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Conserved domains on  [gi|2791612153|ref|WP_371607034|]
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CD20-like domain-containing protein [Streptococcus sp. 27098_8_51]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AzlC super family cl42159
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.98e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1296:

Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 43.62  E-value: 2.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791612153  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVALILGIigLIVNLKKRKTMAIIGTALSIASIVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
 
Name Accession Description Interval E-value
AzlC COG1296
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.98e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 43.62  E-value: 2.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791612153  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVALILGIigLIVNLKKRKTMAIIGTALSIASIVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 10-86 1.95e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.79  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791612153  10 PEEQKV-LGILATIFGAIA----LLGSWIpfINYLSF-----FIAIVALILGIIGLIVNLK--KRKTMAIIGTALSIASI 77
Cdd:cd17504   114 PERVPVaQGILSATFGIGAgiglPLGGWI--VQHLGWrwifwTAAPVAVLLAALVPLIDLRllRRRNVLLANITALLAGF 191


                  ....*....
gi 2791612153  78 VLFFTTQIL 86
Cdd:cd17504   192 GMFMVFQLL 200
DUF308 pfam03729
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ...
 15-81 2.11e-04

Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).


Pssm-ID: 427468  Cd Length: 73  Bit Score: 38.64  E-value: 2.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791612153  15 VLGILATIFGAIALLgswIPFI--NYLSFFIAIVALILGIIGLIVNLKKRKT-------MAIIGTALSIASIVLFF 81
Cdd:pfam03729   1 LLGILLIILGILALI---WPGAalLALVILIGILLLVSGILQLIAAFALRKFggggfwwLLLSGILYLIAGILLLF 73
 
Name Accession Description Interval E-value
AzlC COG1296
Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and ...
 18-81 2.98e-05

Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism];


Pssm-ID: 440907 [Multi-domain]  Cd Length: 225  Bit Score: 43.62  E-value: 2.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791612153  18 ILATIFGAiaLLGSWIPFINYLSFFIAIVALILGIigLIVNLKKRKTMAIIGTALSIASIVLFF 81
Cdd:COG1296   136 VLGTLLGA--LLGSALPDPLAWGLDFALPALFLAL--LVPQLKGRATLVAALVAAVVALLAALL 195
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 10-86 1.95e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.79  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791612153  10 PEEQKV-LGILATIFGAIA----LLGSWIpfINYLSF-----FIAIVALILGIIGLIVNLK--KRKTMAIIGTALSIASI 77
Cdd:cd17504   114 PERVPVaQGILSATFGIGAgiglPLGGWI--VQHLGWrwifwTAAPVAVLLAALVPLIDLRllRRRNVLLANITALLAGF 191


                  ....*....
gi 2791612153  78 VLFFTTQIL 86
Cdd:cd17504   192 GMFMVFQLL 200
DUF308 pfam03729
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ...
 15-81 2.11e-04

Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).


Pssm-ID: 427468  Cd Length: 73  Bit Score: 38.64  E-value: 2.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791612153  15 VLGILATIFGAIALLgswIPFI--NYLSFFIAIVALILGIIGLIVNLKKRKT-------MAIIGTALSIASIVLFF 81
Cdd:pfam03729   1 LLGILLIILGILALI---WPGAalLALVILIGILLLVSGILQLIAAFALRKFggggfwwLLLSGILYLIAGILLLF 73
DUF4190 pfam13828
Domain of unknown function (DUF4190); This integral membrane domain is functionally ...
 16-80 4.00e-04

Domain of unknown function (DUF4190); This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.


Pssm-ID: 433508  Cd Length: 61  Bit Score: 37.50  E-value: 4.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2791612153  16 LGILATIFGAIALLGSWIPfinylsffiAIVALILGIIGLiVNLKKR----KTMAIIGTALSIASIVLF 80
Cdd:pfam13828   1 LAIASLVLGILGLFGLIIG---------SIVAIILGHVAL-RQIRRTgergRGLAIAGIVLGWIGLALT 59
HdeD COG3247
Acid resistance membrane protein HdeD, DUF308 family [General function prediction only];
15-81 5.16e-04

Acid resistance membrane protein HdeD, DUF308 family [General function prediction only];


Pssm-ID: 442478 [Multi-domain]  Cd Length: 178  Bit Score: 39.38  E-value: 5.16e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791612153  15 VLGILATIFGAIALLgswIPFI--NYLSFFIAIVALILGIIGLIVNLKKRKTMAIIGTALS-----IASIVLFF 81
Cdd:COG3247    14 LLGILLILLGILALV---WPGAtlLALVILFGILLLVSGIVQLVAAFRARGWGGRGWLLLLgilyiVAGILLLF 84
DUF6056 pfam19528
Family of unknown function (DUF6056); This family of integral membrane proteins is ...
 18-119 2.22e-03

Family of unknown function (DUF6056); This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.


Pssm-ID: 437360  Cd Length: 444  Bit Score: 38.79  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791612153  18 ILATIFGAIALLGSwiPFINYLSFFIAIVALILGIIGLIVNLKKRKTMA-IIGTALSIASIVLFFTTqilYANIYKDFAK 96
Cdd:pfam19528 300 FLGGLATAYAMIAS--PEFPARAFFGAVIFLIIAILILLRDLAELESLLrKIAAILIVVLTILFIFS---YIEAYADLAR 374

                          90       100
                  ....*....|....*....|...
gi 2791612153  97 eFNRSYREASASMEREEESDLTD 119
Cdd:pfam19528 375 -SYREYNEREAYIQEQKAKGEKD 396
7TM-7TMR_HD pfam07698
7TM receptor with intracellular HD hydrolase; These bacterial 7TM receptor proteins have an ...
 16-91 6.93e-03

7TM receptor with intracellular HD hydrolase; These bacterial 7TM receptor proteins have an intracellular pfam01966. This entry corresponds to the 7 helix transmembrane domain. These proteins also contain an N-terminal extracellular domain.


Pssm-ID: 429603 [Multi-domain]  Cd Length: 190  Bit Score: 36.38  E-value: 6.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791612153  16 LGILATIFgaIALLGSWIPFINYLSFFIAIVALILGIIGLiVNLKKRKTMAIIGTALSIASIVLFFTTQILYANIY 91
Cdd:pfam07698  81 LALVVSVL--LALLLGIMFGNNLEVILYALLSGLVGAYSV-RRLRSRSDLLRAGLFVALVNVLLYLALGLISGNNF 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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