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Conserved domains on  [gi|75044171|sp|Q6SJ82|]
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RecName: Full=Sperm protein associated with the nucleus on the X chromosome N2; AltName: Full=Nuclear-associated protein SPAN-Xn2; Short=SPANX-N2; AltName: Full=SPANX family member N2

Protein Classification

SPAN-X domain-containing protein( domain architecture ID 10538540)

SPAN-X domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-94 2.10e-39

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


:

Pssm-ID: 400025  Cd Length: 94  Bit Score: 128.51  E-value: 2.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75044171     1 MEKPTSSTNGEKRKSPCDSNNRNDEMQETPNRDLALEPSLKKMKTSEYSTVLVLCYRKTKKIHSNQLENDQSQENSVNPV 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNANDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINPL 80

                          90
                  ....*....|....
gi 75044171    81 QEEEDEGSSQEDED 94
Cdd:pfam07458  81 QMEEEEFMEIREES 94
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-160 3.35e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 3.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75044171  83 EEDEGSSQEDEDLDSSAESSKQDEDLQLPEGSFQEDKDLGLSEGSSQEDEDLDSSERSSQEEKDPDASEGSSEEGEED 160
Cdd:COG4547 208 AEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGEDSEE 285
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-94 2.10e-39

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 128.51  E-value: 2.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75044171     1 MEKPTSSTNGEKRKSPCDSNNRNDEMQETPNRDLALEPSLKKMKTSEYSTVLVLCYRKTKKIHSNQLENDQSQENSVNPV 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNANDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINPL 80

                          90
                  ....*....|....
gi 75044171    81 QEEEDEGSSQEDED 94
Cdd:pfam07458  81 QMEEEEFMEIREES 94
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-160 3.35e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 3.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75044171  83 EEDEGSSQEDEDLDSSAESSKQDEDLQLPEGSFQEDKDLGLSEGSSQEDEDLDSSERSSQEEKDPDASEGSSEEGEED 160
Cdd:COG4547 208 AEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGEDSEE 285
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-94 2.10e-39

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 128.51  E-value: 2.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75044171     1 MEKPTSSTNGEKRKSPCDSNNRNDEMQETPNRDLALEPSLKKMKTSEYSTVLVLCYRKTKKIHSNQLENDQSQENSVNPV 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNANDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINPL 80

                          90
                  ....*....|....
gi 75044171    81 QEEEDEGSSQEDED 94
Cdd:pfam07458  81 QMEEEEFMEIREES 94
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 83-160 3.35e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 3.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75044171  83 EEDEGSSQEDEDLDSSAESSKQDEDLQLPEGSFQEDKDLGLSEGSSQEDEDLDSSERSSQEEKDPDASEGSSEEGEED 160
Cdd:COG4547 208 AEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGEDSEE 285
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 62-149 6.17e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 35.92  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75044171  62 IHSNQLENDQSQEnsvnpvQEEEDEGSSQEDEDlDSSAESSKQDEDLQLPEGSFQEDKDlglSEGSSQEDEDLDSSERSS 141
Cdd:COG4547 202 LRDLDLAEELGED------EDEEDEDDEDDSGE-QEEDEEDGEDEDEESDEGAEAEDAE---ASGDDAEEGESEAAEAES 271


                ....*...
gi 75044171 142 QEEKDPDA 149
Cdd:COG4547 272 DEMAEEAE 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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