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Conserved domains on  [gi|123789017|sp|Q3ZAV8|]
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RecName: Full=Enhancer of mRNA-decapping protein 4

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 super family cl25640
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 3.02e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam16529:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.42  E-value: 3.02e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   192 LACLDEAGDLFVWRLALVKGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 123789017   430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 3.02e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.42  E-value: 3.02e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   192 LACLDEAGDLFVWRLALVKGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 123789017   430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 5.35e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  260 HEDraEVWDLDMLRSSH--ST---------WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyi 328
Cdd:cd00200    92 HTS--YVSSVAFSPDGRilSSssrdktikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpevpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200   165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                  .
gi 123789017  409 S 409
Cdd:cd00200   230 D 230
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 3.99e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  159 VRVISVSTSERTL-LKGFTGSVADLAFAHlNSPQLACLDEAGDLFVWRLAlvkgkiqeeilvhiRQPEGTPLNHFRRIIW 237
Cdd:COG2319   186 VRLWDLATGKLLRtLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TGKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  238 CP-FIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319   251 SVaFSPDGR---------LLASGSADGtVRLWDLATGELLR---------------TLTGHSGGVNSVAFSPDGKLLASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  316 SHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLITGADQNReLKMWCTVSWTCLQTIR 395
Cdd:COG2319   307 SDDGTVRLWDL-----ATGKLLRTLTGHTGAVRSVAFSPDG-----------KTLASGSDDGT-VRLWDLATGELLRTLT 369

                         250
                  ....*....|....
gi 123789017  396 ----------FSPD 399
Cdd:COG2319   370 ghtgavtsvaFSPD 383
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 6.04e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 6.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 123789017    292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-440 3.02e-180

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 537.42  E-value: 3.02e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   192 LACLDEAGDLFVWRLALVKGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGFVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017   350 CLLFCDNHKKQdPEVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|.
gi 123789017   430 VLYVMELLQNQ 440
Cdd:pfam16529  317 VLYVLQLGQDG 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 5.35e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  260 HEDraEVWDLDMLRSSH--ST---------WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyi 328
Cdd:cd00200    92 HTS--YVSSVAFSPDGRilSSssrdktikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpevpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200   165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                  .
gi 123789017  409 S 409
Cdd:cd00200   230 D 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 294-409 1.93e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  294 KGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNHkkqdpevpfwrfLITG 373
Cdd:cd00200    48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGECVRTLTGHTSYVSSVAFSPDGR------------ILSS 110

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 123789017  374 ADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPS 409
Cdd:cd00200   111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 3.99e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  159 VRVISVSTSERTL-LKGFTGSVADLAFAHlNSPQLACLDEAGDLFVWRLAlvkgkiqeeilvhiRQPEGTPLNHFRRIIW 237
Cdd:COG2319   186 VRLWDLATGKLLRtLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TGKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  238 CP-FIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319   251 SVaFSPDGR---------LLASGSADGtVRLWDLATGELLR---------------TLTGHSGGVNSVAFSPDGKLLASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  316 SHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLITGADQNReLKMWCTVSWTCLQTIR 395
Cdd:COG2319   307 SDDGTVRLWDL-----ATGKLLRTLTGHTGAVRSVAFSPDG-----------KTLASGSDDGT-VRLWDLATGELLRTLT 369

                         250
                  ....*....|....
gi 123789017  396 ----------FSPD 399
Cdd:COG2319   370 ghtgavtsvaFSPD 383
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-399 7.70e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 7.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  172 LKGFTGSVADLAFaHLNSPQLACLDEAGDLFVWRLALVKGKIQEEilVHIRQPegtplnhfRRIIWCPFipeesedccee 251
Cdd:cd00200     5 LKGHTGGVTCVAF-SPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPV--------RDVAASAD----------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  252 sSPTVALLHEDRA-EVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyieg 330
Cdd:cd00200    63 -GTYLASGSSDKTiRLWDLETGECVR---------------TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---- 122

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123789017  331 qDEPRCLHEWKPHDGrPLSCLLFCDNHKkqdpevpfwrfLITGADQNRELKMWCTVSWTCLQT----------IRFSPD 399
Cdd:cd00200   123 -ETGKCLTTLRGHTD-WVNSVAFSPDGT-----------FVASSSQDGTIKLWDLRTGKCVATltghtgevnsVAFSPD 188
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-405 9.05e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 9.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  159 VRVISVSTSE-RTLLKGFTGSVADLAFaHLNSPQLACLDEAGDLFVWRLAlvKGKIQEEIlvhirqpEGtplnHFRRIIW 237
Cdd:cd00200    33 IKVWDLETGElLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLE--TGECVRTL-------TG----HTSYVSS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  238 CPFIPEEsedcceessPTVALLHEDR-AEVWDLD-----MLRSSHSTWPVDVSQIKQGFIVV------------------ 293
Cdd:cd00200    99 VAFSPDG---------RILSSSSRDKtIKVWDVEtgkclTTLRGHTDWVNSVAFSPDGTFVAsssqdgtiklwdlrtgkc 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  294 ----KGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGrPLSCLLFCDNhkkqdpevpfwRF 369
Cdd:cd00200   170 vatlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-----STGKCLGTLRGHEN-GVNSVAFSPD-----------GY 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 123789017  370 LITGADQNRELKMWCTVSWTCLQTIR----------FSPDIFSSVS 405
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSghtnsvtslaWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
304-399 1.21e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  304 ALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCLLFCDNhkkqdpevpfwRFLITGADQNReLKMW 383
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL-----ATGKLLRTLTGHSGAVTSVAFSPDG-----------KLLASGSDDGT-VRLW 189

                          90       100
                  ....*....|....*....|....*.
gi 123789017  384 CTVSWTCLQTIR----------FSPD 399
Cdd:COG2319   190 DLATGKLLRTLTghtgavrsvaFSPD 215
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 5.80e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  159 VRVISVSTSER-TLLKGFTGSVADLAFAHlNSPQLACLDEAGDLFVWRLAlvKGKIQEEILVHIRQ-------PEGTpln 230
Cdd:COG2319   102 VRLWDLATGLLlRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAvtsvafsPDGK--- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  231 hfrriiwcpfipeesedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDG 309
Cdd:COG2319   176 ------------------------LLASGSDDGtVRLWDLATGKLLR---------------TLTGHTGAVRSVAFSPDG 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  310 TVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLScLLFCDNHKkqdpevpfwrfLITGADQNRELKMWCTVSWT 389
Cdd:COG2319   217 KLLASGSADGTVRLWDL-----ATGKLLRTLTGHSGSVRS-VAFSPDGR-----------LLASGSADGTVRLWDLATGE 279

                         250       260
                  ....*....|....*....|
gi 123789017  390 CLQT----------IRFSPD 399
Cdd:COG2319   280 LLRTltghsggvnsVAFSPD 299
WD40 COG2319
WD40 repeat [General function prediction only];
158-349 9.75e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 9.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  158 MVRVISVST-SERTLLKGFTGSVADLAFAHlNSPQLACLDEAGDLFVWRLAlvkgkiqeeilvhIRQPEGTPLNHFRRII 236
Cdd:COG2319   227 TVRLWDLATgKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA-------------TGELLRTLTGHSGGVN 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  237 WCPFIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHStwpvdvsqikqgfivVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319   293 SVAFSPDGK---------LLASGSDDGtVRLWDLATGKLLRT---------------LTGHTGAVRSVAFSPDGKTLASG 348

                         170       180       190
                  ....*....|....*....|....*....|....
gi 123789017  316 SHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLS 349
Cdd:COG2319   349 SDDGTVRLWDL-----ATGELLRTLTGHTGAVTS 377
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 6.04e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 6.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 123789017    292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 158-325 7.12e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  158 MVRVISVST-SERTLLKGFTGSVADLAFaHLNSPQL--ACLDeaGDLFVWRLAlvKGKiqeeilvHIRQPEGtplnHFRR 234
Cdd:cd00200   158 TIKLWDLRTgKCVATLTGHTGEVNSVAF-SPDGEKLlsSSSD--GTIKLWDLS--TGK-------CLGTLRG----HENG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  235 IIWCPFIPEESedcceesspTVALLHEDRA-EVWDLDMLRSSHstwpvdvsqikqgfiVVKGHS---TCLsegALSPDGT 310
Cdd:cd00200   222 VNSVAFSPDGY---------LLASGSEDGTiRVWDLRTGECVQ---------------TLSGHTnsvTSL---AWSPDGK 274

                         170
                  ....*....|....*
gi 123789017  311 VLATASHDGFVKFWQ 325
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
151-326 8.78e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  151 AANNGSAMVRVISVSTSER-TLLKGFTGSVADLAFahlnSP---QLACLDEAGDLFVWRLALvkgkiqeeilvhiRQPEG 226
Cdd:COG2319   262 ASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAF----SPdgkLLASGSDDGTVRLWDLAT-------------GKLLR 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  227 TPLNHFRRIIWCPFIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGAL 305
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGK---------TLASGSDDGtVRLWDLATGELLR---------------TLTGHTGAVTSVAF 380

                         170       180
                  ....*....|....*....|.
gi 123789017  306 SPDGTVLATASHDGFVKFWQI 326
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
292-324 2.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 2.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 123789017   292 VVKGHS---TCLsegALSPDGTVLATASHDGFVKFW 324
Cdd:pfam00400    6 TLEGHTgsvTSL---AFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
272-399 4.18e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123789017  272 LRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGFVKFWQIyiegqDEPRCLHEWKPHDGRPLSCL 351
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-----ATGLLLRTLTGHTGAVRSVA 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 123789017  352 LFCDNhkkqdpevpfwRFLITGADqNRELKMWCTVSWTCLQTIR----------FSPD 399
Cdd:COG2319   128 FSPDG-----------KTLASGSA-DGTVRLWDLATGKLLRTLTghsgavtsvaFSPD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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