K L V A G E H GL IIR V K G F N H KLP L L FQL I IDY L TE F SST P AV F 802
Cdd:pfam16187 161 SPL AYS S PR N A VL TRLY V EL L KDS L N E Y AY D A EL A G L S Y S L S A T E R GL TLS V S G Y N D KLP V L LEK I LEK L RD F EID P DR F 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1352519 803 TM I T EQL KKT Y F N - I L IK P ETL A K D VR L LI LE YSR W SMID K YR A 845
Cdd:pfam16187 241 EI I K EQL LRS Y K N f A L EQ P YQQ A F D YL L YL LE ERS W TPEE K LE A 284
PRK15101
PRK15101 protease3; Provisional
98-1084
4.06e-105
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 353.90
E-value: 4.06e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 98 P E I I - KS PS DP K QY RY I K L Q NG LQA LL I SD lsnvegktgnatdeeeeeeeeeeegeeeeeeeedddddddedsgaeiqdd 176
Cdd:PRK15101 31 Q E T I r KS EK DP R QY QA I R L D NG MTV LL V SD -------------------------------------------------- 60
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 177 deegfddeeefdddehddddldneeneleeleer VE A R K kttekq S A AAL CVG VGS FA DPD DLP GLAH F LEHMV F MGS L K 256
Cdd:PRK15101 61 ---------------------------------- PQ A V K ------ S L AAL ALP VGS LE DPD AQQ GLAH Y LEHMV L MGS K K 100
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 257 YP DENGFDA FLKKHGGS D NAST DCE RT V F QFD V QRKYFKE A L DR W A QFFIH PL MIRDAI DRE VE AV DS E YQL AR PS D AN R 336
Cdd:PRK15101 101 YP QPDSLAE FLKKHGGS H NAST ASY RT A F YLE V ENDALPP A V DR L A DAIAE PL LDPKNA DRE RN AV NA E LTM AR SR D GM R 180
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 337 KEMLFGSLAR P G HP MGK F FW GN A ETL KHE P kkn NIDTHAR L RE F WM RYYSA HY M TL V VQ S KET L DT L E K WVTEI F SQI PN 416
Cdd:PRK15101 181 MAQVSAETIN P A HP GSR F SG GN L ETL SDK P --- GSKLQDA L VD F YQ RYYSA NL M KA V IY S NQP L PE L A K LAADT F GRV PN 257
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 417 NGLPK P N fsh L T D P FD T P A f N K -- LYRV VP IRKIHA L TITWALPPQQQHY R V K PLH YIS W L V G HEGK G SILSY L R K KCW A 494
Cdd:PRK15101 258 KNASV P E --- I T V P VV T D A - Q K gi IIHY VP AQPRKV L RVEFRIDNNSAKF R S K TDE YIS Y L I G NRSP G TLSDW L Q K QGL A 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 495 LALFG G n GETGFEQ NS ty S VF S IS IT LTD E G YEHFYE V AHTV F Q YL KM L QKL G PE K RV F E E IQKIE D NE F H Y QEQ T DPVE 574
Cdd:PRK15101 334 EGISA G - ADPMVDR NS -- G VF A IS VS LTD K G LAQRDQ V VAAI F S YL NL L REK G ID K SY F D E LAHVL D LD F R Y PSI T RDMD 410
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 575 Y V E NMCEN M QLY P RQDF L TGDQLLFE Y K P EV I AEA L NQLV PQ K A NLVLL S ga NEGRCDLKEKWFGTQ Y SIED I ENSWTEL 654
Cdd:PRK15101 411 Y I E WLADT M LRV P VEHT L DAPYIADR Y D P KA I KAR L AEMT PQ N A RIWYI S -- PQEPHNKTAYFVDAP Y QVDK I SEQTFAD 488
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 655 W K s NFDL N SD L H LP AE N K YI AT DF T L KAF D c PETEY P AK IV NT P QGCLW Y KKDNK F - KI PKA Y I RFH L IS P LIQK SA A N V 733
Cdd:PRK15101 489 W Q - QKAQ N IA L S LP EL N P YI PD DF S L IKA D - KAYKH P EL IV DE P GLRVV Y MPSQY F a DE PKA D I SLV L RN P KAMD SA R N Q 566
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 734 VLF --- D IFVNI lth N L AEPAYE A D V AQLEYKLV A GE h GL IIRVK G FNHK LP L L F Q LIIDYLTE F SS T PAVF tmit E Q L K 810
Cdd:PRK15101 567 VLF aln D YLAGL --- A L DQLSNQ A S V GGISFSTN A NN - GL MVNAN G YTQR LP Q L L Q ALLEGYFS F TP T EEQL ---- A Q A K 638
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 811 KT Y FNI L IKP E T l A K DVRLL I LEYSRW S MI ----- D KY R A L MDGLS L ESL L NFVKDFK S QLFV E G LV Q GN V T STESMDFL 885
Cdd:PRK15101 639 SW Y REQ L DSA E K - G K AYEQA I MPAQML S QV pyfer D ER R K L LPSIT L KDV L AYRDALL S GATP E F LV V GN L T EEQVTTLA 717
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 886 R Y V VDK L N ---------- F V PLEREMP V Q F Q vvelpsghhlckv R A LNKG D - A NSE V T V --- Y -- YQS GTR S lreytlme 949
Cdd:PRK15101 718 R D V QKQ L G adgtewwrgk D V VVDKKQS V N F E ------------- K A GSST D s A LAA V Y V ptg Y de YQS SAY S -------- 776
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 950 L L VMHMEE P C F - DF LRT KQT LGY H V YPT cr NT S ----- G I l GF SVTVGTQATK Y nset VDKKIEE F LSSF E E K IENLTED 1023
Cdd:PRK15101 777 S L LGQIIQ P W F y NQ LRT EEQ LGY A V FAF -- PM S vgrqw G M - GF LLQSNDKQPA Y ---- LWQRYQA F FPQA E A K LRAMKPE 849
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352519 1024 A F NTQVT ALI - K L KECED T h LGEE VD R NWNEVVTQQYL FD RLAHE I EAL K SFSKSD L VSW F K 1084
Cdd:PRK15101 850 E F AQYQQ ALI n Q L LQAPQ T - LGEE AS R LSKDFDRGNMR FD SRDKI I AQI K LLTPQK L ADF F H 910
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
210-348
1.19e-46
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 164.02
E-value: 1.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 210 RV EARKKTTEKQ S AAA L CVGV GS FAD PD DLP GLAHFLEHM V F M G SL KYP D e N GFDAF L K K H GGS D NA S T DC E R TV FQFD V 289
Cdd:pfam00675 1 RV ASESDPPADT S TVG L WIDA GS RYE PD NNN GLAHFLEHM A F K G TK KYP S - N ELEEE L E K L GGS L NA F T SR E N TV YYAE V 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 290 QRKYFKE A L DR W A Q FF IH PL MIRDA I D R ------- EVEAVDSE Y QL ---- ARPSD A N R KEM L FG SL AR PG 348
Cdd:pfam00675 80 LNDDLPK A V DR L A D FF RN PL FTESE I E R erlvvly EVEAVDSE P QL vvle NLHAA A Y R NTP L GR SL LG PG 149
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
220-404
1.19e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 136.15
E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 220 K QS AA A L C V GV GS FAD P DDL PGLAHFLEH MV F M G SLKYPDENGFDAFLKKH GG SD NA S T DCER T V F Q F DVQRKYFKEA L D 299
Cdd:TIGR02110 20 K RA AA L L R V AA GS HDE P SAW PGLAHFLEH LL F L G GERFQGDDRLMPWVQRQ GG QV NA T T LERT T A F F F ELPAAALAAG L A 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 300 R WAQFFIH PL MIRDAID RE V E AVDS EY QLARPSDANRK E MLFGSLARP GHP MGK F FW G NAET L khep KKN N IDTHAR LR E 379
Cdd:TIGR02110 100 R LCDMLAR PL LTAEDQQ RE R E VLEA EY IAWQNDADTLR E AALLDALQA GHP LRR F HA G SRDS L ---- ALP N TAFQQA LR D 175
170 180
....*....|....*....|....*
gi 1352519 380 F WM R Y Y S A HY M T L VV Q SKET LD T LE 404
Cdd:TIGR02110 176 F HR R H Y Q A GN M Q L WL Q GPQS LD E LE 200
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
223-559
1.24e-29
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 123.11
E-value: 1.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 223 AAA L C V G VGS FAD P DDLP GLAHFLEHM V F M G SL K YP d ENGFDAF L KKH GGS D NA S T DCER TV FQFD V QRKYFKE AL DRW A 302
Cdd:COG0612 38 SVR L W V R VGS RDE P PGKT GLAHFLEHM L F K G TK K RS - AGEIAEE L EAL GGS L NA F T SFDY TV YYLS V LSEDLEL AL ELL A 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 303 QFFIH P LMIRDAID RE VEA V DS E YQ -- LAR P SDANRKEM L fg SLARPG HP M G KFFW G NA E TLK hepkkn N I d T HAR LR E F 380
Cdd:COG0612 117 DRLLN P TFDEEELE RE RGV V LE E IR ry EDD P DGLAFEAL L -- AALYGD HP Y G RPII G TE E SIE ------ A I - T RED LR A F 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 381 WM RYY SAHYMT LVV QSKETLDTLEKW V TEI F SQI P NNGL P KP nfshl T DP FDT P AFNKLYR VV PIRKIHALT I TWAL P - P 459
Cdd:COG0612 188 YK RYY RPNNAV LVV VGDVDPEEVLAL V EKY F GDL P AGPA P PR ----- P DP AEP P QTGPRRV VV DDPDAEQAH I LLGY P g P 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 460 QQQHYRVKP L HYISWLV G H e G KG S I L SY - LR - KK CW A LALFG gnget G F EQNSTYSV F S I SITLTDEGY E hfy E VAHTVF 537
Cdd:COG0612 263 ARDDPDYYA L DVLNEIL G G - G FS S R L FQ e LR e KK GL A YSVGS ----- S F SPYRDAGL F T I YAGTAPDKL E --- E ALAAIL 333
330 340
....*....|....*....|..
gi 1352519 538 QY L KM L Q K L G PEK rvf EE IQKI 559
Cdd:COG0612 334 EE L ER L A K E G VTE --- EE LERA 352
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
373-559
3.40e-28
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 112.49
E-value: 3.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 373 T HAR LR E F WMRY YS AHY M T LV VQSKETLDT L EKWVTEI F SQI P NNGLP KP nfsh LTD P FDTPAFNKLYR VVP IR -- KIHA 450
Cdd:pfam05193 3 T RED LR D F YKKH YS PDN M V LV IVGDVDHEE L LDLAEKY F GDL P ASPKG KP ---- RPP P LEPAKLKGREV VVP KK de PQAH 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 451 L TITWAL PP QQQHYRVKP L HYISW L V G HEGKGSILSY LR - K KCW A LALFGG N getgf EQN S TYSV F S I SI T LTD egy E HF 529
Cdd:pfam05193 79 L ALAFPG PP LNNDEDSLA L DVLNE L L G GGMSSRLFQE LR e K EGL A YSVSSF N ----- DSY S DSGL F G I YA T VDP --- E NV 150
170 180 190
....*....|....*....|....*....|
gi 1352519 530 Y EV AHTVFQY L KM L QKL G PEKRVF E EIQKI 559
Cdd:pfam05193 151 D EV IELILEE L EK L AQE G VTEEEL E RAKNQ 180
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
850-1032
9.24e-13
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 67.80
E-value: 9.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 850 L SL E S L LN F V K DFK S QLFVEGLVQ G N V TST E SM D FLRYVVDK L NFV P lerem PVQFQVVE L PSGHHLCKVRALN K G D AN - 928
Cdd:pfam05193 2 L TR E D L RD F Y K KHY S PDNMVLVIV G D V DHE E LL D LAEKYFGD L PAS P ----- KGKPRPPP L EPAKLKGREVVVP K K D EP q 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352519 929 SEVTVYYQS - GTRSLREYTLMEL L VMHMEE ---- PC F DF LR T K QT L G Y H V YPTCRNT S -- G IL G FSV TV gtqatky NS E T 1001
Cdd:pfam05193 77 AHLALAFPG p PLNNDEDSLALDV L NELLGG gmss RL F QE LR E K EG L A Y S V SSFNDSY S ds G LF G IYA TV ------- DP E N 149
170 180 190
....*....|....*....|....*....|..
gi 1352519 1002 VD KK IE EF L SSF E EKIEN - L TE DAFNTQVTA L 1032
Cdd:pfam05193 150 VD EV IE LI L EEL E KLAQE g V TE EELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
