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Conserved domains on  [gi|74752920|sp|Q9NRG1|]
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RecName: Full=Phosphoribosyltransferase domain-containing protein 1

Protein Classification

type I phosphoribosyltransferase( domain architecture ID 27)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRTases_typeI super family cl00309
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 7-224 8.98e-82

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


The actual alignment was detected with superfamily member PTZ00149:

Pssm-ID: 444823  Cd Length: 241  Bit Score: 243.91  E-value: 8.98e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIGgDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74752920  158 EKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 7-224 8.98e-82

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 243.91  E-value: 8.98e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIGgDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74752920  158 EKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-215 8.37e-60

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 185.52  E-value: 8.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRND-QSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   121 MQIIGGDDLSTLaGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYAL 200
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*
gi 74752920   201 DYNEYFRDLNHICVI 215
Cdd:TIGR01203 151 DYAERYRNLPYIGVL 165
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-218 4.23e-54

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 170.98  E-value: 4.23e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRN-DQSMGE 120
Cdd:COG0634   8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920 121 MQIIGGDDLStLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYAL 200
Cdd:COG0634  79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                       170
                ....*....|....*...
gi 74752920 201 DYNEYFRDLNHICVINEH 218
Cdd:COG0634 158 DYAEYYRNLPYIYALKPE 175
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-203 1.69e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 81.26  E-value: 1.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    46 HGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYRNDQSMGEMQIig 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSYNPDTSEVMKTS-- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74752920   126 gDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEiPNLFVVGYALDYN 203
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-189 2.30e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 77.82  E-value: 2.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  53 IERLAKDIMKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTL 132
Cdd:cd06223   2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74752920 133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSR----SDGFRPDYAGFE 189
Cdd:cd06223  70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGarelASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 7-224 8.98e-82

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 243.91  E-value: 8.98e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIGgDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74752920  158 EKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYR 224
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYK 240
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-215 8.37e-60

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 185.52  E-value: 8.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRND-QSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   121 MQIIGGDDLSTLaGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYAL 200
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*
gi 74752920   201 DYNEYFRDLNHICVI 215
Cdd:TIGR01203 151 DYAERYRNLPYIGVL 165
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-218 4.23e-54

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 170.98  E-value: 4.23e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRN-DQSMGE 120
Cdd:COG0634   8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920 121 MQIIGGDDLStLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYAL 200
Cdd:COG0634  79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                       170
                ....*....|....*...
gi 74752920 201 DYNEYFRDLNHICVINEH 218
Cdd:COG0634 158 DYAEYYRNLPYIYALKPE 175
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 35-219 1.64e-39

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 134.39  E-value: 1.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   35 YYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRnsdrfvSMKVDFIRLKSY-R 113
Cdd:PLN02238   3 YEVDIEKVLWTAEDISARVAELAAQIASDYAGKSPVVLGVATGAFMFLADLVRAIQPLPR------GLTVDFIRASSYgG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  114 NDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFR-----PDYAGF 188
Cdd:PLN02238  77 GTESSGVAKVSGADLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVKYElvgdgKEYVGF 156

                        170       180       190
                 ....*....|....*....|....*....|.
gi 74752920  189 EIPNLFVVGYALDYNEYFRDLNHICVINEHG 219
Cdd:PLN02238 157 ECPDEFVVGYGLDFAEKYRNLPYVGVLKPEV 187
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 49-195 2.89e-22

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 88.75  E-value: 2.89e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  49 IVDRIERLAKDIMKDiGYSDIMVLCVLKGGYkFCADLVEHLKNISRnsdrfvsmkVDFIRLKSYRNDQSMGEMQIIGGDD 128
Cdd:COG2236  14 IHELSRRLAEQILES-GFRPDVIVAIARGGL-VPARILADALGVPD---------LASIRVSSYTGTAKRLEEPVVKGPL 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74752920 129 LSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRsdgFRPDYAGFEIPNLFV 195
Cdd:COG2236  83 DEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYKPSSK---FKPDYYAEETDAWIV 146
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 53-212 7.78e-22

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 88.38  E-value: 7.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   53 IERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLknisrnsdRFvSMKVDFIRLKSYRNDQSMGEMQIIGGDDLStL 132
Cdd:PRK09162  26 IDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRL--------DF-PLEFDYLHATRYRNETTGGELVWKVKPRES-L 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSD-GFRPDYAGFEIPNLFVVGYALDYNEYFRDLNH 211
Cdd:PRK09162  96 KGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKAkPLKADFVGLEVPDRYVFGYGMDYKGYWRNLPG 175


                 .
gi 74752920  212 I 212
Cdd:PRK09162 176 I 176
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 69-222 2.56e-21

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 87.77  E-value: 2.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   69 IMVLCVLKGGYKFCADLVEHLknisrnSDRFVSMKVDFIRLKSYRND-QSMGEMQIIGgDDLSTLAGKNVLIVEDVVGTG 147
Cdd:PTZ00271  59 LYLLCVLKGSFIFTADLARFL------ADEGVPVKVEFICASSYGTGvETSGQVRMLL-DVRDSVENRHILIVEDIVDSA 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74752920  148 RTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEK 222
Cdd:PTZ00271 132 ITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKKEYYEK 206
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-203 1.69e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 81.26  E-value: 1.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920    46 HGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYRNDQSMGEMQIig 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSYNPDTSEVMKTS-- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74752920   126 gDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEiPNLFVVGYALDYN 203
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 42-212 1.05e-18

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 80.06  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920   42 VLIPHGIIVDRIERLAKDI---MKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRNDQSM 118
Cdd:PRK15423   7 VMIPEAEIKARIAELGRQIterYKDSG-SDMVLVGLLRGSFMFMADLCREVQ---------VSHEVDFMTASSYGSGMST 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  119 GEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDYAGFEIPNLFVVGY 198
Cdd:PRK15423  77 TRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGY 156

                        170
                 ....*....|....
gi 74752920  199 ALDYNEYFRDLNHI 212
Cdd:PRK15423 157 GIDYAQRYRHLPYI 170
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-189 2.30e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 77.82  E-value: 2.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  53 IERLAKDIMKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTL 132
Cdd:cd06223   2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74752920 133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSR----SDGFRPDYAGFE 189
Cdd:cd06223  70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGarelASPGDPVYSLFT 130
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 118-171 6.32e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 42.27  E-value: 6.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 74752920  118 MGEMQII--GGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLL 171
Cdd:PRK07322 102 TGKPQLLvlDGADAEKLKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIF 157
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
112-191 5.94e-04

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 39.34  E-value: 5.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752920  112 YRNDQS-MGEMQIIGGDDLST-LAGKNVLIVEDVVGTGRTMKALLSNIEKY-KPNMIKVAsLLVKRTSRSDGFRPDYAGF 188
Cdd:PRK05205  71 YRDDLTkKGLHPQVKPTDIPFdIEGKRVILVDDVLYTGRTIRAALDALFDYgRPARVQLA-VLVDRGHRELPIRADYVGK 149


                 ...
gi 74752920  189 EIP 191
Cdd:PRK05205 150 NIP 152
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 104-153 9.69e-04

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 38.30  E-value: 9.69e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74752920  104 VDFIRLKSYrNDQSMGEMQI---IGGDdlstlaGKNVLIVEDVVGTGRTMKAL 153
Cdd:PRK09177  58 VDTVCISSY-DHDNQGELKVlkrAEGD------GEGFLVVDDLVDTGGTARAV 103
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 133-185 5.28e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 36.89  E-value: 5.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74752920  133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDY 185
Cdd:PRK08558 175 KGDRVLIVDDIIRSGETQRALLDLARQAGADVVGVFFLIAVGEVGIDRAREET 227
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 124-159 5.30e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 36.59  E-value: 5.30e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 74752920 124 IGGDDLStlAGKNVLIVEDVVGTGRTMKALLSNIEK 159
Cdd:COG0503 104 LHKDALK--PGDRVLIVDDLLATGGTAKAAIKLVEE 137
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 119-191 8.32e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 36.29  E-value: 8.32e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74752920 119 GEM-QIIGGDdlstLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLvkrtSRSDGFRPDYAGFEIP 191
Cdd:COG0461 100 GTGgQIEGGL----LPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIV----DREEGAAENLEEAGVP 165
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 130-174 8.96e-03

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 36.00  E-value: 8.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 74752920  130 STLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKR 174
Cdd:PRK02277 136 ASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLIDKS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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