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Conserved domains on  [gi|499219701|ref|WP_010917241|]
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helix-turn-helix domain-containing protein [Thermoplasma volcanium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 11448415)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
2-93 6.54e-20

Predicted transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 441383  Cd Length: 113  Bit Score: 80.85  E-value: 6.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499219701   2 IDDIDNFIAAIENSTRREIIRMLTQfERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVpSSVGAKRKLYEPTGF 81
Cdd:COG1777    4 DEDLDRLLDALGNPTRRRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG-REDGRARKYYRLSAF 81

                         90
                 ....*....|..
gi 499219701  82 sTLIVDYGRNFL 93
Cdd:COG1777   82 -RLEVTLTPDLF 92
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
2-93 6.54e-20

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 80.85  E-value: 6.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499219701   2 IDDIDNFIAAIENSTRREIIRMLTQfERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVpSSVGAKRKLYEPTGF 81
Cdd:COG1777    4 DEDLDRLLDALGNPTRRRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG-REDGRARKYYRLSAF 81

                         90
                 ....*....|..
gi 499219701  82 sTLIVDYGRNFL 93
Cdd:COG1777   82 -RLEVTLTPDLF 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-86 1.20e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 47.29  E-value: 1.20e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499219701   9 IAAIENSTRREIIRMLTQFERSyALELSRSIGLSQQAILKQLEMLERANLVTsigfvpSSVGAKRKLYEPTGFSTLIV 86
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVE------SRREGRRVYYSLTDAERLLA 71
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-63 2.25e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 43.30  E-value: 2.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 499219701    6 DNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIG 63
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-61 8.95e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 42.06  E-value: 8.95e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499219701   5 IDNFIAAIENSTRREIIRMLTQFERSyALELSRSIGLSQQAILKQLEMLERANLVTS 61
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
19-61 1.17e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 499219701    19 EIIRMLTQFERSYAlELSRSIGLSQQAILKQLEMLERANLVTS 61
Cdd:smart00418   1 KILKLLAEGELCVC-ELAEILGLSQSTVSHHLKKLREAGLVES 42
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
2-93 6.54e-20

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 80.85  E-value: 6.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499219701   2 IDDIDNFIAAIENSTRREIIRMLTQfERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVpSSVGAKRKLYEPTGF 81
Cdd:COG1777    4 DEDLDRLLDALGNPTRRRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG-REDGRARKYYRLSAF 81

                         90
                 ....*....|..
gi 499219701  82 sTLIVDYGRNFL 93
Cdd:COG1777   82 -RLEVTLTPDLF 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-86 1.20e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 47.29  E-value: 1.20e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499219701   9 IAAIENSTRREIIRMLTQFERSyALELSRSIGLSQQAILKQLEMLERANLVTsigfvpSSVGAKRKLYEPTGFSTLIV 86
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVE------SRREGRRVYYSLTDAERLLA 71
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-63 2.25e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 43.30  E-value: 2.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 499219701    6 DNFIAAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSIG 63
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-61 3.26e-06

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 43.72  E-value: 3.26e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499219701   1 MIDDIDNFIAAIENSTRREIIRMLTQFERSyALELSRSIGLSQQAILKQLEMLERANLVTS 61
Cdd:COG0640    6 ELEELAELFKALADPTRLRILRLLAEGELC-VGELAEALGLSQSTVSHHLKVLREAGLVTS 65
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
10-79 5.91e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 45.30  E-value: 5.91e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499219701  10 AAIENSTRREIIRMLTQFERSYALELSRSIGLSQQAILKQLEMLERANLVTSiGFVPSSVGAKRKLYEPT 79
Cdd:COG2345    8 AALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVER-ETERRGRGRPAKLYRLT 76
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-61 8.95e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 42.06  E-value: 8.95e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499219701   5 IDNFIAAIENSTRREIIRMLTQFERSyALELSRSIGLSQQAILKQLEMLERANLVTS 61
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELC-VCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
19-61 1.17e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 499219701    19 EIIRMLTQFERSYAlELSRSIGLSQQAILKQLEMLERANLVTS 61
Cdd:smart00418   1 KILKLLAEGELCVC-ELAEILGLSQSTVSHHLKKLREAGLVES 42
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-59 5.16e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.57  E-value: 5.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 499219701   14 NSTRREIIRMLTQFERSYAlELSRSIGLSQQAILKQLEMLERANLV 59
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVC-ELAEELGLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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