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Conserved domains on  [gi|73921233|sp|Q66H99|]
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RecName: Full=Nucleolar protein 10

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
 482-508 1.31e-10

NUC153 domain; This small domain is found in a a novel nucleolar family.


:

Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 56.19  E-value: 1.31e-10
                          10        20
                  ....*....|....*....|....*..
gi 73921233   482 DDRFKVMFENPDFQVDEDSEEFRLLNP 508
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFKKTNP 27
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-339 3.10e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 182 CDINTVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTAdseinslptisaLKFNGALSMAVGTST-GQVLLYDLRS 260
Cdd:cd00200  99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS------------VAFSPDGTFVASSSQdGTIKLWDLRT 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 261 DKPLLV-KDHQygLPIKSVHF-QDSLDLVLSADSRIVKMWNKDSGKIFTSLEpEHD--LNDVCLYPSSGMILTANESPKM 336
Cdd:cd00200 167 GKCVATlTGHT--GEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHEngVNSVAFSPDGYLLASGSEDGTI 243


                ...
gi 73921233 337 GIY 339
Cdd:cd00200 244 RVW 246
CCDC34 super family cl37875
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 555-670 8.38e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


The actual alignment was detected with superfamily member pfam13904:

Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233   555 KDWVeeVRKQRRLlQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEA--KHGTLS 632
Cdd:pfam13904  58 ENWL--AAKQRQR-QKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKslAKPERK 134

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 73921233   633 VSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKKL 670
Cdd:pfam13904 135 VSQEEAKEVLQEWERKKLEQQQRKREEEQREQLKKEEE 172
 
Name Accession Description Interval E-value
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
 482-508 1.31e-10

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 56.19  E-value: 1.31e-10
                          10        20
                  ....*....|....*....|....*..
gi 73921233   482 DDRFKVMFENPDFQVDEDSEEFRLLNP 508
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFKKTNP 27
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-339 3.10e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 182 CDINTVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTAdseinslptisaLKFNGALSMAVGTST-GQVLLYDLRS 260
Cdd:cd00200  99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS------------VAFSPDGTFVASSSQdGTIKLWDLRT 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 261 DKPLLV-KDHQygLPIKSVHF-QDSLDLVLSADSRIVKMWNKDSGKIFTSLEpEHD--LNDVCLYPSSGMILTANESPKM 336
Cdd:cd00200 167 GKCVATlTGHT--GEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHEngVNSVAFSPDGYLLASGSEDGTI 243


                ...
gi 73921233 337 GIY 339
Cdd:cd00200 244 RVW 246
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 190-344 1.65e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233  190 LFATGTIEGRVECWDPRVRKRVGVLDCALNsvtadseinslptISALKF--NGALSMAVGTSTGQVLLYDLRSDKPLLVK 267
Cdd:PLN00181 590 LLASGSDDGSVKLWSINQGVSIGTIKTKAN-------------ICCVQFpsESGRSLAFGSADHKVYYYDLRNPKLPLCT 656

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233  268 DHQYGLPIKSVHFQDSLDLVLSADSRIVKMWNKDSGKIFTSLEPEHDL-------NDVCLYPSSGMILTANESPKMGIYY 340
Cdd:PLN00181 657 MIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFmghtnvkNFVGLSVSDGYIATGSETNEVFVYH 736


                 ....*...
gi 73921233  341 ----IPVL 344
Cdd:PLN00181 737 kafpMPVL 744
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 555-670 8.38e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233   555 KDWVeeVRKQRRLlQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEA--KHGTLS 632
Cdd:pfam13904  58 ENWL--AAKQRQR-QKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKslAKPERK 134

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 73921233   633 VSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKKL 670
Cdd:pfam13904 135 VSQEEAKEVLQEWERKKLEQQQRKREEEQREQLKKEEE 172
PTZ00121 PTZ00121
MAEBL; Provisional
 559-669 1.28e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233   559 EEVRKQRRLLQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEAKHGTLSVSDTTV 638
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                          90       100       110
                  ....*....|....*....|....*....|.
gi 73921233   639 GSKQLTftlKRSEQQKKQQEAEKLHRQERKK 669
Cdd:PTZ00121 1690 AAEALK---KEAEEAKKAEELKKKEAEEKKK 1717
WD40 COG2319
WD40 repeat [General function prediction only];
190-330 3.80e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 190 LFATGTIEGRVECWDPRVRKRVGVLDcalnsvTADSEINSLpTISAlkfNGALsMAVGTSTGQVLLYDLRSDKPLLV-KD 268
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSV-AFSP---DGKL-LASGSDDGTVRLWDLATGKLLRTlTG 328

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 73921233 269 HQYglPIKSVHF-QDSLDLVLSADSRIVKMWNKDSGKIFTSLEpEHD--LNDVCLYPSSGMILTA 330
Cdd:COG2319 329 HTG--AVRSVAFsPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTgaVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
 482-508 1.31e-10

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 56.19  E-value: 1.31e-10
                          10        20
                  ....*....|....*....|....*..
gi 73921233   482 DDRFKVMFENPDFQVDEDSEEFRLLNP 508
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFKKTNP 27
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-339 3.10e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 182 CDINTVHGLFATGTIEGRVECWDPRVRKRVGVLDCALNSVTAdseinslptisaLKFNGALSMAVGTST-GQVLLYDLRS 260
Cdd:cd00200  99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS------------VAFSPDGTFVASSSQdGTIKLWDLRT 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 261 DKPLLV-KDHQygLPIKSVHF-QDSLDLVLSADSRIVKMWNKDSGKIFTSLEpEHD--LNDVCLYPSSGMILTANESPKM 336
Cdd:cd00200 167 GKCVATlTGHT--GEVNSVAFsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHEngVNSVAFSPDGYLLASGSEDGTI 243


                ...
gi 73921233 337 GIY 339
Cdd:cd00200 244 RVW 246
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 190-344 1.65e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233  190 LFATGTIEGRVECWDPRVRKRVGVLDCALNsvtadseinslptISALKF--NGALSMAVGTSTGQVLLYDLRSDKPLLVK 267
Cdd:PLN00181 590 LLASGSDDGSVKLWSINQGVSIGTIKTKAN-------------ICCVQFpsESGRSLAFGSADHKVYYYDLRNPKLPLCT 656

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233  268 DHQYGLPIKSVHFQDSLDLVLSADSRIVKMWNKDSGKIFTSLEPEHDL-------NDVCLYPSSGMILTANESPKMGIYY 340
Cdd:PLN00181 657 MIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFmghtnvkNFVGLSVSDGYIATGSETNEVFVYH 736


                 ....*...
gi 73921233  341 ----IPVL 344
Cdd:PLN00181 737 kafpMPVL 744
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 555-670 8.38e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233   555 KDWVeeVRKQRRLlQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEA--KHGTLS 632
Cdd:pfam13904  58 ENWL--AAKQRQR-QKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKslAKPERK 134

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 73921233   633 VSDTTVGSKQLTFTLKRSEQQKKQQEAEKLHRQERKKL 670
Cdd:pfam13904 135 VSQEEAKEVLQEWERKKLEQQQRKREEEQREQLKKEEE 172
PTZ00121 PTZ00121
MAEBL; Provisional
 559-669 1.28e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233   559 EEVRKQRRLLQQEERVKRQEQLKEDQQTVLKPQFYEIKAGEEFRSFKESATKQKLMNKTLEDRLKLEAKHGTLSVSDTTV 638
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                          90       100       110
                  ....*....|....*....|....*....|.
gi 73921233   639 GSKQLTftlKRSEQQKKQQEAEKLHRQERKK 669
Cdd:PTZ00121 1690 AAEALK---KEAEEAKKAEELKKKEAEEKKK 1717
WD40 COG2319
WD40 repeat [General function prediction only];
190-330 3.80e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73921233 190 LFATGTIEGRVECWDPRVRKRVGVLDcalnsvTADSEINSLpTISAlkfNGALsMAVGTSTGQVLLYDLRSDKPLLV-KD 268
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSV-AFSP---DGKL-LASGSDDGTVRLWDLATGKLLRTlTG 328

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 73921233 269 HQYglPIKSVHF-QDSLDLVLSADSRIVKMWNKDSGKIFTSLEpEHD--LNDVCLYPSSGMILTA 330
Cdd:COG2319 329 HTG--AVRSVAFsPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTgaVTSVAFSPDGRTLASG 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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