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Conserved domains on  [gi|1046858887|ref|XP_008768537|]
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DNA-binding protein Ikaros isoform X7 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416206)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
71-96 4.06e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1046858887  71 NLLRHIKLHSGEKPFKCHLCNYACRR 96
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 57-79 6.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.89e-04
                          10        20
                  ....*....|....*....|...
gi 1046858887  57 FQCNQCGASFTQKGNLLRHIKLH 79
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
1-130 1.93e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858887   1 MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQNS-KSDRGMGERPFQCNQCGASFTQKGNLLRHI--K 77
Cdd:COG5048   233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsV 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046858887  78 LHSGE--KPFKC--HLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEE 130
Cdd:COG5048   313 NHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
71-96 4.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1046858887  71 NLLRHIKLHSGEKPFKCHLCNYACRR 96
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 57-79 6.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.89e-04
                          10        20
                  ....*....|....*....|...
gi 1046858887  57 FQCNQCGASFTQKGNLLRHIKLH 79
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-130 1.93e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858887   1 MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQNS-KSDRGMGERPFQCNQCGASFTQKGNLLRHI--K 77
Cdd:COG5048   233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsV 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046858887  78 LHSGE--KPFKC--HLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEE 130
Cdd:COG5048   313 NHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
71-96 4.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1046858887  71 NLLRHIKLHSGEKPFKCHLCNYACRR 96
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 57-79 6.89e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.89e-04
                          10        20
                  ....*....|....*....|...
gi 1046858887  57 FQCNQCGASFTQKGNLLRHIKLH 79
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-130 1.93e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858887   1 MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQNS-KSDRGMGERPFQCNQCGASFTQKGNLLRHI--K 77
Cdd:COG5048   233 SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsV 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046858887  78 LHSGE--KPFKC--HLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEE 130
Cdd:COG5048   313 NHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
57-81 7.83e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 33.68  E-value: 7.83e-03
                          10        20
                  ....*....|....*....|....*
gi 1046858887  57 FQCNQCGASFTQKGNLLRHIKLHSG 81
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
33-153 9.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046858887  33 VPEDLSTSGAQQNSKSDRgmgerPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACR--RRDALTGHLRTHSVG 110
Cdd:COG5048    15 VLSSTPKSTLKSLSNAPR-----PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHLRTHHNN 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1046858887 111 KPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGMYPVIKE 153
Cdd:COG5048    90 PSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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