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Conserved domains on  [gi|122047336|sp|Q4E657|]
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RecName: Full=ATP-dependent 6-phosphofructokinase; Short=ATP-PFK; Short=Phosphofructokinase; AltName: Full=Phosphohexokinase

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10015320)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
1-470 0e+00

6-phospho-1-fructokinase; Provisional


:

Pssm-ID: 185539  Cd Length: 459  Bit Score: 691.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   1 MENRLRDTSRVVRSHAAPLNEVTQEDLKVERLHGRKYMNpskKHVMREEFSDKIEHIMHDPRPQEGVHSElpvsiSPLLC 80
Cdd:PTZ00286   1 TCEIERVNNLIIDLPDAPLPSVVNPDLGECNLRGVFGGN---GFLPREAFVDTNSYILSTPRFGPDDVIV-----NTKRW 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  81 ELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGShtaMELYRTSVTSIH 160
Cdd:PTZ00286  73 LRAGPRKHLYFNPKEVKAGIVTCGGLCPGLNVVIRELVMNLINNYGVKTIYGAKYGYKGLYKEDW---IKLDPKDVKTIH 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 161 RYGGTILGSSRGPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFE 240
Cdd:PTZ00286 150 RLGGTILGSSRGGFDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQ 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 241 TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRSCVII 320
Cdd:PTZ00286 230 TAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASADVNVCLIPEFDIPLEGVLEYIEQRLQKKGHCVIV 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 321 VAEGFGQDWEGGT--GGHDASGNKKLTDIGVVLTKRIQAWLRKNKeryPNGTVKYIDPSYMIRACPPSANDALFCATLST 398
Cdd:PTZ00286 310 VAEGAGQSLKDADldLGTDASGNKKLWDIGVYLKDEITKYLKKKK---PEHTVKYIDPSYMIRAVPANAADAKFCTQLAQ 386
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122047336 399 LAMHEAMAGATNCIIALRYNSYILVPIKV-ATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEA 470
Cdd:PTZ00286 387 NAVHGAMAGFTGFIIGHVHNNYVMIPIKEmSGNYRRRVNPEGRLWQRMLAITGQPSFLNNEEIERHQRRQLES 459
 
Name Accession Description Interval E-value
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
1-470 0e+00

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 691.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   1 MENRLRDTSRVVRSHAAPLNEVTQEDLKVERLHGRKYMNpskKHVMREEFSDKIEHIMHDPRPQEGVHSElpvsiSPLLC 80
Cdd:PTZ00286   1 TCEIERVNNLIIDLPDAPLPSVVNPDLGECNLRGVFGGN---GFLPREAFVDTNSYILSTPRFGPDDVIV-----NTKRW 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  81 ELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGShtaMELYRTSVTSIH 160
Cdd:PTZ00286  73 LRAGPRKHLYFNPKEVKAGIVTCGGLCPGLNVVIRELVMNLINNYGVKTIYGAKYGYKGLYKEDW---IKLDPKDVKTIH 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 161 RYGGTILGSSRGPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFE 240
Cdd:PTZ00286 150 RLGGTILGSSRGGFDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQ 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 241 TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRSCVII 320
Cdd:PTZ00286 230 TAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASADVNVCLIPEFDIPLEGVLEYIEQRLQKKGHCVIV 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 321 VAEGFGQDWEGGT--GGHDASGNKKLTDIGVVLTKRIQAWLRKNKeryPNGTVKYIDPSYMIRACPPSANDALFCATLST 398
Cdd:PTZ00286 310 VAEGAGQSLKDADldLGTDASGNKKLWDIGVYLKDEITKYLKKKK---PEHTVKYIDPSYMIRAVPANAADAKFCTQLAQ 386
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122047336 399 LAMHEAMAGATNCIIALRYNSYILVPIKV-ATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEA 470
Cdd:PTZ00286 387 NAVHGAMAGFTGFIIGHVHNNYVMIPIKEmSGNYRRRVNPEGRLWQRMLAITGQPSFLNNEEIERHQRRQLES 459
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
98-450 6.06e-96

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 293.52  E-value: 6.06e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVNaYRVkRVIGFRFGYWGLSKKgshTAMELYRTSVTSIHRYGGTILGSSRGPQ--- 174
Cdd:COG0205    4 IGILTSGGDAPGLNAAIRAVVRTAIK-YGI-EVYGIRDGYEGLLEG---DIIDLTREDVSGILQRGGTILGSSRSKPfkt 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 175 --DTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKrrganLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:COG0205   79 eeGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-----IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 253 AYAEAISLNyGVGVVKLMGRDSGFIaaeaavasaqaNICLVPENPISEDIVMALIQRRFETSR-SCVIIVAEGFGQDWEG 331
Cdd:COG0205  154 LRDTAASHE-RVFVVEVMGRHAGWLalaag-laggaDLILIPEVPFDLDKLLEKLKERRKRGKgYSIIVVAEGAGDEDGE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 332 --GTGGHDASGNKKLTDIGVVLTKRIqawlrknkERYPNGTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGAT 409
Cdd:COG0205  232 avLEADTDAFGHVRLGGIGEYLAKEI--------EERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKT 303
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 122047336 410 NCIIALRYNSYILVPIKVATSVRRVLDLRGQLWRQVREITV 450
Cdd:COG0205  304 GVMVGIRRGEIVLVPLEEVANKEKPVDPDSPLIQLARELGI 344
PFK pfam00365
Phosphofructokinase;
98-402 3.20e-56

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 187.93  E-value: 3.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRvkRVIGFRFGYWGLSKKGshtAMELYRTSVTSIHRYGGTILGSSRG-PQDT 176
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGH--EVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSkPFKT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  177 SE----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAkrrgaNLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:pfam00365  77 EEgrekIAENLKKLGIDALVVIGGDGSLTGANKLSEER-----GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDR 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  253 AYAEAISLNyGVGVVKLMGRDSGFIaaeaavasaqaNICLVPENPISEDIVMALIQRRFETSRSCVIIVAEGfgqdwegg 332
Cdd:pfam00365 152 IRDTASSHN-RVFVVEVMGRHCGWLalmag-laggaDAILIPEIPFDIEELCEKIKELRKGKRFSIIVVAEG-------- 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  333 tgghdASGnkkltdiGVVLTKRIQAwlRKNKErypngtVKYIDPSYMIRACPPSANDALFCATLSTLAMH 402
Cdd:pfam00365 222 -----ASD-------GEFLAKLIEE--GTGIE------TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
98-429 2.16e-51

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 177.11  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRVKrVIGFRFGYWGLSKKGshTAMELYRTSVTSIHRYGGTILGSSRG-PQDT 176
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEYGWE-VIGIRDGWRGLLEGD--TVPLLDLEDVRGILPRGGTILGSSRTnPFKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  177 SEM-----VDTLERLGVNILFTVGGDGTqrgaLKIAEEAKRRGanLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVR 251
Cdd:TIGR02483  79 EEDgddkiVANLKELGLDALIAIGGDGT----LGIARRLADKG--LPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  252 AAYAEAISLNYgVGVVKLMGRDSGFIaAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRS-CVIIVAEGF---GQ 327
Cdd:TIGR02483 153 RLHTTAESHHR-VMVVEVMGRHAGWI-ALHSGIAGGADVILIPEIPFDIDSVCEKVRERFARGKRfAIVVVAEGAkpkGG 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  328 DWEGGTGGHDASGNKKLTDIGVVLTKRIQAwlRKNKERYPngTVKyidpSYMIRACPPSANDALFCATLSTLAMHEAMAG 407
Cdd:TIGR02483 231 EMVVQEGVKDAFGHVRLGGIGNWLAEEIER--RTGIETRA--TVL----GHLQRGGSPSAFDRVLATRFGVAAVDLVHEG 302
                         330       340
                  ....*....|....*....|..
gi 122047336  408 ATNCIIALRYNSYILVPIKVAT 429
Cdd:TIGR02483 303 QFGHMVALRGTDIVYVPIAEAV 324
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
98-443 3.46e-42

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 152.84  E-value: 3.46e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKkGSHtaMELYRTSVTSIHRYGGTILGSSRGPQDTS 177
Cdd:cd00363    3 IGVLTSGGDAPGMNAAIRGVVRSAI--AEGLEVYGIYEGYAGLVE-GDI--KELDWESVSDIINRGGTIIGSARCKEFRT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 178 E-----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:cd00363   78 EegrakAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 253 AYAEAISLNYgVGVVKLMGRDSGFIaAEAAVASAQANICLVPENP----ISEDIVMALIQRRFETSRSCVIIVAEGFGQD 328
Cdd:cd00363  158 IRDTASSHQR-TFVVEVMGRHCGDI-ALEAGLATGADIIFIPEEPaadeWEEEMVDVIKKRRERGKRHGIVIVAEGAIDF 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 329 WEGGTGGHdasgnkkltDIGVVLTKRIQAWLRknkerypnGTVKyidpSYMIRACPPSANDALFCATLSTLAMHEAMAGA 408
Cdd:cd00363  236 IPKPITEK---------LLAKLVEERLGFDTR--------ATVL----GHVQRGGTPTAFDRILASRLGAEAVELLLEGT 294
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 122047336 409 TN---CIIALRYNSYILVPIKVATSVRR--VLDLRGQLWR 443
Cdd:cd00363  295 GGtpvGIQNLNENQVVRHPLTEAVNMTKrvGVDLEGRPFK 334
 
Name Accession Description Interval E-value
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
1-470 0e+00

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 691.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   1 MENRLRDTSRVVRSHAAPLNEVTQEDLKVERLHGRKYMNpskKHVMREEFSDKIEHIMHDPRPQEGVHSElpvsiSPLLC 80
Cdd:PTZ00286   1 TCEIERVNNLIIDLPDAPLPSVVNPDLGECNLRGVFGGN---GFLPREAFVDTNSYILSTPRFGPDDVIV-----NTKRW 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  81 ELAAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGShtaMELYRTSVTSIH 160
Cdd:PTZ00286  73 LRAGPRKHLYFNPKEVKAGIVTCGGLCPGLNVVIRELVMNLINNYGVKTIYGAKYGYKGLYKEDW---IKLDPKDVKTIH 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 161 RYGGTILGSSRGPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFE 240
Cdd:PTZ00286 150 RLGGTILGSSRGGFDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQ 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 241 TAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRSCVII 320
Cdd:PTZ00286 230 TAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASADVNVCLIPEFDIPLEGVLEYIEQRLQKKGHCVIV 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 321 VAEGFGQDWEGGT--GGHDASGNKKLTDIGVVLTKRIQAWLRKNKeryPNGTVKYIDPSYMIRACPPSANDALFCATLST 398
Cdd:PTZ00286 310 VAEGAGQSLKDADldLGTDASGNKKLWDIGVYLKDEITKYLKKKK---PEHTVKYIDPSYMIRAVPANAADAKFCTQLAQ 386
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122047336 399 LAMHEAMAGATNCIIALRYNSYILVPIKV-ATSVRRVLDLRGQLWRQVREITVGLQDDVRAFKEAEVRRELEA 470
Cdd:PTZ00286 387 NAVHGAMAGFTGFIIGHVHNNYVMIPIKEmSGNYRRRVNPEGRLWQRMLAITGQPSFLNNEEIERHQRRQLES 459
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
22-449 3.04e-180

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 512.11  E-value: 3.04e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  22 VTQEDLKVERLHGRKYMNP---SKKHVMREEFSDKIEHIMHDPRPQEGVHSELPVSISPLLcELAAPRQRIHFNPPETVV 98
Cdd:PRK06830   5 VTELDFAIETLGECKIPSPliySLAAGDTTHFVSDSDRVLFDVSLSLIKEEDAPGTEPPSF-EKAGPREKIYFDPSKVKA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  99 GIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGSHTAMELYRTSVTSIHRYGGTILGSSRGPQDTSE 178
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIVLELHHHYGVRRILGIRYGYQGLIPRYGHDPVELTPEVVADIHEFGGTILGSSRGPQDPEE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 179 MVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRAAYAEAI 258
Cdd:PRK06830 164 IVDTLERMNINILFVIGGDGTLRGASAIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCAHVEAN 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 259 SLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPIS---EDIVMALIQRRFETSRSCVIIVAEGFGQDWEGGTGG 335
Cdd:PRK06830 244 GAPNGIGLVKLMGRHSGFIAAYAALASKDVNFVLIPEVPFDlegPNGLLAALEKRLAERGHAVIVVAEGAGQELFDDTGE 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 336 HDASGNKKLTDIGVVLTKRIQAWLRknKERYPNgTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGATNCIIAL 415
Cdd:PRK06830 324 TDASGNPKLGDIGLFLKDRIKEYFK--ARGIPI-NLKYIDPSYIIRSVPANANDSVYCGFLGQNAVHAAMAGKTGMVVGR 400
                        410       420       430
                 ....*....|....*....|....*....|....
gi 122047336 416 RYNSYILVPIKVATSVRRVLDLRGQLWRQVREIT 449
Cdd:PRK06830 401 WNNRFVHLPIDLAVSKRKKVNPEGDLWRSVLEST 434
PLN02884 PLN02884
6-phosphofructokinase
83-442 7.26e-115

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 344.49  E-value: 7.26e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  83 AAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLTaVNAYRVKRVIGFRFGYWGLSKKGSHTaMELYRTSVTSIHRY 162
Cdd:PLN02884  41 AGPRKKIYFEPEEVKAAIVTCGGLCPGLNDVIRQIVFT-LEIYGVKNIVGIPFGYRGFFEKGLSE-MPLSRKVVQNIHLS 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 163 GGTILGSSRGPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFETA 242
Cdd:PLN02884 119 GGSLLGVSRGGAKTSDIVDSIEARGINMLFVLGGNGTHAGANAIHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 243 VDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPIS---EDIVMALIQRRFETSRSCVI 319
Cdd:PLN02884 199 VEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGQVDICLIPEVPFTldgPNGVLRHLEHLIETKGSAVV 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 320 IVAEGFGQDWEGGTGGHDASGNKKLTDIGVVLTKRIQAWLrknKERYPNGTVKYIDPSYMIRACPPSANDALFCATLSTL 399
Cdd:PLN02884 279 CVAEGAGQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHF---KDIGVPADVKYIDPTYMIRACRANASDAILCTVLGQN 355
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 122047336 400 AMHEAMAGATNCIIALRYNSYILVPIKVATSVRRVLDLRGQLW 442
Cdd:PLN02884 356 AVHGAFAGFSGITVGICNTHYVYLPIPEVIAYPRRVDPNSRMW 398
PLN02564 PLN02564
6-phosphofructokinase
83-442 2.60e-108

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 330.17  E-value: 2.60e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  83 AAPRQRIHFNPPETVVGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGShtaMELYRTSVTSIHRY 162
Cdd:PLN02564  75 AGPRQKVYFESDEVRACIVTCGGLCPGLNTVIREIVCGLSYMYGVTRILGIDGGYRGFYSRNT---IPLTPKVVNDIHKR 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 163 GGTILGSSRGPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFETA 242
Cdd:PLN02564 152 GGTILGTSRGGHDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEIRRRGLKVAVAGIPKTIDNDIPVIDKSFGFDTA 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 243 VDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANICLVPENPI---SEDIVMALIQRRFETSRSCVI 319
Cdd:PLN02564 232 VEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASRDVDCCLIPESPFyleGKGGLFEFIEKRLKENGHMVI 311
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 320 IVAEGFGQDWEG----GTGGHDASGNKKLTDIGVVLTKRIQAWLRKNKERypNGTVKYIDPSYMIRACPPSANDALFCAT 395
Cdd:PLN02564 312 VVAEGAGQDLIAesmeSSDLQDASGNKLLLDVGLWLSQKIKDHFTKVKKM--PINLKYIDPTYMIRAIPSNASDNVYCTL 389
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 122047336 396 LSTLAMHEAMAGATNCIIALRYNSYILVPIKVATSVRRVLDLRGQLW 442
Cdd:PLN02564 390 LAHSAVHGAMAGYTGFTVGPVNGRHAYIPFYRITEKQNKVVITDRMW 436
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
98-450 6.06e-96

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 293.52  E-value: 6.06e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVNaYRVkRVIGFRFGYWGLSKKgshTAMELYRTSVTSIHRYGGTILGSSRGPQ--- 174
Cdd:COG0205    4 IGILTSGGDAPGLNAAIRAVVRTAIK-YGI-EVYGIRDGYEGLLEG---DIIDLTREDVSGILQRGGTILGSSRSKPfkt 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 175 --DTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKrrganLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:COG0205   79 eeGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-----IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 253 AYAEAISLNyGVGVVKLMGRDSGFIaaeaavasaqaNICLVPENPISEDIVMALIQRRFETSR-SCVIIVAEGFGQDWEG 331
Cdd:COG0205  154 LRDTAASHE-RVFVVEVMGRHAGWLalaag-laggaDLILIPEVPFDLDKLLEKLKERRKRGKgYSIIVVAEGAGDEDGE 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 332 --GTGGHDASGNKKLTDIGVVLTKRIqawlrknkERYPNGTVKYIDPSYMIRACPPSANDALFCATLSTLAMHEAMAGAT 409
Cdd:COG0205  232 avLEADTDAFGHVRLGGIGEYLAKEI--------EERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKT 303
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 122047336 410 NCIIALRYNSYILVPIKVATSVRRVLDLRGQLWRQVREITV 450
Cdd:COG0205  304 GVMVGIRRGEIVLVPLEEVANKEKPVDPDSPLIQLARELGI 344
PFK pfam00365
Phosphofructokinase;
98-402 3.20e-56

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 187.93  E-value: 3.20e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRvkRVIGFRFGYWGLSKKGshtAMELYRTSVTSIHRYGGTILGSSRG-PQDT 176
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGH--EVYGIRNGYEGLVEGD---IDELTWRDVSGILNRGGTILGTSRSkPFKT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  177 SE----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAkrrgaNLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:pfam00365  77 EEgrekIAENLKKLGIDALVVIGGDGSLTGANKLSEER-----GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDR 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  253 AYAEAISLNyGVGVVKLMGRDSGFIaaeaavasaqaNICLVPENPISEDIVMALIQRRFETSRSCVIIVAEGfgqdwegg 332
Cdd:pfam00365 152 IRDTASSHN-RVFVVEVMGRHCGWLalmag-laggaDAILIPEIPFDIEELCEKIKELRKGKRFSIIVVAEG-------- 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  333 tgghdASGnkkltdiGVVLTKRIQAwlRKNKErypngtVKYIDPSYMIRACPPSANDALFCATLSTLAMH 402
Cdd:pfam00365 222 -----ASD-------GEFLAKLIEE--GTGIE------TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
98-429 2.16e-51

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 177.11  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRVKrVIGFRFGYWGLSKKGshTAMELYRTSVTSIHRYGGTILGSSRG-PQDT 176
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEYGWE-VIGIRDGWRGLLEGD--TVPLLDLEDVRGILPRGGTILGSSRTnPFKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  177 SEM-----VDTLERLGVNILFTVGGDGTqrgaLKIAEEAKRRGanLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVR 251
Cdd:TIGR02483  79 EEDgddkiVANLKELGLDALIAIGGDGT----LGIARRLADKG--LPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  252 AAYAEAISLNYgVGVVKLMGRDSGFIaAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRS-CVIIVAEGF---GQ 327
Cdd:TIGR02483 153 RLHTTAESHHR-VMVVEVMGRHAGWI-ALHSGIAGGADVILIPEIPFDIDSVCEKVRERFARGKRfAIVVVAEGAkpkGG 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  328 DWEGGTGGHDASGNKKLTDIGVVLTKRIQAwlRKNKERYPngTVKyidpSYMIRACPPSANDALFCATLSTLAMHEAMAG 407
Cdd:TIGR02483 231 EMVVQEGVKDAFGHVRLGGIGNWLAEEIER--RTGIETRA--TVL----GHLQRGGSPSAFDRVLATRFGVAAVDLVHEG 302
                         330       340
                  ....*....|....*....|..
gi 122047336  408 ATNCIIALRYNSYILVPIKVAT 429
Cdd:TIGR02483 303 QFGHMVALRGTDIVYVPIAEAV 324
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
98-443 3.46e-42

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 152.84  E-value: 3.46e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKkGSHtaMELYRTSVTSIHRYGGTILGSSRGPQDTS 177
Cdd:cd00363    3 IGVLTSGGDAPGMNAAIRGVVRSAI--AEGLEVYGIYEGYAGLVE-GDI--KELDWESVSDIINRGGTIIGSARCKEFRT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 178 E-----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:cd00363   78 EegrakAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 253 AYAEAISLNYgVGVVKLMGRDSGFIaAEAAVASAQANICLVPENP----ISEDIVMALIQRRFETSRSCVIIVAEGFGQD 328
Cdd:cd00363  158 IRDTASSHQR-TFVVEVMGRHCGDI-ALEAGLATGADIIFIPEEPaadeWEEEMVDVIKKRRERGKRHGIVIVAEGAIDF 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 329 WEGGTGGHdasgnkkltDIGVVLTKRIQAWLRknkerypnGTVKyidpSYMIRACPPSANDALFCATLSTLAMHEAMAGA 408
Cdd:cd00363  236 IPKPITEK---------LLAKLVEERLGFDTR--------ATVL----GHVQRGGTPTAFDRILASRLGAEAVELLLEGT 294
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 122047336 409 TN---CIIALRYNSYILVPIKVATSVRR--VLDLRGQLWR 443
Cdd:cd00363  295 GGtpvGIQNLNENQVVRHPLTEAVNMTKrvGVDLEGRPFK 334
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
98-324 1.96e-41

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 150.23  E-value: 1.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKKgshTAMELYRTSVTSIHRYGGTILGSSRGPQDTS 177
Cdd:PRK03202   4 IGVLTSGGDAPGMNAAIRAVVRTAI--SEGLEVYGIYDGYAGLLEG---DIVKLDLKSVSDIINRGGTILGSARFPEFKD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 178 E-----MVDTLERLGVNILFTVGGDGTQRGALKIAEEakrrgaNLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:PRK03202  79 EegrakAIENLKKLGIDALVVIGGDGSYMGAKRLTEH------GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDR 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122047336 253 AYAEAISLNYgVGVVKLMGRDSGFIaaeaavasaqaNICLVPENPISEDIVMALIQRRFET-SRSCVIIVAEG 324
Cdd:PRK03202 153 LRDTASSHER-VFIVEVMGRHAGDLalhag-iaggaEVILIPEVPFDIEELCAKIKKGRERgKKHAIIVVAEG 223
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
98-446 3.45e-36

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 137.12  E-value: 3.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRVKrVIGFRFGYWGLSKKGSHtAMELYRTSVTSIHRYGGTILGSS-RG---- 172
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTYGWE-VIGIRDATQGLMARPPQ-YIELDLDQVDDLLRMGGTILGTTnKGdpfa 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 173 -P------QDTS-EMVDTLERLGVNILFTVGGDGTQRGALKIAEEAkrrGANLAvfGIPKTIDNDLSFSHRTFGFETAVD 244
Cdd:PRK14071  85 fPmpdgslRDRSqEIIDGYHSLGLDALIGIGGDGSLAILRRLAQQG---GINLV--GIPKTIDNDVGATEVSIGFDTAVN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 245 KAVEAVRAAYAEAISLNYgVGVVKLMGRDSGFIaAEAAVASAQANICLVPENPISEDIVMALIQRRFETSRS-CVIIVAE 323
Cdd:PRK14071 160 IATEALDRLHFTAASHNR-VMILEVMGRDAGHI-ALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGKNfCLVVVSE 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 324 G--------------FGQDWEGGTGGHdasgnkkltdIGVVLTKRIQAWLRKnkerypngTVKyidpSYMIRACPPSAND 389
Cdd:PRK14071 238 AvrteegeqvtktqaLGEDRYGGIGQY----------LAEQIAERTGAETRV--------TVL----GHIQRGGIPSPRD 295
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 122047336 390 ALFCATLSTLAMHEAMAGATNCIIALRYNSYILVPIKVATSVRRVLDLRGQLWRQVR 446
Cdd:PRK14071 296 RLLASAFGVAAVDLIAQGKFDRMVAWQNRQVVSVPIAEAIATYRAVDPEGTLVKTAR 352
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
98-324 8.90e-29

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 115.58  E-value: 8.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSkkgSHTAMELYRTSVTSIHRYGGTILGSSRGPQDTS 177
Cdd:cd00763    3 IGVLTSGGDAPGMNAAIRGVVRSAI--AEGLEVYGIRDGYAGLI---AGDIVPLDRYSVSDIINRGGTFLGSARFPEFKD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 178 E-----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAkrrganLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRA 252
Cdd:cd00763   78 EegqakAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHG------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDR 151
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122047336 253 AYAEAISLNYgVGVVKLMGRDSGFIAAEAAVASAQANIClVPENPISEDIVMALIQRRFET-SRSCVIIVAEG 324
Cdd:cd00763  152 IRDTSSSHQR-ISVVEVMGRHCGDIALAAGIAGGAEFIV-IPEAEFDREEVANRIKAGIERgKKHAIVVVAEG 222
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
167-434 7.98e-20

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 91.46  E-value: 7.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 167 LGSSR--------GPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRTFG 238
Cdd:PRK14072  75 LGSCRyklksleeDRAEYERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCPG 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 239 FETAVDKAVEAVRAAY--AEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQAN----ICLVPENPISEDIVMALIQRRFE 312
Cdd:PRK14072 155 FGSAAKYIATSVLEAAldVAAMANTSKVFILEVMGRHAGWLAAAAALAKQNPDdaphLIYLPERPFDEEKFLADVRAIVK 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 313 TSRSCVIIVAEGFgQDWEGG----TGGH-DASGNKKLTDIGVVLTKRIqawlrKNKERYPngtVKYIDPSYMIRACP--P 385
Cdd:PRK14072 235 RYGYCVVVVSEGI-RDADGKfiaeAGLAeDAFGHAQLGGVAPVLANLI-----KEKLGKK---VHWAVLDYLQRAARhiA 305
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 122047336 386 SANDALFCATLSTLAMHEAMAGATNCIIALR------YN-SYILVPI-KVATSVRRV 434
Cdd:PRK14072 306 SKTDVEEAYAVGKAAVEYALAGKNGVMPAIRrtsddpYKwKIGLVPLsKVANKEKKM 362
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
98-324 4.07e-19

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 90.48  E-value: 4.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKKGSHTAmELYRTSVTSIHRYGGTILGSSRgpqdTS 177
Cdd:TIGR02478   3 IAVLTSGGDAQGMNAAVRAVVRMAI--YVGCRVYAIREGYQGLVDGGDNIE-EAQWEDVRGILSLGGTIIGTAR----CK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  178 EMVDTLERL---------GVNILFTVGGDGTQRGA-----------------LKIAEEAKRRGANLAVFGIPKTIDNDLS 231
Cdd:TIGR02478  76 EFRERPGRLkaarnlvsnGIDALVVIGGDGSLTGAdlfreewpslleelvdtGKITAEQAEEHRHLTIVGLVGSIDNDMC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  232 FSHRTFGFETAVDKAVEAVRAAYAEAISLNYGVgVVKLMGRDSGFIAAEAAVASAQANIcLVPENPIS----EDIVMALI 307
Cdd:TIGR02478 156 GTDMTIGADSALHRICEAIDAISSTAQSHQRAF-VVEVMGRHCGYLALMAAIATGADYV-FIPERPPEegweDQLCHKLK 233
                         250
                  ....*....|....*..
gi 122047336  308 QRRFETSRSCVIIVAEG 324
Cdd:TIGR02478 234 RNRKAGKRKTIVIVAEG 250
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
98-324 1.03e-18

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 89.50  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKKGSHTAmELYRTSVTSIHRYGGTILGSSRGP---- 173
Cdd:cd00764    6 IAVLTSGGDAQGMNAAVRAVVRMGI--YVGAKVFFVYEGYEGLVKGGDYIK-QAEWESVSNWLQEGGTIIGSARCKefre 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 174 -----QDTSEMVDTlerlGVNILFTVGGDGTQRGAL-----------------KIAEEAKRRGANLAVFGIPKTIDNDLS 231
Cdd:cd00764   83 regrlQAAYNLIQR----GITNLCVIGGDGSLTGADlfrsewpslleelvkdgKITEEEVAKYQHLNIVGMVGSIDNDFC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 232 FSHRTFGFETAVDKAVEAVRAAYAEAISLNYGVgVVKLMGRDSGFIAAEAAVASAQANIcLVPENPIS---EDIVMALIQ 308
Cdd:cd00764  159 GTDMTIGTDSALHRICEVVDAITTTAQSHQRTF-VLEVMGRHCGYLALVSGLATGADWI-FIPERPPEdgwEDQMCRRLS 236
                        250
                 ....*....|....*..
gi 122047336 309 R-RFETSRSCVIIVAEG 324
Cdd:cd00764  237 EhRSRGKRLNIIIVAEG 253
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
98-277 1.46e-16

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 81.59  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLtltaVNAYRVK----RVIGFRFGYWGLSKKGSHTAMELYRTSVTSIHRYGGTILGSSR-- 171
Cdd:PRK06555   6 VALLTAGGLAPCLSSAVGGL----IERYTEIapevEIIAYRSGYQGLLLGDSIEITPAVRANAGLLHRYGGSPIGNSRvk 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 172 --GPQD------TSEMVDTL----ERL---GVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSHRT 236
Cdd:PRK06555  82 ltNVADcvkrglVKEGENPLkvaaERLaadGVDILHTIGGDDTNTTAADLAAYLAENGYDLTVVGLPKTIDNDVVPIRQS 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 122047336 237 FGFETAVDKAveavrAAYAEAISLNYGVG-----VVKLMGRDSGFI 277
Cdd:PRK06555 162 LGAWTAAEQG-----ARFFDNVINEHSANprmliIHEVMGRNCGWL 202
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
98-324 1.32e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 79.19  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSL--TLTAVNAYrvKRVIGFRFGYWGLSKkgsHTAMELYRTSVTSIHRYGG-TILGSSRGPQ 174
Cdd:PRK07085  73 VGVILSGGQAPGGHNVIAGLfdGLKKLNPD--SKLFGFIGGPLGLLN---GKYIEITEEVIDEYRNTGGfDMIGSGRTKI 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 175 DTSE----MVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSH--RTFGFETAVDkave 248
Cdd:PRK07085 148 ETEEqkeaCLETVKKLKLDGLVIIGGDDSNTNAAILAEYFAKHGCKTQVIGVPKTIDGDLKNEFieTSFGFDTATK---- 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 249 avraAYAEAIS-----LNYGVG---VVKLMGRDSGFIaAEAAVASAQANICLVPE---------NPISEDIVMALIQRRF 311
Cdd:PRK07085 224 ----TYSEMIGnisrdALSAKKywhFIKLMGRSASHI-ALECALQTHPNICLISEevaekkmslQDIVHYIASVIADRAA 298
                        250
                 ....*....|...
gi 122047336 312 ETSRSCVIIVAEG 324
Cdd:PRK07085 299 KGKNYGVILIPEG 311
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
98-325 3.30e-15

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 78.54  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKKGSHTAMElyrTSVTSIHRYGG-TILGSSRGP--- 173
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVISGIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITD---SLMNRFRNLGGfNMLWSGRGKvrn 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  174 -QDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFS--HRTFGFETAVDKAVEAV 250
Cdd:PTZ00287  257 kDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISEYFAERQIPISIIGIPKTIDGDLKSEaiEISFGFDTATKTYSEVI 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  251 RAAYAEAISLNYGVGVVKLMGRDSGFIaAEAAVASAQANICLVPE---------NPISEDIVMALIQRRFETSRSCVIIV 321
Cdd:PTZ00287  337 GNLCTDVKTGHNVYHVVRVMGRSASHV-VLECALQTRPNIVLIGEevekenlslKDIVSNIVNTILKRRSLNKNYGVILI 415

                  ....
gi 122047336  322 AEGF 325
Cdd:PTZ00287  416 PEGL 419
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
93-324 4.95e-15

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 77.60  E-value: 4.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  93 PPETVVGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLsKKGSHtaMELYRTSVTSIHRYGG-TILGSSR 171
Cdd:cd00765   70 APKLKIGIVLSGGQAPGGHNVISGLFDYLKERAKGSTLYGFKGGPAGI-LKCDY--IELNAEYIQPYRNTGGfDMICSGR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 172 GPQDTSEM----VDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSH--RTFGFETAVDK 245
Cdd:cd00765  147 TKIETEDQfkqaEETAKKLDLDALVVIGGDDSNTNAALLAENFRSKGLKTRVIGVPKTIDGDLKNKEieTSFGFDTATKI 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 246 AVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIaAEAAVASAQANICLVPE---------NPISEDIVMALIQRRFETSRS 316
Cdd:cd00765  227 YSELIGNVMRDARSTGKYWHFVKLMGRSASHI-ALECALKTHPNICIISEevsaqkqtlKNITDYMVDVICKRAELGYNF 305

                 ....*...
gi 122047336 317 CVIIVAEG 324
Cdd:cd00765  306 GVVLVPEG 313
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
35-277 3.13e-14

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 75.78  E-value: 3.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   35 RKYMNPSKKHVMREEFS----DKIEHIMHDPRpqEGVHSELPVSISPLLCELAAPRQRI----HFnpPETVVGIVTCGGI 106
Cdd:PTZ00468   38 RRRWEPCLPHILRSPLSikevSAFEGMGKMER--SDVSSYFPLTSGNSLVKFEAISDGSsswkKF--PARRIGVVLSGGQ 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  107 CPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSkkgSHTAMELYRTSVTSIHRYGG-TILGSSRGPQDTSEM----VD 181
Cdd:PTZ00468  114 ASGGHNVIAGLMSYIKLCNQSSQLFGFLGGPEGVY---SERYRELTEDDINGILNQGGfNIICSGRHKIETEEQmrasLE 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  182 TLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFS--HRTFGFETAVDKAVEAVRAAYAEAIS 259
Cdd:PTZ00468  191 ICEKLKLHGLVVIGGDDSNTNAAVLAEYFKRNSSSTVVVGCPKTIDGDLKNEviETSFGYDTAVKTYSEQIGSIMDAIKT 270
                         250
                  ....*....|....*...
gi 122047336  260 LNYGVGVVKLMGRDSGFI 277
Cdd:PTZ00468  271 EGYGYYFVRLMGRSASHI 288
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
81-321 1.48e-13

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 73.14  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336   81 ELAAPRQRIHFNPPET---VVGIVTCGGICPGLNDVIRSLTLTAVnaYRVKRVIGFRFGYWGLSKKGSHtamELYRTSVT 157
Cdd:TIGR02478 372 FLSIPDDDKKLVPSEAsrlRIAIIHVGAPAGGMNAATRSAVRYAL--ARGHTVIAIHNGFSGLARHDVR---ELTWSDVE 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  158 SIHRYGGTILGSSRG-PQDTSEMVDT-LERLGVNILFTVGGDGTQRGALKIAEEAKRRGA-NLAVFGIPKTIDNDLSFSH 234
Cdd:TIGR02478 447 GWVGEGGSELGTNRSlPGDDLGTIAYyFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAfRIPMVVIPATISNNVPGTE 526
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  235 RTFGFETAVDKAVEAVRAAYAEAISLNYGVGVVKLMGRDSGFIAAEAAVASAQANIcLVPENPISEDIVMALI---QRRF 311
Cdd:TIGR02478 527 YSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMAGLATGADAA-YIPEEGISLKDLQEDIehlKETF 605
                         250
                  ....*....|
gi 122047336  312 ETSRSCVIIV 321
Cdd:TIGR02478 606 AEGRAGKLIL 615
PLN02251 PLN02251
pyrophosphate-dependent phosphofructokinase
98-277 5.15e-08

pyrophosphate-dependent phosphofructokinase


Pssm-ID: 215140  Cd Length: 568  Bit Score: 55.18  E-value: 5.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVNAYRVKRVIGFRFGYWGLSKkgsHTAMELYRTSVTSIHRYGG-TILGSSRGPQDT 176
Cdd:PLN02251  99 IGVVLSGGQAPGGHNVISGIFDYLQEHAKGSVLYGFKGGPAGIMK---CKYVELTAEFIYPYRNQGGfDMICSGRDKIET 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 177 SEM----VDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDLSFSH--RTFGFETAVDKAVEAV 250
Cdd:PLN02251 176 PEQfkqaEETATKLDLDGLVVIGGDDSNTNACLLAEYFRAKNLKTRVIGCPKTIDGDLKSKEvpTSFGFDTACKIYSEMI 255
                        170       180
                 ....*....|....*....|....*..
gi 122047336 251 RAAYAEAISLNYGVGVVKLMGRDSGFI 277
Cdd:PLN02251 256 GNVMIDARSTGKYYHFVRLMGRAASHI 282
PLN03028 PLN03028
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
27-272 9.79e-08

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 215543  Cd Length: 610  Bit Score: 54.40  E-value: 9.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  27 LKVERLHGRKYMNPSKKHVMREEFSdkieHIMHDPRpqegVHSELPVSISPllcelaaPRQRIHFNPPeTVVGIVTCGGI 106
Cdd:PLN03028  27 VRVELGDATTAADPADAHAISRAFP----HTYGQPL----AHFLRATAKVP-------DAQVITEHPA-VRVGVVFCGRQ 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 107 CPGLNDVIRSL--TLTAVNAYRVkrVIGFRFGYWGLSKKGShtaMELYRTSVTSIHRYGG-TILGSSRGPQDTSEMVD-- 181
Cdd:PLN03028  91 SPGGHNVIWGLhdALKAHNPNSV--LLGFLGGTEGLFAQKT---LEITDDVLSTYKNQGGyDLLGRTKDQIRTTEQVNaa 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 182 --TLERLGVNILFTVGGDGTQRGALKIAEEAKRRGANLAVFGIPKTIDNDL--SFSHRTFGFETAVDKAVEAVRAAYAEA 257
Cdd:PLN03028 166 laACEALKLDGLVIIGGVTSNTDAAQLAETFAEAKCKTKVVGVPVTLNGDLknQFVETNVGFDTICKVNSQLISNVCTDA 245
                        250
                 ....*....|....*
gi 122047336 258 ISLNYGVGVVKLMGR 272
Cdd:PLN03028 246 LSAEKYYYFIRLMGR 260
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
98-299 4.15e-06

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 49.44  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  98 VGIVTCGGICPGLNDVIRSLTLTAVNayRVKRVIGFRFGYWGLSKKGShtaMELYRTSVTSIHRYGGTILGSSR--GPQD 175
Cdd:cd00764  392 IAIVNVGAPAAGMNAAVRSAVRYGLA--HGHRPYAIYDGFEGLAKGQI---VELGWIDVGGWTGRGGSELGTKRtlPKKD 466
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336 176 TSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGA-NLAVFGIPKTIDNDLSFSHRTFGFETAVDKAVEAVRAAY 254
Cdd:cd00764  467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEfCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 122047336 255 AEAISLNYGVGVVKLMGRDSGFIAAeAAVASAQANICLVPENPIS 299
Cdd:cd00764  547 QSASGTKRRVFIVETMGGYCGYLAT-MTGLAVGADAAYVFEEPFN 590
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
172-260 1.10e-03

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 39.11  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122047336  172 GPQDTSEMVDTLERLGVNILFTVGGDGTQRGALKIAEEAKRRGAnLAVfgIPKTIDNDLSfshRTFGFETAVDKAVEAVR 251
Cdd:pfam00781  40 GPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLATRPP-LGI--IPLGTGNDFA---RALGIPGDPEEALEAIL 113

                  ....*....
gi 122047336  252 AAYAEAISL 260
Cdd:pfam00781 114 KGQTRPVDV 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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