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Conserved domains on  [gi|1476413346|sp|Q08431|]
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RecName: Full=Lactadherin; AltName: Full=Breast epithelial antigen BA46; AltName: Full=HMFG; AltName: Full=MFGM; AltName: Full=Milk fat globule-EGF factor 8; Short=MFG-E8; AltName: Full=SED1; Contains: RecName: Full=Lactadherin short form; Contains: RecName: Full=Medin; Flags: Precursor

Protein Classification

calcium-binding EGF-like domain-containing protein; discoidin domain-containing receptor( domain architecture ID 10041971)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| discoidin domain-containing receptor (DDR) is a tyrosine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 232-386 9.98e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 172.15  E-value: 9.98e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346 232 NPLGLkNNSIPDKQITASSSYKTwglhlfSWNPSYARLDKQgnfNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFG 311
Cdd:cd00057     1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1476413346 312 SVQFVASYKVAYSNDSANWTEYQDPrtGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLG 386
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKDK--GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 72-224 4.77e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 4.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  72 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 151
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1476413346 152 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 224
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-67 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 2.54e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1476413346  28 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 67
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 232-386 9.98e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 172.15  E-value: 9.98e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346 232 NPLGLkNNSIPDKQITASSSYKTwglhlfSWNPSYARLDKQgnfNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFG 311
Cdd:cd00057     1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1476413346 312 SVQFVASYKVAYSNDSANWTEYQDPrtGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLG 386
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKDK--GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 72-224 4.77e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 4.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  72 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 151
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1476413346 152 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 224
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 245-384 3.58e-37

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 131.03  E-value: 3.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346 245 QITASSSYktwglhlFSWNPSYARLDkqGNFN-AWVAGSYGNDQWLQVDLGSSKEVTGIITQGaRNFGSVQFVASYKVAY 323
Cdd:pfam00754   1 QITASSSY-------SGEGPAAAALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQG-RQDGSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1476413346 324 SNDSANWTEYQDPRTgsskifPGNWDNHSHKKNLFETPILARYVRILPVAWH--NRIALRLEL 384
Cdd:pfam00754  71 SLDGENWTTVKDEKI------PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 229-387 4.24e-37

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 131.09  E-value: 4.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  229 GCANPLGLKNNSipdkQITASSSYktwglhlfsWNPSYARLDKQGNfNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGAR 308
Cdd:smart00231   1 PCNEPLGLESDS----QITASSSY---------WAAKIARLNGGSD-GGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1476413346  309 NFGSVQfvaSYKVAYSNDSANWTEYQDprtGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 387
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 69-225 7.45e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 125.31  E-value: 7.45e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346   69 KCVEPLGLENgniaNSQIAASSvrvtflglQHWVPELARLNRaGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQgasR 148
Cdd:smart00231   1 PCNEPLGLES----DSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITG---R 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1476413346  149 LASHEYLKAFKVAYSLNGHEFDFIHDVNkkHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGC 225
Cdd:smart00231  65 RHGNGDWVTYKLEYSDDGVNWTTYKDGN--SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 85-222 1.49e-26

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 102.91  E-value: 1.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  85 QIAASSVRvtflgLQHWVPElARLNraGMVN-AWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRlASHEYLKAFKVAYS 163
Cdd:pfam00754   1 QITASSSY-----SGEGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1476413346 164 LNGHEFDFIHDVnkkhkEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT--ACTLRFEL 222
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-67 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 2.54e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1476413346  28 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 67
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 27-65 2.94e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 2.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1476413346  27 CSKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNH 65
Cdd:pfam00008   1 CAPNPCSNGGTCV--------DTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 232-386 9.98e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 172.15  E-value: 9.98e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346 232 NPLGLkNNSIPDKQITASSSYKTwglhlfSWNPSYARLDKQgnfNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFG 311
Cdd:cd00057     1 EPLGM-ESGLADDQITASSSYSS------GWEASRARLNSD---NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1476413346 312 SVQFVASYKVAYSNDSANWTEYQDPrtGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLG 386
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKDK--GEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 72-224 4.77e-48

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 159.83  E-value: 4.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  72 EPLGLENGnIANSQIAASSVRVTFlglqhWVPELARLNRagmVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLAS 151
Cdd:cd00057     1 EPLGMESG-LADDQITASSSYSSG-----WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1476413346 152 HEYLKAFKVAYSLNGHEFDFIHDvNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLG 224
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKD-KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 245-384 3.58e-37

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 131.03  E-value: 3.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346 245 QITASSSYktwglhlFSWNPSYARLDkqGNFN-AWVAGSYGNDQWLQVDLGSSKEVTGIITQGaRNFGSVQFVASYKVAY 323
Cdd:pfam00754   1 QITASSSY-------SGEGPAAAALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQG-RQDGSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1476413346 324 SNDSANWTEYQDPRTgsskifPGNWDNHSHKKNLFETPILARYVRILPVAWH--NRIALRLEL 384
Cdd:pfam00754  71 SLDGENWTTVKDEKI------PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 229-387 4.24e-37

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 131.09  E-value: 4.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  229 GCANPLGLKNNSipdkQITASSSYktwglhlfsWNPSYARLDKQGNfNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGAR 308
Cdd:smart00231   1 PCNEPLGLESDS----QITASSSY---------WAAKIARLNGGSD-GGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1476413346  309 NFGSVQfvaSYKVAYSNDSANWTEYQDprtGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 387
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 69-225 7.45e-35

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 125.31  E-value: 7.45e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346   69 KCVEPLGLENgniaNSQIAASSvrvtflglQHWVPELARLNRaGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQgasR 148
Cdd:smart00231   1 PCNEPLGLES----DSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITG---R 64

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1476413346  149 LASHEYLKAFKVAYSLNGHEFDFIHDVNkkHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGC 225
Cdd:smart00231  65 RHGNGDWVTYKLEYSDDGVNWTTYKDGN--SKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 85-222 1.49e-26

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 102.91  E-value: 1.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476413346  85 QIAASSVRvtflgLQHWVPElARLNraGMVN-AWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRlASHEYLKAFKVAYS 163
Cdd:pfam00754   1 QITASSSY-----SGEGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYS 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1476413346 164 LNGHEFDFIHDVnkkhkEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT--ACTLRFEL 222
Cdd:pfam00754  72 LDGENWTTVKDE-----KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGgnGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 28-67 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 2.54e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1476413346  28 SKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNHCE 67
Cdd:cd00054     7 SGNPCQNGGTCV--------NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 27-65 2.94e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 2.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1476413346  27 CSKNPCHNGGLCEeisqevrgDVFPSYTCTCLKGYAGNH 65
Cdd:pfam00008   1 CAPNPCSNGGTCV--------DTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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