NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|564353965|ref|XP_006239404|]
View 

PRAME family member 27 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
197-388 3.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 197 EILDLDSIQELrvYCISNPvcLLNFAPYLGRMRNLRCLILSHlwqafsmtpvekqQVITQFTSQFLKLKCLQILHLDtvf 276
Cdd:COG4886  108 ELSNLTNLESL--DLSGNQ--LTDLPEELANLTNLKELDLSN-------------NQLTDLPEPLGNLTNLKSLDLS--- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 277 flEGHLDELFWWLK--TPLETLSVIDCNLSKsdwIHISEFQCTSqLKHLNLKWVKLTHLSPEplrillLKSASTLISLDL 354
Cdd:COG4886  168 --NNQLTDLPEELGnlTNLKELDLSNNQITD---LPEPLGNLTN-LEELDLSGNQLTDLPEP------LANLTNLETLDL 235

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564353965 355 EGCQMMDsqlsaiLPALRCCTQLTKFNFHGNYIS 388
Cdd:COG4886  236 SNNQLTD------LPELGNLTNLEELDLSNNQLT 263
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
197-388 3.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 197 EILDLDSIQELrvYCISNPvcLLNFAPYLGRMRNLRCLILSHlwqafsmtpvekqQVITQFTSQFLKLKCLQILHLDtvf 276
Cdd:COG4886  108 ELSNLTNLESL--DLSGNQ--LTDLPEELANLTNLKELDLSN-------------NQLTDLPEPLGNLTNLKSLDLS--- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 277 flEGHLDELFWWLK--TPLETLSVIDCNLSKsdwIHISEFQCTSqLKHLNLKWVKLTHLSPEplrillLKSASTLISLDL 354
Cdd:COG4886  168 --NNQLTDLPEELGnlTNLKELDLSNNQITD---LPEPLGNLTN-LEELDLSGNQLTDLPEP------LANLTNLETLDL 235

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564353965 355 EGCQMMDsqlsaiLPALRCCTQLTKFNFHGNYIS 388
Cdd:COG4886  236 SNNQLTD------LPELGNLTNLEELDLSNNQLT 263
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
197-388 3.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 197 EILDLDSIQELrvYCISNPvcLLNFAPYLGRMRNLRCLILSHlwqafsmtpvekqQVITQFTSQFLKLKCLQILHLDtvf 276
Cdd:COG4886  108 ELSNLTNLESL--DLSGNQ--LTDLPEELANLTNLKELDLSN-------------NQLTDLPEPLGNLTNLKSLDLS--- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564353965 277 flEGHLDELFWWLK--TPLETLSVIDCNLSKsdwIHISEFQCTSqLKHLNLKWVKLTHLSPEplrillLKSASTLISLDL 354
Cdd:COG4886  168 --NNQLTDLPEELGnlTNLKELDLSNNQITD---LPEPLGNLTN-LEELDLSGNQLTDLPEP------LANLTNLETLDL 235

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564353965 355 EGCQMMDsqlsaiLPALRCCTQLTKFNFHGNYIS 388
Cdd:COG4886  236 SNNQLTD------LPELGNLTNLEELDLSNNQLT 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH