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Conserved domains on  [gi|57015268|sp|Q63159|]
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RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial; AltName: Full=3-demethylubiquinol 3-O-methyltransferase; AltName: Full=Polyprenyldihydroxybenzoate methyltransferase; Flags: Precursor

Protein Classification

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG( domain architecture ID 11493423)

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG is a class I SAM-dependent methyltransferase that catalyzes both methylation steps in ubiquinone biosynthesis

CATH:  3.40.50.150
EC:  2.1.1.222|2.1.1.64
Gene Ontology:  GO:0102208|GO:0008425|GO:0032259|GO:0006744
PubMed:  10419476|11583838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 96-326 1.01e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


:

Pssm-ID: 273910  Cd Length: 224  Bit Score: 346.97  E-value: 1.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268    96 EVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNhdpgkPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 175
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFKN-----PLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   176 PVAENIKIAQHHKSFDPVLdkrIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNK 255
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57015268   256 TQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNY 326
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 96-326 1.01e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 346.97  E-value: 1.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268    96 EVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNhdpgkPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 175
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFKN-----PLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   176 PVAENIKIAQHHKSFDPVLdkrIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNK 255
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57015268   256 TQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNY 326
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 87-332 2.35e-75

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 235.01  E-value: 2.35e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   87 STSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKT-STNHDPGKPLSGMKILDVGCGGGLLTEPLG 165
Cdd:PLN02396  71 STTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRHfSKDPSSAKPFEGLKFIDIGCGGGLLSEPLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  166 RLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYrVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPG 245
Cdd:PLN02396 151 RMGATVTGVDAVDKNVKIARLHADMDPVTST-IEY-LCTTAEKLADEGRKFDAVLSLEVIEHVANPAEFCKSLSALTIPN 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  246 GSLFITTVNKTQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLN 325
Cdd:PLN02396 229 GATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISVN 308


                 ....*..
gi 57015268  326 YAAHAVR 332
Cdd:PLN02396 309 YIAYGTK 315
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 145-254 7.11e-33

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 118.58  E-value: 7.11e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 145 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHksfdpVLDKRIQYRVCSLEEtLNENAECFDAVVASEV 224
Cdd:COG2227  23 PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-----AAELNVDFVQGDLED-LPLEDGSFDLVICSEV 96

                        90       100       110
                ....*....|....*....|....*....|
gi 57015268 225 VEHVNNLEMFIQCCYQVLKPGGSLFITTVN 254
Cdd:COG2227  97 LEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-250 5.34e-26

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 99.28  E-value: 5.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   151 LDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVldkriQYRVCSLEEtLNENAECFDAVVASEVVEHVNN 230
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-----TFVVGDAED-LPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 57015268   231 LEMFIQCCYQVLKPGGSLFI 250
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-253 6.06e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 6.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 149 KILDVGCGGGLLTEPLGRL-GASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEH 227
Cdd:cd02440   1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELAR--KAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*..
gi 57015268 228 -VNNLEMFIQCCYQVLKPGGSLFITTV 253
Cdd:cd02440  79 lVEDLARFLEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 96-326 1.01e-120

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 346.97  E-value: 1.01e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268    96 EVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNhdpgkPLSGMKILDVGCGGGLLTEPLGRLGASVVGID 175
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFKN-----PLDGLRVLDVGCGGGLLSEPLARLGANVTGID 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   176 PVAENIKIAQHHKSFDPVLdkrIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNK 255
Cdd:TIGR01983  76 ASEENIEVAKLHAKKDPLQ---IDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINR 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57015268   256 TQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNY 326
Cdd:TIGR01983 153 TPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNY 223
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 87-332 2.35e-75

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 235.01  E-value: 2.35e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   87 STSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKT-STNHDPGKPLSGMKILDVGCGGGLLTEPLG 165
Cdd:PLN02396  71 STTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRHfSKDPSSAKPFEGLKFIDIGCGGGLLSEPLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  166 RLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYrVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPG 245
Cdd:PLN02396 151 RMGATVTGVDAVDKNVKIARLHADMDPVTST-IEY-LCTTAEKLADEGRKFDAVLSLEVIEHVANPAEFCKSLSALTIPN 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  246 GSLFITTVNKTQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLN 325
Cdd:PLN02396 229 GATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISVN 308


                 ....*..
gi 57015268  326 YAAHAVR 332
Cdd:PLN02396 309 YIAYGTK 315
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 145-254 7.11e-33

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 118.58  E-value: 7.11e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 145 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHksfdpVLDKRIQYRVCSLEEtLNENAECFDAVVASEV 224
Cdd:COG2227  23 PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARER-----AAELNVDFVQGDLED-LPLEDGSFDLVICSEV 96

                        90       100       110
                ....*....|....*....|....*....|
gi 57015268 225 VEHVNNLEMFIQCCYQVLKPGGSLFITTVN 254
Cdd:COG2227  97 LEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-250 5.34e-26

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 99.28  E-value: 5.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   151 LDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVldkriQYRVCSLEEtLNENAECFDAVVASEVVEHVNN 230
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL-----TFVVGDAED-LPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 57015268   231 LEMFIQCCYQVLKPGGSLFI 250
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 147-258 3.54e-24

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 96.22  E-value: 3.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 147 GMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKsfdPVLDKRIQYRVCSLEEtLNENAECFDAVVASEVVE 226
Cdd:COG2226  23 GARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERA---AEAGLNVEFVVGDAED-LPFPDGSFDLVISSFVLH 98

                        90       100       110
                ....*....|....*....|....*....|..
gi 57015268 227 HVNNLEMFIQCCYQVLKPGGSLFITTVNKTQL 258
Cdd:COG2226  99 HLPDPERALAEIARVLKPGGRLVVVDFSPPDL 130
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 150-246 7.05e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 91.09  E-value: 7.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   150 ILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQHHKSFDPVldkRIQYRVCSLEEtLNENAECFDAVVASEVVEHV 228
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLERARERAAEAGL---NVEFVQGDAED-LPFPDGSFDLVVSSGVLHHL 76

                          90       100
                  ....*....|....*....|
gi 57015268   229 N--NLEMFIQCCYQVLKPGG 246
Cdd:pfam13649  77 PdpDLEAALREIARVLKPGG 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 127-303 8.67e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 90.18  E-value: 8.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   127 FIRDNLLKTStnhdpGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIA---QHHKSFDPVLDKriqyrvc 203
Cdd:pfam13489   8 LLADLLLRLL-----PKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAllnVRFDQFDEQEAA------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   204 sleetlnENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNKTQLSYVLGivfsEQIAGIVPKGTHTWek 283
Cdd:pfam13489  76 -------VPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLL----LEWPYLRPRNGHIS-- 142

                         170       180
                  ....*....|....*....|
gi 57015268   284 FVSPEKLESILEPNGLSVET 303
Cdd:pfam13489 143 LFSARSLKRLLEEAGFEVVS 162
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 147-252 1.67e-17

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 78.43  E-value: 1.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 147 GMKILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQhHKSFDPVLDKRIQYRVCSLEETLNEnaECFDAVVASEVV 225
Cdd:COG2230  52 GMRVLDIGCGWGGLALYLaRRYGVRVTGVTLSPEQLEYAR-ERAAEAGLADRVEVRLADYRDLPAD--GQFDAIVSIGMF 128

                        90       100
                ....*....|....*....|....*....
gi 57015268 226 EHVN--NLEMFIQCCYQVLKPGGSLFITT 252
Cdd:COG2230 129 EHVGpeNYPAYFAKVARLLKPGGRLLLHT 157
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
98-254 5.73e-17

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 77.73  E-value: 5.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  98 KTFQALAHSWwDEQgkfapLHSMNDLRVPF-IRDNLLKTstnHDPGKPLSgmkILDVGCGGGLLTEPLGRLGASVVGIDP 176
Cdd:COG4976   9 ALFDQYADSY-DAA-----LVEDLGYEAPAlLAEELLAR---LPPGPFGR---VLDLGCGTGLLGEALRPRGYRLTGVDL 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57015268 177 VAENIKIAQHHKSFDPVldkrIQYRVCSLEETlnenAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGsLFITTVN 254
Cdd:COG4976  77 SEEMLAKAREKGVYDRL----LVADLADLAEP----DGRFDLIVAADVLTYLGDLAAVFAGVARALKPGG-LFIFSVE 145
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 149-251 2.03e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 76.49  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 149 KILDVGCGGGLLTEPL-GRLGASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEH 227
Cdd:COG0500  29 RVLDLGCGTGRNLLALaARFGGRVIGIDLSPEAIALAR--ARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAFGVLHH 106

                        90       100
                ....*....|....*....|....*.
gi 57015268 228 VN--NLEMFIQCCYQVLKPGGSLFIT 251
Cdd:COG0500 107 LPpeEREALLRELARALKPGGVLLLS 132
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
147-252 4.82e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 72.55  E-value: 4.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 147 GMKILDVGCGGGLLTEPLGRL--GASVVGIDPVAENIKIAQHHKSfdpvldkRIQYRVCSLEE-TLNENaecFDAVVASE 223
Cdd:COG4106   2 PRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLP-------NVRFVVADLRDlDPPEP---FDLVVSNA 71

                        90       100
                ....*....|....*....|....*....
gi 57015268 224 VVEHVNNLEMFIQCCYQVLKPGGSLFITT 252
Cdd:COG4106  72 ALHWLPDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-248 2.20e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 70.86  E-value: 2.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   151 LDVGCGGGLLTEPLGRL--GASVVGIDPVAENIKIA-QHHKSFDPVLDKRIQYRVCSLEETLNENaecFDAVVASEVVEH 227
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAArERLAALGLLNAVRVELFQLDLGELDPGS---FDVVVASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 57015268   228 VNNLEMFIQCCYQVLKPGGSL 248
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-253 6.06e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 6.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 149 KILDVGCGGGLLTEPLGRL-GASVVGIDPVAENIKIAQhhKSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEH 227
Cdd:cd02440   1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELAR--KAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*..
gi 57015268 228 -VNNLEMFIQCCYQVLKPGGSLFITTV 253
Cdd:cd02440  79 lVEDLARFLEEARRLLKPGGVLVLTLV 105
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 145-227 1.30e-11

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 63.32  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  145 LSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVlDKRIQYRVCSLEETLNEnaecFDAVVASEV 224
Cdd:PRK07580  62 LTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGL-AGNITFEVGDLESLLGR----FDTVVCLDV 136


                 ...
gi 57015268  225 VEH 227
Cdd:PRK07580 137 LIH 139
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 147-253 3.13e-11

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 63.11  E-value: 3.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   147 GMKILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQhhKSFDPV-LDKRIQYRVCSLEEtLNENaecFDAVVASEV 224
Cdd:pfam02353  62 GMTLLDIGCGwGGLMRRAAERYDVNVVGLTLSKNQYKLAR--KRVAAEgLARKVEVLLQDYRD-FDEP---FDRIVSVGM 135

                          90       100       110
                  ....*....|....*....|....*....|.
gi 57015268   225 VEHV--NNLEMFIQCCYQVLKPGGSLFITTV 253
Cdd:pfam02353 136 FEHVghENYDTFFKKLYNLLPPGGLMLLHTI 166
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 146-254 8.37e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 59.35  E-value: 8.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   146 SGMKILDVGCGGGLLTEPLGRL---GASVVGIDPVAENIKIAQHHKSFDPVldKRIQYRVCSLEE-TLNENAECFDAVVA 221
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEElgpNAEVVGIDISEEAIEKARENAQKLGF--DNVEFEQGDIEElPELLEDDKFDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 57015268   222 SEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVN 254
Cdd:pfam13847  81 NCVLNHIPDPDKVLQEILRVLKPGGRLIISDPD 113
PRK08317 PRK08317
hypothetical protein; Provisional
 147-250 3.37e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 59.57  E-value: 3.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  147 GMKILDVGCGGGLLTEPLGRL---GASVVGIDPVAENIKIAQHHKSFDPVldkRIQYrVCSLEETLNENAECFDAVVASE 223
Cdd:PRK08317  20 GDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGP---NVEF-VRGDADGLPFPDGSFDAVRSDR 95

                         90       100
                 ....*....|....*....|....*..
gi 57015268  224 VVEHVNNLEMFIQCCYQVLKPGGSLFI 250
Cdd:PRK08317  96 VLQHLEDPARALAEIARVLRPGGRVVV 122
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 149-252 5.37e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 49.98  E-value: 5.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   149 KILDVGCGGGLLTEPLGRLG--ASVVGIDPVAENIKIAQHHKSfdpvldKRIQYrVCSLEETLNENAECFDAVVASEVVE 226
Cdd:TIGR02072  37 SVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTKLS------ENVQF-ICGDAEKLPLEDSSFDLIVSNLALQ 109

                          90       100
                  ....*....|....*....|....*.
gi 57015268   227 HVNNLEMFIQCCYQVLKPGGSLFITT 252
Cdd:TIGR02072 110 WCDDLSQALSELARVLKPGGLLAFST 135
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 144-314 1.70e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 48.61  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  144 PLSGMKILDVGCGGGLLTEPLGRLG---ASVVGIDPVAENIKIAQhHKSFDPVLDKRIQYRVCSLEETLNENaECFDAVV 220
Cdd:PRK00216  49 VRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVGR-EKLRDLGLSGNVEFVQGDAEALPFPD-NSFDAVT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  221 AS----EVVEHVNNL-EMfiqccYQVLKPGGSLFI---TTVNKTQLS-----YVLGIVfsEQIAGIVPKGT-------HT 280
Cdd:PRK00216 127 IAfglrNVPDIDKALrEM-----YRVLKPGGRLVIlefSKPTNPPLKkaydfYLFKVL--PLIGKLISKNAeaysylaES 199

                        170       180       190
                 ....*....|....*....|....*....|....
gi 57015268  281 WEKFVSPEKLESILEPNGLSVETvagmvYNPFSG 314
Cdd:PRK00216 200 IRAFPDQEELAAMLEEAGFERVR-----YRNLTG 228
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 144-299 2.36e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 48.03  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   144 PLSGMKILDVGCGGGLLTEPLGRLG---ASVVGIDPVAENIKIAQ-HHKSFDPVldkriqyrvcsleETLNENAEC---- 215
Cdd:TIGR01934  37 VFKGQKVLDVACGTGDLAIELAKSApdrGKVTGVDFSSEMLEVAKkKSELPLNI-------------EFIQADAEAlpfe 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   216 ---FDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFI---TTVNKTQLSYVLGIVFSE---QIAGIVPKGTH--TW--- 281
Cdd:TIGR01934 104 dnsFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVIlefSKPANALLKKFYKFYLKNvlpSIGGLISKNAEayTYlpe 183

                         170       180
                  ....*....|....*....|
gi 57015268   282 --EKFVSPEKLESILEPNGL 299
Cdd:TIGR01934 184 siRAFPSQEELAAMLKEAGF 203
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 145-251 6.90e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 46.88  E-value: 6.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   145 LSGMKILDVGCGGGLLTEPLGRLGA-SVVG--IDPVAenIKIAQHHKSFDPVlDKRIQYRVcsleeTLNENAECFDAVVA 221
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAkKVVGvdIDPVA--VRAAKENAELNGV-EARLEVYL-----PGDLPKEKADVVVA 231

                          90       100       110
                  ....*....|....*....|....*....|...
gi 57015268   222 ---SEVvehvnnLEMFIQCCYQVLKPGGsLFIT 251
Cdd:pfam06325 232 nilADP------LIELAPDIYALVKPGG-YLIL 257
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
147-259 8.83e-06

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 47.15  E-value: 8.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  147 GMKILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVlDKRIQ-YRvcsleeTLNENaecFDAVVASEV 224
Cdd:PRK11705 168 GMRVLDIGCGwGGLARYAAEHYGVSVVGVTISAEQQKLAQERCAGLPV-EIRLQdYR------DLNGQ---FDRIVSVGM 237

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 57015268  225 VEHV--NNLEMFIQCCYQVLKPGGSLFITTV--NKTQLS 259
Cdd:PRK11705 238 FEHVgpKNYRTYFEVVRRCLKPDGLFLLHTIgsNKTDTN 276
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
215-252 9.17e-06

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 45.24  E-value: 9.17e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 57015268 215 CFDAVVASEVVEHVNNLEM--FIQCCYQVLKPGGSLFITT 252
Cdd:COG4627  46 SVDAIYSSHVLEHLDYEEAplALKECYRVLKPGGILRIVV 85
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 146-259 1.13e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 45.92  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 146 SGMKILDVGCGGGLLTEPLGR-LGAS--VVGIDPVAENIKIAQHH-KSFDpvLDKRIQYRVCSLEETLNENAecFDAVVA 221
Cdd:COG2519  91 PGARVLEAGTGSGALTLALARaVGPEgkVYSYERREDFAEIARKNlERFG--LPDNVELKLGDIREGIDEGD--VDAVFL 166

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 57015268 222 sEVVEHVNNLEMfiqcCYQVLKPGGSL--FITTVNktQLS 259
Cdd:COG2519 167 -DMPDPWEALEA----VAKALKPGGVLvaYVPTVN--QVS 199
PRK14968 PRK14968
putative methyltransferase; Provisional
 147-257 6.41e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.35  E-value: 6.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  147 GMKILDVGCGGGLLTEPLGRLGASVVGID--PVAenIKIAQHHKSFDPVLDKRIQYRVCSLEEtlNENAECFDAVV---- 220
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKKVVGVDinPYA--VECAKCNAKLNNIRNNGVEVIRSDLFE--PFRGDKFDVILfnpp 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 57015268  221 ---ASEVVEHVNNLEM--------------FIQCCYQVLKPGGSLFI-----TTVNKTQ 257
Cdd:PRK14968 100 ylpTEEEEEWDDWLNYalsggkdgrevidrFLDEVGRYLKPGGRILLlqsslTGEDEVL 158
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
144-248 7.80e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 43.62  E-value: 7.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 144 PLSGMKILDVGCGGGLLTepLG--RLGAS-VVG--IDPVA-----ENIKIAQhhksfdpvLDKRIQYRVCSLEETlnena 213
Cdd:COG2264 146 LKPGKTVLDVGCGSGILA--IAaaKLGAKrVLAvdIDPVAveaarENAELNG--------VEDRIEVVLGDLLED----- 210

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 57015268 214 ECFDAVVA---SEVvehvnnLEMFIQCCYQVLKPGGSL 248
Cdd:COG2264 211 GPYDLVVAnilANP------LIELAPDLAALLKPGGYL 242
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
144-305 1.03e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  144 PLSGMKILDVGCGGGLLTEPLGRLGA-SVVG--IDPVAenIKIAQHHksfdpvldkrIQYRVCSLEETLNENAECFDAVV 220
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAkKVLAvdIDPQA--VEAAREN----------AELNGVELNVYLPQGDLKADVIV 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  221 A---SEVvehvnnLEMFIQCCYQVLKPGGSLFittvnktqLSyvlGIVfSEQIagivpkgthtwekfvspEKLESILEPN 297
Cdd:PRK00517 185 AnilANP------LLELAPDLARLLKPGGRLI--------LS---GIL-EEQA-----------------DEVLEAYEEA 229


                 ....*...
gi 57015268  298 GLSVETVA 305
Cdd:PRK00517 230 GFTLDEVL 237
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 143-251 1.55e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 43.20  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  143 KPlsGMKILDVGCG-GG---LLTEplgRLGASVVGIDPVAENIKIAqhhksfdpvLDKRIQyRVCSLEetlNENAEC--- 215
Cdd:PLN02336 265 KP--GQKVLDVGCGiGGgdfYMAE---NFDVHVVGIDLSVNMISFA---------LERAIG-RKCSVE---FEVADCtkk 326

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 57015268  216 ------FDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFIT 251
Cdd:PLN02336 327 typdnsFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLIS 368
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
141-248 2.10e-04

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 42.26  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  141 PGKPLSgmkILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKrIQYRVCSLEETLNENAECFDAVV 220
Cdd:PRK11036  42 PPRPLR---VLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVSDN-MQFIHCAAQDIAQHLETPVDLIL 117

                         90       100
                 ....*....|....*....|....*...
gi 57015268  221 ASEVVEHVNNLEMFIQCCYQVLKPGGSL 248
Cdd:PRK11036 118 FHAVLEWVADPKSVLQTLWSVLRPGGAL 145
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
120-248 2.90e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.66  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268   120 MNDLrVPFIRDNLLKTSTNhDPGKPLSGMKILDVGCGGGLLTEPLGRL-GAS--VVGIDPVAENIKIAQhhKSFDPVLDK 196
Cdd:pfam01209  18 MNDV-ISFGIHRLWKDFTM-KCMGVKRGNKFLDVAGGTGDWTFGLSDSaGSSgkVVGLDINENMLKEGE--KKAKEEGKY 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 57015268   197 RIQYrVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSL 248
Cdd:pfam01209  94 NIEF-LQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRV 144
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 149-222 3.09e-04

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 40.78  E-value: 3.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57015268   149 KILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDkRIQYRVCSLEETLN---ENAECFDAVVAS 222
Cdd:pfam09445   3 RILDVFCGGGGNTIQFANVFDSVISIDINLEHLACAQHNAEVYGVSD-RIWLIHGDWFELLAklkFEKIKYDCVFAS 78
PLN02244 PLN02244
tocopherol O-methyltransferase
 108-252 4.04e-04

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 41.65  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  108 WDEQ---GKFAPLHSMNDLRVPFIR--DNLLKTS--TNHDPGKPlsgMKILDVGCGGGLLTEPLGR-LGASVVGI--DPV 177
Cdd:PLN02244  76 WGEHmhhGYYDPGASRGDHRQAQIRmiEESLAWAgvPDDDEKRP---KRIVDVGCGIGGSSRYLARkYGANVKGItlSPV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  178 ----AENIKIAQHhksfdpvLDKRIQYRVC-SLEETLNENaeCFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITT 252
Cdd:PLN02244 153 qaarANALAAAQG-------LSDKVSFQVAdALNQPFEDG--QFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVT 223
PRK06202 PRK06202
hypothetical protein; Provisional
 141-232 1.32e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.60  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  141 PGKPLSgmkILDVGCGGGLLTEPLGRLGA------SVVGIDPVAENIKIAQHHksfdpVLDKRIQYRVCSLEEtLNENAE 214
Cdd:PRK06202  58 ADRPLT---LLDIGCGGGDLAIDLARWARrdglrlEVTAIDPDPRAVAFARAN-----PRRPGVTFRQAVSDE-LVAEGE 128

                         90
                 ....*....|....*...
gi 57015268  215 CFDAVVASEVVEHVNNLE 232
Cdd:PRK06202 129 RFDVVTSNHFLHHLDDAE 146
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
144-252 1.76e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 39.84  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  144 PLSGMKILDVGCGGGL-LTEPLGRLGASVVGIDPVaenikiAQHHKSFDPV-----LDKRIQYRVCSLEETlnENAECFD 217
Cdd:PRK15068 120 PLKGRTVLDVGCGNGYhMWRMLGAGAKLVVGIDPS------QLFLCQFEAVrkllgNDQRAHLLPLGIEQL--PALKAFD 191

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 57015268  218 AVVASEVVEHVNN-LEMFIQcCYQVLKPGGSLFITT 252
Cdd:PRK15068 192 TVFSMGVLYHRRSpLDHLKQ-LKDQLVPGGELVLET 226
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 149-251 2.04e-03

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 39.18  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268  149 KILDVGCG-GGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSfdpvlDK-RIQYRVCS-LEETLNENAecFDAVVASEVV 225
Cdd:PTZ00098  55 KVLDIGSGlGGGCKYINEKYGAHVHGVDICEKMVNIAKLRNS-----DKnKIEFEANDiLKKDFPENT--FDMIYSRDAI 127

                         90       100
                 ....*....|....*....|....*...
gi 57015268  226 EHVN--NLEMFIQCCYQVLKPGGSLFIT 251
Cdd:PTZ00098 128 LHLSyaDKKKLFEKCYKWLKPNGILLIT 155
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 144-176 5.25e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 38.15  E-value: 5.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 57015268   144 PLSGMKILDVGCGGGL-LTEPLGRLGASVVGIDP 176
Cdd:pfam08003 113 PLKGRTILDVGCGNGYhMWRMLGEGAAMVVGIDP 146
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 143-220 7.23e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 37.85  E-value: 7.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57015268 143 KPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVldKRIQYRVCSLEETLNENAEC--FDAVV 220
Cdd:COG2265 230 DLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGL--KNVEFVAGDLEEVLPELLWGgrPDVVV 307
2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_ cd08255
2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup ...
 144-195 9.27e-03

2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family has members identified as 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase and alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.


Pssm-ID: 176217 [Multi-domain]  Cd Length: 277  Bit Score: 37.25  E-value: 9.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 57015268 144 PLSGMKILDVGCG--GGLLTEPLGRLGAS-VVGIDPVAENIKIAQHHKSFDPVLD 195
Cdd:cd08255  95 PRLGERVAVVGLGlvGLLAAQLAKAAGAReVVGVDPDAARRELAEALGPADPVAA 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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