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Conserved domains on  [gi|81916005|sp|Q8VHK6|]
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RecName: Full=Interleukin-13 receptor subunit alpha-2; Short=IL-13 receptor subunit alpha-2; Short=IL-13R subunit alpha-2; Short=IL-13R-alpha-2; Short=IL-13RA2; AltName: CD_antigen=CD213a2; Flags: Precursor

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10557932)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 138-231 2.35e-41

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 140.62  E-value: 2.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81916005   138 DMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNL--DSSDYKDFFIRVNGSSK 215
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLegLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 81916005   216 LEPIRSSYMVFQLQNI 231
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 138-231 2.35e-41

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 140.62  E-value: 2.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81916005   138 DMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNL--DSSDYKDFFIRVNGSSK 215
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLegLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 81916005   216 LEPIRSSYMVFQLQNI 231
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 138-231 2.35e-41

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 140.62  E-value: 2.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81916005   138 DMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNL--DSSDYKDFFIRVNGSSK 215
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLegLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 81916005   216 LEPIRSSYMVFQLQNI 231
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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