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Conserved domains on  [gi|20177881|sp|Q91Z62|]
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RecName: Full=F-box only protein 32; AltName: Full=Atrogin-1; AltName: Full=Muscle atrophy F-box protein; Short=MAFbx

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO32 cd22103
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ...
 218-265 2.55e-26

F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438875  Cd Length: 48  Bit Score: 99.16  E-value: 2.55e-26
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 20177881 218 LTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLC 265
Cdd:cd22103   1 LTLTDLPLCLQLNIMQRLSDGRDIVSLGQVSPDLQVLSEDRLLWKKLC 48
Elongin_A super family cl06096
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 260-297 2.78e-03

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


The actual alignment was detected with superfamily member pfam06881:

Pssm-ID: 462026  Cd Length: 105  Bit Score: 36.81  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20177881   260 LWKRLCQYHFSERqiRKRLILSDKGQLDWKKMYFKLVR 297
Cdd:pfam06881  41 LWKRFIKRDFPNW--AEEKDYEPKNPKSWRKLYEKLKE 76
 
Name Accession Description Interval E-value
F-box_FBXO32 cd22103
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ...
 218-265 2.55e-26

F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438875  Cd Length: 48  Bit Score: 99.16  E-value: 2.55e-26
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 20177881 218 LTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLC 265
Cdd:cd22103   1 LTLTDLPLCLQLNIMQRLSDGRDIVSLGQVSPDLQVLSEDRLLWKKLC 48
Elongin_A pfam06881
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 260-297 2.78e-03

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


Pssm-ID: 462026  Cd Length: 105  Bit Score: 36.81  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20177881   260 LWKRLCQYHFSERqiRKRLILSDKGQLDWKKMYFKLVR 297
Cdd:pfam06881  41 LWKRFIKRDFPNW--AEEKDYEPKNPKSWRKLYEKLKE 76
 
Name Accession Description Interval E-value
F-box_FBXO32 cd22103
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ...
 218-265 2.55e-26

F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438875  Cd Length: 48  Bit Score: 99.16  E-value: 2.55e-26
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 20177881 218 LTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLC 265
Cdd:cd22103   1 LTLTDLPLCLQLNIMQRLSDGRDIVSLGQVSPDLQVLSEDRLLWKKLC 48
F-box_FBXO25 cd22099
F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called ...
 219-263 1.30e-14

F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called FBX25, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. It controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. FBXO25 also plays a crucial role in tumorigenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438871  Cd Length: 45  Bit Score: 67.19  E-value: 1.30e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 20177881 219 TITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKR 263
Cdd:cd22099   1 TLSDLPLHMQNNILYRFTDGWDIINLGQVTPTLHMLSEDRHLWKK 45
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 219-265 8.75e-05

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 39.70  E-value: 8.75e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 20177881 219 TITDLPVCLQLNIMQRLSDgRDLVSLGQAAPDLHVLSEDRLLWKRLC 265
Cdd:cd22085   2 LLNHLPIDLQLYILSFLSP-HDLCQLGLTSHYWHTLVRDPLLWRYFL 47
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 223-265 3.54e-04

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 37.66  E-value: 3.54e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 20177881 223 LPVCLQLNIMqRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLC 265
Cdd:cd22087   4 LPPEIKLRIL-SLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
Elongin_A pfam06881
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 260-297 2.78e-03

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


Pssm-ID: 462026  Cd Length: 105  Bit Score: 36.81  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20177881   260 LWKRLCQYHFSERqiRKRLILSDKGQLDWKKMYFKLVR 297
Cdd:pfam06881  41 LWKRFIKRDFPNW--AEEKDYEPKNPKSWRKLYEKLKE 76
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 222-269 4.04e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 34.93  E-value: 4.04e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 20177881 222 DLPVCLQLNIMQRLsDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHF 269
Cdd:cd22084   3 DLPSDPLLNILSFL-DYRDLISCSQVCRRLNQLCSHDPLWKRLCKKYW 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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