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Conserved domains on  [gi|122014459|sp|Q4CNL4|]
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RecName: Full=tRNA (guanine(37)-N1)-methyltransferase 1; AltName: Full=M1G-methyltransferase 1; AltName: Full=tRNA [GM37] methyltransferase 1; AltName: Full=tRNA methyltransferase 5 homolog 1

Protein Classification

tRNA (guanine(37)-N1)-methyltransferase( domain architecture ID 1012667)

tRNA (guanine(37)-N1)-methyltransferase catalyzes methyl transfer from S-adenosylmethionine (AdoMet) to the N(1) position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Met_10 super family cl37511
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
173-390 6.00e-47

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


The actual alignment was detected with superfamily member pfam02475:

Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 161.75  E-value: 6.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  173 GFEQVGHIAHVNLSAAHLPYRADIGAVILDCNPtVRVVVNKVDNIASVFREFKMEVIArrtthsdmkGSpaeensgDEEK 252
Cdd:pfam02475   2 SFDIIGDVVILNLREELDEYRKVIGEAILEKTK-VKTVLRKVSEVYGEFRTPRYEVLA---------GS-------DTET 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  253 LHRlllatvrQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGDMLYDAMAGVGPFAIPAAVAG--VKTYANDLNPVAAE 330
Cdd:pfam02475  65 IHK-------ENGCRFKVDVAKVYWSPRLIAERERIAKLVEPGEVVVDMFAGIGPFSIPIAKHSkaRRVYAIELNPESYK 137
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  331 YLRINAELNHINkDTFHVFNMDGREFlntvlyrdVVSGAAvcgrRHVTMNLPAMAVEFLD 390
Cdd:pfam02475 138 YLKENIKLNKVE-DVVKPILGDVREV--------ILEDVA----DRVVMNLPGSAHEFLD 184
 
Name Accession Description Interval E-value
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
173-390 6.00e-47

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 161.75  E-value: 6.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  173 GFEQVGHIAHVNLSAAHLPYRADIGAVILDCNPtVRVVVNKVDNIASVFREFKMEVIArrtthsdmkGSpaeensgDEEK 252
Cdd:pfam02475   2 SFDIIGDVVILNLREELDEYRKVIGEAILEKTK-VKTVLRKVSEVYGEFRTPRYEVLA---------GS-------DTET 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  253 LHRlllatvrQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGDMLYDAMAGVGPFAIPAAVAG--VKTYANDLNPVAAE 330
Cdd:pfam02475  65 IHK-------ENGCRFKVDVAKVYWSPRLIAERERIAKLVEPGEVVVDMFAGIGPFSIPIAKHSkaRRVYAIELNPESYK 137
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  331 YLRINAELNHINkDTFHVFNMDGREFlntvlyrdVVSGAAvcgrRHVTMNLPAMAVEFLD 390
Cdd:pfam02475 138 YLKENIKLNKVE-DVVKPILGDVREV--------ILEDVA----DRVVMNLPGSAHEFLD 184
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
158-484 3.04e-41

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 150.78  E-value: 3.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 158 ELLQRILPPGTIPL--SGFEQVGHIAHVNLSAAHLPYRADIGAVILDCNPTVRVVVNKVDNIASVFREFKMEVIArrtth 235
Cdd:COG2520   64 ELLEGGLPEELLELlpSSYDIIGDIAIIKIPDELEEYKEEIAEAILESHPNVKTVLAKASGVEGEFRVPELELLA----- 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 236 sdmkGSPAEEnsgdeeklhrlllaTV-RQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGDMLYDAMAGVGPFAIPAAV 314
Cdd:COG2520  139 ----GEGRTE--------------TIhRENGCRFKLDVAKVYFSPRLATERLRIAELVKPGERVLDMFAGVGPFSIPIAK 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 315 A-GVKTYANDLNPVAAEYLRINAELNHInKDTFHVFNMDGREFLNTVLYR-DvvsgaavcgrrHVTMNLPAMAVEFLDvf 392
Cdd:COG2520  201 RsGAKVVAIDINPDAVEYLKENIRLNKV-EDRVTPILGDAREVAPELEGKaD-----------RIIMNLPHSADEFLD-- 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 393 tkppwsqplVSLSLLEekekakegkekeehvemhpDKRVLfHVYCFSKNmDDFLGDAVKQVERwlAFSLAGENLE--AVH 470
Cdd:COG2520  267 ---------AALRALK-------------------PGGVI-HYYEIVPE-EDPFERAEERIEE--AAEEAGYEVEilEKR 314
                        330
                 ....*....|....
gi 122014459 471 MVRDVAPLKRMVCV 484
Cdd:COG2520  315 RVKSYSPGVYHVVV 328
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
300-366 1.34e-05

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 47.22  E-value: 1.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122014459 300 DAMAGVGPFAIPAAVAG--VKTYANDLNPVAAEYLRINAELNHINKDTfhVFNMDGreflNTVLYR----DVV 366
Cdd:PRK04338  63 DALSASGIRGIRYALETgvEKVTLNDINPDAVELIKKNLELNGLENEK--VFNKDA----NALLHEerkfDVV 129
 
Name Accession Description Interval E-value
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
173-390 6.00e-47

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 161.75  E-value: 6.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  173 GFEQVGHIAHVNLSAAHLPYRADIGAVILDCNPtVRVVVNKVDNIASVFREFKMEVIArrtthsdmkGSpaeensgDEEK 252
Cdd:pfam02475   2 SFDIIGDVVILNLREELDEYRKVIGEAILEKTK-VKTVLRKVSEVYGEFRTPRYEVLA---------GS-------DTET 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  253 LHRlllatvrQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGDMLYDAMAGVGPFAIPAAVAG--VKTYANDLNPVAAE 330
Cdd:pfam02475  65 IHK-------ENGCRFKVDVAKVYWSPRLIAERERIAKLVEPGEVVVDMFAGIGPFSIPIAKHSkaRRVYAIELNPESYK 137
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459  331 YLRINAELNHINkDTFHVFNMDGREFlntvlyrdVVSGAAvcgrRHVTMNLPAMAVEFLD 390
Cdd:pfam02475 138 YLKENIKLNKVE-DVVKPILGDVREV--------ILEDVA----DRVVMNLPGSAHEFLD 184
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
158-484 3.04e-41

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 150.78  E-value: 3.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 158 ELLQRILPPGTIPL--SGFEQVGHIAHVNLSAAHLPYRADIGAVILDCNPTVRVVVNKVDNIASVFREFKMEVIArrtth 235
Cdd:COG2520   64 ELLEGGLPEELLELlpSSYDIIGDIAIIKIPDELEEYKEEIAEAILESHPNVKTVLAKASGVEGEFRVPELELLA----- 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 236 sdmkGSPAEEnsgdeeklhrlllaTV-RQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGDMLYDAMAGVGPFAIPAAV 314
Cdd:COG2520  139 ----GEGRTE--------------TIhRENGCRFKLDVAKVYFSPRLATERLRIAELVKPGERVLDMFAGVGPFSIPIAK 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 315 A-GVKTYANDLNPVAAEYLRINAELNHInKDTFHVFNMDGREFLNTVLYR-DvvsgaavcgrrHVTMNLPAMAVEFLDvf 392
Cdd:COG2520  201 RsGAKVVAIDINPDAVEYLKENIRLNKV-EDRVTPILGDAREVAPELEGKaD-----------RIIMNLPHSADEFLD-- 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122014459 393 tkppwsqplVSLSLLEekekakegkekeehvemhpDKRVLfHVYCFSKNmDDFLGDAVKQVERwlAFSLAGENLE--AVH 470
Cdd:COG2520  267 ---------AALRALK-------------------PGGVI-HYYEIVPE-EDPFERAEERIEE--AAEEAGYEVEilEKR 314
                        330
                 ....*....|....
gi 122014459 471 MVRDVAPLKRMVCV 484
Cdd:COG2520  315 RVKSYSPGVYHVVV 328
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
300-366 2.41e-09

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 59.12  E-value: 2.41e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 122014459 300 DAMAGVGPFAIPAAV-AGVKTYANDLNPVAAEYLRINAELNhiNKDTFHVFNMDGREFLNTVLYR-DVV 366
Cdd:COG1867   63 DALAASGIRGLRYALeVGIKVTLNDIDPEAVELIRENLELN--GLEDVEVYNRDANALLHELGRRfDVV 129
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
286-356 3.82e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 47.25  E-value: 3.82e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 122014459 286 ARVV---GMMQSGDMLYDAMAGVGPFAIPAAVAGVKTYANDLNPVAAEYLRINaeLNHINKDTFHVFNMDGREF 356
Cdd:COG1041   15 ARALvnlAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGAREN--LEHYGYEDADVIRGDARDL 86
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
300-366 1.34e-05

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 47.22  E-value: 1.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122014459 300 DAMAGVGPFAIPAAVAG--VKTYANDLNPVAAEYLRINAELNHINKDTfhVFNMDGreflNTVLYR----DVV 366
Cdd:PRK04338  63 DALSASGIRGIRYALETgvEKVTLNDINPDAVELIKKNLELNGLENEK--VFNKDA----NALLHEerkfDVV 129
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
293-348 6.10e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 42.09  E-value: 6.10e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 122014459 293 QSGDMLYDAMAGVGPFAIPAAVAGVKTYANDLNPVAAEYLRINAELNHINKDTFHV 348
Cdd:COG2265  232 TGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVA 287
COG1743 COG1743
Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and ...
254-329 1.34e-03

Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and repair];


Pssm-ID: 441349 [Multi-domain]  Cd Length: 871  Bit Score: 41.47  E-value: 1.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 122014459 254 HRLLLATVRQHGCIFRVPYDRVYWNSRLSHEHARVVGMMQSGD-MLYDAMAGVGpfAIP--AAVAGVKTYANDLNPVAA 329
Cdd:COG1743   68 PEEFLTELGIGPERELVAWENSPNEEVLEEARAEIREAWGGELpTVLDPFAGGG--SIPleALRLGLEVVASDLNPVAV 144
PRK14968 PRK14968
putative methyltransferase; Provisional
303-352 3.40e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.73  E-value: 3.40e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 122014459 303 AGVGPFAIPAAVAGVKTYANDLNPVAAEYLRINAELNHINKDTFHVFNMD 352
Cdd:PRK14968  32 TGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSD 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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