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Conserved domains on  [gi|2770961992|ref|WP_366975074|]
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CD20-like domain-containing protein [Streptococcus oralis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AzlC super family cl42159
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.25e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1296:

Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 44.01  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2770961992  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVAFILGIigLIVNLKKRKTMAIIGTSLAVASVVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
DUF3862 super family cl19285
Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity ...
 151-215 5.09e-03

Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex. (REF http://www.topsan.org/Proteins/JCSG/3d4e)


The actual alignment was detected with superfamily member pfam12978:

Pssm-ID: 473159  Cd Length: 159  Bit Score: 36.40  E-value: 5.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770961992 151 NKGKGGTNYKDIIKKHGLPDSEFDSTIGGYNTRKITYIS---IGDKIKTVTLTFakqDNGQLLLVQKH 215
Cdd:pfam12978  93 DSIKDGMSYNKVVKRLGEPDDLSQAKSSDKEELQATWVSgikTKSSSATITLTF---ENGGLTNKTQV 157
 
Name Accession Description Interval E-value
AzlC COG1296
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.25e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 44.01  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2770961992  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVAFILGIigLIVNLKKRKTMAIIGTSLAVASVVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 10-86 6.66e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770961992  10 PEEQRV-LGILATIFGAIA----LLGSWIpfINYLSF-----FIAIVAFILGIIGLIVNLK--KRKTMAIIGTSLAVASV 77
Cdd:cd17504   114 PERVPVaQGILSATFGIGAgiglPLGGWI--VQHLGWrwifwTAAPVAVLLAALVPLIDLRllRRRNVLLANITALLAGF 191


                  ....*....
gi 2770961992  78 VLFFTTQVL 86
Cdd:cd17504   192 GMFMVFQLL 200
DUF308 pfam03729
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ...
 15-81 7.26e-04

Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).


Pssm-ID: 427468  Cd Length: 73  Bit Score: 37.10  E-value: 7.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2770961992  15 VLGILATIFGAIALLgswIPFI--NYLSFFIAIVAFILGIIGLIVNLKKRKT-------MAIIGTSLAVASVVLFF 81
Cdd:pfam03729   1 LLGILLIILGILALI---WPGAalLALVILIGILLLVSGILQLIAAFALRKFggggfwwLLLSGILYLIAGILLLF 73
DUF3862 pfam12978
Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity ...
 151-215 5.09e-03

Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex. (REF http://www.topsan.org/Proteins/JCSG/3d4e)


Pssm-ID: 432914  Cd Length: 159  Bit Score: 36.40  E-value: 5.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770961992 151 NKGKGGTNYKDIIKKHGLPDSEFDSTIGGYNTRKITYIS---IGDKIKTVTLTFakqDNGQLLLVQKH 215
Cdd:pfam12978  93 DSIKDGMSYNKVVKRLGEPDDLSQAKSSDKEELQATWVSgikTKSSSATITLTF---ENGGLTNKTQV 157
 
Name Accession Description Interval E-value
AzlC COG1296
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.25e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 44.01  E-value: 2.25e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2770961992  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVAFILGIigLIVNLKKRKTMAIIGTSLAVASVVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 10-86 6.66e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2770961992  10 PEEQRV-LGILATIFGAIA----LLGSWIpfINYLSF-----FIAIVAFILGIIGLIVNLK--KRKTMAIIGTSLAVASV 77
Cdd:cd17504   114 PERVPVaQGILSATFGIGAgiglPLGGWI--VQHLGWrwifwTAAPVAVLLAALVPLIDLRllRRRNVLLANITALLAGF 191


                  ....*....
gi 2770961992  78 VLFFTTQVL 86
Cdd:cd17504   192 GMFMVFQLL 200
DUF308 pfam03729
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ...
 15-81 7.26e-04

Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).


Pssm-ID: 427468  Cd Length: 73  Bit Score: 37.10  E-value: 7.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2770961992  15 VLGILATIFGAIALLgswIPFI--NYLSFFIAIVAFILGIIGLIVNLKKRKT-------MAIIGTSLAVASVVLFF 81
Cdd:pfam03729   1 LLGILLIILGILALI---WPGAalLALVILIGILLLVSGILQLIAAFALRKFggggfwwLLLSGILYLIAGILLLF 73
YoaK COG3619
Uncharacterized membrane protein YoaK, UPF0700 family [Function unknown];
21-81 1.02e-03

Uncharacterized membrane protein YoaK, UPF0700 family [Function unknown];


Pssm-ID: 442837  Cd Length: 228  Bit Score: 39.14  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2770961992  21 TIFGAIAL-LGSWIPFINYLsffIAIVAFILGII--GLIVNLKKRKTMAIIGTSLAVASVVLFF 81
Cdd:COG3619    48 VVLLGIALaGGDWAGALLAL---LAILAFVLGAAlsGLLIRRARRRLRRWYALLLLLEAVLLLL 108
DUF3862 pfam12978
Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity ...
 151-215 5.09e-03

Domain of Unknown Function with PDB structure (DUF3862); PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex. (REF http://www.topsan.org/Proteins/JCSG/3d4e)


Pssm-ID: 432914  Cd Length: 159  Bit Score: 36.40  E-value: 5.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770961992 151 NKGKGGTNYKDIIKKHGLPDSEFDSTIGGYNTRKITYIS---IGDKIKTVTLTFakqDNGQLLLVQKH 215
Cdd:pfam12978  93 DSIKDGMSYNKVVKRLGEPDDLSQAKSSDKEELQATWVSgikTKSSSATITLTF---ENGGLTNKTQV 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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