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Conserved domains on  [gi|1925247020|gb|QOV03946|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Nerodia fasciata fasciata]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-196 3.84e-100

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00124:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 457  Bit Score: 296.72  E-value: 3.84e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   1 LPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00124  259 YPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLANTNYERTH 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP 160
Cdd:MTH00124  339 SRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLSTQRGT 418

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1925247020 161 -PLSNTPIQPSHSREHLLMLLHTLPLMLISLKPELVI 196
Cdd:MTH00124  419 lPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELIS 455
 
Name Accession Description Interval E-value
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-196 3.84e-100

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 296.72  E-value: 3.84e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   1 LPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00124  259 YPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLANTNYERTH 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP 160
Cdd:MTH00124  339 SRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLSTQRGT 418

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1925247020 161 -PLSNTPIQPSHSREHLLMLLHTLPLMLISLKPELVI 196
Cdd:MTH00124  419 lPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELIS 455
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 2-140 5.50e-30

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 111.64  E-value: 5.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLA-NTSYERTK 80
Cdd:pfam00361 149 ILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRVH 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGL 140
Cdd:pfam00361 229 TRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-153 2.24e-29

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 112.87  E-value: 2.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:COG1008   278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:COG1008   358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY 428
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-153 9.57e-28

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 108.49  E-value: 9.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLY 422
 
Name Accession Description Interval E-value
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-196 3.84e-100

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 296.72  E-value: 3.84e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   1 LPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00124  259 YPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLANTNYERTH 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP 160
Cdd:MTH00124  339 SRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLSTQRGT 418

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1925247020 161 -PLSNTPIQPSHSREHLLMLLHTLPLMLISLKPELVI 196
Cdd:MTH00124  419 lPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELIS 455
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-195 3.62e-78

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 240.59  E-value: 3.62e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   1 LPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00068  259 YPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAIILMISHGLTSSALFCLANTNYERTH 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP 160
Cdd:MTH00068  339 SRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAAYTLYMFLMTQRGP 418

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1925247020 161 -PLSNTPIQPSHSREHLLMLLHTLPLMLISLKPELV 195
Cdd:MTH00068  419 lPNHLKTLFPTYTREHLLLALHILPMLLLILKPELI 454
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 2-195 5.44e-70

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 219.76  E-value: 5.44e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:MTH00110  260 PFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIHS 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  82 RIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNPP 161
Cdd:MTH00110  340 RTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGKL 419

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1925247020 162 LSNT-PIQPSHSREHLLMLLHTLPLMLISLKPELV 195
Cdd:MTH00110  420 THHInNIKPSFTRENTLMALHLLPLLLLSLNPKII 454
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 2-195 3.16e-61

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 197.10  E-value: 3.16e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:MTH00127  261 PFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGALILMIAHGLTSSALFCLANTNYERTHS 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  82 RIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP- 160
Cdd:MTH00127  341 RTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAGYSLYMFLMTQRGPl 420

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1925247020 161 PLSNTPIQPSHSREHLLMLLHTLPLMLISLKPELV 195
Cdd:MTH00127  421 PDHIIALNPSHTREHLLMALHLLPLLLLILKPELI 455
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 2-195 2.84e-56

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 183.99  E-value: 2.84e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:MTH00206  256 FFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGALLLMIAHGLVSSALFCLANLLYERSHT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  82 RIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNPP 161
Cdd:MTH00206  336 RTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYMFVMTQHGKT 415

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1925247020 162 LSNTP-IQPSHSREHLLMLLHTLPLMLISLKPELV 195
Cdd:MTH00206  416 PNHLLsLSPSSTREHLLLFLHLFPVILLILNPNLI 450
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-174 1.24e-48

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 163.99  E-value: 1.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   1 LPFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00044  261 FILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSGTNWGINGALILMIAHGLVSSALFCLANILYERSG 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNP 160
Cdd:MTH00044  341 TRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIYQLTNSGS 420

                         170
                  ....*....|....*
gi 1925247020 161 PLS-NTPIQPSHSRE 174
Cdd:MTH00044  421 FPSwISNVSPISSRE 435
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 3-164 3.48e-48

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 162.63  E-value: 3.48e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:MTH00163  249 WISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLANIIYERLGSR 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNPPL 162
Cdd:MTH00163  329 SLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHGKYY 408


                  ..
gi 1925247020 163 SN 164
Cdd:MTH00163  409 SG 410
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 3-157 3.77e-43

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 148.83  E-value: 3.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:MTH00150  220 LISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSR 299

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQ 157
Cdd:MTH00150  300 SLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQ 374
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 3-157 3.64e-41

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 144.35  E-value: 3.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:MTH00205  253 FFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSR 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQ 157
Cdd:MTH00205  333 SMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQ 407
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 2-196 1.70e-40

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 142.57  E-value: 1.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:MTH00014  254 PFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGALAMMIAHGLCSSALFALANMTYETTHT 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  82 RIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNPP 161
Cdd:MTH00014  334 RSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYTSTQHGSP 413

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1925247020 162 LSNT-PIQPSHSREHLLMLLHTLPLMLISLKPELVI 196
Cdd:MTH00014  414 PSFMnPLNLFTPRNHTLMTLHLVPLFILILKPDLIT 449
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 2-140 5.50e-30

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 111.64  E-value: 5.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLA-NTSYERTK 80
Cdd:pfam00361 149 ILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRVH 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGL 140
Cdd:pfam00361 229 TRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-153 2.24e-29

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 112.87  E-value: 2.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:COG1008   278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:COG1008   358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY 428
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-153 9.57e-28

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 108.49  E-value: 9.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLY 422
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 2-153 3.63e-25

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 101.28  E-value: 3.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFI-VLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTK 80
Cdd:MTH00217  273 PLIqTLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHH 352

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:MTH00217  353 TRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYLY 425
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 4-154 1.24e-24

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 99.89  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLAL----WGATLAnltcLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERT 79
Cdd:PRK05846  281 ITLGViaiiYGALVA----LAQTDIKKLIAYSSISHMGFVTLGIFAGNQLGIQGAIFQMISHGLSSAALFLLVGVLYDRL 356

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1925247020  80 KTRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFL 154
Cdd:PRK05846  357 HTRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAFIATTGLILAAVYSLWLYQ 431
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 4-153 3.13e-24

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 98.60  E-value: 3.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:MTH00204  279 VMLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPLGLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERHHTRL 358

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMF 153
Cdd:MTH00204  359 IKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLY 428
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 4-151 4.96e-22

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 92.68  E-value: 4.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:MTH00226  300 IAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRL 379

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLH 151
Cdd:MTH00226  380 IKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFY 447
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 3-164 5.47e-19

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 5.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:MTH00094  216 WIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSR 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  83 IMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFLSTQMNPPL 162
Cdd:MTH00094  296 LIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSFMKNKFSFFFIFFYFLVSFYYSLFLIVSSFMGKKF 375


                  ..
gi 1925247020 163 SN 164
Cdd:MTH00094  376 SN 377
ndhD CHL00011
NADH dehydrogenase subunit 4
 14-152 5.41e-17

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 78.06  E-value: 5.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  14 ANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRIMILTRGLHNI 93
Cdd:CHL00011  291 AASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQIISHGFIGAALFFLAGTSYDRIRLVYLDEMGGIAIP 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1925247020  94 LPMMTTWWLLINLMNIATPPSMNFTGELL-----IASSLFNWCPTTIIMF--GLSMLITASYSLHM 152
Cdd:CHL00011  371 MPKIFTMFSSFSMASLALPGMSGFVAELIvffgiITSQKYLLMPKILITFvmAIGMILTPIYLLSM 436
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 4-194 1.13e-16

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 76.99  E-value: 1.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGAtlanLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:PRK12561  259 VVNIIYGA----LNAFAQDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLS 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLI---------ASSLFnwCPTTIIMFGLSMLITASYSLHM-- 152
Cdd:PRK12561  335 IPNMGGLAKVMPKTFALFTASSMASLALPGMSGFVSELTVflgitssdvYSSTF--RTITILLAAVGLILTPIYLLSMlr 412

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1925247020 153 --FLSTQMNPPLSNTPIQPSHSREHLLMLLHTLPLMLISLKPEL 194
Cdd:PRK12561  413 rvFYGPRSELLPALAVVEDAKPRELFIALSLLVPIIGIGFYPKL 456
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 3-157 3.87e-16

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 75.57  E-value: 3.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:COG0651   275 LLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAGAIERATGTR 354

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1925247020  83 IMILTRGLHNILPmMTTWWLLINLMNIA-TPPSMNFTGELLIASSLFN-WCPTTIIMFGLSMLITASYSLHMFLSTQ 157
Cdd:COG0651   355 DLDKLGGLGKRMP-LTAAAFLIGALALAgLPPLSGFVSKWLLLQAALEaGAWLLAAVLLLSSLLTLAYFVRIFGRAQ 430
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 4-123 8.24e-15

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 71.66  E-value: 8.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:PRK02546  283 IVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMISHGLIGASLFFLVGATYDRTHTLM 362

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLI 123
Cdd:PRK02546  363 LDEMGGVGQKMRKMFAMWTACSLASLALPGMSGFVAELMV 402
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
3-152 5.98e-14

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 69.34  E-value: 5.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCL-------QQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTS 75
Cdd:PRK06473  267 WVYLAPWLATWAVVSVLygascaiAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQMISHGLISALLFLLVGVV 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  76 YERTKTRIMILTRGLHNI---LPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHM 152
Cdd:PRK06473  347 YKKTGSRDVDVLRGLLNPergLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQTLLCMIGTGLTAVYFLLL 426
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-150 2.72e-12

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 64.61  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:PRK12667  298 LIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTR 377

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1925247020  83 IMILTRGLHNILPMMTTWWlLINLMNIATPPSMN-FTGELLIASSLFNwcpTTIIMFGLSMLITASYSL 150
Cdd:PRK12667  378 DIDELAGLGRKMPIASFAF-LIGALSLVGIPPLNgFFSKLLLFNALLE---SGFYLPALVLLIASAISL 442
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 3-142 4.09e-12

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 63.80  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTR 82
Cdd:PRK06458  284 LLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLNHSLTKSAIFFASGNVLQKYGTR 363

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1925247020  83 IMILTRGLHNILPmMTTWWLLINLMNIA-TPPSMNFTGELLIASSLFN---WCPTTIIMFGLSM 142
Cdd:PRK06458  364 DINVIRGLLKVSP-LTGWGLMLGALAIAgMPPFGVFISEFLILTAGLArgpLLIAILLLLLLTL 426
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
5-148 3.02e-10

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 58.57  E-value: 3.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   5 VLALWGATLA---NLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:PRK07363  273 GLAIIGTISViygALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQMISHGLILALLFHLVGIVERKVGT 352

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  82 RIMILTRGLHNI---LPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASY 148
Cdd:PRK07363  353 RDLDVLNGLMNPirgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIPTLLCIVASGLTAVY 422
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
3-69 1.26e-09

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 56.75  E-value: 1.26e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF 69
Cdd:PRK05777  273 LAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMTLGAF 339
PRK12650 PRK12650
DUF4040 family protein;
4-117 1.89e-09

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 56.20  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:PRK12650  276 IIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLIGVVDHQAGTRD 355

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1925247020  84 MILTRGLHNILPMMTTWWLLINLMNIATPPSMNF 117
Cdd:PRK12650  356 IRRLGSLWRRMPFTFVSVTIAALSMAAVPPLFGF 389
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 3-69 4.14e-09

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 55.12  E-value: 4.14e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF 69
Cdd:COG1007   272 LAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAF 338
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-126 8.28e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 51.27  E-value: 8.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANT-SYERTKT 81
Cdd:PRK12662  282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSiSYHFGTT 361

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1925247020  82 RIMILTrGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASS 126
Cdd:PRK12662  362 KLEDCL-NLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYILDA 405
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 7-172 1.08e-07

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 50.92  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   7 ALWGATLAnltcLQQTDLKSLIAYSSISHMGLVISAIMIQtqwSLSGTMALMIAHGFTSSALFCLANTSYERTKTRIMIL 86
Cdd:COG1009   286 ALFAALIA----LAQTDIKRVLAYSTVSQLGYMFLALGVG---AYVAALFHLLTHAFFKALLFLGAGSVIHATGTRDIRK 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  87 TRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSML---ITASYSLHMFLSTQMNPPLS 163
Cdd:COG1009   359 MGGLRKKMPITAITFLIGALSLAGIPPFAGFFSKEAILEAALEAGGLGPLLLAVALLgafLTAFYSFRLFFLVFFGKPRP 438


                  ....*....
gi 1925247020 164 NTPIQPSHS 172
Cdd:COG1009   439 KTPKHPHES 447
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 3-127 3.67e-07

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 49.53  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGAT---LANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERT 79
Cdd:PRK12647  259 QTILPLFGGLtmlTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHET 338

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1925247020  80 KTRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTG-ELLIASSL 127
Cdd:PRK12647  339 GTRDITKLGGLRRAMPITAAAALLAALSMAGLPPLFGFLAkELIYEALL 387
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 4-69 2.02e-06

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 47.07  E-value: 2.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF 69
Cdd:PRK08377  277 IIMATLTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLF 342
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 4-69 2.44e-06

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 47.06  E-value: 2.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF 69
Cdd:PRK08676  277 IGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLF 342
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 2-143 2.52e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 46.80  E-value: 2.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   2 PFIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:PRK08375  273 LLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAIEVTYGT 352

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1925247020  82 RIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLF--NWCPTTIIMFGLSML 143
Cdd:PRK08375  353 RRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVeaGQWLVLAVLLASSLL 416
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 14-154 5.39e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 45.96  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  14 ANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRIMILTRGLHNI 93
Cdd:PRK06589  294 SSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGTSKS 373

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1925247020  94 LPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSMLITASYSLHMFL 154
Cdd:PRK06589  374 FPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMLVVIASSILSALYL 434
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 21-143 6.88e-06

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 45.74  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  21 QTDLKSLIAYSSISHMGLVISAIMIQ---TQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRIMILTRGLHNILPMM 97
Cdd:PRK06525  293 QQDMKRLLAYSTITQLGYMFFGLSLAilgSRLALEGSIAYIFNHAFAKSLFFLVAGALSYSCGTRLLPRLRGVLKKLPLV 372

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1925247020  98 TTWWLLINLMNIATPPSMNFTGELLIASSLFNWCPTTIIMFGLSML 143
Cdd:PRK06525  373 GVGFCVAALAITGVPPFNGFFSKFPIFAAGFELSVEYWILLPAMVL 418
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 3-129 3.94e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 43.40  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF-CLANT-SYERTK 80
Cdd:TIGR01770 272 LAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALMSLGAFgVLSLLrSYKDEW 351

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1925247020  81 TRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFN 129
Cdd:TIGR01770 352 IEYISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLK 400
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 11-128 4.12e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 43.57  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  11 ATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSG--TMALM---------IAHGFTSSALFCLANTSYERT 79
Cdd:PRK08667  281 ALLGVIYALKEHDLKGLLAYSSIENIGIILMGIGLYVIFGVYGldTLALLalggalfhsLNHALFKSLLFLTAGSVVHAT 360

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1925247020  80 KTRIMILTRGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLF 128
Cdd:PRK08667  361 GTRNIEKMGGLVKLMPYTSALFLVGAVSIAALPPFNGFASELLLYESFF 409
PRK06521 PRK06521
hydrogenase 4 subunit B; Validated
 4-128 1.13e-04

hydrogenase 4 subunit B; Validated


Pssm-ID: 235820 [Multi-domain]  Cd Length: 667  Bit Score: 42.18  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGAT--LANLTCLQQTDLKSLIAYSSISHMGLV-----ISAIMIQTQWSLSGTMALMIA------HGFTSSALFC 70
Cdd:PRK06521  278 LVLALGAISavLGVLYALAEHDLKRLLAYSTIENIGIIfvglgLAMVFIAYGMPLLAALALTAAlyhllnHALFKSLLFL 357

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1925247020  71 LANTSYERTKTRIMILTRGLHNILPmMTTWWLLINLMNIATPPSMN-FTGELLIASSLF 128
Cdd:PRK06521  358 GAGAVLHATGTRDMEKLGGLIRRMP-WTAWAFLIGCLAISALPPLNgFVSEWLLLQSLL 415
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 4-162 1.19e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 42.01  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMI------QTQWSLSGTMAL------MIAHGFTSSALFCL 71
Cdd:PRK08376  291 IILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMLLGLGVglaalgDPAMASYGEIALaggiyhIVNHALYKALLFLT 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020  72 ANTSYERTKTRIMILTRGLHNILPmMTTWWLLINLMNIATPPSMN-FTGELLI--ASSLFNWCPTTIIMFGlSMLITASY 148
Cdd:PRK08376  371 AGAVIYETGTRNLNELGGLARTMP-KTTIAFLIGAAAIVGLPPFNgFASKWLIyeSSALFNPILGVIAMIG-SVLTLASF 448

                         170
                  ....*....|....
gi 1925247020 149 sLHMFLSTQMNPPL 162
Cdd:PRK08376  449 -VKVFHTAFFGPPS 461
PRK12644 PRK12644
putative monovalent cation/H+ antiporter subunit A; Reviewed
 4-69 2.38e-04

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237154 [Multi-domain]  Cd Length: 965  Bit Score: 41.06  E-value: 2.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1925247020   4 IVLALWGAT--LANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALF 69
Cdd:PRK12644  269 TVLVLGLATmlLGGWRALRQHDLKLILAYGTVSQLGFLTVLVGIGTRDAALAGLAMLLAHALFKAALF 336
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 3-129 2.73e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 40.78  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLAnTSYERTKTR 82
Cdd:MTH00196  155 LLIGGLFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIQASLVYLFIYIIMSICVFSII-LALNVYKNL 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1925247020  83 IMILTrGLHNILPMMTTWWLLINLMNIATPPSMNFTGELLIASSLFN 129
Cdd:MTH00196  234 IIEFS-GLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVV 279
PRK06277 PRK06277
energy conserving hydrogenase EhbF;
4-142 5.65e-04

energy conserving hydrogenase EhbF;


Pssm-ID: 235767 [Multi-domain]  Cd Length: 478  Bit Score: 40.01  E-value: 5.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1925247020   4 IVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKTRI 83
Cdd:PRK06277  270 IALSVLAMVFGVVMALLQTDYKRLLAYHAISQGGYVAAGLALGTPLGIVAGIFHAINHVIYKSALFLGAGIVSYRTKTSN 349

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1925247020  84 milTRGLHNILPMMTTWWLLINLMNIA---TPPSMNFTGELLIASSLF--NWCPTTIIMFGLSM 142
Cdd:PRK06277  350 ---LRKLGGLLPVMPVVAFMVLCAKLAisgVPPFNGFQSKLMLAQAAMqaNMPELAIIMIIVSI 410
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
3-71 7.57e-04

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 39.65  E-value: 7.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1925247020   3 FIVLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAH------GFTSSALFCL 71
Cdd:PRK02504  279 FTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVMIGLVAGTEAGYASMVFYLLAYlfmnlgAFACVILFSL 353
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 21-81 1.04e-03

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 39.21  E-value: 1.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1925247020  21 QTDLKSLIAYSSISHMGLVISAIMIQTQWSLSGTMALMIAHGFTSSALFCLANTSYERTKT 81
Cdd:PRK08668  293 QEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFFLIFAAVIYRTGT 353
PRK07234 PRK07234
putative monovalent cation/H+ antiporter subunit D; Reviewed
 5-81 2.09e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235978 [Multi-domain]  Cd Length: 470  Bit Score: 38.01  E-value: 2.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1925247020   5 VLALWGATLANLTCLQQTDLKSLIAYSSISHMGLVISAIMIqtqwslSGTMALmiAHGFTSSALFCLANTSYERTKT 81
Cdd:PRK07234  250 IFGVGTALLGVLFALLEKDLKRMLAFSTISQLGFILAAPLV------GGLYAL--AHGLVKSTLFLCAGALPSRNFT 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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